All Stories

  1. Hydroxyketone Tyrosinase Inhibitors: Mechanism of Action, Applications and Perspectives in Depigmentation and Melanoma Therapy
  2. Lepidium peruvianum as a Source of Compounds with Anticancer and Cosmetic Applications
  3. Discovery and in vitro Evaluation of Novel Serotonin 5‐HT2A Receptor Ligands Identified Through Virtual Screening
  4. The Depressiveness, Quality of Life and NEO-FFI Scale in Patients with Selected Genodermatoses
  5. Novel 1-(1-Arylimiazolin-2-Yl)-3-Arylalkilurea Derivatives with Modulatory Activity on Opioid MOP Receptors
  6. Caspases in Alzheimer’s Disease: Mechanism of Activation, Role, and Potential Treatment
  7. Neonatal Maternal Separation Induces Sexual Dimorphism in Brain Development: The Influence on Amino Acid Levels and Cognitive Disorders
  8. Experimental and Computational Structural Studies of 2,3,5-Trisubstituted and 1,2,3,5-Tetrasubstituted Indoles as Non-Competitive Antagonists of GluK1/GluK2 Receptors
  9. Current Approaches and Tools Used in Drug Development against Parkinson’s Disease
  10. Tuning Down the Pain – An Overview of Allosteric Modulation of Opioid Receptors: Mechanisms of Modulation, Allosteric Sites, Modulator Syntheses
  11. The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases
  12. Novel Positive Allosteric Modulators of µ Opioid Receptor—Insight from In Silico and In Vivo Studies
  13. Effects of the Positive Allosteric Modulator of Metabotropic Glutamate Receptor 5, VU-29, on Maintenance Association between Environmental Cues and Rewarding Properties of Ethanol in Rats
  14. Toxicity of Carlina Oxide—A Natural Polyacetylene from the Carlina acaulis Roots—In Vitro and in Vivo Study
  15. Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics
  16. New tirapazamine derivatives protect cardiomyocytes from doxorubicin toxicity
  17. Preferential Coupling of Dopamine D2S and D2L Receptor Isoforms with Gi1 and Gi2 Proteins—In Silico Study
  18. The effect of statins on psoriasis severity: a meta-analysis of randomized clinical trials
  19. Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs
  20. The Universal 3D QSAR Model for Dopamine D2 Receptor Antagonists
  21. Thyroid Peroxidase Activity is Inhibited by Phenolic Compounds—Impact of Interaction
  22. Role of N-terminus in function and dynamics of sirtuin 7: an in silico study
  23. In Vitro Evaluation of Sulforaphane and a Natural Analog as Potent Inducers of 5-Fluorouracil Anticancer Activity
  24. Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D2 Receptor Ligand
  25. Corrigendum to ‘Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line’ Food Chem Toxicol. 111 (2018) 1-8
  26. Potential Future of New Glutamate Agonists and Antagonists Development
  27. Molecular Modelling Approaches to Antibacterial Drug Design and Discovery
  28. Synthesis, Experimental and Computational Studies of N-(4-amino-6-oxo- 1,6-dihydropyrimidin-5-yl)benzamide
  29. Thermal and spectroscopic studies of 2,3,5-trisubstituted and 1,2,3,5-tetrasubstituted indoles as non-competitive antagonists of GluK1/GluK2 receptors
  30. Comparative molecular field analysis and molecular dynamics studies of the dopamine D2 receptor antagonists without a protonatable nitrogen atom
  31. Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line
  32. Protein–Protein Docking in Drug Design and Discovery
  33. Molecular mechanisms of allosteric probe dependence in μ opioid receptor
  34. Opportunities and Challenges in the Discovery of Allosteric Modulators of GPCRs
  35. Application of Raman spectroscopy for direct analysis of Carlina acanthifolia subsp. utzka root essential oil
  36. The influence of metallic impurities on the free silanol activity of commercial thin-layer chromatography adsorbents demonstrated by retention changes of basic/amphoteric compounds such as peptides
  37. Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors
  38. Recent Advances and Applications of Molecular Docking to G Protein-Coupled Receptors
  39. Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry
  40. Synthesis and Pharmacological Evaluation of Novel 1-(1,4-Alkylaryldisubstituted-4,5-dihydro-1H-imidazo)-3-substituted Urea Derivatives
  41. Influence of carboxylic ion-pairing reagents on retention of peptides in thin-layer chromatography systems with C18 silica-based adsorbents
  42. Inversion of type of separation system in planar chromatography of peptides, using C18 silica-based adsorbents
  43. Interplay between Two Allosteric Sites and Their Influence on Agonist Binding in Human μ Opioid Receptor
  44. The xanthophyll cycle pigments, violaxanthin and zeaxanthin, modulate molecular organization of the photosynthetic antenna complex LHCII
  45. Computational methods for studying G protein-coupled receptors (GPCRs)
  46. Fragmental Method KowWIN as the Powerful Tool for Prediction of Chromatographic Behavior of Novel Bioactive Urea Derivatives
  47. Activation and Allosteric Modulation of Human μ Opioid Receptor in Molecular Dynamics
  48. Synthesis, Structural Studies and Molecular Modelling of a Novel Imidazoline Derivative with Antifungal Activity
  49. Structural investigations of a series of 1,6-aryl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-ones with potential antinociceptive activity
  50. Synthesis, antiviral activity and structure–activity relationship of 1-(1-aryl-4,5-dihydro-1H-imidazoline)-3-chlorosulfonylureas and products of their cyclization
  51. Discovery of nitroaryl urea derivatives with antiproliferative properties
  52. The Pseudo-Michael Reaction of 2-Hydrazinylidene-1-Arylimidazolidines with Diethyl Ethoxymethylenemalonate
  53. Synthesis and antiviral activity of 1-(1,3-disubstitutedimidazolidyn-2-ylidene)-3-ethoxycarbonylmethylurea derivatives
  54. Synthesis, Central Nervous System Activity and Structure-Activity Relationships of Novel 1-(1-Alkyl-4-aryl-4,5-dihydro-1H-imidazo)-3-substituted Urea Derivatives
  55. Synthesis, central nervous system activity and structure–activity relationship of N-substituted derivatives of 1-arylimidazolidyn-2-ylideneurea and products of their cyclization
  56. Synthesis, in vitro and in vivo studies, and molecular modeling of N-alkylated dextromethorphan derivatives as non-competitive inhibitors of α3β4 nicotinic acetylcholine receptor
  57. Microwave-assisted preparation, structural characterization, lipophilicity, and anti-cancer assay of some hydroxycoumarin derivatives
  58. Modeling the Active Conformation of Human µ Opioid Receptor
  59. Synthesis and molecular docking of novel non-competitive antagonists of GluK2 receptor
  60. Synthesis, Pharmacological Activity and Molecular Modeling of 1-Aryl-7- hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones and their 6-Substituted Derivatives
  61. Synthesis, Experimental and Computational Spectroscopic Studies, and Formation Thermodynamics of Diethyl [[2-(1-Aryl-4,5-dihydro-1H-imidazol- 2-yl)hydrazinyl]methylene]propanedioates
  62. Synthesis, central nervous system activity, and structure–activity relationship of 1-aryl-6-benzyl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones
  63. Structural Studies on N-(1-naphthyl)-3-amino-5-oxo-4-phenyl-1Hpyrazole- 1-carboxamide with Antibacterial Activity
  64. Isothermal titration calorimetry in membrane protein research
  65. Structural studies, homology modeling and molecular docking of novel non-competitive antagonists of GluK1/GluK2 receptors
  66. Synthesis and molecular docking of indole and carbazole derivatives with potential pharmacological activity
  67. Experimental and computational studies on the tautomerism of N-substituted 3-amino-5-oxo-4-phenyl-1H-pyrazolo-1-carboxamides with antibacterial activity
  68. Nuclear Estrogen Receptors Co-activation Mechanisms
  69. The pseudo-Michael reaction of 1-aryl-4,5-dihydro-1H-imidazol-2-amines with ethyl ethoxymethylenecyanoacetate
  70. Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
  71. Structural and Molecular Docking Studies of 4-Benzyl-3-[(1-methylpyrrol- 2-yl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one with Anticancer Activity
  72. Novel Non-Competitive Antagonists of Kainate GluK1/GluK2 Receptors
  73. Usefulness of reversed-phase HPLC enriched with room temperature imidazolium based ionic liquids for lipophilicity determination of the newly synthesized analgesic active urea derivatives
  74. Synthesis of new derivatives of 9-aryl-3-ethoxycarbonylmethyl-2,4,5(9H)-trioxo- 7,8-dihydroimidazo[1,2-a][1,3,5]triazepine
  75. Synthesis of new derivatives of 1-[1-(2-pyridyl)-imidazolidine-2-ylidene]-3-aryl(arylakyl)ureas
  76. Experimental and theoretical investigations on the keto–enol tautomerism of 4-substituted 3-[1-methylpyrrol-2-yl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives
  77. 6-(2-Chlorobenzyl)-1-(4-chlorophenyl)-7-hydroxy-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one
  78. Molecular Structure of Ionotropic Glutamate Receptors
  79. Structure-based virtual screening for novel inhibitors of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase
  80. Modeling of Glutamate GluR6 Receptor and Its Interactions with Novel Noncompetitive Antagonists
  81. Synthesis of new derivatives of 9-aryl-2,5(9H)-dioxo-2,3,4,5,7,8-hexahydroimidazo[1,2-a][1,3,5]triazepine
  82. Distributed Drug Discovery, Part 2: Global Rehearsal of Alkylating Agents for the Synthesis of Resin-Bound Unnatural Amino Acids and Virtual D3 Catalog Construction
  83. 1-(3-Chlorophenyl)-3-(1-p-tolylimidazolidin-2-ylidene)urea
  84. Determination of the lipophilicity of selected isoquinoline alkaloids by RP-TLC
  85. Theoretical Studies on the Structure and Symmetry of the Transmembrane Region of Glutamatergic GluR5 Receptor
  86. Crystal Structure of 1-(4-Chlorophenyl)-5(1H)-oxo-2,3-dihydroimidazo[1,2-a]-pyrimidine-6-carbonitrile
  87. Standardized reversed-phase thin-layer chromatographic study of the lipophilicity of five anti-diabetic thiazolidinediones
  88. Electron ionization mass spectra of aryl- and benzyl-substituted 2,3-dihydroimidazo[1,2-a]pyrimidine-5,7(1H,6H)-diones
  89. Use of RP‐HPTLC Systems for the Determination of Lipophilicity of 3,5‐Dioxo‐4‐azatricyclo[5.2.2.02,6]undecanes–5‐HT1A Antagonists
  90. 6-Benzyl-7-hydroxy-1-(2-methoxyphenyl)-2,3-dihydro-1H,7H-imidazo[1,2-a]pyrimidin-5-one
  91. Electron ionization mass spectra of 8-aryl-3,4-dioxo-2H,8H-6,7-dihydroimidazo[2,1-c][1,2,4]triazines. Do they exhibit tautomerism in the gas phase?
  92. Electron ionization mass spectra of 8-aryl-3,4-dioxo-2H,8H-6,7-dihydroimidazo[2,1-c][1,2,4]triazines. Do they exhibit tautomerism in the gas phase?
  93. EMCA and DEEM as Michael Reagents Used in Organic Synthesis
  94. Antinociceptive activity of new imidazolidine carbonyl derivatives.
  95. Synthesis and Structure of 1-(4-chlorophenyl)-2-aminoimidazoline-2
  96. Properties and Application of a Chelating Sorbent Prepared by Modification of LiChroprep-NH 2 with Calcon
  97. Use of binary and ternary mobile phases in reversed-phase high performance liquid chromatographic separation of chiral compounds
  98. Effect of impregnation of silica gel with different zinc salts on the TLC behavior of aromatic hydrocarbons with polar groups
  99. Synthesis and Structure of 1-Methyl-5-(1-naphthyl)-2-aminoimidazoline-2 hydrobromide
  100. The psuedo-michael reaction of 2-aminoimidazolines 2. Part 1. Synthesis and structure assignment of isomeric 5(1H)-Oxo and 7(1H)-Oxo-2,3-dihydroimidazo[1,2-a]pyrimidine-6-carboxylates
  101. DETERMINATION OF CHIRAL DIAMINES BY LC-DAD AND LC WITH POLARIMETRIC DETECTION
  102. Effect of impregnation conditions on the structure and chromatographic behavior of TLC adsorbents modified with Cu(II) and Ni(II) salts
  103. Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine
  104. Non-peptide Opioid Receptor Ligands - Recent Advances. Part I - Agonists
  105. Non-peptide Opioid Receptor Ligands - Recent Advances. Part II - Antagonists
  106. Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine
  107. Comparison of retention of aromatic hydrocarbons with polar groups in binary reversed-phase high-performance liquid chromatography systems
  108. Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine Part 1. Synthesis and pharmacological activity of chain derivatives of 1-aryl-2-iminoimidazolidine containing urea moiety
  109. Electron ionisation induced fragmentation of ethyl 5(1H)-oxo- and 7(1H)-oxo-1-aryl-2,3-dihydroimidazo[1,2-a]-pyrimidine-6-carboxylates: evidence for an unusually regioselective rearrangement of M+? ions
  110. Electron-impact mass spectra of substituted 1-alkyl-2-arylsulphonylamino-1,4,5,6-tetrahydropyrimidines
  111. Electron Impact Mass Spectra of Substituted 1-Aryl-2-arylsulphonylamino-1,4,5,6-tetrahydropyrimidines
  112. Electron impact mass spectra of substituted 1-aryl-2-arylsulphonylamino-δ2-imidzazolines
  113. Synthesis of 1,6-Diaryl-5,7-dioxo(dithio)imidazo[1,2-a][1,3,5]triazines. A Novel Pathway for Imidazo[1,2-a] [1,3,5]triazine Systems Obtained via 1-(Imidazolin-2-yl)urea and Thiourea Derivatives