All Stories

  1. A high-resolution plasma proteomic framework for stratifying treatment resistance and ultra-resistance in schizophrenia
  2. Plasma but not salivary p-Tau181 reflects Alzheimer's disease in a Latin American Cohort
  3. Corticosterone-Induced Depression in Rats: Region-Specific and Time-Dependent Dysregulation of Glutamatergic Signaling, Synaptic Markers, and MMP-2 Expression
  4. Blood-based biomarkers of neuroaxonal and astroglial injury identify ultra-treatment-resistant schizophrenia
  5. The sleep-mood connection: Temperament modulates neuroinflammation, clock genes, and dopaminergic receptors expression in rats
  6. The Sleep-Mood Connection: Temperament Modulates Neuroinflammation, Clock Genes, and Dopaminergic Receptors Expression in Rats
  7. In silico Identification of Lanostane Triterpenes as GluN1-GluN2B NMDA Receptor Inhibitors
  8. Unraveling the role of the renin-angiotensin system in severe mental illnesses: An insight into psychopathology and cognitive deficits
  9. Age and sex-dependent gut alterations in mice induced by neonatal immune activation with lipopolysaccharide
  10. Long-term Environmental Enrichment Normalizes Schizophrenia-like Abnormalities and Promotes Hippocampal Slc6a4 Promoter Demethylation in Mice Submitted to a Two-hit Model
  11. Cyclooxygenase-2 inhibitors alleviated depressive and anxious-like behaviors in mice exposed to lipopolysaccharide: Involvement of oxidative stress and neuroinflammation
  12. Benzydamine induces apoptosis in astrocytes in vitro
  13. Targeting the Renin-Angiotensin System (RAS) for Neuropsychiatric Disorders
  14. tratamentos da loucura e a história dos antipsicóticos
  15. Persistence of anti-spike antibody in samples from 6-month infants correlates with anti-S IgG placental transfer ratio in a Brazilian Cohort
  16. Alpha Lipoic Acid for Schizophrenia: Future Investigations With Low Doses and Treatment-Resistant Patients—Reply to Letter by Kishi and Colleagues
  17. Decrease in cognitive performance and increase of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with higher doses of antipsychotics in women with schizophrenia: a cross-sectional study
  18. Immunoinflammatory and oxidative alterations in subjects with schizophrenia under clozapine: A meta-analysis
  19. Long-term environmental enrichment prevents schizophrenia-like abnormalities and promotes hippocampal Slc6a4 gene demethylation in mice submitted to a two-hit model
  20. Sex and the Estrous-Cycle Phase Influence the Expression of G Protein-Coupled Estrogen Receptor 1 (GPER) in Schizophrenia: Translational Evidence for a New Target
  21. α-Lipoic Acid as Adjunctive Treatment for Schizophrenia
  22. In vitro immunogenic profile of recombinant SARS-CoV2 S1-RBD peptide in murine macrophage and microglial cells
  23. The tetrapartite synapse in neuropsychiatric disorders: Matrix metalloproteinases (MMPs) as promising targets for treatment and rational drug design
  24. Sex and the estrous-cycle phase influence the expression of G protein-coupled estrogen receptor 1 (GPER) in schizophrenia: translational evidence for a new target.
  25. R- and S-ketamine abrogate lipopolysaccharide-induced depressive-like behavior through microglial modulation: a differential anti-inflammatory and neurotrophic effect of the enantiomers
  26. Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway
  27. Lectin isolated from the red marine alga Solieria filiformis (Kützing) P.W. Gabrielson: Secondary structure and antidepressant-like effect in mice submitted to the lipopolysaccharide-induced inflammatory model of depression
  28. Recombinant SARS-CoV2 S1-RBD peptide induces a concentration-dependent activation of macrophages and microglia cell lines in vitro
  29. Stress, Spirituality, and Altruism of Brazilian Medical Students during the COVID-19 Pandemic: A Cross-sectional Analysis
  30. Gut microbiota composition correlates with disease severity in myelodysplastic syndrome
  31. Animal Model of Neonatal Immune Challenge by Lipopolysaccharide: A Study of Sex Influence in Behavioral and Immune/Neurotrophic Alterations in Juvenile Mice
  32. Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway
  33. Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression
  34. Ad libitum consumption of milk supplemented with omega 3, 6, and 9 oils from infancy to middle age alters behavioral and oxidative outcomes in male mice
  35. Anxiolytic Effect of Carvedilol in Chronic Unpredictable Stress Model
  36. Involvement of oxidative pathways and BDNF in the antidepressant effect of carvedilol in a depression model induced by chronic unpredictable stress
  37. What Can We Learn from Animal Models to Study Schizophrenia?
  38. Correction to: Perinatal Inflammation and Adult Psychopathology
  39. Low-dose candesartan prevents schizophrenia-like behavioral alterations in a neurodevelopmental two-hit model of schizophrenia
  40. Shared metabolic and neuroimmune mechanisms underlying Type 2 Diabetes Mellitus and Major Depressive Disorder
  41. Involvement of anti-inflammatory, antioxidant, and BDNF up-regulating properties in the antipsychotic-like effect of the essential oil of Alpinia zerumbet in mice: a comparative study with olanzapine
  42. Doxycycline at subantimicrobial dose combined with escitalopram reverses depressive-like behavior and neuroinflammatory hippocampal alterations in the lipopolysaccharide model of depression
  43. Is Riparin III a promising drug in the treatment for depression?
  44. Early maternal separation enhances melanoma progression in adult female mice by immune mechanisms
  45. The role of the microbiota-gut-brain axis in neuropsychiatric disorders
  46. Sex influences in the preventive effects of peripubertal supplementation with N-3 polyunsaturated fatty acids in mice exposed to the two-hit model of schizophrenia
  47. Involvement of Anti-Inflammatory, Antioxidant, and BDNF Up-Regulating Properties in the Antipsychotic-Like Effect of the Essential Oil of Alpinia Zerumbet in Mice: A Comparative Study With Olanzapine
  48. Tetracyclines, a promise for neuropsychiatric disorders: from adjunctive therapy to the discovery of new targets for rational drug design in psychiatry
  49. Repurposing of Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations: A Valid Option to Control SARS-CoV-2-Associated Neuroinflammation?
  50. Bothrops pauloensis snake venom-derived Asp-49 and Lys-49 phospholipases A2 mediates acute kidney injury by oxidative stress and release of inflammatory cytokines
  51. Doxycycline reverses cognitive impairment, neuroinflammation and oxidative imbalance induced by D-amphetamine mania model in mice: A promising drug repurposing for bipolar disorder treatment?
  52. Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation
  53. Shared neuroimmune and oxidative pathways underpinning Chagas disease and major depressive disorder
  54. Stress, Spirituality and Altruism of Brazilian Medical Students during the Covid-19 Pandemic: A Cross-sectional Analysis
  55. CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders
  56. Protective Effects Of A Lipid Transfer Protein Isolated from Morinda citrifolia Seeds in Gentamicin-Induced Nephrotoxicity in Rats
  57. A Proline Derivative-Enriched Fraction from Sideroxylon obtusifolium Protects the Hippocampus from Intracerebroventricular Pilocarpine-Induced Injury Associated with Status Epilepticus in Mice
  58. Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression
  59. Involvement of monoaminergic targets in the antidepressant- and anxiolytic-like effects of the synthetic alkamide riparin IV: Elucidation of further mechanisms through pharmacological, neurochemistry and computational approaches
  60. The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder
  61. Phosphodiesterase-5 inhibitors: Shedding new light on the darkness of depression?
  62. Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells
  63. G Protein-Coupled Estrogen Receptor 1 (GPER) as a Novel Target for Schizophrenia Drug Treatment
  64. Correction to: Inflammation as a Mechanism of Bipolar Disorder Neuroprogression
  65. Inflammation as a Mechanism of Bipolar Disorder Neuroprogression
  66. Maternal Immune Activation as a Risk Factor for Schizophrenia: Evidence From Preclinical and Clinical Studies
  67. Sex and Age Influence in The Effects of Perinatal Immune Activation in Animals
  68. Bothrops alternatus Snake Venom Induces Cytokine Expression and Oxidative Stress on Renal Function
  69. Thymol reverses depression‐like behaviour and upregulates hippocampal BDNF levels in chronic corticosterone‐induced depression model in female mice
  70. Shared microglial mechanisms underpinning depression and chronic fatigue syndrome and their comorbidities
  71. A Link Between Plasma Microbial Translocation, Microbiome, and Autoantibody Development in First‐Degree Relatives of Systemic Lupus Erythematosus Patients
  72. N-acetylcysteine prevents schizophrenia-like symptoms
  73. Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats
  74. Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice
  75. Novel insights into the mechanisms underlying depression-associated experimental autoimmune encephalomyelitis
  76. Proconvulsant effects of sildenafil citrate on pilocarpine-induced seizures: Involvement of cholinergic, nitrergic and pro-oxidant mechanisms
  77. Evidence for Host Epigenetic Signatures Arising From Arbovirus Infections: A Systematic Review
  78. Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice
  79. Leptin Prevents Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of Dopamine Receptors
  80. N-3 polyunsaturated fatty acids and clozapine abrogates poly I: C-induced immune alterations in primary hippocampal neurons
  81. Peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and BDNF alterations
  82. Prevention of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: Involvement of brain antioxidant and BDNF upregulating properties
  83. Ivabradine possesses anticonvulsant and neuroprotective action in mice
  84. The effect of paroxetine, venlafaxine and bupropion administration alone and combined on spatial and aversive memory performance in rats
  85. Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations
  86. Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review
  87. Riparin II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms
  88. Sex influences in behavior and brain inflammatory and oxidative alterations in mice submitted to lipopolysaccharide-induced inflammatory model of depression
  89. Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression
  90. Antinociceptive activity of Riparin II from Aniba riparia: Further elucidation of the possible mechanisms
  91. Involvement of the dopaminergic system in the antidepressant-like effect of the lectin isolated from the red marine alga Solieria filiformis in mice
  92. Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer
  93. Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences
  94. IDO chronic immune activation and tryptophan metabolic pathway: A potential pathophysiological link between depression and obesity
  95. Antimanic activity of minocycline in a GBR12909-induced model of mania in mice: Possible role of antioxidant and neurotrophic mechanisms
  96. Early life experience contributes to the developmental programming of depressive-like behaviour, neuroinflammation and oxidative stress
  97. Effects of standard ethanolic extract from Erythrina velutina in acute cerebral ischemia in mice
  98. The translocator protein (18 kDa) and its role in neuropsychiatric disorders
  99. α-Lipoic Acid as Adjunctive Treatment for Schizophrenia
  100. The interplay between ventro striatal BDNF levels and the effects of valproic acid on the acquisition of ethanol-induced conditioned place preference in mice
  101. Average spectral power changes at the hippocampal electroencephalogram in schizophrenia model induced by ketamine
  102. Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone
  103. Two-hit model of schizophrenia induced by neonatal immune activation and peripubertal stress in rats: Study of sex differences and brain oxidative alterations
  104. In vitro anti-Candida activity of selective serotonin reuptake inhibitors against fluconazole-resistant strains and their activity against biofilm-forming isolates
  105. Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting Sex- and Age-related Behavioral and Immune/Neurotrophic Alterations in Mice: Relevance to Autism Spectrum Disorders
  106. Impact of the Chronic Omega-3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6-Hydroxydopamine in Rats
  107. Electroencephalographic study of chlorpromazine alone or combined with alpha-lipoic acid in a model of schizophrenia induced by ketamine in rats
  108. HIV antiretroviral drug Efavirenz induces anxiety-like and depression-like behavior in rats: evaluation of neurotransmitter alterations in the striatum
  109. Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood
  110. Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs
  111. Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness
  112. Telomere length in subjects with schizophrenia, their unaffected siblings and healthy controls: Evidence of accelerated aging
  113. N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats
  114. Antidepressant, antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice
  115. Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice
  116. Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression
  117. Antimanic-like activity of candesartan in mice: Possible involvement of antioxidant, anti-inflammatory and neurotrophic mechanisms
  118. Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review
  119. Gender and estrous cycle influences on behavioral and neurochemical alterations in adult rats neonatally administered ketamine
  120. Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms
  121. GBR 12909 administration as an animal model of bipolar mania: time course of behavioral, brain oxidative alterations and effect of mood stabilizing drugs
  122. Subchronic administration of riparin III induces antidepressive-like effects and increases BDNF levels in the mouse hippocampus
  123. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system
  124. Preclinical Evidences for an Antimanic Effect of Carvedilol
  125. Minocycline protects against oxidative damage and alters energy metabolism parameters in the brain of rats subjected to chronic mild stress
  126. Screening for bipolar depression in family medicine practices: Prevalence and clinical correlates
  127. Antifungal Activity of Naphthoquinoidal Compounds In Vitro against Fluconazole-Resistant Strains of Different Candida Species: A Special Emphasis on Mechanisms of Action on Candida tropicalis
  128. Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice
  129. Major depressive disorder in breast cancer: A critical systematic review of pharmacological and psychotherapeutic clinical trials
  130. Differences in eotaxin serum levels patients with recent onset and in chronic stable schizophrenia: A clue for understanding accelerating aging profile
  131. Synergistic Effect of the Flavonoid Catechin, Quercetin, or Epigallocatechin Gallate with Fluconazole Induces Apoptosis in Candida tropicalis Resistant to Fluconazole
  132. Evidences for a progressive microglial activation and increase in iNOS expression in rats submitted to a neurodevelopmental model of schizophrenia: Reversal by clozapine
  133. Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration
  134. N-Acetylcysteine Augmentation to Tranylcypromine in Treatment-Resistant Major Depression
  135. Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: Possible involvement of antioxidant and nitrergic pathways
  136. Affective temperaments and ego defense mechanisms associated with somatic symptom severity in a large sample
  137. Time course of the effects of lipopolysaccharide on prepulse inhibition and brain nitrite content in mice
  138. The Psychological Defensive Profile of Hemodialysis Patients and Its Relationship to Health-Related Quality of Life
  139. Effects of Agomelatine on Oxidative Stress in the Brain of Mice After Chemically Induced Seizures
  140. Effects of lithium on oxidative stress and behavioral alterations induced by lisdexamfetamine dimesylate: Relevance as an animal model of mania
  141. Is there a role for curcumin in the treatment of bipolar disorder?
  142. Augmentation therapy with alpha-lipoic acid and desvenlafaxine: A future target for treatment of depression?
  143. The relationship between affective temperaments, defensive styles and depressive symptoms in a large sample
  144. Angiotensin receptor blockers for bipolar disorder
  145. Synergistic Effects of Amiodarone and Fluconazole on Candida tropicalis Resistant to Fluconazole
  146. Antidepressant Effect of Aminophylline After Ethanol Exposure
  147. Antidepressant Combination Strategies for Major Depressive Disorder
  148. Screening for bipolar disorder in the primary care: A Brazilian survey
  149. Prevention of haloperidol-induced alterations in brain acetylcholinesterase activity by vitamins B co-administration in a rodent model of tardive dyskinesia
  150. Involvement of monoaminergic system in the antidepressant-like effect of riparin I fromAniba riparia(Nees) Mez (Lauraceae) in mice
  151. Effects of alpha-lipoic acid in an animal model of mania induced byd-amphetamine
  152. Antidepressant-like effect ofbis-eugenol in the mice forced swimming test: evidence for the involvement of the monoaminergic system
  153. Differences in vulnerability to nicotine-induced kindling between female and male periadolescent rats
  154. Anticonvulsant effects of agomelatine in mice
  155. Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice
  156. Reversal of cocaine withdrawal-induced anxiety by ondansetron, buspirone and propranolol
  157. Development and validation of the Intrinsic Religiousness Inventory (IRI)
  158. Animal models of prenatal immune challenge and their contribution to the study of schizophrenia: a systematic review
  159. Development and validation of the Intrinsic Religiousness Inventory (IRI)
  160. Anticonvulsant action of Calotropis procera latex proteins
  161. The relationship between religious coping, psychological distress and quality of life in hemodialysis patients
  162. Oxidative Stress and Epilepsy: Literature Review
  163. Validação da versão brasileira da escala de religiosidade de Duke (DUREL)
  164. Anti-inflammatory activities of the hydroalcoholic extracts from Erythrina velutina and E. mulungu in mice
  165. Susceptibility to caspofungin of Candida spp. strains isolated in Ceará, Northeastern Brazil
  166. (−)-α-Bisabolol-induced gastroprotection is associated with reduction in lipid peroxidation, superoxide dismutase activity and neutrophil migration
  167. B vitamins attenuate haloperidol-induced orofacial dyskinesia in rats
  168. Antidepressant-like effect of riparin II fromAniba ripariain mice: evidence for the involvement of the monoaminergic system
  169. Inhibition of ketamine-induced hyperlocomotion in mice by the essential oil of Alpinia zerumbet: possible involvement of an antioxidant effect
  170. Antidepressant-like effect of carvacrol (5-Isopropyl-2-methylphenol) in mice: involvement of dopaminergic system
  171. Ego defense mechanisms in COPD: impact on health-related quality of life and dyspnoea severity
  172. Implications of Efavirenz for Neuropsychiatry: A Review
  173. Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice
  174. Melatonin: Pharmacological Aspects and Clinical Trends
  175. Cocaine-induced status epilepticus and death generate oxidative stress in prefrontal cortex and striatum of mice
  176. Esquizofrenia: uma doença inflamatória?
  177. Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: Possible involvement of GABAergic system and antioxidant activity
  178. Central nervous system effects of the essential oil of the leaves of <I>Alpinia zerumbet</I> in mice
  179. Central nervous system effects of the essential oil of the leaves of Alpinia zerumbet in mice
  180. Gastroprotective activity of isopulegol on experimentally induced gastric lesions in mice: investigation of possible mechanisms of action
  181. Coumarin effects on amino acid levels in mice prefrontal cortex and hippocampus
  182. Sleep-disordered breathing and chronic atrial fibrillation
  183. CSC, an adenosine A2A receptor antagonist and MAO B inhibitor, reverses behavior, monoamine neurotransmission, and amino acid alterations in the 6-OHDA-lesioned rats
  184. Effects of Ethanol or Naltrexone after Ethanol Exposure on Plasma Levels of Hepatic Enzymes, Lipid Profile and Apolipoprotein in Rats
  185. Anticonvulsant activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu
  186. Neuroprotective effects of caffeine in the model of 6-hydroxydopamine lesion in rats
  187. Differential Effects of Cocaine-Induced Seizures and Lethality on M1-Like Muscarinic and Dopaminergic D1- and D2-Like Binding Receptors in Mice Brain
  188. Cocaine alters catalase activity in prefrontal cortex and striatum of mice
  189. Protective effects of N-acetylserotonin against 6-hydroxydopamine-induced neurotoxicity
  190. Cetamina: aspectos gerais e relação com a esquizofrenia
  191. Effect of anxiolytic, antidepressant, and antipsychotic drugs on cocaine-induced seizures and mortality
  192. Alterations in monoamine levels after cocaine-induced status epilepticus and death in striatum and prefrontal cortex of mice
  193. Effects of ethanol and haloperidol on plasma levels of hepatic enzymes, lipid profile, and apolipoprotein in rats
  194. Central activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice
  195. Cocaine Treatment Causes Early and Long-Lasting Changes in Muscarinic and Dopaminergic Receptors
  196. Effect of one-week ethanol treatment on monoamine levels and dopaminergic receptors in rat striatum
  197. Buspirona aumenta a densidade de receptores dopaminérgicos D2- símile em corpo estriado de rato
  198. Different times of withdrawal from cocaine administration cause changes in muscarinic and dopaminergic receptors in rat premotor cortex
  199. Effects of dopaminergic and cholinergic interactions on rat behavior
  200. Early Withdrawal From Repeated Cocaine Administration Upregulates Muscarinic and Dopaminergic D2-Like Receptors in Rat Neostriatum
  201. Effects of Dopaminergic Agonists and Antagonists on the Muscarinic and Dopaminergic Receptors from Rat Neostriatum