All Stories

  1. Asymmetric Synthesis of MK-7845, an Investigational Treatment for COVID-19

    Article • Organic Letters, October 2025, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  2. A Scalable Flow Electrolysis of Heterogeneous Mixtures Using a Rotating Cylinder Electrode Reactor: Access to a Chiral Iminophosphorane

    Article • Organic Process Research & Development, February 2025, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  3. Selective hydrogenolysis of organohalides

    Article • Nature Synthesis, February 2025, Springer Science + Business Media

    Dr. Dan Lehnherr

  4. Adoption of Electrochemistry within the Pharmaceutical Industry: Insights from an Industry-Wide Survey

    Article • Organic Process Research & Development, January 2025, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  5. Scalable Flow Electrosynthesis of Iminophosphoranes

    Article • Organic Process Research & Development, January 2025, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  6. Hydrogen Isotope Labeling of Pharmaceuticals Via Dual Hydrogen Isotope Exchange Pathways Using CdS Quantum Dot Photocatalyst

    Article • Journal of the American Chemical Society, November 2024, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  7. Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023)

    Article • Organic Process Research & Development, January 2024, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  8. Accelerating Pharmaceutical Process Development with an Acoustic Droplet Ejection-Multiple Reaction Monitoring-Mass Spectrometry Workflow

    Article • Analytical Chemistry, January 2024, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  9. Electrosynthesis of iminophosphoranes and applications in nickel catalysis

    Article • Chemical Science, January 2024, Royal Society of Chemistry

    Dr. Dan Lehnherr

  10. Industrial Applications of Asymmetric Oxidations

    Article • January 2024, Elsevier

    Dr. Dan Lehnherr

  11. Multigram Electrochemical Hofmann Rearrangement Using a Spinning Three-Dimensional Anode

    Article • Organic Process Research & Development, November 2023, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  12. Front Cover Picture: Copper‐Enabled Photo‐Sulfonylation of Aryl Halides Using Alkylsulfinates (Adv. Synth. Catal. 22/2023)

    Article • Advanced Synthesis & Catalysis, September 2023, Wiley

    Dr. Dan Lehnherr

  13. Quinone-mediated hydrogen anode for non-aqueous reductive electrosynthesis

    Article • Nature, August 2023, Springer Science + Business Media

    Dr. Dan Lehnherr

  14. High-Throughput Determination of Stern–Volmer Quenching Constants for Common Photocatalysts and Quenchers

    Article • ACS Organic & Inorganic Au, June 2023, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  15. Copper‐Enabled Photo‐Sulfonylation of Aryl Halides Using Alkylsulfinates

    Article • Advanced Synthesis & Catalysis, June 2023, Wiley

    Dr. Dan Lehnherr

  16. Emerging reaction technologies in pharmaceutical development: Challenges and opportunities in electrochemistry, photochemistry, and biocatalysis

    Article • Chemical Engineering Research and Design, April 2023, Elsevier

    Dr. Dan Lehnherr

  17. Overview of outer-sphere electron transfer mediators for electrosynthesis

    Article • January 2023, Elsevier

    Dr. Dan Lehnherr

  18. Pentacenones as Divergent Intermediates to Unsymmetrically Substituted Pentacenes: Synthesis and Crystallographic Analysis

    Article • The Journal of Organic Chemistry, November 2022, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  19. Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis

    Article • Organic Process Research & Development, July 2022, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  20. Parallel versus Twisted Pentacenes: Conformational Impact on Singlet Fission

    Article • The Journal of Physical Chemistry Letters, June 2022, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  21. Efficient Aliphatic Hydrogen-Isotope Exchange with Tritium Gas through the Merger of Photoredox and Hydrogenation Catalysts

    Article • Journal of the American Chemical Society, March 2022, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  22. Electrochemically driven cross-electrophile coupling of alkyl halides

    Article • Nature, February 2022, Springer Science + Business Media

    Dr. Dan Lehnherr

  23. Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination

    Article • Organic Process Research & Development, November 2021, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  24. Photons or Electrons? A Critical Comparison of Electrochemistry and Photoredox Catalysis for Organic Synthesis

    Article • Chemical Reviews, November 2021, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  25. Benzylic Photobromination for the Synthesis of Belzutifan: Elucidation of Reaction Mechanisms Using In Situ LED-NMR

    Article • The Journal of Organic Chemistry, September 2021, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  26. Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

    Article • ACS Central Science, August 2021, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  27. Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation–Cyclization Sequence to the Diaminopyrimidine Core

    Article • Organic Process Research & Development, October 2020, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  28. Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis

    Article • Organic Process Research & Development, October 2020, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  29. Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview

    Article • Organic Process Research & Development, October 2020, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  30. Generic Enhanced Sub/Supercritical Fluid Chromatography: Blueprint for Highly Productive and Sustainable Separation of Primary Hindered Amines

    Article • ACS Sustainable Chemistry & Engineering, March 2020, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  31. Synthesis of Sterically Hindered Primary Amines by Concurrent Tandem Photoredox Catalysis

    Article • Journal of the American Chemical Society, January 2020, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  32. Electrochemical Synthesis of Hindered Primary and Secondary Amines via Proton-Coupled Electron Transfer

    Article • Journal of the American Chemical Society, December 2019, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  33. Mechanistic Study of a Re-Catalyzed Monoalkylation of Phenols

    Article • Organometallics, October 2018, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  34. Discovery of a Photoinduced Dark Catalytic Cycle Using in Situ LED-NMR Spectroscopy

    Article • Journal of the American Chemical Society, September 2018, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  35. Alkyne Benzannulation Reactions for the Synthesis of Novel Aromatic Architectures

    Article • Accounts of Chemical Research, November 2017, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  36. Reductive Aromatization/Dearomatization and Elimination Reactions to Access Conjugated Polycyclic Hydrocarbons, Heteroacenes, and Cumulenes

    Article • ChemPlusChem, July 2017, Wiley

    Dr. Dan Lehnherr

  37. Diazatetracenes Derived from the Benzannulation of Acetylenes: Electronic Tuning via Substituent Effects and External Stimuli

    Article • The Journal of Organic Chemistry, January 2017, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  38. Rapid access to substituted 2-naphthyne intermediates via the benzannulation of halogenated silylalkynes

    Article • Chemical Science, January 2017, Royal Society of Chemistry

    Dr. Dan Lehnherr

  39. Tautomerization and Dimerization of 6,13-Disubstituted Derivatives of Pentacene

    Article • Chemistry - A European Journal, October 2016, Wiley

    Dr. Dan Lehnherr

  40. Synthesis, physical properties, and chemistry of donor/acceptor substituted pentacenes

    Article • Canadian Journal of Chemistry, October 2016, Canadian Science Publishing

    Dr. Dan Lehnherr

  41. Mechanism-Guided Development of a Highly Active Bis-thiourea Catalyst for Anion-Abstraction Catalysis

    Article • Journal of the American Chemical Society, October 2016, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  42. Conformational Control of Chiral Amido-Thiourea Catalysts Enables Improved Activity and Enantioselectivity

    Article • Organic Letters, July 2016, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  43. Anion-Abstraction Catalysis: The Cooperative Mechanism of α-Chloroether Activation by Dual Hydrogen-Bond Donors

    Article • ACS Catalysis, July 2016, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  44. On- and Off-Cycle Catalyst Cooperativity in Anion-Binding Catalysis

    Article • Journal of the American Chemical Society, June 2016, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  45. ChemInform Abstract: Regioselective Synthesis of Polyheterohalogenated Naphthalenes via the Benzannulation of Haloalkynes.

    Article • ChemInform, April 2016, Wiley

    Dr. Dan Lehnherr

  46. Solution-based intramolecular singlet fission in cross-conjugated pentacene dimers

    Article • Nanoscale, January 2016, Royal Society of Chemistry

    Dr. Dan Lehnherr

  47. Sequence-defined oligo(ortho-arylene) foldamers derived from the benzannulation of ortho(arylene ethynylene)s

    Article • Chemical Science, January 2016, Royal Society of Chemistry

    Dr. Dan Lehnherr

  48. Inside Cover: Regioselective Synthesis of Polyheterohalogenated Naphthalenes via the Benzannulation of Haloalkynes (Chem. Eur. J. 50/2015)

    Article • Chemistry - A European Journal, November 2015, Wiley

    Dr. Dan Lehnherr

  49. Regioselective Synthesis of Polyheterohalogenated Naphthalenes via the Benzannulation of Haloalkynes

    Article • Chemistry - A European Journal, October 2015, Wiley

    Dr. Dan Lehnherr

  50. Singlet fission in pentacene dimers

    Article • Proceedings of the National Academy of Sciences, April 2015, Proceedings of the National Academy of Sciences

    Dr. Dan Lehnherr

  51. Aryl substitution of pentacenes

    Article • Beilstein Journal of Organic Chemistry, July 2014, Beilstein Institut

    Dr. Dan Lehnherr

  52. Isomerically Pure syn -Anthradithiophenes: Synthesis, Properties, and FET Performance

    Article • Organic Letters, July 2012, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  53. Synthesis and Properties of Isomerically Pure Anthrabisbenzothiophenes

    Article • Organic Letters, January 2012, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  54. Conjugated Oligomers and Polymers Based on Anthracene, Tetracene, Pentacene, Naphthodithiophene, and Anthradithiophene Building Blocks

    Article • Australian Journal of Chemistry, January 2011, CSIRO Publishing

    Dr. Dan Lehnherr

  55. A Modular Synthetic Approach to Conjugated Pentacene Di-, Tri-, and Tetramers

    Article • Angewandte Chemie, July 2010, Wiley

    Dr. Dan Lehnherr

  56. A Modular Synthetic Approach to Conjugated Pentacene Di-, Tri-, and Tetramers

    Article • Angewandte Chemie, July 2010, Wiley

    Dr. Dan Lehnherr

  57. Oligomers and Polymers Based on Pentacene Building Blocks

    Article • Materials, April 2010, MDPI AG

    Dr. Dan Lehnherr

  58. Pentacene-Based Polycyclic Aromatic Hydrocarbon Dyads with Cofacial Solid-State π-Stacking

    Article • Chemistry - A European Journal, November 2009, Wiley

    Dr. Dan Lehnherr

  59. Pentacene-Based Dendrimers: Synthesis and Thin Film Photoconductivity Measurements of Branched Pentacene Oligomers

    Article • The Journal of Organic Chemistry, July 2009, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  60. ChemInform Abstract: Synthesis of Soluble Oligo- and Polymeric Pentacene-Based Materials.

    Article • ChemInform, March 2009, Wiley

    Dr. Dan Lehnherr

  61. ChemInform Abstract: Exploring Electronically Polarized Pentacenes.

    Article • ChemInform, February 2009, Wiley

    Dr. Dan Lehnherr

  62. Synthesis of soluble oligo- and polymeric pentacene-based materials

    Article • Tetrahedron, December 2008, Elsevier

    Dr. Dan Lehnherr

  63. Synthesis and Electronic Properties of Conjugated Pentacene Dimers

    Article • Organic Letters, November 2008, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  64. Exploring Electronically Polarized Pentacenes

    Article • Organic Letters, October 2008, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  65. Pentacene Oligomers and Polymers:  Functionalization of Pentacene to Afford Mono-, Di-, Tri-, and Polymeric Materials

    Article • Organic Letters, October 2007, American Chemical Society (ACS)

    Dr. Dan Lehnherr

  66. Formal Intramolecular Photoredox Chemistry of Meta-Substituted Benzophenones

    Article • Organic Letters, July 2005, American Chemical Society (ACS)

    Dr. Dan Lehnherr