All Stories

  1. Neutron scattering from myelin revisited: bilayer asymmetry and water-exchange kinetics

    Article • Acta Crystallographica Section D Biological Crystallography, November 2014, International Union of Crystallography

    Professor D.A. Kirschner

  2. Myelin Organization in the Nodal, Paranodal, and Juxtaparanodal Regions Revealed by Scanning X-Ray Microdiffraction

    Article • PLoS ONE, July 2014, PLOS

    Professor D.A. Kirschner

  3. A Bacteriophage Capsid Protein Provides a General Amyloid Interaction Motif (GAIM) That Binds and Remodels Misfolded Protein Assemblies

    Article • Journal of Molecular Biology, June 2014, Elsevier

    Dr Rajaraman Krishnan, Professor D.A. Kirschner

  4. 22 NPT002: a novel approach for targeting β-amyloid and tau aggregates in Alzheimer's disease

    Article • Neurobiology of Aging, May 2012, Elsevier

    Professor D.A. Kirschner

  5. Myelin structure is unaltered in chemotherapy-induced peripheral neuropathy

    Article • NeuroToxicology, January 2012, Elsevier

    Professor D.A. Kirschner

  6. P4‐412: NPT001: A candidate therapeutic for clearance of beta‐amyloid and tau aggregates in Alzheimer's disease

    Article • Alzheimer s & Dementia, July 2011, Wiley

    Dr Rajaraman Krishnan, Professor D.A. Kirschner

  7. P2‐456: NPT001: A candidate therapeutic for clearance of β‐amyloid and tau aggregates in Alzheimer's disease

    Article • Alzheimer s & Dementia, July 2011, Wiley

    Dr Rajaraman Krishnan, Professor D.A. Kirschner

  8. P0 (Protein Zero) Mutation S34C Underlies Instability of Internodal Myelin in S63C Mice

    Article • Journal of Biological Chemistry, October 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor D.A. Kirschner

  9. SCAP is required for timely and proper myelin membrane synthesis

    Article • Proceedings of the National Academy of Sciences, December 2009, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  10. Myelin: A One-Dimensional Biological “Crystal” for X-Ray and Neutron Scattering

    Article • April 2009, World Scientific Pub Co Pte Lt

    Professor D.A. Kirschner

  11. Myelin Structural Integrity in a Model for Human Early-Onset CMT1B

    Article • Biophysical Journal, February 2009, Elsevier

    Professor D.A. Kirschner

  12. Rapid assessment of internodal myelin integrity in central nervous system tissue

    Article • Journal of Neuroscience Research, January 2009, Wiley

    Professor D.A. Kirschner

  13. O3-05-01: A novel approach to screening inhibitors of amyloid formation

    Article • Alzheimer s & Dementia, July 2008, Elsevier

    Professor D.A. Kirschner

  14. Protein and Lipid Composition of Radial Component-Enriched CNS Myelin

    Article • Journal of Neurochemistry, June 2008, Wiley

    Professor D.A. Kirschner

  15. Fiber Diffraction As a Screen for Amyloid Inhibitors

    Article • Current Alzheimer Research, June 2008, Bentham Science Publishers

    Professor D.A. Kirschner

  16. Myelin structure and composition of myelinated tissue in the African lungfish

    Article • Neuron Glia Biology, May 2008, Cambridge University Press

    Professor D.A. Kirschner

  17. Peripheral myelin of Xenopus laevis: Role of electrostatic and hydrophobic interactions in membrane compaction

    Article • Journal of Structural Biology, April 2008, Elsevier

    Professor D.A. Kirschner

  18. Molecular characterization of myelin protein zero in Xenopus laevis peripheral nerve: Equilibrium between non-covalently associated dimer and monomer

    Article • International Journal of Mass Spectrometry, December 2007, Elsevier

    Professor D.A. Kirschner

  19. Cytoplasmic Domain of Zebrafish Myelin Protein Zero: Adhesive Role Depends on β-Conformation

    Article • Biophysical Journal, November 2007, Elsevier

    Professor D.A. Kirschner

  20. Refined Fibril Structures: The Hydrophobic Core in Alzheimer's Amyloid β-Protein and Prion as Revealed by X-ray Diffraction

    Article • September 2007, Wiley

    Professor D.A. Kirschner

  21. Peripheral nervous system manifestations in a Sandhoff disease mouse model: nerve conduction, myelin structure, lipid analysis

    Article • Journal of Negative Results in BioMedicine, July 2007, Springer Science + Business Media

    Professor D.A. Kirschner

  22. Cytoplasmic Domain of Human Myelin Protein Zero Likely Folded as β-Structure in Compact Myelin

    Article • Biophysical Journal, March 2007, Elsevier

    Professor D.A. Kirschner

  23. Myelin Structure and Composition in Zebrafish

    Article • Neurochemical Research, January 2007, Springer Science + Business Media

    Professor D.A. Kirschner

  24. Myelin Structure and Composition in Zebrafish

    Article • Neurochemical Research, September 2006, Springer Science + Business Media

    Professor D.A. Kirschner

  25. Gerstmann-Straussler-Scheinker Disease Amyloid Protein Polymerizes According to the "Dock-and-Lock" Model

    Article • Journal of Biological Chemistry, November 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor D.A. Kirschner

  26. Structure and Stability of Internodal Myelin in Mouse Models of Hereditary Neuropathy

    Article • Journal of Neuropathology & Experimental Neurology, November 2005, Oxford University Press (OUP)

    Professor D.A. Kirschner

  27. Poly-(L-alanine) expansions form core β-sheets that nucleate amyloid assembly

    Article • Proteins Structure Function and Bioinformatics, August 2005, Wiley

    Professor D.A. Kirschner

  28. P3-357 Structural properties of gerstmann-Sträussler-Scheinker disease amyloid protein

    Article • Neurobiology of Aging, July 2004, Elsevier

    Professor D.A. Kirschner

  29. O2-06-01 Protein folding and amyloid formation: studies on poly(L-alanine) and poly(L-glutamine)

    Article • Neurobiology of Aging, July 2004, Elsevier

    Professor D.A. Kirschner

  30. The P0 Gene

    Article • January 2004, Elsevier

    Professor D.A. Kirschner

  31. Structural Properties of Gerstmann-Sträussler-Scheinker Disease Amyloid Protein

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor D.A. Kirschner

  32. Effects of Rumpshaker Mutation on CNS Myelin Composition and Structure

    Article • Journal of Neurochemistry, November 2002, Wiley

    Professor D.A. Kirschner

  33. Molecular Organization of Amyloid Protofilament-Like Assembly of Betabellin 15D: Helical Array of β-Sandwiches

    Article • Biophysical Journal, September 2002, Elsevier

    Professor D.A. Kirschner

  34. Myelin protein zero exists as dimers and tetramers in native membranes ofXenopus laevis peripheral nerve

    Article • Journal of Neuroscience Research, February 2002, Wiley

    Professor D.A. Kirschner

  35. Expression and Purification of the Extracellular Domain of Human Myelin Protein Zero

    Article • Protein Expression and Purification, December 2001, Elsevier

    Professor D.A. Kirschner

  36. Twist and Sheet: Variations on the Theme of Amyloid

    Article • Journal of Structural Biology, June 2000, Elsevier

    Professor D.A. Kirschner

  37. Electron microscopy and X-ray diffraction studies further confirm the efficacy of PTI-000703™ (Cat's claw derivative) as a potent inhibitor of Alzheimer's beta-amyloid protein fibrillogenesis

    Article • Neurobiology of Aging, May 2000, Elsevier

    Professor D.A. Kirschner

  38. Multilamellar packing of myelin modeled by lipid-bound MBP

    Article • Journal of Neuroscience Research, February 2000, Wiley

    Professor D.A. Kirschner

  39. Histidine residues underlie Congo red binding to Aβ analogs

    Article • Amyloid, January 2000, Taylor & Francis

    Professor D.A. Kirschner

  40. Laminin inhibition of ?-amyloid protein (A?) fibrillogenesis and identification of an A? binding site localized to the globular domain repeats on the laminin a chain

    Article • Journal of Neuroscience Research, January 2000, Wiley

    Professor D.A. Kirschner

  41. Tetrameric Assembly of Full-Sequence Protein Zero Myelin Glycoprotein by Synchrotron X-Ray Scattering

    Article • Biophysical Journal, January 1999, Elsevier

    Professor D.A. Kirschner

  42. In VitroAmyloid Fibril Formation by Synthetic Peptides Corresponding to the Amino Terminus of apoSAA Isoforms from Amyloid-Susceptible and Amyloid-Resistant Mice

    Article • Journal of Structural Biology, December 1998, Elsevier

    Professor D.A. Kirschner

  43. Analysis of x-ray diffraction patterns from amyloid of biopsied vitreous humor and kidney of transthyretin (TTR) Met30 familial amyloidotic polyneuropathy (FAP) patients: axially arrayed TTR monomers constitute the protofilament

    Article • Amyloid, January 1998, Taylor & Francis

    Professor D.A. Kirschner

  44. Structural Analysis of Alzheimer's β(1–40) Amyloid: Protofilament Assembly of Tubular Fibrils

    Article • Biophysical Journal, January 1998, Elsevier

    Professor D.A. Kirschner

  45. Kinetic theory of fibrillogenesis of amyloid β-protein

    Article • Proceedings of the National Academy of Sciences, July 1997, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  46. Spinal cord myelin is vulnerable to decompression

    Article • Molecular and Chemical Neuropathology, April 1997, Springer Science + Business Media

    Professor D.A. Kirschner

  47. Membrane adhesion in peripheral myelin: good and bad wraps with protein P0

    Article • Structure, November 1996, Elsevier

    Professor D.A. Kirschner

  48. On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants.

    Article • Proceedings of the National Academy of Sciences, February 1996, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  49. 526 Kinetic analysis of all fibrillogenesis

    Article • Neurobiology of Aging, January 1996, Elsevier

    Professor D.A. Kirschner

  50. Immunolocalization of 17 and 21.5 kDa MBP isoforms in compact myelin and radial component

    Article • Journal of Neurocytology, January 1996, Springer Science + Business Media

    Professor D.A. Kirschner

  51. Implications of the sequence similarities between tau and myelin basic protein

    Article • Medical Hypotheses, September 1995, Elsevier

    Professor D.A. Kirschner

  52. Conformation and Fibrillogenesis of Alzheimer Aβ Peptides with Selected Substitution of Charged Residues

    Article • Journal of Molecular Biology, November 1994, Elsevier

    Professor D.A. Kirschner

  53. Mutations in demyelinating peripheral neuropathies support molecular model of myelin PO-glycoprotein extracellular domain

    Article • Journal of Neuroscience Research, September 1994, Wiley

    Professor D.A. Kirschner

  54. Membrane topology of PLP in CNS myelin: Evaluation of models

    Article • Neurochemical Research, August 1994, Springer Science + Business Media

    Professor D.A. Kirschner

  55. Mice deficient for the glycoprotein show subtle abnormalities in myelin

    Article • Neuron, July 1994, Elsevier

    Professor D.A. Kirschner, Dirk Montag

  56. Restricted hypotonic swelling of peripheral nerve myelin in streptozocin-induced diabetic rats

    Article • Journal of Neuroscience Research, June 1994, Wiley

    Professor D.A. Kirschner

  57. Myelin P0-Glycoprotein: Predicted Structure and Interactions of Extracellular Domain

    Article • Journal of Neurochemistry, December 1993, Wiley

    Professor D.A. Kirschner

  58. Thioridazine induces lipid peroxidation in myelin of rat brain

    Article • Neuropharmacology, February 1993, Elsevier

    Professor D.A. Kirschner

  59. Structure of beta-crystallite assemblies formed by Alzheimer beta-amyloid protein analogues: analysis by x-ray diffraction

    Article • Biophysical Journal, February 1993, Elsevier

    Professor D.A. Kirschner

  60. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogs of Alzheimer amyloid .beta.-protein

    Article • Biochemistry, November 1992, American Chemical Society (ACS)

    Professor D.A. Kirschner

  61. Effects of Sulfate Ions on Alzheimer ?/A4 Peptide Assemblies: Implications for Amyloid Fibril-Proteoglycan Interactions

    Article • Journal of Neurochemistry, October 1992, Wiley

    Professor D.A. Kirschner

  62. Is myelin basic protein crystallizable?

    Article • Neurochemical Research, February 1992, Springer Science + Business Media

    Professor D.A. Kirschner

  63. Amyloid-like properties of a synthetic peptide corresponding to the carboxy terminus of β-amyloid protein precursor

    Article • Archives of Biochemistry and Biophysics, January 1992, Elsevier

    Professor D.A. Kirschner

  64. pH-dependent structural transitions of Alzheimer amyloid peptides

    Article • Biophysical Journal, November 1991, Elsevier

    Professor D.A. Kirschner

  65. Morphology and antibody recognition of synthetic ?-amyloid peptides

    Article • Journal of Neuroscience Research, April 1991, Wiley

    Professor D.A. Kirschner

  66. P0-glycoprotein of myelin: Orientation of its extracellular domain in homophilic adhesion

    Article • Journal of Neuroimmunology, January 1991, Elsevier

    Professor D.A. Kirschner

  67. Quantitative Differences between Homozygous 'USA' and 'Swiss' mldMutant Mice

    Article • Developmental Neuroscience, January 1991, Karger Publishers

    Professor D.A. Kirschner

  68. Folding and function of the myelin proteins from primary sequence data

    Article • Journal of Neuroscience Research, January 1991, Wiley

    Professor D.A. Kirschner

  69. Morphology, conformation and stability of Alzheimer β-amyloid peptide fibrils

    Article • January 1991, Springer Science + Business Media

    Professor D.A. Kirschner

  70. Fine-Structure and Supramolecular Organization of the Radial Component of CNS Myelin

    Article • Annals of the New York Academy of Sciences, November 1990, Wiley

    Professor D.A. Kirschner

  71. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

    Article • Science, October 1990, American Association for the Advancement of Science

    Professor D.A. Kirschner

  72. Radial component of CNS myelin: Junctional subunit structure and supramolecular assembly

    Article • Journal of Neurocytology, April 1990, Springer Science + Business Media

    Professor D.A. Kirschner

  73. Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic .beta.-protein fragments

    Article • Biochemistry, March 1990, American Chemical Society (ACS)

    Professor D.A. Kirschner

  74. Phylogenetic Aspects of Myelin Structure

    Article • January 1990, Springer Science + Business Media

    Professor D.A. Kirschner

  75. Myelin Membrane Structure and Composition Correlated: A Phylogenetic Study

    Article • Journal of Neurochemistry, November 1989, Wiley

    Professor D.A. Kirschner

  76. X-ray diffraction analysis of myelin lipid/proteolipid protein multilayers

    Article • Journal of Neuroscience Research, October 1989, Wiley

    Professor D.A. Kirschner

  77. Membrane structure in isolated and intact myelins

    Article • Biophysical Journal, July 1989, Elsevier

    Professor D.A. Kirschner

  78. Proton magnetic resonance in myelin deficient brains of mutant mice

    Article • Journal of the Neurological Sciences, June 1989, Elsevier

    Professor D.A. Kirschner

  79. Orientation of Proteolipid Protein in Myelin: Comparison of Models with X-Ray Diffraction Measurements

    Article • Developmental Neuroscience, January 1989, Karger Publishers

    Professor D.A. Kirschner

  80. Membrane Interactions Are Altered in Myelin Isolated from Central and Peripheral Nervous System Tissues

    Article • Journal of Neurochemistry, July 1988, Wiley

    Professor D.A. Kirschner

  81. Membrane interactions in nerve myelin: II. Determination of surface charge from biochemical data

    Article • Biophysical Journal, February 1988, Elsevier

    Professor D.A. Kirschner

  82. Membrane interactions in nerve myelin. I. Determination of surface charge from effects of pH and ionic strength on period

    Article • Biophysical Journal, February 1988, Elsevier

    Professor D.A. Kirschner

  83. Comparison of amyloid from Alzheimer’s disease with synthetic peptide

    Article • January 1988, Springer Science + Business Media

    Professor D.A. Kirschner

  84. Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.

    Article • Proceedings of the National Academy of Sciences, October 1987, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  85. 171 Hl-NMR RELAXATION TIMES IN MYELIN DEFICIENT BRAINS OF MUTANT MICE

    Article • Investigative Radiology, September 1986, Wolters Kluwer Health

    Professor D.A. Kirschner

  86. X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.

    Article • Proceedings of the National Academy of Sciences, January 1986, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  87. Shiverer and Normal Peripheral Myelin Compared: Basic Protein Localization, Membrane Interactions, and Lipid Composition

    Article • Journal of Neurochemistry, December 1985, Wiley

    Professor D.A. Kirschner

  88. Effects of ZnCl2 on membrane interactions in myelin of normal and shiverer mice

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, October 1984, Elsevier

    Professor D.A. Kirschner

  89. Diffraction Studies of Molecular Organization and Membrane Interactions in Myelin

    Article • January 1984, Springer Science + Business Media

    Professor D.A. Kirschner

  90. Myelin Membrane from Adrenoleukodystrophy Brain White Matter?Biochemical Properties

    Article • Journal of Neurochemistry, August 1983, Wiley

    Professor D.A. Kirschner

  91. Triethyl tin-induced myelin oedema: an intermediate swelling state detected by X-ray diffraction

    Article • Journal of Neurocytology, August 1982, Springer Science + Business Media

    Professor D.A. Kirschner

  92. Myelin labeled with mercuric chloride

    Article • Journal of Molecular Biology, June 1982, Elsevier

    Professor D.A. Kirschner

  93. Structure of myelin lipid bilayers

    Article • Journal of Molecular Biology, February 1982, Elsevier

    Professor D.A. Kirschner

  94. Processing for electron microscopy alters membrane structure and packing in myelin

    Article • Journal of Ultrastructure Research, November 1980, Elsevier

    Professor D.A. Kirschner

  95. Compact myelin exists in the absence of basic protein in the shiverer mutant mouse

    Article • Nature, January 1980, Springer Science + Business Media

    Professor D.A. Kirschner

  96. X-ray diffraction study of the kinetics of myelin lattice swelling. Effect of divalent cations

    Article • Biophysical Journal, November 1979, Elsevier

    Ph.D. Raúl Padrón, Professor D.A. Kirschner

  97. Structural states of myelin observed by x-ray diffraction and freeze- fracture electron microscopy

    Article • The Journal of Cell Biology, July 1979, Rockefeller University Press

    Professor D.A. Kirschner

  98. Diffraction Studies of Molecular Organization in Myelin

    Article • January 1977, Springer Science + Business Media

    Professor D.A. Kirschner

  99. Morphological evidence of alteration in myelin structure with maturation

    Article • Brain Research, September 1976, Elsevier

    Professor D.A. Kirschner

  100. X-ray diffraction study of myelin structure in immature and mutant mice

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, September 1976, Elsevier

    Professor D.A. Kirschner

  101. Myelin structure transformed by dimethylsulfoxide.

    Article • Proceedings of the National Academy of Sciences, September 1975, Proceedings of the National Academy of Sciences

    Professor D.A. Kirschner

  102. COMPARATIVE X-RAY AND NEUTRON DIFFRACTION FROM NERVE MYELIN MEMBRANES

    Article • January 1974, Elsevier

    Professor D.A. Kirschner

  103. COMPARATIVE DIFFRACTION STUDIES ON MYELIN MEMBRANES*

    Article • Annals of the New York Academy of Sciences, June 1972, Wiley

    Professor D.A. Kirschner

  104. Alzheimer’s β-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding

    Article • Springer Science + Business Media

    Professor D.A. Kirschner

  105. Electron Microscopy and X-ray Diffraction Studies further Confirm the Efficacy of PTI-00703® (Cat's Claw Derivative) as a Potential Inhibitor of Alzheimer's β-Amyloid Protein Fibrillogenesis

    Article • Wiley

    Professor D.A. Kirschner