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  1. The Dilated Cardiomyopathy E525K Mutation Stabilizes the Cardiac Myosin Interacting-Heads Motif While Activating the Isolated Motor Domain

    Article • October 2026, openRxiv

    Ph.D. Raúl Padrón

  2. The structure of the cardiac thick filament helps improve risk assessment of HCM patients

    Article • Proceedings of the National Academy of Sciences, June 2026, Proceedings of the National Academy of Sciences

    Ph.D. Raúl Padrón

  3. Cryo-EM reveals how cardiomyopathy therapeutic drugs modulate the myosin motors of the heart

    Article • Science Advances, May 2026, American Association for the Advancement of Science

    Ph.D. Raúl Padrón

  4. Comparing cryo-EM structures of the vertebrate cardiac muscle thick filament

    Article • Biophysical Reviews, January 2026, Springer Science + Business Media

    Ph.D. Raúl Padrón

  5. Cryo-EM Reveals How Cardiomyopathy Therapeutic Drugs Modulate the Myosin Motors of the Heart

    Article • October 2025, Cold Spring Harbor Laboratory Press

    Ph.D. Raúl Padrón

  6. “QuickStainer”: a rapid negative staining device for improved preservation of molecular structure

    Article • October 2025, Cold Spring Harbor Laboratory Press

    Ph.D. Raúl Padrón

  7. Thick filament molecular interfaces play a critical role in pathogenesis of hypertrophic and dilated cardiomyopathy

    Article • October 2025, Cold Spring Harbor Laboratory Press

    Ph.D. Raúl Padrón

  8. Dominant myosin storage myopathy mutations disrupt striated muscles in Drosophila and the myosin tail–tail interactome of human cardiac thick filaments

    Article • Genetics, November 2024, Oxford University Press (OUP)

    Ph.D. Raúl Padrón

  9. Cryo-EM structure of the human cardiac myosin filament

    Article • Nature, November 2023, Springer Science + Business Media

    Ph.D. Raúl Padrón

  10. Cryo-EM structure of the human cardiac myosin filament

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Ph.D. Raúl Padrón

  11. Variants of the myosin interacting-heads motif

    Article • Journal of General Physiology, November 2022, Rockefeller University Press

    Ph.D. Raúl Padrón

  12. Interacting-heads motif explains the X-ray diffraction pattern of relaxed vertebrate skeletal muscle

    Article • Biophysical Journal, April 2022, Elsevier

    Ph.D. Raúl Padrón

  13. Structural basis of the super- and hyper-relaxed states of myosin II

    Article • Journal of General Physiology, December 2021, Rockefeller University Press

    Ph.D. Raúl Padrón

  14. Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms

    Article • Journal of General Physiology, January 2021, Rockefeller University Press

    Ph.D. Raúl Padrón

  15. Cryo-EM structure of the inhibited (10S) form of myosin II

    Article • Nature, December 2020, Springer Science + Business Media

    Ph.D. Raúl Padrón

  16. The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms

    Article • Proceedings of the National Academy of Sciences, May 2020, Proceedings of the National Academy of Sciences

    Ph.D. Raúl Padrón

  17. Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

    Article • Circulation, March 2020, Wolters Kluwer Health

    Ph.D. Raúl Padrón, Christopher Chen

  18. 18O labeling on Ser45 but not on Ser35 supports the cooperative phosphorylation mechanism on tarantula thick filament activation

    Article • Biochemical and Biophysical Research Communications, March 2020, Elsevier

    Ph.D. Raúl Padrón

  19. Interacting-heads motif has been conserved since before the origin of animals

    Article • Proceedings of the National Academy of Sciences, February 2018, Proceedings of the National Academy of Sciences

    Ph.D. Raúl Padrón

  20. Lessons from a tarantula: new insights into muscle thick filament and myosin interacting-heads motif structure and function

    Article • Biophysical Reviews, September 2017, Springer Science + Business Media

    Ph.D. Raúl Padrón

  21. Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease

    Article • Biophysical Reviews, September 2017, Springer Science + Business Media

    Ph.D. Raúl Padrón

  22. Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

    Article • eLife, June 2017, eLife

    Ph.D. Raúl Padrón

  23. Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis

    Article • Journal of Molecular Biology, March 2016, Elsevier

    Ph.D. Raúl Padrón

  24. An invertebrate smooth muscle with striated muscle myosin filaments

    Article • Proceedings of the National Academy of Sciences, October 2015, Proceedings of the National Academy of Sciences

    Ph.D. Raúl Padrón

  25. Tarantula myosin free head regulatory light chain phosphorylation stiffens N-terminal extension, releasing it and blocking its docking back

    Article • Molecular BioSystems, May 2015, Oxford University Press (OUP)

    Ph.D. Raúl Padrón

  26. Sequential myosin phosphorylation activates tarantula thick filament via a disorder–order transition

    Article • Molecular BioSystems, May 2015, Oxford University Press (OUP)

    Ph.D. Raúl Padrón

  27. Improved Imaging, 3D Reconstruction and Homology Modeling of Tarantula Thick Filaments

    Article • Biophysical Journal, January 2015, Elsevier

    Ph.D. Raúl Padrón

  28. The Inhibited, Interacting-Heads Motif Characterizes Myosin II from the Earliest Animals with Muscles

    Article • Biophysical Journal, January 2015, Elsevier

    Ph.D. Raúl Padrón

  29. A method for 3D-reconstruction of a muscle thick filament using the tilt series images of a single filament electron tomogram

    Article • Journal of Structural Biology, May 2014, Elsevier

    Ph.D. Raúl Padrón

  30. Corrigendum to “A Molecular Model of Phosphorylation-Based Activation and Potentiation of Tarantula Muscle Thick Filaments” [J. Mol. Biol. 414 (2011) 44–61]

    Article • Journal of Molecular Biology, January 2014, Elsevier

    Ph.D. Raúl Padrón

  31. Schistosome Muscles Contain Striated Muscle-Like Myosin Filaments in a Smooth Muscle-Like Architecture

    Article • Biophysical Journal, January 2014, Elsevier

    Ph.D. Raúl Padrón

  32. Different Head Environments in Tarantula Thick Filaments Support a Cooperative Activation Process

    Article • Biophysical Journal, November 2013, Elsevier

    Ph.D. Raúl Padrón

  33. The myosin interacting-heads motif is present in the relaxed thick filament of the striated muscle of scorpion

    Article • Journal of Structural Biology, December 2012, Elsevier

    Ph.D. Raúl Padrón

  34. A Molecular Model of Phosphorylation-Based Activation and Potentiation of Tarantula Muscle Thick Filaments

    Article • Journal of Molecular Biology, November 2011, Elsevier

    Ph.D. Raúl Padrón

  35. Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle

    Article • Proceedings of the National Academy of Sciences, June 2011, Proceedings of the National Academy of Sciences

    Ph.D. Raúl Padrón

  36. Matching structural densities from different biophysical origins with gain and bias

    Article • Journal of Structural Biology, March 2011, Elsevier

    Ph.D. Raúl Padrón

  37. Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity

    Article • Journal of Molecular Biology, December 2008, Elsevier

    Ph.D. Raúl Padrón

  38. Understanding the Organisation and Role of Myosin Binding Protein C in Normal Striated Muscle by Comparison with MyBP-C Knockout Cardiac Muscle

    Article • Journal of Molecular Biology, December 2008, Elsevier

    Ph.D. Raúl Padrón

  39. Blebbistatin Stabilizes the Helical Order of Myosin Filaments by Promoting the Switch 2 Closed State

    Article • Biophysical Journal, October 2008, Elsevier

    Ph.D. Raúl Padrón

  40. Electron Tomography Reveals the Structure of the C-Zone in Striated Muscle

    Article • Microscopy and Microanalysis, August 2007, Oxford University Press (OUP)

    Ph.D. Raúl Padrón

  41. Electron tomography reveals the structure of the C-zone in striated muscle

    Article • Journal of Molecular and Cellular Cardiology, June 2007, Elsevier

    Ph.D. Raúl Padrón

  42. WITHDRAWN: Electron tomography reveals the structure of the C-zone in striated muscle

    Article • Journal of Molecular and Cellular Cardiology, March 2007, Elsevier

    Ph.D. Raúl Padrón

  43. Atomic model of a myosin filament in the relaxed state

    Article • Nature, August 2005, Springer Science + Business Media

    Ph.D. Raúl Padrón

  44. Helical Order in Tarantula Thick Filaments Requires the “Closed” Conformation of the Myosin Head

    Article • Journal of Molecular Biology, September 2004, Elsevier

    Ph.D. Raúl Padrón

  45. Heterogeneity of Z-band Structure Within a Single Muscle Sarcomere: Implications for Sarcomere Assembly

    Article • Journal of Molecular Biology, September 2003, Elsevier

    Ph.D. Raúl Padrón

  46. Venezuela: the other side of the story

    Article • Nature, March 2003, Springer Science + Business Media

    Ph.D. Raúl Padrón

  47. Purification of Native Myosin Filaments from Muscle

    Article • Biophysical Journal, November 2001, Elsevier

    Ph.D. Raúl Padrón

  48. Article • Journal of Muscle Research and Cell Motility, January 2001, Springer Science + Business Media

    Ph.D. Raúl Padrón

  49. A new model for the surface arrangement of myosin molecules in tarantula thick filaments

    Article • Journal of Molecular Biology, September 2000, Elsevier

    Ph.D. Raúl Padrón

  50. A new model for the surface arrangement of myosin molecules in tarantula thick filaments

    Article • Journal of Molecular Biology, April 2000, Elsevier

    Ph.D. Raúl Padrón

  51. Towards an atomic model of the thick filaments of muscle 1 1Edited by W. Baumeister

    Article • Journal of Molecular Biology, January 1998, Elsevier

    Ph.D. Raúl Padrón

  52. The action of local anesthetics on myelin structure and nerve conduction in toad sciatic nerve

    Article • Biophysical Journal, June 1997, Elsevier

    Ph.D. Raúl Padrón

  53. Use of Morphology Index Histograms to Quantify Populations of the Fungal Pathogen Paracoccidioides Brasiliensis

    Article • Microbiology, January 1997, Society for General Microbiology

    Ph.D. Raúl Padrón

  54. Three-Dimensional Reconstruction of Thick Filaments from Rapidly Frozen, Freeze-Substituted Tarantula Muscle

    Article • Journal of Structural Biology, November 1995, Elsevier

    Ph.D. Raúl Padrón

  55. Direct Visualization of Myosin Filament Symmetry in Tarantula Striated Muscle by Electron Microscopy

    Article • Journal of Structural Biology, July 1993, Elsevier

    Ph.D. Raúl Padrón

  56. Structure of the myosin filaments of relaxed and rigor vertebrate striated muscle studied by rapid freezing electron microscopy

    Article • Journal of Molecular Biology, November 1992, Elsevier

    Ph.D. Raúl Padrón

  57. Visualization of myosin helices in sections of rapidly frozen relaxed tarantula muscle

    Article • Journal of Structural Biology, May 1992, Elsevier

    Ph.D. Raúl Padrón

  58. Direct determination of myosin filament symmetry in scallop striated adductor muscle by rapid freezing and freeze substitution

    Article • Journal of Molecular Biology, July 1991, Elsevier

    Ph.D. Raúl Padrón

  59. X-ray diffraction study of the structural changes accompanying phosphorylation of tarantula muscle

    Article • Journal of Muscle Research and Cell Motility, June 1991, Springer Science + Business Media

    Ph.D. Raúl Padrón

  60. Disorder induced in nonoverlap myosin cross-bridges by loss of adenosine triphosphate

    Article • Biophysical Journal, November 1989, Elsevier

    Ph.D. Raúl Padrón

  61. A method for quick‐freezing live muscles at known instants during contraction with simultaneous recording of mechanical tension

    Article • Journal of Microscopy, August 1988, Wiley

    Ph.D. Raúl Padrón

  62. Arrangement of the heads of myosin in relaxed thick filaments from tarantula muscle

    Article • Journal of Molecular Biology, August 1985, Elsevier

    Ph.D. Raúl Padrón

  63. The effect of the ATP analogue AMPPNP on the structure of crossbridges in vertebrate skeletal muscles: X-ray diffraction and mechanical studies

    Article • Journal of Muscle Research and Cell Motility, December 1984, Springer Science + Business Media

    Ph.D. Raúl Padrón

  64. X-ray diffraction evidence that actin is a 100 Å filament

    Article • Nature, January 1984, Springer Science + Business Media

    Ph.D. Raúl Padrón

  65. Repetitive propagation of action potentials destabilizes the structure of the myelin sheath. A dynamic x-ray diffraction study

    Article • Biophysical Journal, August 1982, Elsevier

    Ph.D. Raúl Padrón

  66. The effect of the repetitive propagation of action potentials on the structure of toad sciatic nerve myelin membranes: An X-ray diffraction study at 11 Å resolution

    Article • Journal of Neuroscience Research, January 1980, Wiley

    Ph.D. Raúl Padrón

  67. X-ray diffraction study of the kinetics of myelin lattice swelling. Effect of divalent cations

    Article • Biophysical Journal, November 1979, Elsevier

    Ph.D. Raúl Padrón, Professor D.A. Kirschner

  68. A dynamic X-ray diffraction study of anesthesia action. Thickening of the myelin membrane by n-pentane

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, April 1979, Elsevier

    Ph.D. Raúl Padrón

  69. Small‐angle X‐ray scattering study of human serum low‐density lipoproteins with differential reactivity for an arterial proteoglycan

    Article • Journal of Supramolecular Structure, January 1977, Wiley

    Ph.D. Raúl Padrón