Dr Christopher A Lipinski

The rule of five should not impede anti-parasitic drug development

• International Journal for Parasitology Drugs and Drug Resistance
• August 2017

Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemi...

• Advanced Drug Delivery Reviews
• June 2016

Badapple: promiscuity patterns from noisy evidence

• Journal of Cheminformatics
• May 2016

simple proxies for enthalpy and entropy

• Pharmaceutical Research
• August 2015

small molecules active against Ebola

• F1000Research
• February 2015

Associated challenges with the divergent expansions of public and commercial sources of...

• Journal of Medicinal Chemistry
• December 2014

Modeling the decisions of a medicinal chemist

• Journal of Chemical Information and Computer Sciences
• October 2014

A Perspective on the Evolution of Collaborative Drug Discovery and Future Challenges

• April 2014

My Perspective on Time, Managers—and Scientific Fun

• January 2013

Experimental and computational approaches to estimate solubility and permeability in dr...

• Advanced Drug Delivery Reviews
• December 2012

PhenotypicIn VivoScreening to Identify New, Unpredicted Indications for Existing Drugs ...

• April 2012

MLR-1023 Is a Potent and Selective Allosteric Activator of Lyn Kinase In Vitro That Imp...

• Journal of Pharmacology and Experimental Therapeutics
• April 2012

The Lyn Kinase Activator MLR-1023 Is a Novel Insulin Receptor Potentiator that Elicits ...

• Journal of Pharmacology and Experimental Therapeutics
• March 2012

Chapter 6. Phenotypic and In Vivo Screening: Lead Discovery and Drug Repurposing

• January 2012

Drug repurposing

• Drug Discovery Today Therapeutic Strategies
• December 2011

Analysis and hit filtering of a very large library of compounds screened against Mycoba...

• Molecular BioSystems
• January 2010

Erratum: A crowdsourcing evaluation of the NIH chemical probes

• August 2009

A crowdsourcing evaluation of the NIH chemical probes

• July 2009

Beautiful Biology But Bad Chemistry: Recognizing Chemistry Problems Earlier Rather Than...

• Antiviral Research
• May 2009

Overview of Hit to Lead: The Medicinal Chemist's Role from HTS Retest to Lead Optimizat...

• January 2009

Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trif...

• Bioorganic & Medicinal Chemistry Letters
• April 2008

Drug Solubility in Water and Dimethylsulfoxide

• March 2008

Compound Properties and Drug Quality

• January 2008

CHRISTOPHER LIPINSKI

• Chemical & Engineering News
• November 2007

The anti-intellectual effects of intellectual property

• Current Opinion in Chemical Biology
• August 2006

High Throughput Sonication: Evaluation for Compound Solubilization

• Combinatorial Chemistry & High Throughput Screening
• September 2005

Capter 11 Filtering in Drug Discovery

• January 2005

Chemical Tools for Indications Discovery

• January 2005

Navigating chemical space for biology and medicine

• December 2004

Lead- and drug-like compounds: the rule-of-five revolution

• Drug Discovery Today Technologies
• December 2004

Solubility in the Design of Combinatorial Libraries

• January 2004

COMPOUND PROPERTIES AND DRUG QUALITY

• January 2003

Chris Lipinski discusses life and chemistry after the Rule of Five

• Drug Discovery Today
• January 2003

Single-Mode Compound Retrieval for QSAR, QSPR Data Sets, and Batch Mode Exact Structure...

• Journal of Pharmaceutical Sciences
• December 2002

Experimental and computational approaches to estimate solubility and permeability in dr...

• Advanced Drug Delivery Reviews
• March 2001

Drug-like properties and the causes of poor solubility and poor permeability

• Journal of Pharmacological and Toxicological Methods
• July 2000

Quantitative Structure−Activity Relationships among Macrolide Antibacterial Agents:  I...

• Journal of Medicinal Chemistry
• April 1997

Experimental and computational approaches to estimate solubility and permeability in dr...

• Advanced Drug Delivery Reviews
• January 1997

Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhib...

• Journal of Medicinal Chemistry
• June 1992

pKa, Log P and MedChem CLOGP Fragment Values of Acidic Heterocyclic Potential Bioisosteres

• Quantitative Structure-Activity Relationships
• January 1991

Physical parameters for brian uptake: optimizing log P, log D and pKa of T H A

• Bioorganic & Medicinal Chemistry Letters
• January 1991

N-chlorination of dilantin and sorbinil

• Journal of Heterocyclic Chemistry
• September 1990

Acidic isostere design: Synthetic strategies and recent progress in understanding elect...

• Pesticide Science
• January 1990

Medicinal chemistry of aldose reductase inhibitors

• Medicinal Research Reviews
• April 1988

Bioisosteric prototype design of biaryl imidazolyl and triazolyl competitive histamine ...

• Journal of Medicinal Chemistry
• November 1986

Chapter 27. Bioisosterism in Drug Design

• January 1986

2-Amino- and 2-guanidino-4-thiazolylpyrimidines

• Journal of Heterocyclic Chemistry
• November 1985

Pseudosymmetry and bioisosterism in biaryl pyridyl competitive histamine H2-receptor an...

• Journal of Medicinal Chemistry
• November 1985

An improved preparation and use of 2-bromoacetoacetaldehyde in a new synthesis of 2-sub...

• The Journal of Organic Chemistry
• February 1984

Chapter 17. Aldose Reductase Inhibitors as a New Approach to the Treatment of Diabetic ...

• January 1984

Bioisosteric design of conformationally restricted pyridyltriazole histamine H2-recepto...

• Journal of Medicinal Chemistry
• January 1983

Chapter 10. Agents Affecting Gastrointestinal Functions

• January 1977

Chapter 10. Agents Affecting Gastrointestinal Functions

• January 1977

Total synthesis of terpenes. XIX. Synthesis of 8-methoxy-4a.beta., 10b.beta., 12a.alpha...

• The Journal of Organic Chemistry
• April 1975

Chapter 10. Agents Affecting Gastrointestinal Functions

• January 1975

Total synthesis of dl-shionone, a tetracyclic triterpene

• Journal of the American Chemical Society
• May 1974

Transmission of substituent effects in heterocycles. Rates of solvolysis of substituted...

• The Journal of Organic Chemistry
• August 1972

Correlation of the reactivity of thiophene derivatives

• The Journal of Organic Chemistry
• May 1970

The utility of the coupling reaction between propargyl grignard reagent and allylic hal...

• Tetrahedron Letters
• January 1970

ADMET Screen