All Stories

  1. Autism genes and the leukocyte transcriptome in autistic toddlers relate to pathogen interactomes, infection and the immune system. A role for excess neurotrophic sAPPα and reduced antimicrobial Aβ
  2. The Porphyromonas gingivalis/Host Interactome Shows Enrichment in GWASdb Genes Related to Alzheimer's Disease, Diabetes and Cardiovascular Diseases
  3. Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease
  4. Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products
  5. The barrier, airway particle clearance, placental and detoxification functions of autism susceptibility genes
  6. Microbes and Alzheimer’s Disease
  7. Susceptibility genes are enriched in those of the herpes simplex virus 1/host interactome in psychiatric and neurological disorders
  8. Toxoplasmosis and Polygenic Disease Susceptibility Genes: ExtensiveToxoplasma gondiiHost/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders
  9. Vaccinia and other viruses with available vaccines show marked homology with the HIV-1 envelope glycoprotein: The prospect of using existing vaccines to stem the AIDS pandemic
  10. Extensive viral mimicry of 22 AIDS-related autoantigens by HIV-1 proteins and pathway analysis of 561 viral/human homologues suggest an initial treatable autoimmune component of AIDS
  11. Pathogen and autoantigen homologous regions within the cystic fibrosis transmembrane conductance regulator (CFTR) protein suggest an autoimmune treatable component of cystic fibrosis
  12. Epstein–Barr and other viral mimicry of autoantigens, myelin and vitamin D-related proteins and of EIF2B, the cause of vanishing white matter disease: massive mimicry of multiple sclerosis relevant proteins by theSynechococcusphage
  13. Alzheimer's disease plaques and tangles: Cemeteries of a Pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction
  14. Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex,C. Pneumoniae, Other Suspect Pathogens, and the Immune System
  15. Schizophrenia: A Pathogenetic Autoimmune Disease Caused by Viruses and Pathogens and Dependent on Genes
  16. The Fox and the Rabbits—Environmental Variables and Population Genetics (1) Replication Problems in Association Studies and the Untapped Power of GWAS (2) Vitamin A Deficiency, Herpes Simplex Reactivation and Other Causes of Alzheimer's Disease
  17. APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle
  18. Alzheimer's Disease: A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent Manner
  19. Schizophrenia Susceptibility Genes Directly Implicated in the Life Cycles of Pathogens: Cytomegalovirus, Influenza, Herpes simplex, Rubella, and Toxoplasma gondii
  20. Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: Relevance to pathological-signalling cascades
  21. Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation: Implications for oligodendrocyte viability
  22. Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis
  23. EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?
  24. Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability
  25. SL25.1131 [3(S),3a(S)-3-Methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a New, Reversible, and Mixed Inhibitor of Monoamine Oxidase-A and Monoamine Oxidase-B: Biochemical and Behavioral Profile
  26. Sequence Identification and Characterization of Human Carnosinase and a Closely Related Non-specific Dipeptidase
  27. The pharmacology of native N-methtl-D-aspartate receptor subtypes: Different receptors control the release of different striatal and spinal transmitters
  28. Inhibition of synaptosomal veratridine-induced sodium influx by antidepressants and neuroleptics used in chronic pain
  29. Evidence for native NMDA receptor subtype pharmacology as revealed by differential effects on the NMDA-evoked release of striatal neuromodulators: Eliprodil, ifenprodil and other native NMDA receptor subtype selective compounds
  30. Pharmacology of N-methyl-d-aspartate-evoked [3H]noradrenaline release in adult rat spinal cord
  31. Striatal NMDA receptor subtypes: the pharmacology of N-methyl-d-aspartate-evoked dopamine, γ-aminobutyric acid, acetylcholine and spermidine release
  32. Release of spermidine from the rat cortex following permanent middle cerebral artery occlusion
  33. Synergism between the NMDA receptor antagonistic effects of ifenprodil and the glycine antagonist, 7-chlorokynurenate, in vivo
  34. Ornithine decarboxylase inhibition or NMDA receptor antagonism reduce cortical polyamine efflux associated with dialysis probe implantation
  35. Neurotoxic effects of the intrastriatal injection of spermine and spermidine: lack of involvement of NMDA receptors
  36. Selective Release of Spermine and Spermidine from the Rat Striatum by N-Methyl-d-Aspartate Receptor Activation In Vivo
  37. Difluoromethyl ornithine protects against the neurotoxic effects of intrastriatally administered N-methyl-D-aspartate in vivo
  38. The effects ofN-methyl-d-aspartate and kainate lesions of the rat striatum on striatal ornithine decar☐ylase activity and polyamine levels
  39. Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor
  40. Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease
  41. Sodium dependence of NMDA's effects on cyclic GMP production in immature rat cerebellar slices
  42. Noradrenaline Antagonizes and Ouabain Potentiates the Effects of iV-Methyl-D-Aspartate on Rat Cerebellar Cyclic GMP Production
  43. Differential Control by N-Methyl-D-Aspartate and Kainate of Striatal Dopamine Release In Vivo: A Trans-Striatal Dialysis Study
  44. Differential modulation of [3H]TCP binding to the NMDA receptor by L-glutamate and glycine
  45. Raised extracellular potassium relieves the blockade by magnesium of NMDA-induced cerebellar cyclic GMP production
  46. Peripheral type benzodiazepine binding sites are a sensitive indirect index of neuronal damage
  47. Ionic Mechanisms Implicated in the Stimulation of Cerebellar Cyclic GMP Levels by N-Methyl-D-Aspartate
  48. 2-Oxo-[14C]glutarate is taken up by glutamatergic nerve terminals in the rat striatum
  49. Increased alanine aminotransferase activity in the Huntington's disease putamen
  50. Reduced GABA transaminase activity in the Huntington's disease putamen
  51. Glutamine synthetase and fructose-1, 6-diphosphatase activity in the putamen of control and Huntington's disease brain post mortem
  52. Glutamine synthetase activity in Huntington's disease
  53. Topographical distribution of possible glutamatergic pathways from the frontal cortex to the striatum and substantia nigra in rats
  54. GLUTAMINE, GLUTAMINE SYNTHETASE AND HUNTINGTON'S DISEASE
  55. LOSS OF GLUTAMINE SYNTHETASE ACTIVITY IN THE BRAIN IN HUNTINGTON'S DISEASE
  56. The role of 5-hydroxytryptamine in dopamine-dependent stereotyped behaviour
  57. Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats
  58. 5,7-dihydroxytryptamine lesions of the amygdala reduce amphetamine-and apomorphine-induced stereotyped behaviour in the rat
  59. Behavioural and biochemical effects of dopamine and noradrenaline depletion within the medial prefrontal cortex of the rat
  60. Effect of 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex on Neurotransmitter Systems in Subcortical Sites in the Rat
  61. A comparison of l- and d-baclofen on dopamine dependent behaviour in the rat
  62. Potentiation of haloperidol-induced catalepsy by dopamine agonists: Possible involvement of central 5-hydroxytryptamine
  63. The effects of 5,7-dihydroxytryptamine lesions of extrapyramidal and mesolimbic sites on spontaneous motor behaviour, and amphetamine-induced stereotypy
  64. A study of the sites of interaction between dopamine and 5-hydroxytryptamine for the production of fluphenazine-induced catalepsy
  65. Differential effects of central serotonin manipulation on hyperactive and stereotyped behaviour