All Stories

  1. Open and sustainable AI: challenges, opportunities and the road ahead in the life sciences
  2. The missing link in FAIR data policy: biodata resources in life sciences
  3. AmpliPhy improves gene trees by adding homologs without affecting alignments
  4. OMAnnotator: a novel approach to building an annotated consensus genome sequence
  5. PhytClust: efficient and optimal node clustering in phylogenetic trees
  6. Quest for Orthologs in the era of Data Deluge and AI: Challenges and Innovations in Orthology Prediction and Data Integration
  7. Structural phylogenetics unravels the evolutionary diversification of communication systems in gram-positive bacteria and their viruses
  8. OrthoXML-Tools: A Toolkit for Manipulating OrthoXML Files for Orthology Data
  9. EdgeHOG: a method for fine-grained ancestral gene order inference at large scale
  10. Unveiling the functional fate of duplicated genes through expression profiling and structural analysis
  11. Invest in data resources to make FAIR a reality
  12. Annotation matters: the effect of structural gene annotation on orthology inference
  13. Federated SPARQL query performance evaluation for exploring disease model mouse: combining gene expression, orthology, and disease knowledge graphs
  14. Orthology inference at scale with FastOMA
  15. OMAnnotator: a novel approach to building an annotated consensus genome sequence
  16. Reconstructing the last common ancestor of all eukaryotes
  17. When less is more: sketching with minimizers in genomics
  18. Quest for Orthologs in the Era of Biodiversity Genomics
  19. New developments for the Quest for Orthologs benchmark service
  20. EdgeHOG: fine-grained ancestral gene order inference at tree-of-life scale
  21. Matreex: Compact and Interactive Visualization for Scalable Studies of Large Gene Families
  22. Frequent jumps from human hosts
  23. AI and the democratization of knowledge
  24. Quality assessment of gene repertoire annotations with OMArk
  25. Orthology inference at scale with FastOMA
  26. DrosOMA: the Drosophila Orthologous Matrix browser
  27. OMA orthology in 2024: improved prokaryote coverage, ancestral and extant GO enrichment, a revamped synteny viewer and more in the OMA Ecosystem
  28. The SIB Swiss Institute of Bioinformatics Semantic Web of data
  29. Structural phylogenetics unravels the evolutionary diversification of communication systems in gram-positive bacteria and their viruses
  30. Exploring Disease Model Mouse Using Knowledge Graphs: Combining Gene Expression, Orthology, and Disease Datasets
  31. Protein length distribution is remarkably uniform across the tree of life
  32. Phylogenetic profiling in eukaryotes comes of age
  33. Inference of phylogenetic trees directly from raw sequencing reads using Read2Tree
  34. Protein S-acylation controls the subcellular localization and biological activity of PHYTOCHROME KINASE SUBSTRATE
  35. Matreex: compact and interactive visualisation for scalable studies of large gene families
  36. Bringing science to the public in the light of evolution
  37. Multifaceted quality assessment of gene repertoire annotation with OMArk
  38. Reconstructing protein interactions across time using phylogeny-aware graph neural networks
  39. Bio-SODA UX: enabling natural language question answering over knowledge graphs with user disambiguation
  40. Control of PHYTOCHROME KINASE SUBSTRATE subcellular localization and biological activity by protein S-acylation
  41. Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins
  42. ISMB 2022 proceedings
  43. The Quest for Orthologs orthology benchmark service in 2022
  44. Read2Tree: scalable and accurate phylogenetic trees from raw reads
  45. A Linear Time Solution to the Labeled Robinson–Foulds Distance Problem
  46. OMAMO: orthology-based alternative model organism selection
  47. How to build phylogenetic species trees with OMA
  48. Citrullination Was Introduced into Animals by Horizontal Gene Transfer from Cyanobacteria
  49. Discovery of archaeal Fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins
  50. Bio-SODA: Enabling Natural Language Question Answering over Knowledge Graphs without Training Data
  51. ISMB/ECCB 2021 proceedings
  52. Homoeolog Inference Methods Requiring Bidirectional Best Hits or Synteny Miss Many Pairs
  53. Ten Years of Collaborative Progress in the Quest for Orthologs
  54. OMAmer: tree-driven and alignment-free protein assignment to subfamilies outperforms closest sequence approaches
  55. Want to track pandemic variants faster? Fix the bioinformatics bottleneck
  56. Gene Duplication and Gain in the Trematode Atriophallophorus winterbourni Contributes to Adaptation to Parasitism
  57. A putative origin of the insect chemosensory receptor superfamily in the last common eukaryotic ancestor
  58. NGS-Based S. aureus Typing and Outbreak Analysis in Clinical Microbiology Laboratories: Lessons Learned From a Swiss-Wide Proficiency Test
  59. OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more
  60. A generalized Robinson-Foulds distance for labeled trees
  61. Parallel and Scalable Precise Clustering
  62. A Linear Time Solution to the Labeled Robinson-Foulds Distance Problem
  63. A putative origin of insect chemosensory receptors in the last common eukaryotic ancestor
  64. Large scale phylogenetic profiling and investigating gene networks involved in sexual reproduction
  65. A hands-on introduction to querying evolutionary relationships across multiple data sources using SPARQL
  66. Benchmarking gene ontology function predictions using negative annotations
  67. Only a Single Taxonomically Restricted Gene Family in the Drosophila melanogaster Subgroup Can Be Identified with High Confidence
  68. Protein citrullination was introduced into animals by horizontal gene transfer from cyanobacteria
  69. How to build phylogenetic species trees with OMA
  70. The phylogenetic range of bacterial and viral pathogens of vertebrates
  71. Corrigendum: OMA standalone: orthology inference among public and custom genomes and transcriptomes
  72. The Quest for Orthologs benchmark service and consensus calls in 2020
  73. Genomic Encryption of Digital Data Stored in Synthetic DNA
  74. New genome assembly of the barn owl ( Tyto alba alba )
  75. Identifying orthologs with OMA: A primer
  76. Scalable Phylogenetic Profiling using MinHash Uncovers Likely Eukaryotic Sexual Reproduction Genes
  77. Structural variant calling: the long and the short of it
  78. The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
  79. Genomic encryption of digital data stored in synthetic DNA
  80. A hands-on introduction to querying evolutionary relationships across multiple data sources using SPARQL
  81. Parallel and Scalable Precise Clustering for Homologous Protein Discovery
  82. Enabling Semantic Queries Across Federated Bioinformatics Databases
  83. Advances and Applications in the Quest for Orthologs
  84. OMA standalone: orthology inference among public and custom genomes and transcriptomes
  85. The phylogenetic range of bacterial and viral pathogens of vertebrates
  86. Mitigating Anticipated Effects of Systematic Errors Supports Sister-Group Relationship between Xenacoelomorpha and Ambulacraria
  87. The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
  88. Expanding the Orthologous Matrix (OMA) programmatic interfaces: REST API and the OmaDB packages for R and Python
  89. Assigning confidence scores to homoeologs using fuzzy logic
  90. Expanding the Orthologous Matrix (OMA) programmatic interfaces: REST API and the OmaDB packages for R and Python
  91. Inferring Orthology and Paralogy
  92. Enabling semantic queries across federated bioinformatics databases
  93. VoIDext: Vocabulary and Patterns for Enhancing Interoperable Datasets with Virtual Links
  94. How Much Does GenoGuard Really "Guard"?
  95. iHam & pyHam: visualizing and processing hierarchical orthologous groups
  96. Phylogenetic approaches to identifying fragments of the same gene, with application to the wheat genome
  97. Prioritising candidate genes causing QTL using hierarchical orthologous groups
  98. OMA standalone: orthology inference among public and custom genomes and transcriptomes
  99. GOATOOLS: A Python library for Gene Ontology analyses
  100. Submit a Topic Page to PLOS Computational Biology and Wikipedia
  101. RecPhyloXML - a format for reconciled gene trees
  102. The OMA orthology database in 2018: retrieving evolutionary relationships among all domains of life through richer web and programmatic interfaces
  103. Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
  104. Assessing the potential of RAD-sequencing to resolve phylogenetic relationships within species radiations: The fly genus Chiastocheta (Diptera: Anthomyiidae) as a case study
  105. Lessons Learned: Recommendations for Establishing Critical Periodic Scientific Benchmarking
  106. Phylogenetic approaches to identifying fragments of the same gene, with application to the wheat genome
  107. Taxon sampling unequally affects individual nodes in a phylogenetic tree: consequences for model gene tree construction in SwissTree
  108. Orthologous Matrix (OMA) algorithm 2.0: more robust to asymmetric evolutionary rates and more scalable hierarchical orthologous group inference
  109. Tracking the Evolution of Non–Small-Cell Lung Cancer
  110. Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
  111. Comparative genomics reveals contraction in olfactory receptor genes in bats
  112. Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast
  113. The Gene Ontology Handbook
  114. OUP accepted manuscript
  115. A Gene Ontology Tutorial in Python
  116. Gene Ontology: Pitfalls, Biases, and Remedies
  117. Primer on the Gene Ontology
  118. An expanded evaluation of protein function prediction methods shows an improvement in accuracy
  119. Membrane Proteins Are Dramatically Less Conserved than Water-Soluble Proteins across the Tree of Life
  120. Homoeologs: What Are They and How Do We Infer Them?
  121. Phylo.io: Interactive Viewing and Comparison of Large Phylogenetic Trees on the Web
  122. Transient structural variations alter gene expression and quantitative traits in Schizosaccharomyces pombe.
  123. Standardized benchmarking in the quest for orthologs
  124. Compensation of Dosage-Sensitive Genes on the Chicken Z Chromosome
  125. Clustering Genes of Common Evolutionary History
  126. Current Methods for Automated Filtering of Multiple Sequence Alignments Frequently Worsen Single-Gene Phylogenetic Inference
  127. Inferring Horizontal Gene Transfer
  128. A Transcriptomic-Phylogenomic Analysis of the Evolutionary Relationships of Flatworms
  129. Phylogenetic Profiling: How Much Input Data Is Enough?
  130. Simple chained guide trees give poorer multiple sequence alignments than inferred trees in simulation and phylogenetic benchmarks
  131. The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease
  132. The OMA orthology database in 2015: function predictions, better plant support, synteny view and other improvements
  133. Speeding up all-against-all protein comparisons while maintaining sensitivity by considering subsequence-level homology
  134. Big data and other challenges in the quest for orthologs
  135. Preface of Proceedings of GNOME 2014 — Festschrift for Gaston Gonnet
  136. CAFA and the Open World of protein function predictions
  137. Bidirectional Best Hits Miss Many Orthologs in Duplication-Rich Clades such as Plants and Animals
  138. Who Watches the Watchmen? An Appraisal of Benchmarks for Multiple Sequence Alignment
  139. The Impact of Gene Duplication, Insertion, Deletion, Lateral Gene Transfer and Sequencing Error on Orthology Inference: A Simulation Study
  140. Towards practical, high-capacity, low-maintenance information storage in synthesized DNA
  141. Inferring Hierarchical Orthologous Groups from Orthologous Gene Pairs
  142. Approximate Bayesian Computation
  143. Global regulatory architecture of human, mouse and rat tissue transcriptomes
  144. Quality of Computationally Inferred Gene Ontology Annotations
  145. Resolving the Ortholog Conjecture: Orthologs Tend to Be Weakly, but Significantly, More Similar in Function than Paralogs
  146. Toward community standards in the quest for orthologs
  147. Inferring Orthology and Paralogy
  148. ALF--A Simulation Framework for Genome Evolution
  149. Editorial: Orthology and applications
  150. Conceptual framework and pilot study to benchmark phylogenomic databases based on reference gene trees
  151. Comparative genomics approach to detecting split-coding regions in a low-coverage genome: lessons from the chimaera Callorhinchus milii (Holocephali, Chondrichthyes)
  152. iTRAQ-based analysis of changes in the cassava root proteome reveals pathways associated with post-harvest physiological deterioration
  153. Survey of Branch Support Methods Demonstrates Accuracy, Power, and Robustness of Fast Likelihood-based Approximation Schemes
  154. The what, where, how and why of gene ontology--a primer for bioinformaticians
  155. Base-calling for next-generation sequencing platforms
  156. OMA 2011: orthology inference among 1000 complete genomes
  157. Phylogenetic assessment of alignments reveals neglected tree signal in gaps
  158. The Microbe browser for comparative genomics
  159. Phylogenetic and Functional Assessment of Orthologs Inference Projects and Methods
  160. Algorithm of OMA for large-scale orthology inference
  161. Joining forces in the quest for orthologs
  162. Evaluating the robustness of phylogenetic methods to among-site variability in substitution processes
  163. Algorithm of OMA for large-scale orthology inference
  164. Covariance of maximum likelihood evolutionary distances between sequences aligned pairwise
  165. SWPS3 – fast multi-threaded vectorized Smith-Waterman for IBM Cell/B.E. and ×86/SSE2
  166. Alignments with non-overlapping moves, inversions and tandem duplications in O(n 4) time
  167. OMA Browser Exploring orthologous relations across 352 complete genomes
  168. Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
  169. A DIMENSIONLESS FIT MEASURE FOR PHYLOGENETIC DISTANCE TREES
  170. OMA, A Comprehensive, Automated Project for the Identification of Orthologs from Complete Genome Data: Introduction and First Achievements
  171. DLIGHT – Lateral Gene Transfer Detection Using Pairwise Evolutionary Distances in a Statistical Framework
  172. Alignments with Non-overlapping Moves, Inversions and Tandem Duplications in O(n 4) Time