All Stories

  1. Calcium-Sensing Receptor as a Novel Target for the Treatment of Idiopathic Pulmonary Fibrosis

    Article • Biomolecules, April 2025, MDPI AG

    Professor Chris Corrigan, Professor Luis Mur

  2. Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial

    Article • Nature Communications, July 2023, Springer Science + Business Media

    Professor Chris Corrigan

  3. Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?

    Article • European Respiratory Journal, January 2022, European Respiratory Society (ERS)

    Professor Chris Corrigan

  4. Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3

    Article • American Journal of Respiratory Cell and Molecular Biology, May 2021, American Thoracic Society

    Professor Chris Corrigan

  5. Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome

    Article • Cells, July 2020, MDPI AG

    Professor Chris Corrigan

  6. <p>Inhaled Corticosteroids Prescribed for COPD Patients with Mild or Moderate Airflow Limitation: Who Warrants a Trial of Withdrawal?</p>

    Article • International Journal of Chronic Obstructive Pulmonary Disease, January 2020, Taylor & Francis

    Prof Nicholas Hart, Professor Chris Corrigan

  7. Why inhalers are helpful to control asthma and COPD.

    Article • ERJ Open Research, April 2018, European Respiratory Society (ERS)

    Professor Chris Corrigan

  8. Prevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK

    Article • The Journal of Steroid Biochemistry and Molecular Biology, January 2018, Elsevier

    Angshu Bhowmik, Professor Chris Corrigan

  9. Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK

    Article • The Journal of Steroid Biochemistry and Molecular Biology, January 2018, Elsevier

    Angshu Bhowmik, Professor Chris Corrigan

  10. Characteristics of Proinflammatory Cytokines and Chemokines in Airways of Asthmatics

    Article • Chinese Medical Journal, September 2017, Wolters Kluwer Health

    Professor Chris Corrigan

  11. Cigarette smoking increases bronchial mucosal IL‐17A expression in asthmatics, which acts in concert with environmental aeroallergens to engender neutrophilic inflammation

    Article • Clinical & Experimental Allergy, March 2017, Wiley

    Professor Chris Corrigan

  12. Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

    Article • Cancer Research, February 2017, American Association for Cancer Research (AACR)

    Professor Chris Corrigan

  13. AllergoOncology – the impact of allergy in oncology: EAACI position paper

    Article • Allergy, January 2017, Wiley

    Professor Chris Corrigan

  14. Azithromycin for Acute Exacerbations of Asthma

    Article • JAMA Internal Medicine, November 2016, American Medical Association (AMA)

    Professor Chris Corrigan

  15. Inhaler technique: facts and fantasies. A view from the Aerosol Drug Management Improvement Team (ADMIT)

    Article • npj Primary Care Respiratory Medicine, April 2016, Springer Science + Business Media

    Professor Chris Corrigan

  16. Activin-A is overexpressed in severe asthma and is implicated in angiogenic processes

    Article • European Respiratory Journal, February 2016, European Respiratory Society (ERS)

    Professor Chris Corrigan

  17. Urban Particulate Matter–Activated Human Dendritic Cells Induce the Expansion of Potent Inflammatory Th1, Th2, and Th17 Effector Cells

    Article • American Journal of Respiratory Cell and Molecular Biology, February 2016, American Thoracic Society

    Catherine Hawrylowicz, Professor Chris Corrigan

  18. Inhaled corticosteroid dose-response on blood eosinophils in asthma – Authors' reply

    Article • The Lancet Respiratory Medicine, January 2016, Elsevier

    Professor Chris Corrigan

  19. Farewell

    Article • Clinical & Experimental Allergy, November 2015, Wiley

    Professor Chris Corrigan

  20. The Editor takes a closer look at some of this month's articles

    Article • Clinical & Experimental Allergy, November 2015, Wiley

    Professor Chris Corrigan

  21. Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study

    Article • The Lancet Respiratory Medicine, November 2015, Elsevier

    Professor Chris Corrigan

  22. Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol

    Article • Journal of Allergy and Clinical Immunology, September 2015, Elsevier

    Catherine Hawrylowicz, Professor Chris Corrigan

  23. Analysis of a Panel of 48 Cytokines in BAL Fluids Specifically Identifies IL-8 Levels as the Only Cytokine that Distinguishes Controlled Asthma from Uncontrolled Asthma, and Correlates Inversely with FEV1

    Article • PLOS One, May 2015, PLOS

    Professor Chris Corrigan

  24. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

    Article • Science Translational Medicine, April 2015, American Association for the Advancement of Science

    Professor Emma J Kidd, Professor Chris Corrigan

  25. Resistin-like molecule-β (RELM-β) targets airways fibroblasts to effect remodelling in asthma: from mouse to man

    Article • Clinical & Experimental Allergy, April 2015, Wiley

    Professor Chris Corrigan

  26. Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33

    Article • Journal of Allergy and Clinical Immunology, March 2015, Elsevier

    Catherine Hawrylowicz, Professor Chris Corrigan

  27. Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3supplementation in adults with asthma (ViDiAs)

    Article • Thorax, February 2015, BMJ

    Catherine Hawrylowicz, Angshu Bhowmik, Professor Chris Corrigan

  28. Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial

    Article • The Lancet Respiratory Medicine, February 2015, Elsevier

    Catherine Hawrylowicz, Angshu Bhowmik, Professor Chris Corrigan

  29. “Auto-anti-IgE”: Naturally occurring IgG anti-IgE antibodies may inhibit allergen-induced basophil activation

    Article • Journal of Allergy and Clinical Immunology, December 2014, Elsevier

    Dr Prathap Pillai, Professor Chris Corrigan

  30. Imaging Inflammation in Asthma: Real Time, Differential Tracking of Human Neutrophil and Eosinophil Migration in Allergen Challenged, Atopic Asthmatics in Vivo

    Article • EBioMedicine, December 2014, Elsevier

    Professor Chris Corrigan

  31. Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells

    Article • Allergy, September 2014, Wiley

    Professor Chris Corrigan

  32. Poster Session Group I

    Article • Allergy, August 2014, Wiley

    Professor Chris Corrigan

  33. The effects of calcitriol treatment in glucocorticoid-resistant asthma

    Article • Journal of Allergy and Clinical Immunology, June 2014, Elsevier

    Catherine Hawrylowicz, Professor Chris Corrigan

  34. Direct comparison of the dynamics of IL-25- and ‘allergen’-induced airways inflammation, remodelling and hypersensitivity in a murine asthma model

    Article • Clinical & Experimental Allergy, April 2014, Wiley

    Professor Chris Corrigan

  35. Real-time differential tracking of human neutrophil and eosinophil migration in vivo

    Article • Journal of Allergy and Clinical Immunology, January 2014, Elsevier

    Professor Chris Corrigan

  36. CCL17/thymus and activation-regulated chemokine induces calcitonin gene–related peptide in human airway epithelial cells through CCR4

    Article • Journal of Allergy and Clinical Immunology, October 2013, Elsevier

    Professor Chris Corrigan

  37. Epidemiological associations of allergy, IgE and cancer

    Article • Clinical & Experimental Allergy, September 2013, Wiley

    Professor Chris Corrigan

  38. Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion

    Article • Journal of Allergy and Clinical Immunology, August 2013, Elsevier

    Catherine Hawrylowicz, Professor Chris Corrigan

  39. Real-life comparison of beclometasone dipropionate as an extrafine- or larger-particle formulation for asthma

    Article • Respiratory Medicine, July 2013, Elsevier

    Professor David Price, Professor Chris Corrigan

  40. Beurteilung der Wirksamkeit der spezifischen Immuntherapie anhand einer neuartigen Methode auf der Basis des Plazebo-Scores

    Article • Allergologie, June 2013, Dustri-Verlgag Dr. Karl Feistle

    Professor Chris Corrigan

  41. Inhaler devices – From theory to practice

    Article • Respiratory Medicine, April 2013, Elsevier

    Professor Chris Corrigan

  42. Assessment of specific immunotherapy efficacy using a novel placebo score–based method

    Article • Annals of Allergy Asthma & Immunology, November 2012, Elsevier

    Professor Chris Corrigan

  43. Interleukin‐25 promotes basic fibroblast growth factor expression by human endothelial cells through interaction with IL‐17RB, but not IL‐17RA

    Article • Clinical & Experimental Allergy, October 2012, Wiley

    Professor Chris Corrigan

  44. Serum 25-dihydroxyvitamin D levels correlate with CD4+Foxp3+ T-cell numbers in moderate/severe asthma

    Article • Journal of Allergy and Clinical Immunology, August 2012, Elsevier

    Catherine Hawrylowicz, Professor Chris Corrigan

  45. T cells producing the anti-inflammatory cytokine IL-10 regulate allergen-specific Th2 responses in human airways

    Article • Allergy, June 2012, Wiley

    Catherine Hawrylowicz, A/Professor Narinder Pal Singh, Professor Chris Corrigan

  46. Reduced expression of the prostaglandin E2 receptor E-prostanoid 2 on bronchial mucosal leukocytes in patients with aspirin-sensitive asthma

    Article • Journal of Allergy and Clinical Immunology, June 2012, Elsevier

    Professor Chris Corrigan

  47. Special issue on severe asthma

    Article • Clinical & Experimental Allergy, April 2012, Wiley

    Professor Chris Corrigan

  48. Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application

    Article • Medical Oncology, December 2011, Springer Science + Business Media

    Professor Chris Corrigan

  49. Lung Homing of Endothelial Progenitor Cells in Humans with Asthma after Allergen Challenge

    Article • American Review of Respiratory Disease, October 2011, American Thoracic Society

    Professor Chris Corrigan

  50. Identifying and testing potential new anti-asthma agents

    Article • Expert Opinion on Drug Discovery, September 2011, Taylor & Francis

    Professor Chris Corrigan

  51. Immunotherapy for allergic rhinitis

    Article • Clinical & Experimental Allergy, August 2011, Wiley

    Professor Chris Corrigan

  52. Resistin-like molecule-β is a human airway remodelling mediator

    Article • European Respiratory Journal, August 2011, European Respiratory Society (ERS)

    Professor Chris Corrigan

  53. Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses

    Article • Journal of Allergy and Clinical Immunology, July 2011, Elsevier

    Professor Chris Corrigan

  54. Retail sales of inhalation devices in European countries: So much for a global policy

    Article • Respiratory Medicine, July 2011, Elsevier

    Professor Chris Corrigan

  55. Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI‐mediated basophil activation by a tumour‐specific IgE antibody to evaluate the risk of type I hypersensitivity

    Article • Clinical & Experimental Allergy, May 2011, Wiley

    Professor Chris Corrigan

  56. T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma

    Article • Proceedings of the National Academy of Sciences, January 2011, Proceedings of the National Academy of Sciences

    Professor Chris Corrigan

  57. A novel technique to explore the functions of bronchial mucosal T cells in chronic obstructive pulmonary disease: application to cytotoxicity and cytokine immunoreactivity

    Article • Clinical & Experimental Immunology, August 2010, Wiley

    Catherine Hawrylowicz, Professor Chris Corrigan

  58. The Role of Thymic Stromal Lymphopoietin in Allergic Inflammation and Chronic Obstructive Pulmonary Disease

    Article • Archivum Immunologiae et Therapiae Experimentalis, February 2010, De Gruyter

    Professor Chris Corrigan

  59. IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

    Article • The Journal of Immunology, November 2009, Oxford University Press (OUP)

    Professor Chris Corrigan

  60. Diminished sarco/endoplasmic reticulum Ca2+ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma

    Article • Proceedings of the National Academy of Sciences, June 2009, Proceedings of the National Academy of Sciences

    Professor Chris Corrigan

  61. Early production of thymic stromal lymphopoietin precedes infiltration of dendritic cells expressing its receptor in allergen‐induced late phase cutaneous responses in atopic subjects

    Article • Allergy, June 2009, Wiley

    Professor Chris Corrigan

  62. Counter regulation of the high affinity IgE receptor, FcεRI, on human airway dendritic cells by IL-4 and IL-10

    Article • Allergy, April 2009, Wiley

    Catherine Hawrylowicz, A/Professor Narinder Pal Singh, Professor Chris Corrigan

  63. Ligation of TLR9 induced on human IL-10–secreting Tregs by 1α,25-dihydroxyvitamin D3 abrogates regulatory function

    Article • Journal of Clinical Investigation, January 2009, American Society for Clinical Investigation

    Catherine Hawrylowicz, Professor Chris Corrigan

  64. Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD

    Article • Respiratory Medicine, April 2008, Elsevier

    Professor Chris Corrigan

  65. Role of cysteinyl leukotrienes in human allergen-specific Th2 responses induced by granulocyte macrophage-colony stimulating factor

    Article • Allergy, January 2008, Wiley

    Catherine Hawrylowicz, Professor Chris Corrigan

  66. Effect of grass pollen immunotherapy with Alutard SQ® on quality of life in seasonal allergic rhinoconjunctivitis

    Article • Allergy, August 2007, Wiley

    Professor Chris Corrigan

  67. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC–activated Th2 memory cells

    Article • Journal of Experimental Medicine, July 2007, Rockefeller University Press

    Professor Chris Corrigan

  68. Increased prevalence of gastrointestinal symptoms in patients with allergic disease

    Article • Postgraduate Medical Journal, March 2007, Oxford University Press (OUP)

    Professor Chris Corrigan

  69. Sublingual immunotherapy

    Article • Journal of Allergy and Clinical Immunology, February 2007, Elsevier

    Professor Chris Corrigan

  70. Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma

    Article • Journal of Allergy and Clinical Immunology, January 2007, Elsevier

    Professor Chris Corrigan

  71. Lack of filaggrin expression in the human bronchial mucosa

    Article • Journal of Allergy and Clinical Immunology, December 2006, Elsevier

    Professor Chris Corrigan

  72. Germinal-centre reactions in allergic inflammation

    Article • Trends in Immunology, October 2006, Elsevier

    Professor Chris Corrigan

  73. Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients

    Article • Journal of Allergy and Clinical Immunology, August 2006, Elsevier

    Professor Chris Corrigan

  74. Aspirin-sensitive rhinosinusitis is associated with reduced E-prostanoid 2 receptor expression on nasal mucosal inflammatory cells

    Article • Journal of Allergy and Clinical Immunology, February 2006, Elsevier

    Professor Chris Corrigan

  75. Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis

    Article • Journal of Allergy and Clinical Immunology, February 2006, Elsevier

    Professor Chris Corrigan

  76. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients

    Article • Journal of Clinical Investigation, December 2005, American Society for Clinical Investigation

    Catherine Hawrylowicz, Professor Chris Corrigan

  77. Eph and NMDA receptors control Ca2+/calmodulin-dependent protein kinase II activation duringC. elegansoocyte meiotic maturation

    Article • Development, December 2005, The Company of Biologists

    Professor Chris Corrigan

  78. Functional plasticity of human respiratory tract dendritic cells: GM-CSF enhances TH2 development

    Article • Journal of Allergy and Clinical Immunology, November 2005, Elsevier

    Catherine Hawrylowicz, Professor Chris Corrigan

  79. IL-4–expressing bronchoalveolar T cells from asthmatic and healthy subjects preferentially express CCR3 and CCR4

    Article • Journal of Allergy and Clinical Immunology, September 2005, Elsevier

    Professor Chris Corrigan

  80. Interleukin-10–Secreting “Regulatory” T Cells Induced by Glucocorticoids and β2-Agonists

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2005, American Thoracic Society

    Catherine Hawrylowicz, Professor Chris Corrigan

  81. Methotrexate therapy of oral corticosteroid‐dependent asthmatics reduces serum immunoglobulins: correlation with clinical response to therapy

    Article • Clinical & Experimental Allergy, May 2005, Wiley

    Professor Chris Corrigan

  82. Efficacy and safety of preseasonal‐specific immunotherapy with an aluminium‐adsorbed six‐grass pollen allergoid

    Article • Allergy, April 2005, Wiley

    Professor Chris Corrigan

  83. Expression of the cysteinyl leukotriene receptors cysLT1 and cysLT2 in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis

    Article • Journal of Allergy and Clinical Immunology, February 2005, Elsevier

    Professor Chris Corrigan

  84. Glucocorticoid Action and Resistance in Asthma

    Article • Allergology International, January 2005, Japanese Society of Allergology

    Professor Chris Corrigan

  85. Expression of prostaglandin E2 receptor subtypes on cells in sputum from patients with asthma and controls: Effect of allergen inhalational challenge

    Article • Journal of Allergy and Clinical Immunology, December 2004, Elsevier

    Professor Chris Corrigan

  86. Mechanisms of intrinsic asthma

    Article • Current Opinion in Allergy and Clinical Immunology, February 2004, Wolters Kluwer Health

    Professor Chris Corrigan

  87. Methotrexate therapy in asthma increases T cell susceptibility to corticosteroid inhibition

    Article • Clinical & Experimental Allergy, August 2003, Wiley

    Professor Chris Corrigan

  88. Leukotriene-Receptor Expression on Nasal Mucosal Inflammatory Cells in Aspirin-Sensitive Rhinosinusitis

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, November 2002, New England Journal of Medicine (NEJM/MMS)

    Professor Chris Corrigan

  89. Effect of fluticasone on the elastase:antielastase profile of the normal lung

    Article • European Journal of Clinical Investigation, September 2002, Wiley

    Professor Chris Corrigan

  90. Glucocorticoid-resistant asthma

    Article • Current Allergy and Asthma Reports, March 2002, Springer Science + Business Media

    Professor Chris Corrigan

  91. A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients

    Article • Journal of Allergy and Clinical Immunology, February 2002, Elsevier

    Catherine Hawrylowicz, Professor Chris Corrigan

  92. The immunomodulatory drugs cyclosporin A, mycophenolate mofetil, and sirolimus (rapamycin) inhibit allergen-induced proliferation and IL-5 production by PBMCs from atopic asthmatic patients

    Article • Journal of Allergy and Clinical Immunology, December 2001, Elsevier

    Professor Chris Corrigan

  93. Monocytes and macrophages - friend or foe?

    Article • Clinical & Experimental Allergy Reviews, July 2001, Wiley

    Catherine Hawrylowicz, Professor Chris Corrigan

  94. An annexin 1 (ANXA1)‐derived peptide inhibits prototype antigen‐driven human T cell Th1 and Th2 responses in vitro

    Article • Clinical & Experimental Allergy, July 2001, Wiley

    Professor Chris Corrigan

  95. The topical glucocorticoids beclomethasone dipropionate and fluticasone propionate inhibit human T-cell allergen-induced production of IL-5, IL-3 and GM-CSF mRNA and protein

    Article • Clinical & Experimental Allergy, January 2001, Wiley

    Professor Chris Corrigan

  96. Effect of oral glucocorticoid treatment on serum inflammatory markers in acute asthma

    Article • Archives of Disease in Childhood, August 2000, BMJ

    Professor Chris Corrigan

  97. Allergen-induced Proliferation and Interleukin-5 Production by Bronchoalveolar Lavage and Blood T Cells after Segmental Allergen Challenge

    Article • American Review of Respiratory Disease, August 1998, American Thoracic Society

    Professor Chris Corrigan

  98. IL-5 production by allergen-stimulated T cells following grass pollen immunotherapy for seasonal allergic rhinitis

    Article • Clinical & Experimental Immunology, September 1997, Oxford University Press (OUP)

    Professor Chris Corrigan

  99. Relationship between IL-4 and IL-5 mRNA Expression and Disease Severity in Atopic Asthma

    Article • American Review of Respiratory Disease, September 1997, American Thoracic Society

    Professor Chris Corrigan

  100. IL‐13 production by allergen‐stimulated T cells is increased in allergic disease and associated with IL‐5 but not IFN‐γ expression

    Article • Immunology, May 1997, Wiley

    Professor Chris Corrigan

  101. IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: Relationship to expression of allergic disease

    Article • Journal of Allergy and Clinical Immunology, April 1997, Elsevier

    Professor Chris Corrigan

  102. Secretion of the eosinophil‐active cytokines interleukin‐5, granulocyte/macrophage colonystimulating factor and interleukin‐3 by bronchoalveolar lavage CD4+ and CD8+ T cell lines in atopics asthmatics, and atopic and nonatopic con...

    Article • European Journal of Immunology, October 1995, Wiley

    Professor Chris Corrigan

  103. Mechanism of glucocorticoid action in asthma: too little, too late

    Article • Clinical & Experimental Allergy, March 1992, Wiley

    Professor Chris Corrigan