All Stories

  1. High-Intensity Interval Exercise Drives Vitamin D Receptor Expression in Skeletal Muscle via Recruitment of Non-Parenchymal Cells, Not Upregulation in Muscle Fibers

    Article • Nutrients, November 2025, MDPI AG

    Bruce Troen

  2. Provocative testing in community dwelling older adults: a path to identify physical resilience

    Article • The Journals of Gerontology Series A, September 2025, Oxford University Press (OUP)

    Bruce Troen

  3. Effects of a 6-Week Treadmill Training With and Without Virtual Reality on Frailty in People With Multiple Sclerosis

    Article • Archives of Physical Medicine and Rehabilitation, February 2025, Elsevier

    Bruce Troen

  4. Frailty in multiple sclerosis: A scoping review

    Article • Multiple Sclerosis and Related Disorders, December 2024, Elsevier

    Bruce Troen

  5. VO2MAX, 6-minute walk, and muscle strength each correlate with frailty in US veterans

    Article • Frontiers in Physiology, September 2024, Frontiers

    Bruce Troen

  6. Age‐related increase of CD38 directs osteoclastogenic potential of monocytic myeloid‐derived suppressor cells through mitochondrial dysfunction in male mice

    Article • Aging Cell, August 2024, Wiley

    Bruce Troen

  7. Multimodal Exercise Training to Reduce Frailty in People with Multiple Sclerosis: Study Protocol for a Pilot Randomized Controlled Trial

    Article • Multiple Sclerosis and Related Disorders, June 2024, Elsevier

    Bruce Troen

  8. Multimodal exercise training to reduce frailty in people with multiple sclerosis: study protocol for a pilot randomized controlled trial

    Article • Pilot and Feasibility Studies, April 2024, Springer Science + Business Media

    Bruce Troen

  9. The Relationships between Caregiver Burden, Physical Frailty, Race, Behavioral and Psychological Symptoms (BPSD), and Other Associated Variables: An Exploratory Study

    Article • Medicina, March 2024, MDPI AG

    Bruce Troen

  10. Proline restores mitochondrial function and reverses aging hallmarks in senescent cells

    Article • Cell Reports, February 2024, Elsevier

    Bruce Troen

  11. Tristetraprolin regulates the skeletal phenotype and osteoclastogenic potential through monocytic myeloid‐derived suppressor cells

    Article • The FASEB Journal, December 2023, Wiley

    Bruce Troen

  12. Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle

    Article • Nature Communications, February 2023, Springer Science + Business Media

    Bruce Troen

  13. Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells

    Article • Cell Reports, November 2022, Elsevier

    Bruce Troen

  14. Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells

    Article • Frontiers in Immunology, October 2022, Frontiers

    Bruce Troen

  15. World guidelines for falls prevention and management for older adults: a global initiative

    Article • Age and Ageing, September 2022, Oxford University Press (OUP)

    Bruce Troen, Dr. Jose F Parodi

  16. HIIT, Sleep and Cognition in Older Adults

    Article • August 2022, Research Square

    Bruce Troen

  17. Leukotriene inhibitors with dexamethasone show promise in the prevention of death in COVID-19 patients with low oxygen saturations

    Article • Journal of Clinical and Translational Science, January 2022, Cambridge University Press

    Bruce Troen

  18. Front Matter

    Article • January 2022, Elsevier

    Bruce Troen

  19. Frailty: The end of the osteosarcopenia continuum?

    Article • January 2022, Elsevier

    Bruce Troen

  20. Both Vitamin D Supplementation and HIIT Boost Muscle VDR Expression, Which May Underlie Benefits for Frailty

    Article • Innovation in Aging, December 2021, Oxford University Press (OUP)

    Bruce Troen

  21. Ameliorating the hallmarks of cellular senescence in skeletal muscle myogenic progenitors in vitro and in vivo

    Article • Science Advances, September 2021, American Association for the Advancement of Science

    Bruce Troen

  22. Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors

    Article • Nutrition, July 2021, Elsevier

    Bruce Troen

  23. Falls: To D or Not to D—That Is Not the (Only) Question!

    Article • Annals of Internal Medicine, February 2021, American College of Physicians

    Bruce Troen

  24. The Association of Muscle Mass Measured by D3-Creatine Dilution Method With Dual-Energy X-Ray Absorptiometry and Physical Function in Postmenopausal Women

    Article • The Journals of Gerontology Series A, January 2021, Oxford University Press (OUP)

    Bruce Troen

  25. Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?

    Article • Advances in Geriatric Medicine and Research, January 2021, Qingres Limited

    Bruce Troen

  26. SRT2183 and SRT1720, but not Resveratrol, Inhibit Osteoclast Formation and Resorption in the Presence or Absence of Sirt1

    Article • December 2020, Research Square

    Bruce Troen

  27. Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice

    Article • Nutrients, September 2020, MDPI AG

    Bruce Troen

  28. Absence of complement factor H reduces physical performance in C57BL6 mice

    Article • Immunobiology, September 2020, Elsevier

    Bruce Troen

  29. Racial Disparities in a Sample of Inpatient Youth with ASD

    Article • Autism Research, January 2020, Wiley

    Professor Sarah Dababnah, Bruce Troen

  30. AGS and NIA Bench‐to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders

    Article • Journal of the American Geriatrics Society, December 2019, Wiley

    Bruce Troen

  31. Investigating and Remediating Selection Bias in Geriatrics Research: The Selection Bias Toolkit

    Article • Journal of the American Geriatrics Society, June 2019, Wiley

    Bruce Troen

  32. High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools

    Article • Mechanisms of Ageing and Development, June 2019, Elsevier

    Bruce Troen

  33. Treatment with an inhibitor of fatty acid synthase attenuates bone loss in ovariectomized mice

    Article • Bone, May 2019, Elsevier

    Bruce Troen

  34. AP‐1 and Mitf interact with NFATc1 to stimulate cathepsin K promoter activity in osteoclast precursors

    Article • Journal of Cellular Biochemistry, February 2019, Wiley

    Bruce Troen

  35. Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice

    Article • Journal of Visualized Experiments, February 2019, MyJove Corporation

    Bruce Troen

  36. Absence of complement factor H alters bone architecture and dynamics

    Article • Immunobiology, December 2018, Elsevier

    Jeyantt Sankaran, Bruce Troen

  37. Myeloid-Derived Suppressor Cells at the Intersection of Inflammaging and Bone Fragility

    Article • Immunological Investigations, November 2018, Taylor & Francis

    Bruce Troen

  38. Chronic vitamin D insufficiency impairs physical performance in C57BL/6J mice

    Article • Aging, June 2018, Impact Journals, LLC

    Bruce Troen

  39. Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway

    Article • Journal of Neuroimmune Pharmacology, April 2018, Springer Science + Business Media

    Bruce Troen

  40. Micro-CT analysis of trabecular parameters gradients in femurs of mice affected by chronic kidney disease

    Article • March 2018, SPIE

    Bruce Troen

  41. Neuropeptide Y Y2 antagonist treated ovariectomized mice exhibit greater bone mineral density

    Article • Neuropeptides, February 2018, Elsevier

    Bruce Troen

  42. Sleep Problems and Their Relationship to Maladaptive Behavior Severity in Psychiatrically Hospitalized Children with Autism Spectrum Disorder (ASD)

    Article • Journal of Autism and Developmental Disorders, October 2017, Springer Science + Business Media

    Bruce Troen

  43. Verbal Ability and Psychiatric Symptoms in Clinically Referred Inpatient and Outpatient Youth with ASD

    Article • Journal of Autism and Developmental Disorders, October 2017, Springer Science + Business Media

    Bruce Troen

  44. Talking About Death or Suicide: Prevalence and Clinical Correlates in Youth with Autism Spectrum Disorder in the Psychiatric Inpatient Setting

    Article • Journal of Autism and Developmental Disorders, June 2017, Springer Science + Business Media

    Bruce Troen

  45. High Intensity Interval Training Improves Physical Performance and Frailty in Aged Mice

    Article • The Journals of Gerontology Series A, June 2017, Oxford University Press (OUP)

    Bruce Troen

  46. Problem Behaviors in Autism Spectrum Disorder: Association with Verbal Ability and Adapting/Coping Skills

    Article • Journal of Autism and Developmental Disorders, June 2017, Springer Science + Business Media

    Bruce Troen

  47. Predictors of Inpatient Psychiatric Hospitalization for Children and Adolescents with Autism Spectrum Disorder

    Article • Journal of Autism and Developmental Disorders, May 2017, Springer Science + Business Media

    Bruce Troen

  48. A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?

    Article • Nutrition & Metabolism, March 2017, Springer Science + Business Media

    Bruce Troen

  49. Cellular and Molecular Aging

    Article • January 2017, Springer Science + Business Media

    Bruce Troen

  50. Calciotropic Hormones

    Article • January 2016, Springer Science + Business Media

    Bruce Troen

  51. Mouse Models of Frailty: an Emerging Field

    Article • Current Osteoporosis Reports, August 2015, Springer Science + Business Media

    Bruce Troen

  52. Statement of Principle

    Article • Journal of the American Geriatrics Society, August 2015, Wiley

    Bruce Troen

  53. Vitamin D: A Regulator of Metabolism and Inflammation

    Article • Current Nutrition & Food Science, March 2014, Bentham Science Publishers

    Bruce Troen

  54. Resveratrol: Effects on Lipids and Cardiovascular Risk

    Article • Current Cardiovascular Risk Reports, January 2013, Springer Science + Business Media

    Bruce Troen

  55. Do Vitamin D Levels Influence the Risk of Diabetes Mellitus and Play a Role in Healthier Aging?

    Article • Journal of the American Geriatrics Society, October 2011, Wiley

    Bruce Troen

  56. 3. Impact of Vitamin D on the Aging Population

    Article • June 2011, Endocrine Society

    Bruce Troen

  57. Retinoic acid inhibits NFATc1 expression and osteoclast differentiation

    Article • Journal of Bone and Mineral Metabolism, March 2011, Springer Science + Business Media

    Bruce Troen

  58. The Response of Elderly Veterans to Daily Vitamin D3 Supplementation of 2,000 IU: A Pilot Efficacy Study

    Article • Journal of the American Geriatrics Society, February 2011, Wiley

    Bruce Troen

  59. Cell and Molecular Aging

    Article • January 2011, Springer Science + Business Media

    Bruce Troen

  60. Treatment for osteoporosis in Australian residential aged care facilities: consensus recommendations for fracture prevention

    Article • The Medical Journal of Australia, August 2010, Australasian Medical Publishing Co. Pty Ltd. (AMPCo)

    Bruce Troen

  61. The cathepsin L gene is a direct target of FOXO1 in skeletal muscle

    Article • Biochemical Journal, March 2010, Portland Press Ltd.

    Bruce Troen

  62. Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand

    Article • Gene, October 2009, Elsevier

    Bruce Troen

  63. Vitamin D Supplementation in Older Persons: Benefits and Requirements

    Article • Aging Health, October 2009, Taylor & Francis

    Bruce Troen

  64. Some new food for thought: The role of vitamin D in the mental health of older adults

    Article • Current Psychiatry Reports, January 2009, Springer Science + Business Media

    Bruce Troen

  65. Calciotropic Hormones

    Article • January 2009, Springer Science + Business Media

    Bruce Troen

  66. Hypovitaminosis D in the elderly: From bone to brain

    Article • The journal of nutrition health & aging, July 2008, Elsevier

    Bruce Troen

  67. ERRATUM

    Article • Journal of the American Geriatrics Society, July 2008, Wiley

    Bruce Troen

  68. Understanding the Mechanisms of Senile Osteoporosis: New Facts for a Major Geriatric Syndrome

    Article • Journal of the American Geriatrics Society, May 2008, Wiley

    Bruce Troen

  69. Fat and Inflammaging: A Dual Path to Unfitness in Elderly People?

    Article • Journal of the American Geriatrics Society, February 2008, Wiley

    Bruce Troen

  70. Functional grouping of osteoclast genes revealed through microarray analysis

    Article • Biochemical and Biophysical Research Communications, February 2008, Elsevier

    Bruce Troen

  71. AP-1 stimulates the cathepsin K promoter in RAW 264.7 cells

    Article • Gene, November 2007, Elsevier

    Bruce Troen

  72. RESPONSE LETTER TO DRS. FISHER AND DAVIS

    Article • Journal of the American Geriatrics Society, December 2006, Wiley

    Bruce Troen

  73. Osteoporosis in Older People: A Tale of Two Studies (and Three Treatments)

    Article • Journal of the American Geriatrics Society, May 2006, Wiley

    Bruce Troen

  74. The Regulation of Cathepsin K Gene Expression

    Article • Annals of the New York Academy of Sciences, April 2006, Wiley

    Bruce Troen

  75. RANK ligand and interferon gamma differentially regulate cathepsin gene expression in pre-osteoclastic cells

    Article • Biochemical and Biophysical Research Communications, March 2005, Elsevier

    Bruce Troen

  76. RANK-L induces the expression of NFATc1, but not of NFκB subunits during osteoclast formation

    Article • Biochemical and Biophysical Research Communications, December 2004, Elsevier

    Bruce Troen

  77. The role of cathepsin K in normal bone resorption

    Article • Drug News & Perspectives, January 2004, Portico

    Bruce Troen

  78. Molecular mechanisms underlying osteoclast formation and activation

    Article • Experimental Gerontology, June 2003, Elsevier

    Bruce Troen

  79. Molecular cloning, expression, and function of osteoclastic calcineurin Aα

    Article • AJP Renal Physiology, March 2003, American Physiological Society

    Bruce Troen

  80. Differential effects of interleukin-6 receptor activation on intracellular signaling and bone resorption by isolated rat osteoclasts

    Article • Journal of Endocrinology, June 2002, Bioscientifica

    Bruce Troen

  81. Cathepsin K, Osteoclastic Resorption, and Osteoporosis Therapy

    Article • Journal of Bone and Mineral Research, October 2001, Oxford University Press (OUP)

    Bruce Troen

  82. Macrophage Colony-Stimulating Factor Suppresses Osteoblast Formation

    Article • Biochemical and Biophysical Research Communications, July 2001, Elsevier

    Bruce Troen

  83. New Insights into the Regulation of Cathepsin K Gene Expression by Osteoprotegerin Ligand

    Article • Biochemical and Biophysical Research Communications, July 2001, Elsevier

    Bruce Troen

  84. Cell and Molecular Aging

    Article • January 2001, Springer Science + Business Media

    Bruce Troen

  85. Transcription of Human Cathepsin B Is Mediated by Sp1 and Ets Family Factors in Glioma

    Article • DNA and Cell Biology, February 2000, Mary Ann Liebert Inc

    Bruce Troen

  86. Differentiating agents regulate cathepsin B gene expression in HL-60 cells

    Article • Journal of Leukocyte Biology, October 1999, Oxford University Press (OUP)

    Bruce Troen

  87. Cd38/Adp-Ribosyl Cyclase

    Article • Journal of Cell Biology, September 1999, Rockefeller University Press

    Bruce Troen

  88. Comparative responsiveness of HL-60, HL-60R, and HL-60R+ (LRARSN) cells to retinoic acid, calcitriol, 9 cis-retinoic acid, and sodium butyrate

    Article • Blood, October 1995, American Society of Hematology

    Bruce Troen

  89. Cloning, genomic organization, and chromosomal localization of human cathepsin L.

    Article • Journal of Biological Chemistry, January 1993, Elsevier

    Bruce Troen

  90. Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease.

    Article • Molecular and Cellular Biology, August 1988, ASM Journals

    Bruce Troen

  91. Use of a Cloned Multidrug Resistance Gene for Coamplification and Overproduction of Major Excreted Protein, a Transformation-Regulated Secreted Acid Protease

    Article • Molecular and Cellular Biology, August 1988, Taylor & Francis

    Bruce Troen

  92. Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation.

    Article • Journal of Biological Chemistry, January 1988, Elsevier

    Bruce Troen

  93. Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin

    Article • Biochemical Journal, September 1987, Portland Press Ltd.

    Bruce Troen

  94. [30] Colony screening of genomic cosmid libraries

    Article • January 1987, Elsevier

    Bruce Troen

  95. Effect of age on the 3,5,3′-tri-iodothyronine-induced increase in sugar uptake in rat thymocytes

    Article • Journal of Endocrinology, September 1986, Bioscientifica

    Bruce Troen

  96. Influence of age and sex on the concentrations of thyroid hormone in serum in the rat

    Article • Journal of Endocrinology, May 1982, Bioscientifica

    Bruce Troen

  97. Sympathetic Nervous System and Aging in Man

    Article • Endocrine Reviews, April 1980, Endocrine Society

    Bruce Troen

  98. Plasma epinephrine and control of plasma renin activity: possible extrarenal mechanisms

    Article • AJP Heart and Circulatory Physiology, June 1979, American Physiological Society

    Bruce Troen

  99. Studies of the human testis

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, July 1974, Elsevier

    Bruce Troen

  100. Studies of the Human Testis. III. Effect of Estrogen on Testosterone Formation in Human Testisin Vitro

    Article • The Journal of Clinical Endocrinology & Metabolism, June 1972, Endocrine Society

    Bruce Troen