All Stories

  1. Mifepristone alone and in combination with scAAV9-SMN1 gene therapy improves disease phenotypes in Smn2B/- spinal muscular atrophy mice
  2. Gene therapy-mediated overexpression of wild-type MFN2 improves Charcot-Marie-Tooth disease type 2A
  3. NATO3 protects dopaminergic neurons in mouse in vivo and human in vitro Parkinson’s disease models
  4. One-shot design of functional protein binders with BindCraft
  5. Highly frequent undesired insertional mutagenesis during Drosophila genome editing
  6. Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants
  7. Cerebellar dysfunction in frontotemporal dementia: intra-cerebellar pathology and cerebellar network degeneration
  8. Interactions of VMAT2 with CDCrel-1 and Parkin in Methamphetamine Neurotoxicity
  9. Liver SMN restoration rescues the Smn mouse model of spinal muscular atrophy
  10. TNFα prevents FGF4-mediated rescue of astrocyte dysfunction and reactivity in human ALS models
  11. Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica
  12. Production and Purification of Adeno-Associated Viral Vectors (AAVs) Using Orbitally Shaken HEK293 Cells
  13. Long term peripheral AAV9-SMN gene therapy promotes survival in a mouse model of spinal muscular atrophy
  14. TNFα hinders FGF4 efficacy to mitigate ALS astrocyte dysfunction and cGAS-STING pathway-induced innate immune reactivity
  15. Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth
  16. Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo
  17. Recovery of walking after paralysis by regenerating characterized neurons to their natural target region
  18. AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A/C and elastin dysregulation in Smn 2B/− spinal muscular atrophy mice
  19. Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function
  20. Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity
  21. Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity
  22. Central and peripheral delivered AAV9-SMN are both efficient but target different pathomechanisms in a mouse model of spinal muscular atrophy
  23. Astrocyte‐targeting RNA interference against mutated superoxide dismutase 1 induces motoneuron plasticity and protects fast‐fatigable motor units in a mouse model of amyotrophic lateral sclerosis
  24. Dopamine and Methamphetamine Differentially Affect Electron Transport Chain Complexes and Parkin in Rat Striatum: New Insight into Methamphetamine Neurotoxicity
  25. The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging
  26. Mitofusin-2 in the Nucleus Accumbens Regulates Anxiety and Depression-like Behaviors Through Mitochondrial and Neuronal Actions
  27. Central anorexigenic actions of bile acids are mediated by TGR5
  28. Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder
  29. The Links between ALS and NF-κB
  30. CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice
  31. Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice
  32. IL10- and IL35-Secreting MutuDC Lines Act in Cooperation to Inhibit Memory T Cell Activation Through LAG-3 Expression
  33. SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease
  34. Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology
  35. Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B
  36. Nano-imaging trace elements at organelle levels in substantia nigra overexpressing α-synuclein to model Parkinson’s disease
  37. Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice
  38. Blood Flow to the Spleen is Altered in a Mouse Model of Spinal Muscular Atrophy
  39. Glutaredoxin1 Diminishes Amyloid Beta-Mediated Oxidation of F-Actin and Reverses Cognitive Deficits in an Alzheimer's Disease Mouse Model
  40. Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss
  41. Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells
  42. The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging
  43. Altered interplay between endoplasmic reticulum and mitochondria in Charcot–Marie–Tooth type 2A neuropathy
  44. Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: Converging roads to therapeutic development
  45. Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate
  46. PM20D1 is a quantitative trait locus associated with Alzheimer’s disease
  47. Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion
  48. Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?
  49. PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease
  50. Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
  51. Scalable Production and Purification of Adeno-Associated Viral Vectors (AAV)
  52. Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL
  53. Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity
  54. In vivo neurochemical measurements in cerebral tissues using a droplet-based monitoring system
  55. G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain
  56. Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects
  57. An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator
  58. α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP
  59. Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons
  60. Un implant bioactif pour prévenir la maladie d’Alzheimer
  61. Gene Therapy: A Promising Approach for Neuroprotection in Parkinson’s Disease?
  62. Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent
  63. Amyloid-β plaque deposition measured using propagation-based X-ray phase contrast CT imaging
  64. A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies
  65. Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson's disease
  66. Regulation of Memory Formation by the Transcription Factor XBP1
  67. In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons
  68. Lentiviral Vectors for the Engineering of Implantable Cells Secreting Recombinant Antibodies
  69. Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease
  70. Chondroitinase gene therapy improves upper limb function following cervical contusion injury
  71. Tmc gene therapy restores auditory function in deaf mice
  72. Pathway-specific reorganization of projection neurons in somatosensory cortex during learning
  73. Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System
  74. Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease
  75. PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein
  76. Channel-Mediated Lactate Release by K+-Stimulated Astrocytes
  77. Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology
  78. SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice
  79. Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS
  80. α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9)
  81. The adipocyte differentiation protein APMAP is an endogenous suppressor of A  production in the brain
  82. Overview of Mouse Models of Parkinson's Disease
  83. Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation
  84. A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity
  85. Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
  86. Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration
  87. Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury
  88. Intracerebroventricular Injection of Adeno-Associated Virus 6 and 9 Vectors for Cell Type–Specific Transgene Expression in the Spinal Cord
  89. A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells
  90. Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation
  91. Measurement of autophagy flux in the nervous system in vivo
  92. FOXO3 determines the accumulation of  -synuclein and controls the fate of dopaminergic neurons in the substantia nigra
  93. Application of Viral Vectors to Motor Neuron Disorders
  94. Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity
  95. Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo
  96. Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex
  97. Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain
  98. Direct and Retrograde Transduction of Nigral Neurons with AAV6, 8, and 9 and Intraneuronal Persistence of Viral Particles
  99. Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model
  100. Proton and Phosphorus Magnetic Resonance Spectroscopy of a Mouse Model of Alzheimer's Disease
  101. Overexpression of tau in the mouse forebrain using adeno-associated virus (AAV) leads to tau hyperphosphorylation, formation of neurofibrillary tangles and neurodegeneration
  102. Anin vivoultrahigh field 14.1 T1H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker
  103. Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo
  104. Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity
  105.  -Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer
  106. Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human  -Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease
  107. Parkinson's Disease: Gene Therapies
  108. Sustained expression of PGC-1  in the rat nigrostriatal system selectively impairs dopaminergic function
  109. Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons
  110. Behavioral and neuropathological characterization of a viral-based model of amyloid pathology
  111. Modelling Alzheimer's disease through Adeno-Associated Virus (AAV) vector gene delivery in the mouse brain
  112. Neuroprotection by Gene Therapy Targeting Mutant SOD1 in Individual Pools of Motor Neurons Does not Translate Into Therapeutic Benefit in fALS Mice
  113. A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2
  114. Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson's Disease
  115. Long-range connectivity of mouse primary somatosensory barrel cortex
  116. Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits  -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions
  117. Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6
  118. Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease
  119. Phosphorylation Does Not Prompt, Nor Prevent, the Formation of  -synuclein Toxic Species in a Rat Model of Parkinson's Disease
  120. Regulation of Prenatal Human Retinal Neurosphere Growth and Cell Fate Potential by Retinal Pigment Epithelium and Mash1
  121. Viral vectors, animal models and new therapies for Parkinson's disease
  122. Systemic AAV6 Delivery Mediating RNA Interference Against SOD1: Neuromuscular Transduction Does Not Alter Disease Progression in fALS Mice
  123. Viral Vectors
  124. Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy
  125. Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation
  126. Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease
  127. Inducing Tolerance to a Soluble Foreign Antigen by Encapsulated Cell Transplants
  128. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates
  129. Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an α-synuclein rat model of Parkinson's disease
  130. Survival of Encapsulated Human Primary Fibroblasts and Erythropoietin Expression Under Xenogeneic Conditions
  131. Wlds-Mediated Protection of Dopaminergic Fibers in an Animal Model of Parkinson Disease
  132. Wlds-Mediated Protection of Dopaminergic Fibers in an Animal Model of Parkinson Disease
  133. Using human neural stem cells to model neurological disease
  134. Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery
  135. Cellular implants: pioneers in xenotransplantation?
  136. Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia
  137. Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia
  138. Long-Term Doxycycline-Regulated Secretion of Erythropoietin by Encapsulated Myoblasts
  139. α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
  140. Encapsulation as a Strategy for Cell Xenotransplantation
  141. INDUCING HOST ACCEPTANCE TO ENCAPSULATED XENOGENEIC MYOBLASTS
  142. A self-immunomodulating myoblast cell line for erythropoietin delivery
  143. Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts