All Stories

  1. Selective striatal pathological changes in a novel human HTT exon 1 knock-in mouse model of Huntington's disease

    Article • Experimental Neurology, December 2025, Elsevier

    Professor Nicole Déglon

  2. Gene editing for Spinocerebellar ataxia type 3 taking advantage of the human ATXN3L paralog as replacement gene

    Article • Gene Therapy, July 2025, Springer Science + Business Media

    Professor Nicole Déglon

  3. Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity

    Article • Translational Neurodegeneration, March 2025, Springer Science + Business Media

    Professor Nicole Déglon

  4. Plasminogen activator inhibitor-1 regulates Zika virus infection

    Article • March 2025, Springer Science + Business Media

    Professor Nicole Déglon

  5. Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice

    Article • Brain, July 2024, Oxford University Press (OUP)

    Professor Nicole Déglon

  6. Gene editing as a therapeutic strategy for spinocerebellar ataxia type-3

    Article • Revue Neurologique, April 2024, Elsevier

    Professor Nicole Déglon

  7. Mono- and Biallelic Inactivation of Huntingtin Gene in Patient-Specific Induced Pluripotent Stem Cells Reveal HTT Roles in Striatal Development and Neuronal Functions

    Article • Journal of Huntington s Disease, February 2024, IOS Press

    Professor Nicole Déglon

  8. Limitations of Dual-Single Guide RNA CRISPR Strategies for the Treatment of Central Nervous System Genetic Disorders

    Article • Human Gene Therapy, September 2023, Mary Ann Liebert Inc

    Professor Nicole Déglon

  9. Tau Transfer via Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System

    Article • Cells, March 2023, MDPI AG

    Professor Nicole Déglon

  10. Semi-automated workflows to quantify AAV transduction in various brain areas and predict gene editing outcome for neurological disorders

    Article • Molecular Therapy — Methods & Clinical Development, March 2023, Elsevier

    Professor Nicole Déglon

  11. Revisiting the outcome of adult wild-type Htt inactivation in the context of HTT-lowering strategies for Huntington’s disease

    Article • Brain Communications, January 2023, Oxford University Press (OUP)

    Professor Nicole Déglon

  12. Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: possible implication for Alzheimer’s disease

    Article • Progress in Neurobiology, December 2022, Elsevier

    Professor Nicole Déglon

  13. Disruption of astrocyte-dependent dopamine control in the developing medial prefrontal cortex leads to excessive grooming in mice

    Article • Biological Psychiatry, December 2022, Elsevier

    Professor Nicole Déglon

  14. Central Nervous System Gene Therapy: Present Developments and Emerging Trends Accelerating Industry-Academia Pathways

    Article • Human Gene Therapy, September 2022, Mary Ann Liebert Inc

    Professor Nicole Déglon

  15. Correction: Maximizing lentiviral vector gene transfer in the CNS

    Article • Gene Therapy, April 2022, Springer Science + Business Media

    Professor Nicole Déglon

  16. Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance

    Article • Proceedings of the National Academy of Sciences, November 2021, Proceedings of the National Academy of Sciences

    Professor Nicole Déglon

  17. Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia

    Article • Autophagy, September 2021, Taylor & Francis

    Professor Nicole Déglon

  18. Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies

    Article • Molecular Therapy, September 2021, Elsevier

    Professor Nicole Déglon

  19. Corrigendum: Genome Editing for CNS Disorders

    Article • Frontiers in Neuroscience, May 2021, Frontiers

    Professor Nicole Déglon

  20. Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation

    Article • Cell Reports, April 2021, Elsevier

    Professor Nicole Déglon

  21. Astrocytic VMAT2 in the developing prefrontal cortex is required for normal grooming behavior in mice

    Article • January 2021, Cold Spring Harbor Laboratory Press

    Professor Nicole Déglon

  22. Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease

    Article • Nature Neuroscience, November 2020, Springer Science + Business Media

    Professor Nicole Déglon

  23. Genome Editing for CNS Disorders

    Article • Frontiers in Neuroscience, October 2020, Frontiers

    Professor Nicole Déglon

  24. Glucose metabolism links astroglial mitochondria to cannabinoid effects

    Article • Nature, July 2020, Springer Science + Business Media

    Professor Nicole Déglon

  25. Maximizing lentiviral vector gene transfer in the CNS

    Article • Gene Therapy, July 2020, Springer Science + Business Media

    Professor Nicole Déglon

  26. Efficacy of THN201, a Combination of Donepezil and Mefloquine, to Reverse Neurocognitive Deficits in Alzheimer’s Disease

    Article • Frontiers in Neuroscience, June 2020, Frontiers

    Professor Nicole Déglon

  27. Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level

    Article • Scientific Reports, June 2020, Springer Science + Business Media

    Professor Nicole Déglon

  28. Emerging technologies to study glial cells

    Article • Glia, January 2020, Wiley

    Professor Nicole Déglon

  29. Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs

    Article • Acta Physiologica, January 2020, Wiley

    Professor Nicole Déglon

  30. A New Tool for In Vivo Study of Astrocyte Connexin 43 in Brain

    Article • Scientific Reports, December 2019, Springer Science + Business Media

    Professor Nicole Déglon

  31. The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

    Article • Neurobiology of Disease, October 2019, Elsevier

    Professor Nicole Déglon

  32. Development of Efficient AAV2/DJ-Based Viral Vectors to Selectively Downregulate the Expression of Neuronal or Astrocytic Target Proteins in the Rat Central Nervous System

    Article • Frontiers in Molecular Neuroscience, August 2019, Frontiers

    Professor Nicole Déglon

  33. Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

    Article • Molecular Therapy — Methods & Clinical Development, June 2019, Elsevier

    Professor Nicole Déglon, Dr Bernard L Schneider

  34. Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

    Article • Cell Reports, February 2019, Elsevier

    Professor Nicole Déglon

  35. Different tau species lead to heterogeneous tau pathology propagation and misfolding

    Article • Acta Neuropathologica Communications, November 2018, Springer Science + Business Media

    Professor Nicole Déglon

  36. Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free “GeneSwitch” vector

    Article • Experimental Neurology, November 2018, Elsevier

    Professor Nicole Déglon

  37. Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines

    Article • Stem Cell Reports, November 2018, Elsevier

    Professor Nicole Déglon

  38. Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

    Article • Molecular Psychiatry, August 2018, Springer Science + Business Media

    Professor Nicole Déglon

  39. Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation

    Article • Cell Reports, August 2018, Elsevier

    Professor Nicole Déglon

  40. Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease

    Article • Scientific Reports, April 2018, Springer Science + Business Media

    Professor Nicole Déglon, Dr. Jonasz Jeremiasz Weber

  41. The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

    Article • Brain, March 2018, Oxford University Press (OUP)

    Professor Nicole Déglon

  42. CRISPR/Cas9-Mediated Genome Editing for Huntington’s Disease

    Article • January 2018, Springer Science + Business Media

    Professor Nicole Déglon

  43. Scalable Production and Purification of Adeno-Associated Viral Vectors (AAV)

    Article • January 2018, Springer Science + Business Media

    Professor Nicole Déglon, Dr Bernard L Schneider

  44. βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer’s Disease

    Article • Cerebral Cortex, October 2017, Oxford University Press (OUP)

    Professor Nicole Déglon

  45. The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes

    Article • Cell Reports, September 2017, Elsevier

    Professor Nicole Déglon

  46. AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington’s disease

    Article • Gene Therapy, August 2017, Nature

    Professor Nicole Déglon

  47. Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing

    Article • Molecular Therapy — Methods & Clinical Development, June 2017, Elsevier

    Professor Nicole Déglon

  48. A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

    Article • PLOS One, April 2017, PLOS

    Professor Nicole Déglon

  49. Formation of hippocampal mHTT aggregates leads to impaired spatial memory, hippocampal activation and adult neurogenesis

    Article • Neurobiology of Disease, March 2017, Elsevier

    Professor Nicole Déglon

  50. From huntingtin gene to Huntington’s disease-altering strategies

    Article • January 2017, Elsevier

    Professor Nicole Déglon

  51. Adeno-associated virus and lentivirus vectors: a refined toolkit for the central nervous system

    Article • Current Opinion in Virology, December 2016, Elsevier

    Professor Nicole Déglon

  52. Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin

    Article • European Journal of Neuroscience, October 2016, Wiley

    Professor Nicole Déglon

  53. L5 Pre-clinical evaluation of aav5-mihtt gene therapy of huntington’s disease in rodents

    Article • Journal of Neurology Neurosurgery & Psychiatry, September 2016, BMJ

    Professor Nicole Déglon

  54. L4 Sustained and strong HTT silencing by AAV5-miHTT as therapy for huntington’s disease

    Article • Journal of Neurology Neurosurgery & Psychiatry, September 2016, BMJ

    Professor Nicole Déglon

  55. Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease

    Article • Glia, July 2016, Wiley

    Professor Nicole Déglon

  56. 463. Suspension-Adapted HEK 293 Cells in Orbital Shaken Bioreactors for the Production of Adeno-Associated Virus Vectors

    Article • Molecular Therapy, May 2016, Elsevier

    Professor Nicole Déglon

  57. 327. Genetic Editing for Huntington's Disease

    Article • Molecular Therapy, May 2016, Elsevier

    Professor Nicole Déglon

  58. Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

    Article • PLOS One, February 2016, PLOS

    Professor Nicole Déglon

  59. Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

    Article • Molecular Neurodegeneration, January 2016, Springer Science + Business Media

    Professor Nicole Déglon

  60. Attenuated Levels of Hippocampal Connexin 43 and its Phosphorylation Correlate with Antidepressant- and Anxiolytic-Like Activities in Mice

    Article • Frontiers in Cellular Neuroscience, December 2015, Frontiers

    Professor Nicole Déglon

  61. AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease

    Article • Human Molecular Genetics, December 2015, Oxford University Press (OUP)

    Professor Nicole Déglon

  62. Non-human primate model of tauopathy

    Article • Alzheimer s & Dementia, July 2015, Elsevier

    Professor Nicole Déglon, Alexis Bemelmans

  63. Gene transfer of both app and ps1 induces hippocampal impairments close to human early phases of Alzheimer’s disease

    Article • Alzheimer s & Dementia, July 2015, Elsevier

    Professor Nicole Déglon, Alexis Bemelmans

  64. Gene transfer engineering for astrocyte-specific silencing in the CNS

    Article • Gene Therapy, June 2015, Nature

    Professor Nicole Déglon

  65. Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth

    Article • Nature Communications, June 2015, Nature

    Professor Nicole Déglon

  66. 465. Transient Production of Recombinant Adeno-Associated Virus (AAV) Vectors for Gene Therapy Applications Using Suspension-Adapted HEK 293 Cells in Orbital Shaken Bioreactors

    Article • Molecular Therapy, May 2015, Elsevier

    Professor Nicole Déglon

  67. The striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo

    Article • Neurobiology of Aging, March 2015, Elsevier

    Professor Nicole Déglon

  68. The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases

    Article • Journal of Neuroscience, February 2015, Society for Neuroscience

    Professor Nicole Déglon

  69. Approches degene silencingpour le traitement de la maladie de Huntington

    Article • médecine/sciences, February 2015, EDP Sciences

    Professor Nicole Déglon

  70. Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease

    Article • Human Molecular Genetics, November 2014, Oxford University Press (OUP)

    Professor Nicole Déglon

  71. RNA Interference Mitigates Motor and Neuropathological Deficits in a Cerebellar Mouse Model of Machado-Joseph Disease

    Article • PLOS One, August 2014, PLOS

    Mr David Albuquerque, Professor Nicole Déglon

  72. AMYLOID CASCADE INDUCTION IN AN AAV-BASED MOUSE MODEL OF ALZHEIMER'S DISEASE

    Article • Alzheimer s & Dementia, July 2014, Elsevier

    Professor Nicole Déglon, Alexis Bemelmans

  73. Allele-Specific Silencing of Mutant Huntingtin in Rodent Brain and Human Stem Cells

    Article • PLOS One, June 2014, PLOS

    Professor Nicole Déglon, Diana ZALA

  74. SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients

    Article • Neurobiology of Aging, May 2014, Elsevier

    Professor Nicole Déglon

  75. Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

    Article • Nature Neuroscience, March 2014, Nature

    Professor Nicole Déglon

  76. Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

    Article • Acta Neuropathologica Communications, January 2014, Springer Science + Business Media

    Professor Nicole Déglon

  77. Lentiviral Vectors in Huntington’s Disease Research and Therapy

    Article • September 2013, Springer Science + Business Media

    Professor Nicole Déglon

  78. Lentiviral Vectors: A Powerful Tool to Target Astrocytes In Vivo

    Article • Current Drug Targets, September 2013, Bentham Science Publishers

    Professor Nicole Déglon

  79. Lentiviral Delivery of the Human Wild-type Tau Protein Mediates a Slow and Progressive Neurodegenerative Tau Pathology in the Rat Brain

    Article • Molecular Therapy, July 2013, Elsevier

    Professor Nicole Déglon

  80. In vivo tau spreading relies on the transsynaptic transfer of soluble wild-type tau species

    Article • Alzheimer s & Dementia, July 2013, Elsevier

    Professor Nicole Déglon

  81. Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado–Joseph disease

    Article • Brain, June 2013, Oxford University Press (OUP)

    Mr David Albuquerque, Professor Nicole Déglon

  82. A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

    Article • Human Molecular Genetics, May 2013, Oxford University Press (OUP)

    Professor Nicole Déglon

  83. BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities

    Article • Translational Psychiatry, April 2013, Nature

    Professor Nicole Déglon

  84. Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice

    Article • PLOS One, January 2013, PLOS

    Mr David Albuquerque, Professor Nicole Déglon

  85. Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors

    Article • Frontiers in Cellular Neuroscience, January 2013, Frontiers

    Professor Nicole Déglon

  86. Lentiviral-Mediated Gene Transfer of siRNAs for the Treatment of Huntington’s Disease

    Article • January 2013, Springer Science + Business Media

    Professor Nicole Déglon

  87. Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology

    Article • The Cerebellum, December 2012, Springer Science + Business Media

    Mr David Albuquerque, Professor Nicole Déglon

  88. Viral-mediated overexpression of mutant huntingtin to model HD in various species

    Article • Neurobiology of Disease, November 2012, Elsevier

    Professor Nicole Déglon

  89. Restricted transgene expression in the brain with cell-type specific neuronal promoters

    Article • Human Gene Therapy Methods, October 2012, Mary Ann Liebert Inc

    Professor Nicole Déglon

  90. Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo

    Article • Neurobiology of Aging, August 2012, Elsevier

    Professor Nicole Déglon

  91. Restricted Transgene Expression in the Brain with Cell-Type Specific Neuronal Promoters

    Article • Human Gene Therapy Methods, August 2012, Mary Ann Liebert Inc

    Professor Nicole Déglon

  92. Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease

    Article • Brain, July 2012, Oxford University Press (OUP)

    Professor Nicole Déglon

  93. Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells

    Article • Human Molecular Genetics, June 2012, Oxford University Press (OUP)

    Professor Nicole Déglon

  94. Lentiviral delivery of human wild-type Tau protein mediates a slow and progressive spatio-temporal Tau pathology in rat brain

    Article • Alzheimer s & Dementia, July 2011, Elsevier

    Professor Nicole Déglon

  95. Nuclear Factor Erythroid 2-Related Factor 2 Facilitates Neuronal Glutathione Synthesis by Upregulating Neuronal Excitatory Amino Acid Transporter 3 Expression

    Article • Journal of Neuroscience, May 2011, Society for Neuroscience

    Professor Nicole Déglon

  96. Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter

    Article • Human Molecular Genetics, April 2011, Oxford University Press (OUP)

    Professor Nicole Déglon

  97. Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado–Joseph disease

    Article • Brain, April 2011, Oxford University Press (OUP)

    Professor Nicole Déglon

  98. In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

    Article • Human Molecular Genetics, May 2010, Oxford University Press (OUP)

    Professor Nicole Déglon

  99. Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?

    Article • Human Molecular Genetics, March 2010, Oxford University Press (OUP)

    Professor Nicole Déglon

  100. Mitochondria in Huntington's disease

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, January 2010, Elsevier

    Professor Nicole Déglon

  101. Diminished hippocalcin expression in Huntington’s disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

    Article • Journal of Neurochemistry, October 2009, Wiley

    Professor Nicole Déglon

  102. Engineered lentiviral vector targeting astrocytesIn vivo

    Article • Glia, April 2009, Wiley

    Professor Nicole Déglon

  103. Human α-Iduronidase Gene Transfer Mediated by Adeno-Associated Virus Types 1, 2, and 5 in the Brain of Nonhuman Primates: Vector Diffusion and Biodistribution

    Article • Human Gene Therapy, April 2009, Mary Ann Liebert Inc

    Professor Nicole Déglon

  104. Sustained effects of nonallele-specificHuntingtinsilencing

    Article • Annals of Neurology, March 2009, Wiley

    Professor Nicole Déglon

  105. Normal Aging Modulates the Neurotoxicity of Mutant Huntingtin

    Article • PLOS One, February 2009, PLOS

    Professor Nicole Déglon

  106. Positron Emission Tomography Imaging Demonstrates Correlation between Behavioral Recovery and Correction of Dopamine Neurotransmission after Gene Therapy

    Article • Journal of Neuroscience, February 2009, Society for Neuroscience

    Professor Nicole Déglon

  107. Viral Vectors for in Vivo Gene Transfer

    Article • January 2009, Springer Science + Business Media

    Professor Nicole Déglon

  108. Implication of the JNK pathway in a rat model of Huntington's disease

    Article • Experimental Neurology, January 2009, Elsevier

    Professor Nicole Déglon

  109. Applications of Lentiviral Vectors for Biology and Gene Therapy of Neurological Disorders

    Article • Current Gene Therapy, December 2008, Bentham Science Publishers

    Professor Nicole Déglon

  110. Allele-Specific RNA Silencing of Mutant Ataxin-3 Mediates Neuroprotection in a Rat Model of Machado-Joseph Disease

    Article • PLOS One, October 2008, PLOS

    Professor Nicole Déglon

  111. Gene Transfer Techniques for the Delivery of GDNF in Parkinson's Disease

    Article • October 2008, Wiley

    Professor Nicole Déglon

  112. Dysregulation of Gene Expression in Primary Neuron Models of Huntington's Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry

    Article • Journal of Neuroscience, September 2008, Society for Neuroscience

    Professor Nicole Déglon

  113. Efficient Gene Transfer and Expression of Biologically Active Glial Cell Line-Derived Neurotrophic Factor in Rat Motoneurons Transduced with Lentiviral Vectors

    Article • Journal of Neurochemistry, July 2008, Wiley

    Professor Nicole Déglon

  114. Vers un nouveau rôle du récepteur PPAR-γ dans le syndrome d’immunodéficience acquise et les hémopathies chez l’homme

    Article • médecine/sciences, May 2008, EDP Sciences

    Professor Nicole Déglon

  115. Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

    Article • Human Molecular Genetics, April 2008, Oxford University Press (OUP)

    Professor Nicole Déglon

  116. Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARγ/STAT5 signaling pathway in macaques

    Article • Journal of Clinical Investigation, April 2008, American Society for Clinical Investigation

    Professor Nicole Déglon

  117. Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II

    Article • Human Molecular Genetics, February 2008, Oxford University Press (OUP)

    Professor Nicole Déglon

  118. Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo

    Article • Neurobiology of Disease, January 2008, Elsevier

    Professor Nicole Déglon

  119. Expression of Mutated Huntingtin Fragment in the Putamen Is Sufficient to Produce Abnormal Movement in Non-human Primates

    Article • Molecular Therapy, August 2007, Elsevier

    Professor Nicole Déglon

  120. Activation of Astrocytes by CNTF Induces Metabolic Plasticity and Increases Resistance to Metabolic Insults

    Article • Journal of Neuroscience, July 2007, Society for Neuroscience

    Professor Nicole Déglon

  121. Neuroprotection by Hsp104 and Hsp27 in Lentiviral-based Rat Models of Huntington's Disease

    Article • Molecular Therapy, May 2007, Elsevier

    Professor Nicole Déglon

  122. Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts

    Article • Journal of the Neurological Sciences, April 2007, Elsevier

    Professor Nicole Déglon

  123. Transplants of CNTF-producing Cells for the Treatment of Huntington's Disease

    Article • January 2007, Elsevier

    Professor Nicole Déglon

  124. Ciliary Neurotrophic Factor Activates Astrocytes, Redistributes Their Glutamate Transporters GLAST and GLT-1 to Raft Microdomains, and Improves Glutamate Handling In Vivo

    Article • Journal of Neuroscience, May 2006, Society for Neuroscience

    Professor Nicole Déglon

  125. CA150 Expression Delays Striatal Cell Death in Overexpression and Knock-In Conditions for Mutant Huntingtin Neurotoxicity

    Article • Journal of Neuroscience, April 2006, Society for Neuroscience

    Professor Nicole Déglon

  126. Inhibition of Calcineurin by FK506 Protects against Polyglutamine-Huntingtin Toxicity through an Increase of Huntingtin Phosphorylation at S421

    Article • Journal of Neuroscience, February 2006, Society for Neuroscience

    Professor Nicole Déglon

  127. Involvement of Mitochondrial Complex II Defects in Neuronal Death Produced by N-Terminus Fragment of Mutated Huntingtin

    Article • Molecular Biology of the Cell, January 2006, American Society for Cell Biology (ASCB)

    Professor Nicole Déglon

  128. Lentivirus-mediated expression of glutathione peroxidase: Neuroprotection in murine models of Parkinson's disease

    Article • Neurobiology of Disease, January 2006, Elsevier

    Professor Nicole Déglon

  129. Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

    Article • Neurobiology of Disease, December 2005, Elsevier

    Professor Nicole Déglon, Diana ZALA

  130. Akt is altered in an animal model of Huntington's disease and in patients

    Article • European Journal of Neuroscience, March 2005, Wiley

    Professor Nicole Déglon

  131. Minocycline in phenotypic models of Huntington's disease

    Article • Neurobiology of Disease, February 2005, Elsevier

    Professor Nicole Déglon

  132. Viral vectors as tools to model and treat neurodegenerative disorders

    Article • The Journal of Gene Medicine, January 2005, Wiley

    Professor Nicole Déglon

  133. Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an α-synuclein rat model of Parkinson's disease

    Article • Proceedings of the National Academy of Sciences, December 2004, Proceedings of the National Academy of Sciences

    Dr Bernard L Schneider, Professor Nicole Déglon

  134. Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease

    Article • Neurobiology of Disease, November 2004, Elsevier

    Professor Nicole Déglon

  135. Neuroprotective Gene Therapy for Huntington's Disease, Using Polymer-Encapsulated Cells Engineered to Secrete Human Ciliary Neurotrophic Factor: Results of a Phase I Study

    Article • Human Gene Therapy, October 2004, Mary Ann Liebert Inc

    Professor Nicole Déglon

  136. Survival of Encapsulated Human Primary Fibroblasts and Erythropoietin Expression Under Xenogeneic Conditions

    Article • Human Gene Therapy, July 2004, Mary Ann Liebert Inc

    Dr Bernard L Schneider, Professor Nicole Déglon

  137. Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

    Article • Neurobiology of Disease, July 2004, Elsevier

    Professor Nicole Déglon

  138. Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1G93A transgenic mice

    Article • Neurobiology of Disease, June 2004, Elsevier

    Professor Nicole Déglon

  139. Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

    Article • Experimental Neurology, January 2004, Elsevier

    Professor Nicole Déglon, Diana ZALA

  140. Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

    Article • Human Molecular Genetics, September 2003, Oxford University Press (OUP)

    Professor Nicole Déglon

  141. Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina

    Article • Gene Therapy, May 2003, Nature

    Professor Nicole Déglon

  142. Presence of Gal-alpha1,3Gal epitope on xenogeneic lines: implications for cellular gene therapy based on the encapsulation technology

    Article • Xenotransplantation, May 2003, Wiley

    Professor Nicole Déglon

  143. Multiply Attenuated, Self-Inactivating Lentiviral Vectors Efficiently Deliver and Express Genes for Extended Periods of Time in Adult Rat Cardiomyocytes In Vivo

    Article • Circulation, April 2003, Wolters Kluwer Health

    Professor Nicole Déglon

  144. Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy

    Article • The Journal of Gene Medicine, February 2003, Wiley

    Professor Nicole Déglon

  145. Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors

    Article • Journal of Controlled Release, February 2003, Elsevier

    Professor Nicole Déglon

  146. Delivery of Ciliary Neurotrophic Factor via Lentiviral-Mediated Transfer Protects Axotomized Retinal Ganglion Cells for an Extended Period of Time

    Article • Human Gene Therapy, January 2003, Mary Ann Liebert Inc

    Professor Nicole Déglon

  147. French gene therapy group reports on the adverse event in a clinical trial of gene therapy for X-linked severe combined immune deficiency (X-SCID)

    Article • The Journal of Gene Medicine, January 2003, Wiley

    Professor Nicole Déglon

  148. Lentiviral-Mediated RNA Interference

    Article • Human Gene Therapy, December 2002, Mary Ann Liebert Inc

    Professor Nicole Déglon

  149. Dose-Dependent Neuroprotective Effect of Ciliary Neurotrophic Factor Delivered via Tetracycline-Regulated Lentiviral Vectors in the Quinolinic Acid Rat Model of Huntington's Disease

    Article • Human Gene Therapy, November 2002, Mary Ann Liebert Inc

    Professor Nicole Déglon

  150. Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia

    Article • Kidney International, October 2002, Elsevier

    Dr Bernard L Schneider, Professor Nicole Déglon

  151. Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia

    Article • Kidney International, October 2002, Elsevier

    Dr Bernard L Schneider, Professor Nicole Déglon

  152. Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons

    Article • Journal of Neuroscience Research, August 2002, Wiley

    Professor Nicole Déglon

  153. Long-Term Doxycycline-Regulated Secretion of Erythropoietin by Encapsulated Myoblasts

    Article • Molecular Therapy, August 2002, Elsevier

    Dr Bernard L Schneider, Professor Nicole Déglon

  154. Seizure Suppression by Adenosine‐releasing Cells Is Independent of Seizure Frequency

    Article • Epilepsia, August 2002, Wiley

    Professor Nicole Déglon

  155. α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease

    Article • Proceedings of the National Academy of Sciences, July 2002, Proceedings of the National Academy of Sciences

    Dr Bernard L Schneider, Professor Nicole Déglon

  156. Lentivirally Delivered Glial Cell Line-Derived Neurotrophic Factor Increases the Number of Striatal Dopaminergic Neurons in Primate Models of Nigrostriatal Degeneration

    Article • Journal of Neuroscience, June 2002, Society for Neuroscience

    Professor Nicole Déglon

  157. Lentiviral-Mediated Delivery of Mutant Huntingtin in the Striatum of Rats Induces a Selective Neuropathology Modulated by Polyglutamine Repeat Size, Huntingtin Expression Levels, and Protein Length

    Article • Journal of Neuroscience, May 2002, Society for Neuroscience

    Professor Nicole Déglon

  158. Lentiviruses as Vectors for CNS Diseases

    Article • January 2002, Springer Science + Business Media

    Professor Nicole Déglon

  159. Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

    Article • European Journal of Neuroscience, December 2001, Wiley

    Professor Nicole Déglon

  160. Viral vector-mediated gene therapy for Parkinson's disease

    Article • Clinical Neuroscience Research, December 2001, Elsevier

    Professor Nicole Déglon

  161. Isolation of Multipotent Neural Precursors Residing in the Cortex of the Adult Human Brain

    Article • Experimental Neurology, July 2001, Elsevier

    Professor Nicole Déglon

  162. Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

    Article • Proceedings of the National Academy of Sciences, June 2001, Proceedings of the National Academy of Sciences

    Professor Nicole Déglon

  163. Neuroprotective Effect of a CNTF-Expressing Lentiviral Vector in the Quinolinic Acid Rat Model of Huntington's Disease

    Article • Neurobiology of Disease, June 2001, Elsevier

    Professor Nicole Déglon

  164. Gene Transfer into Neurons from Hippocampal Slices: Comparison of Recombinant Semliki Forest Virus, Adenovirus, Adeno-Associated Virus, Lentivirus, and Measles Virus

    Article • Molecular and Cellular Neuroscience, May 2001, Elsevier

    Professor Nicole Déglon

  165. Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease

    Article • Science, October 2000, American Association for the Advancement of Science

    Professor Nicole Déglon

  166. Neuroprotective Gene Therapy for Huntington’s Disease Using a Polymer Encapsulated BHK Cell Line Engineered to Secrete Human CNTF

    Article • Human Gene Therapy, August 2000, Mary Ann Liebert Inc

    Professor Nicole Déglon

  167. Complete and Long-Term Rescue of Lesioned Adult Motoneurons by Lentiviral-Mediated Expression of Glial Cell Line-Derived Neurotrophic Factor in the Facial Nucleus

    Article • Journal of Neuroscience, August 2000, Society for Neuroscience

    Professor Nicole Déglon

  168. Lentiviral Vectors as a Gene Delivery System in the Mouse Midbrain: Cellular and Behavioral Improvements in a 6-OHDA Model of Parkinson's Disease Using GDNF

    Article • Experimental Neurology, July 2000, Elsevier

    Professor Nicole Déglon

  169. Restoration of Cognitive and Motor Functions by Ciliary Neurotrophic Factor in a Primate Model of Huntington's Disease

    Article • Human Gene Therapy, May 2000, Mary Ann Liebert Inc

    Professor Nicole Déglon

  170. Self-Inactivating Lentiviral Vectors with Enhanced Transgene Expression as Potential Gene Transfer System in Parkinson's Disease

    Article • Human Gene Therapy, January 2000, Mary Ann Liebert Inc

    Professor Nicole Déglon

  171. Lentiviral Gene Transfer to the Nonhuman Primate Brain

    Article • Experimental Neurology, November 1999, Elsevier

    Professor Nicole Déglon

  172. Cellular xenotransplantation

    Article • Nature Medicine, August 1999, Springer Science + Business Media

    Professor Nicole Déglon

  173. Improvement of mouse β-thalassemia upon erythropoietin delivery by encapsulated myoblasts

    Article • Gene Therapy, February 1999, Nature

    Professor Nicole Déglon

  174. Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts

    Article • Gene Therapy, August 1998, Springer Science + Business Media

    Dr Bernard L Schneider, Professor Nicole Déglon

  175. A Gene Therapy Approach to Regulated Delivery of Erythropoietin as a Function of Oxygen Tension

    Article • Human Gene Therapy, November 1997, Mary Ann Liebert Inc

    Professor Nicole Déglon

  176. A Gene Therapy Approach for the Treatment of Amyotrophic Lateral Sclerosis and Parkinson's Disease

    Article • January 1997, Elsevier

    Professor Nicole Déglon

  177. Central Nervous System Delivery of Recombinant Ciliary Neurotrophic Factor by Polymer Encapsulated Differentiated C2C12 Myoblasts

    Article • Human Gene Therapy, November 1996, Mary Ann Liebert Inc

    Professor Nicole Déglon

  178. Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF

    Article • Cell Transplantation, October 1996, Elsevier

    Professor Nicole Déglon

  179. Errata

    Article • Nature Medicine, September 1996, Nature

    Professor Nicole Déglon

  180. Continuous delivery of erythropoietin in mice using encapsulated genetically engineered cells lines

    Article • Cell Transplantation, September 1996, Elsevier

    Professor Nicole Déglon

  181. Rescue of Motoneurons from Axotomy-Induced Cell Death by Polymer Encapsulated Cells Genetically Engineered to Release CNTF

    Article • Cell Transplantation, September 1996, SAGE Publications

    Professor Nicole Déglon

  182. Intrathecal delivery of CNTF using encapsulated genetically modifiedxenogeneic cells in amyotrophic lateral sclerosis patients

    Article • Nature Medicine, June 1996, Nature

    Professor Nicole Déglon

  183. Gene Therapy for Amyotrophic Lateral Sclerosis (ALS) Using a Polymer Encapsulated Xenogenic Cell Line Engineered to Secrete hCNTF. Lausanne University Medical School, Lausanne, Switzerland

    Article • Human Gene Therapy, May 1996, Mary Ann Liebert Inc

    Professor Nicole Déglon

  184. Fatty Acids Regulate Thy-1 Antigen mRNA Stability in T Lymphocyte Precursors

    Article • European Journal of Biochemistry, August 1995, Wiley

    Professor Nicole Déglon

  185. Fatty Acids Regulate Thy-1 Antigen mRNA Stability in T Lymphocyte Precursors

    Article • European Journal of Biochemistry, August 1995, Wiley

    Professor Nicole Déglon

  186. Encapsulation of neurotrophic factor-releasing cells for the treatment of neurodegenerative diseases

    Article • Restorative Neurology and Neuroscience, January 1995, IOS Press

    Professor Nicole Déglon

  187. Minimal membrane and secreted μ poly(A) signals specify developmentally-regulated immunoglobulin heavy chain mRNA ratios without RNA splicing

    Article • Molecular Immunology, May 1994, Elsevier

    Professor Nicole Déglon

  188. Membrane μ poly(A) signal and 3′ flanking sequences function as a transcription terminator for immunoglobulin-encoding genes

    Article • Gene, December 1992, Elsevier

    Professor Nicole Déglon

  189. Multi-level regulation of Thy-1 antigen expression in mouse T lymphomas

    Article • Immunogenetics, January 1992, Springer Science + Business Media

    Professor Nicole Déglon

  190. Evaluation of somatic cell variants deficient in glycosylphosphatidyl-inositol anchoring as candidates for genetic correction

    Article • Cell Biology International Reports, November 1991, Wiley

    Professor Nicole Déglon

  191. Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg)

    Article • Biochemical and Biophysical Research Communications, July 1991, Elsevier

    Professor Nicole Déglon

  192. Translocation of the yeast Dolichol-phosphate-mannose synthase into microsomal membranes

    Article • Biochemical and Biophysical Research Communications, February 1991, Elsevier

    Professor Nicole Déglon

  193. Lentiviral-Mediated Gene Transfer to Model Triplet Repeat Disorders

    Article • Springer Science + Business Media

    Diana ZALA, Professor Nicole Déglon