All Stories

  1. An Economical, Quantitative, and Robust Protocol for High-Throughput T Cell Receptor Sequencing from Tumor or Blood
  2. Clinical T Cell Receptor Repertoire Deep Sequencing and Analysis: An Application to Monitor Immune Reconstitution Following Cord Blood Transplantation
  3. Immune profiling of cord blood after prolonged rupture of membranes.
  4. Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment
  5. Learning from Excellence: the ‘Yaytix’ programme
  6. Induction of CD4 T cell memory by local cellular collectivity
  7. Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor
  8. Quantitative Characterization of the T Cell Receptor Repertoire of Naïve and Memory Subsets Using an Integrated Experimental and Computational Pipeline Which Is Robust, Economical, and Versatile
  9. The “Achilles' Heel” of Cancer and Its Implications for the Development of Novel Immunotherapeutic Strategies
  10. Specificity, Privacy, and Degeneracy in the CD4 T Cell Receptor Repertoire Following Immunization
  11. The T Cell Response to the Contact Sensitizer Paraphenylenediamine Is Characterized by a Polyclonal Diverse Repertoire of Antigen-Specific Receptors
  12. High-throughput sequencing of the T-cell receptor repertoire: pitfalls and opportunities
  13. Feature selection using a one dimensional naïve Bayes’ classifier increases the accuracy of support vector machine classification of CDR3 repertoires
  14. Validation of Immune Cell Modules in Multicellular Transcriptomic Data
  15. Blood transcriptomic diagnosis of pulmonary and extrapulmonary tuberculosis
  16. Cell-type-specific modulation of innate immune signalling by vitamin D in human mononuclear phagocytes
  17. PD1-Expressing T Cell Subsets Modify the Rejection Risk in Renal Transplant Patients
  18. In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis
  19. Carbon nano materials for protein crystallization
  20. Transcriptional Profiling of Endobronchial Ultrasound-Guided Lymph Node Samples Aids Diagnosis of Mediastinal Lymphadenopathy
  21. Dynamic Perturbations of the T-Cell Receptor Repertoire in Chronic HIV Infection and following Antiretroviral Therapy
  22. The sequence of sequencers: The history of sequencing DNA
  23. Clonal expansion under the microscope: studying lymphocyte activation and differentiation using live-cell imaging
  24. Identification of Therapeutic Targets of Inflammatory Monocyte Recruitment to Modulate the Allogeneic Injury to Donor Cornea
  25. Computational analysis of stochastic heterogeneity in PCR amplification efficiency revealed by single molecule barcoding
  26. Immune Tolerance Maintained by Cooperative Interactions between T Cells and Antigen Presenting Cells Shapes a Diverse TCR Repertoire
  27. A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody
  28. Hybrid Epidemics—A Case Study on Computer Worm Conficker
  29. Optimizing Hybrid Spreading in Metapopulations
  30. Hybrid Spreading Mechanisms and T Cell Activation Shape the Dynamics of HIV-1 Infection
  31. Erratum to: Neutrophil Myeloperoxidase: Soldier and Statesman
  32. Sequence and primer independent stochastic heterogeneity in PCR amplification efficiency revealed by single molecule barcoding
  33. Tracking global changes induced in the CD4 T-cell receptor repertoire by immunization with a complex antigen using short stretches of CDR3 protein sequence
  34. T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity
  35. Regulation of CYP27B1 and CYP24A1 hydroxylases limits cell-autonomous activation of vitamin D in dendritic cells
  36. Tracking global changes induced in the CD4 T cell receptor repertoire by immunization with a complex antigen using short stretches of CDR3 protein sequence.
  37. HIV-1 Infection of Macrophages Dysregulates Innate Immune Responses to Mycobacterium tuberculosis by Inhibition of Interleukin-10
  38. Coupled IL-2-Dependent Extracellular Feedbacks Govern Two Distinct Consecutive Phases of CD4 T Cell Activation
  39. The immune system as a biomonitor: explorations in innate and adaptive immunity
  40. Decombinator: a tool for fast, efficient gene assignment in T-cell receptor sequences using a finite state machine
  41. Importin-7 Mediates Nuclear Trafficking of DNA in Mammalian Cells
  42. Directional Migration of Recirculating Lymphocytes through Lymph Nodes via Random Walks
  43. Adherent Human Alveolar Macrophages Exhibit a Transient Pro-Inflammatory Profile That Confounds Responses to Innate Immune Stimulation
  44. Pre-clinical assessment of autologous DC-based therapy in ovarian cancer patients with progressive disease
  45. Role of DNA topology in uptake of polyplex molecules by dendritic cells
  46. Chemical toxicity to keratinocytes triggers dendritic cell activation via an IL-1α path
  47. Neutrophil Myeloperoxidase: Soldier and Statesman
  48. Differential Requirement for Cathepsin D for Processing of the Full Length and C-Terminal Fragment of the Malaria Antigen MSP1
  49. The impact of DNA topology on polyplex uptake and transfection efficiency in mammalian cells
  50. Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test
  51. Epitope spreading contributes to effective immunotherapy in metastatic melanoma patients
  52. Ten years of progress in vaccination against cancer: the need to counteract cancer evasion by dual targeting in future therapies
  53. Proteomic Evaluation and Validation of Cathepsin D Regulated Proteins in Macrophages Exposed toStreptococcus pneumoniae
  54. DC Priming by M. vaccae Inhibits Th2 Responses in Contrast to Specific TLR2 Priming and Is Associated with Selective Activation of the CREB Pathway
  55. A Cardinal Role for Cathepsin D in Co-Ordinating the Host-Mediated Apoptosis of Macrophages and Killing of Pneumococci
  56. A Quantitative Proteomics Design for Systematic Identification of Protease Cleavage Events
  57. Error, reproducibility and sensitivity: a pipeline for data processing of Agilent oligonucleotide expression arrays
  58. Targeted Delivery of Antigen Processing Inhibitors to Antigen Presenting Cells via Mannose Receptors
  59. Src-mediated regulation of inflammatory responses by actin polymerization
  60. Conventional protein kinase C plays a critical role in negative regulation of CD98-induced homotypic aggregation
  61. Hypochlorous Acid: A Natural Adjuvant That Facilitates Antigen Processing, Cross-Priming, and the Induction of Adaptive Immunity
  62. HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation
  63. Dengue Virus NS5 Inhibits Interferon‐α Signaling by Blocking Signal Transducer and Activator of Transcription 2 Phosphorylation
  64. Lentiviral Vectors Transduce Proliferating Dendritic Cell Precursors Leading to Persistent Antigen Presentation and Immunization
  65. Transcriptional and functional defects of dendritic cells derived from the MUTZ-3 leukaemia line
  66. Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of κBα via activation of the phosphoinositide-3-kinase and Akt pathways
  67. Genome-Wide Innate Immune Responses in HIV-1-Infected Macrophages Are Preserved Despite Attenuation of the NF- B Activation Pathway
  68. Dengue virus NS5 inhibits IFNa signalling and together with ns4b reduces cellular stat2 levels
  69. HIV-1 infection can infect and replicate in human macrophages undetected by the host innate immune system
  70. HIV blocking antibodies following immunisation with chimaeric peptides coding a short N-terminal sequence of the CCR5 receptor
  71. Oxidation of Ovarian Epithelial Cancer Cells by Hypochlorous Acid Enhances Immunogenicity and Stimulates T Cells that Recognize Autologous Primary Tumor
  72. Glycoprotein-Dependent and TLR2-Independent Innate Immune Recognition of Herpes Simplex Virus-1 by Dendritic Cells
  73. Quantitative imaging assay for NF-κB nuclear translocation in primary human macrophages
  74. Natural cathepsin E deficiency in the immune system of C57BL/6J mice
  75. Dendritic cells and myeloid leukaemias: plasticity and commitment in cell differentiation
  76. Expression and function of mixed lineage kinases in dendritic cells
  77. Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?
  78. Haematopoietic development and immunological function in the absence of cathepsin D
  79. Understanding HSV-1 entry glycoproteins
  80.  1-Integrins determine the dendritic morphology which enhances DC-SIGN-mediated particle capture by dendritic cells
  81. Modulation of dendritic cell differentiation and cytokine secretion by the hydatid cyst fluid of Echinococcus granulosus
  82. Autocrine Type I Interferon Amplifies Dendritic Cell Responses to Lipopolysaccharide via the Nuclear Factor-kappaB/p38 Pathways
  83. Hypochlorous acid enhances immunogenicity and uptake of allogeneic ovarian tumor cells by dendritic cells to cross-prime tumor-specific T cells
  84. Immunization with a Lentiviral Vector Stimulates both CD4 and CD8 T Cell Responses to an Ovalbumin Transgene
  85. Mannose–pepstatin conjugates as targeted inhibitors of antigen processing
  86. Monocyte derived dendritic cells from HIV-1 infected individuals partially reconstitute CD4 T-cell responses
  87. Dendritic cells in viral pathogenesis: protective or defective?
  88. JNK activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis
  89. The interaction between staphylococcal superantigen-like proteins and human dendritic cells
  90. Generation of Potent Antitumor CTL from Patients with Multiple Myeloma Directed against HM1.24
  91. Is hepatitis C virus infection of dendritic cells a mechanism facilitating viral persistence?
  92. The Expression and Function of Cathepsin E in Dendritic Cells
  93. The use of targeted microbeads for quantitative analysis of the phagocytic properties of human monocyte-derived dendritic cells
  94. LIGHTing up dendritic cell activation: Immune regulation and viral exploitation
  95. Herpes Simplex Virus Type-1-Induced Activation of Myeloid Dendritic Cells: The Roles of Virus Cell Interaction and Paracrine Type I IFN Secretion
  96. Structural Relationships and Cellular Tropism of Staphylococcal Superantigen-Like Proteins
  97. The host response to herpes simplex virus infection
  98. The functional consequences of delivery of HIV-1 Nef to dendritic cells using an adenoviral vector
  99. Cynaropicrin, a sesquiterpene lactone, as a new strong regulator of CD29 and CD98 functions
  100. Current issues in antigen presentation—focus on the dendritic cell
  101. Regulation of CD43-induced U937 homotypic aggregation
  102. Staurosporine induces rapid homotypic intercellular adhesion of U937 cellsviamultiple kinase activation
  103. Autologous apoptotic T cells interact with dendritic cells, but do not affect their surface phenotype or their ability to induce recall immune responses
  104. Local Cooperation Dominates Over Competition Between CD4+ T Cells of Different Antigen/MHC Specificity
  105. Instruction of naive CD4+ T cells by polarized CD4+ T cells within dendritic cell clusters
  106. CD98-dependent homotypic aggregation is associated with translocation of protein kinase cδ and activation of mitogen-activated protein kinases
  107. Deletion of the Virion Host Shutoff Protein (vhs) from Herpes Simplex Virus (HSV) Relieves the Viral Block to Dendritic Cell Activation: Potential of vhs− HSV Vectors for Dendritic Cell-Mediated Immunotherapy
  108. Modulation of dendritic cell endocytosis and antigen processing pathways by Escherichia coli heat-labile enterotoxin and mutant derivatives
  109. Ribotoxic stress activates p38 and JNK kinases and modulates the antigen-presenting activity of dendritic cells
  110. Herpes Simplex Virus Infection of Dendritic Cells: Balance among Activation, Inhibition, and Immunity
  111. LCPTP–MAP kinase interaction: permanent partners or transient associates?
  112. Effects of oxidised low density lipoprotein on dendritic cells: a possible immunoregulatory component of the atherogenic micro-environment?
  113. Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases
  114. The role of advanced oxidation protein products in regulation of dendritic cell function
  115. Placentally derived prostaglandin E2acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells
  116. Regulation of primary HIV-1 isolate replication in dendritic cells
  117. The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation
  118. Dendritic Cell Activation and Cytokine Production Induced by Group B Neisseria meningitidis: Interleukin-12 Production Depends on Lipopolysaccharide Expression in Intact Bacteria
  119. A defect in bone marrow derived dendritic cell maturation in the nonobesediabetic mouse
  120. Immunomodulation Using Bacterial Enterotoxins
  121. Early commitment of adoptively transferred CD4+ T cells following particle-mediated DNA vaccination: implications for the study of immunomodulation
  122. Inhibition of T-cell Response by Escherichia coli Heat-Labile Enterotoxin-Treated Epithelial Cells
  123. Novel molecular mechanisms of dendritic cell-induced T cell activation
  124. Self/nonself discrimination among immunoregulatory (CD4) T cells
  125. Antimicrobial and cytotoxic activity of hypochlorous acid: interactions with taurine and nitrite
  126. Protein degradation in MHC class II antigen presentation: opportunities for immunomodulation
  127. How can dendritic cells cause autoimmune disease?
  128. Regulation of murine dendritic cell functions in vitro by taurine chloramine, a major product of the neutrophil myeloperoxidase-halide system
  129. Vectorial function of major histocompatibility complex class II in a human intestinal cell line
  130. The antigen-presenting environment in normal and human papillomavirus (HPV)-related premalignant cervical epithelium
  131. Molecular characterization of U937‐dependent T‐cell co‐stimulation
  132. Reactive oxygen species activate human peripheral blood dendritic cells
  133. The role of reactive oxygen species in triggering proliferation and IL-2 secretion in T cells
  134. In vivopriming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen
  135. Responses to human rhinovirus in CD45 T cell subsets isolated from tonsil
  136. Differential regulation of HLA-DQ expression by keratinocytes and Langerhans cells in normal and premalignant cervical epithelium
  137. From sentinel to messenger: an extended phenotypic analysis of the monocyte to dendritic cell transition
  138. Modulation of antigen‐specific T‐cell activation in vitro by taurine chloramine
  139. Pure populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry
  140. Characterization of the T Cell Response to Human Rhinovirus in Children: Implications for Understanding the Immunopathology of the Common Cold
  141. Mechanisms for variability in a member of the scavenger-receptor cysteine-rich superfamily
  142. Enhancement of CD4 + T‐cell‐dependent interleukin‐2 production in vitro by murine alveolar macrophages: the role of leukotriene B 4
  143. Isolation and N-terminal sequence determination of a novel γ/δ T cell surface antigen
  144. Regulation of cathepsin E expression during human B cell differentiationin vitro
  145. Nitric oxide up-regulates the release of inflammatory mediators by mouse macrophages
  146. The injured cell: the role of the dendritic cell system as a sentinel receptor pathway
  147. The gold anti-rheumatic drug auranofin governs T cell activation by enhancing oxygen free radical production
  148. Immune response to human papillomavirus type 16 E6 gene in a live vaccinia vector
  149. Analysis of the Cellular Requirements for the Binding of Exogenous Peptides to MHC Class II Molecules
  150. Isolation and characterization of a new murine MHC class II transcription mutant cell line
  151. Lysosomal Enzyme Transfer from Different Types of Lymphoid Cell
  152. The effects of auranofin on activation and interleukin-2 release from human peripheral blood mononuclear cells
  153. The Interaction of Auranofin and Buthionine Sulfoximine Blocks Activation of Human Peripheral T Lymphocytes
  154. Epitope analysis of the T cell response to a complex antigen: Proliferative responses to human rhinovirus capsids
  155. Multilevel Regulation of Lysosomal Gene Expression in Lymphocytes
  156. Differential Cytokine Regulation by Eicosanoids in T Cells Primed by Contact Sensitisation with TNP
  157. Antigen processing and presentation of human rhinovirus to CD4 T cells is facilitated by binding to cellular receptors for virus
  158. Regulation of in Vitro Release of TH2 Type Cytokines (IL-4, IL-6) in the T Cell Response to the Trinitrophenyl (TNP) Hapten
  159. Antigen Processing
  160. Endocytosis by antigen presenting cells: dendritic cells are as endocytically active as other antigen presenting cells.
  161. Induction of cytotoxic T lymphocytes with peptides in vitro: identification of candidate T-cell epitopes in human papilloma virus.
  162. Adjuvant Composition Determines the Induction of Type II Collagen-Induced Arthritis
  163. Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E
  164. Liposome-mediated delivery stimulates a class I-restricted cytotoxic T cell response to soluble antigen
  165. Antigen presentation by dendritic cells provides optimal stimulation for the production of interleukin (IL) 2, IL 4 and interferon-γ by allogeneic T cells
  166. Temperature-induced stress abrogates co-stimulatory function in antigen-presenting cells
  167. Penicillin and beyond
  168. Suppression of lymphokine production in anti-minor histocompatibility antigen responses
  169. Enhancement of immunogenic properties of ovalbumin as a result of its chlorination
  170. The Cell Biology of Antigen Processing
  171. Definition of murine T helper cell determinants in the major capsid protein of human papillomavirus type 16
  172. Further studies on the regulation of lymphokine biosynthesis in contact sensitivity
  173. Antigen processing: Current issues, exceptional cases (Thy 1 alloantigen, MHC Class-II-restricted cytolytic T cell), and implications for vaccine development
  174. A cell-free model system for the study of antigen processing
  175. The Biochemistry and Cell Biology of Antigen Processing
  176. Chromatographic analysis of the trinitrophenyl derivatives of insulin
  177. Does the T-cell receptor bind to the MHC?
  178. Improvement of the in vitro T cell proliferation assay by a modified method that separates the antigen recognition and IL-2-dependent steps
  179. Blood cells contribute to glial repair in an insect
  180. Observations on the cytochemistry of the hemocytes of an insect, Galleria mellonella.