All Stories

  1. AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact
  2. TANGO2 binds crystallin alpha B and its loss causes desminopathy
  3. The mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to mitochondria
  4. Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
  5. Quantitative subcellular reconstruction reveals a lipid mediated inter-organelle biogenesis network
  6. Unconventional initiation of PINK1/Parkin mitophagy by Optineurin
  7. Engineering Heart Valve Interfaces Using Melt Electrowriting: Biomimetic Design Strategies from Multi‐Modal Imaging
  8. Multi-omics approach characterises CRLS1 deficiency, a novel mitochondrial disorder
  9. Deleterious variants inCRLS1lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease
  10. Immunofluorescence-Based Measurement of Autophagosome Formation During Mitophagy
  11. ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
  12. STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain
  13. Human hepatitis A virus 3C protease exerts a cytostatic effect on Saccharomyces cerevisiae and affects the vacuolar compartment
  14. Autophagy receptors don't "recruit" membranes, the membranes recruit autophagy receptors
  15. Ablation of tau causes an olfactory deficit in a murine model of Parkinson’s disease
  16. BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
  17. Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers
  18. LC3s & GABARAP proteins go to autophagosomes, but they don't build or seal them.
  19. Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation
  20. Deciphering the Molecular Signals of PINK1/Parkin Mitophagy
  21. An Improved Procedure for Subcellular Spatial Alignment during Live-Cell CLEM
  22. Live-Cell CLEM of Subcellular Targets
  23. CCCP interferes with lysosomes by stealing their protons
  24. Multimodal Analysis of PEI-Mediated Endocytosis of Nanoparticles in Neural Cells