All Stories

  1. Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction

    Article • Annual Review of Biochemistry, June 2016, Annual Reviews

    Dr John J. M. Bergeron, Dr. Barry I Posner

  2. The Canadian Diabetes Association Names Dr. Barry I. Posner as the 2015 Clinical & Scientific Section Lifetime Achievement Award Recipient

    Article • Canadian Journal of Diabetes, October 2015, Elsevier

    Dr. Barry I Posner

  3. Assessment of Internalization and Endosomal Signaling

    Article • January 2014, Elsevier

    Dr. Barry I Posner

  4. ChemInform Abstract: Periodinates: A New Class of Protein Tyrosine Phosphatase Inhibitors.

    Article • ChemInform, June 2010, Wiley

    Dr. Barry I Posner

  5. Compartmentalization of EGFR in cellular membranes: Role of membrane rafts

    Article • Journal of Cellular Biochemistry, January 2010, Wiley

    Dr. Barry I Posner

  6. Cellular Signalling: Peptide Hormones and Growth Factors

    Article • January 2010, Elsevier

    Dr. Barry I Posner

  7. Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

    Article • Nature Genetics, October 2009, Nature

    Dr. Barry I Posner

  8. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

    Article • Nature Genetics, September 2009, Nature

    Dr. Barry I Posner

  9. EGF Receptor Compartments in Plasma Membrane

    Article • Journal of Cellular Biochemistry, May 2009, Wiley

    Dr. Barry I Posner

  10. Quantitative analysis of a proteome by N-terminal stable-isotope labelling of tryptic peptides

    Article • Rapid Communications in Mass Spectrometry, August 2007, Wiley

    Dr. Barry I Posner

  11. Compartmentalization of Signaling-Competent Epidermal Growth Factor Receptors in Endosomes

    Article • Endocrinology, June 2007, Endocrine Society

    Dr. Barry I Posner

  12. A genome-wide association study identifies novel risk loci for type 2 diabetes

    Article • Nature, February 2007, Nature

    Dr. Barry I Posner

  13. Transcriptional regulation by insulin: from the receptor to the geneThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference.

    Article • Canadian Journal of Physiology and Pharmacology, July 2006, Canadian Science Publishing

    Dr. Barry I Posner

  14. Regulation of Hepatic Insulin-Like Growth Factor-Binding Protein-1 Gene Expression by Insulin: Central Role for Mammalian Target of Rapamycin Independent of Forkhead Box O Proteins

    Article • Endocrinology, May 2006, Endocrine Society

    Dr. Barry I Posner

  15. Insulin Receptor Kinase-Associated Phosphotyrosine Phosphatases in Hepatic Endosomes: Assessing the Role of Phosphotyrosine Phosphatase-1B

    Article • Endocrinology, February 2006, Endocrine Society

    Dr. Barry I Posner

  16. The G protein-coupled receptor kinase-2 is a TGFβ-inducible antagonist of TGFβ signal transduction

    Article • The EMBO Journal, August 2005, Wiley

    Dr. Barry I Posner

  17. Peptide Hormones and Growth Factors: Cellular Signaling Mechanisms

    Article • January 2004, Elsevier

    Dr. Barry I Posner

  18. Gab2 Tyrosine Phosphorylation by a Pleckstrin Homology Domain-Independent Mechanism: Role in Epidermal Growth Factor-Induced Mitogenesis

    Article • Molecular Endocrinology, May 2003, Endocrine Society

    Dr. Barry I Posner

  19. Different Forms of Vanadate on Sugar Transport in Insulin Target and Nontarget Cells

    Article • Journal of Biomedicine and Biotechnology, January 2002, Hindawi Publishing Corporation

    Dr. Barry I Posner

  20. Specific inhibition by hGRB10ζ of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway

    Article • Molecular and Cellular Endocrinology, February 2001, Elsevier

    Dr. Barry I Posner

  21. Compartmentalization and Insulin-Induced Translocations of Insulin Receptor Substrates, Phosphatidylinositol 3-Kinase, and Protein Kinase B in Rat Liver1

    Article • Endocrinology, November 2000, Endocrine Society

    Dr. Barry I Posner

  22. Peroxovanadium-mediated protection against murine leishmaniasis: role of the modulation of nitric oxide

    Article • European Journal of Immunology, September 2000, Wiley

    Dr. Barry I Posner

  23. The insulin receptor kinase: modulation and therapeutic implications

    Article • Emerging Therapeutic Targets, August 2000, Informa Healthcare

    Dr. Barry I Posner

  24. The Insulin Receptor Kinase

    Article • January 2000, Springer Science + Business Media

    Dr. Barry I Posner

  25. Epidermal Growth Factor and Insulin-Induced Deoxyribonucleic Acid Synthesis in Primary Rat Hepatocytes Is Phosphatidylinositol 3-Kinase Dependent and Dissociated from Protooncogene Induction1

    Article • Endocrinology, December 1999, Endocrine Society

    Dr. Barry I Posner

  26. Periodinates: A new class of protein tyrosine phosphatase inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, February 1999, Elsevier

    Dr. Barry I Posner

  27. Insulin receptor-associated protein tyrosine phosphatase(s): Role in insulin action

    Article • January 1998, Springer Science + Business Media

    Dr. Barry I Posner

  28. Insulin receptor internalization and signalling

    Article • January 1998, Springer Science + Business Media

    Dr. Barry I Posner

  29. Early Signaling Events Triggered by Peroxovanadium [bpV(phen)] Are Insulin Receptor Kinase (IRK)-Dependent: Specificity of Inhibition of IRK-Associated Protein Tyrosine Phosphatase(s) by bpV(phen)

    Article • Molecular Endocrinology, December 1997, Endocrine Society

    Dr. Barry I Posner

  30. Endosomal proteolysis of internalized proteins

    Article • FEBS Letters, June 1996, Wiley

    Dr. Barry I Posner

  31. Intracellular signal transduction: The role of endosomes

    Article • Trends in Endocrinology and Metabolism, January 1996, Elsevier

    Dr. Barry I Posner

  32. S-1: The Insulin Receptor Kinase (IRK)-associated Phosphotyrosine phosphatase (PTP): A key regulator of IRK function and a therapeutic target

    Article • Experimental and Clinical Endocrinology & Diabetes, January 1996, Thieme Publishing Group

    Dr. Barry I Posner

  33. Effects of peroxovanadate and vanadate on insulin binding, degradation and sensitivity in rat adipocytes

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, January 1996, Elsevier

    Dr. Barry I Posner

  34. Endosomes, receptor tyrosine kinase internalization and signal transduction

    Article • Bioscience Reports, December 1995, Portland Press Ltd.

    Dr. Barry I Posner

  35. Compartmentalized signal transduction by receptor tyrosine kinases

    Article • Trends in Cell Biology, December 1995, Elsevier

    Dr. Barry I Posner

  36. Arrest at the G2/M transition of the cell cycle by protein-tyrosine phosphatase inhibition: Studies on a neuronal and a glial cell line

    Article • Journal of Cellular Biochemistry, November 1995, Wiley

    Dr. Barry I Posner

  37. Bisperoxovanadium compounds: synthesis and reactivity of some insulin mimetic complexes

    Article • Inorganica Chimica Acta, February 1995, Elsevier

    Dr. Barry I Posner

  38. Peroxovanadium compounds: Biological actions and mechanism of insulin-mimesis

    Article • January 1995, Springer Science + Business Media

    Dr. Barry I Posner

  39. The chemistry of peroxovanadium compounds relevant to insulin mimesis

    Article • January 1995, Springer Science + Business Media

    Dr. Barry I Posner

  40. The chemistry of peroxovanadium compounds relevant to insulin mimesis

    Article • Molecular and Cellular Biochemistry, January 1995, Springer Science + Business Media

    Dr. Barry I Posner

  41. Peroxovanadium compounds: Biolgoical actions and mechanism of insulin-mimesis

    Article • Molecular and Cellular Biochemistry, January 1995, Springer Science + Business Media

    Dr. Barry I Posner

  42. Differential intracellular compartmentalization of phosphotyrosine phosphatases in a glial cell line: TC-PTP versus PTP-1B

    Article • Glia, December 1993, Wiley

    Dr. Barry I Posner

  43. Insulin mimetic peroxovanadium complexes: preparation and structure of potassium oxodiperoxo(pyridine-2-carboxylato)vanadate(V), K2[VO(O2)2(C5H4NCOO)].2H2O, and potassium oxodiperoxo(3-hydroxypyridine-2-carboxylato)vanadate(V), K2[VO(O2)2(OHC5H3NCOO)]....

    Article • Inorganic Chemistry, July 1993, American Chemical Society (ACS)

    Dr. Barry I Posner

  44. Endosomes and Cell Signalling

    Article • January 1993, Springer Science + Business Media

    Dr. Barry I Posner

  45. Pharmacological doses of insulin equalize insulin receptor phosphotyrosine content but not tyrosine kinase activity in plasmalemmal and endosomal membranes

    Article • Biochemistry and Cell Biology, October 1992, Canadian Science Publishing

    Dr. Barry I Posner

  46. A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases

    Article • Nature, August 1991, Nature

    Dr. Barry I Posner

  47. The Differential Regulation by Glucagon and Growth Hormone of Insulin-Like Growth Factor (IGF)-I and IGF Binding Proteins in Cultured Rat Hepatocytes*

    Article • Endocrinology, April 1991, Endocrine Society

    Dr. Barry I Posner

  48. The distribution of lactogen receptors in the mammalian hypothalamus: an in vitro autoradiographic analysis of the rabbit and rat

    Article • Brain Research, October 1990, Elsevier

    Dr. Barry I Posner

  49. Effects of Mannose-6-Phosphate on Receptor-Mediated Endocytosis of Insulin-Like Growth Factor-II*

    Article • Endocrinology, October 1990, Endocrine Society

    Dr. Barry I Posner

  50. Determination of insulin and insulin-like growth factors in the ovarian circulation**Supported by grant HJ6 MRC MT 4403 from the Medical Research Council of Canada.

    Article • Fertility and Sterility, January 1990, Elsevier

    Dr. Barry I Posner

  51. Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

    Article • Biochemistry, October 1989, American Chemical Society (ACS)

    Dr. Barry I Posner

  52. Homologous induction of growth hormone receptors in cultured rat hepatocytes

    Article • Molecular and Cellular Endocrinology, April 1989, Elsevier

    Dr. Barry I Posner

  53. Magnesium-dependent non-specific binding of [125I] prolactin to myelinated tracts in the rat central nervous system

    Article • Biochemical and Biophysical Research Communications, February 1989, Elsevier

    Dr. Barry I Posner

  54. Case Report: Catecholamine-Secreting Paraganglioma of Glomus Jugulare Region

    Article • The American Journal of the Medical Sciences, January 1989, Elsevier

    Dr. Barry I Posner

  55. Mannose 6-phosphate increases the affinity of its cation-independent receptor for insulin-like growth factor II by displacing inhibitory endogenous ligands

    Article • Biochemical and Biophysical Research Communications, December 1988, Elsevier

    Dr. Barry I Posner

  56. Insulin-Like Growth Factor-Binding Proteins in Hypophysectomized Rat Liver: Characterization and Subcellular Localization*

    Article • Endocrinology, June 1988, Endocrine Society

    Dr. Barry I Posner

  57. Free Insulin-Like Growth Factor I (IGF-I) and IGF-II in Human Saliva*

    Article • The Journal of Clinical Endocrinology & Metabolism, May 1988, Endocrine Society

    Dr. Barry I Posner

  58. Characterization of the insulin-like growth factor (IGF) receptor hi K562 erythroleukemia cells; evidence for a biological function for the type II IGF receptor

    Article • Molecular and Cellular Endocrinology, April 1988, Elsevier

    Dr. Barry I Posner

  59. Prolactin (PRL) Receptor Induction in Cultured Rat Hepatocytes: Dual Regulation by PRL and Growth Hormone*

    Article • Endocrinology, March 1988, Endocrine Society

    Dr. Barry I Posner

  60. Specificity of insulin-like growth factor binding to type-II IGF receptors in rabbit mammary gland and hypophysectomized rat liver

    Article • Biochemical and Biophysical Research Communications, December 1987, Elsevier

    Dr. Barry I Posner

  61. Effect of chronically elevated androgen or estrogen on the lucose tolerance test and insulin response in female rhesus monkeys

    Article • American Journal of Obstetrics and Gynecology, November 1987, Elsevier

    Dr. Barry I Posner

  62. Peroxide(s) of vanadium : A novel and potent insulin-mimetic agent which activates the insulin receptor kinase

    Article • Biochemical and Biophysical Research Communications, August 1987, Elsevier

    Dr. Barry I Posner

  63. A Receptor-Mediated Mechanism for the Transport of Prolactin from Blood to Cerebrospinal Fluid*

    Article • Endocrinology, May 1987, Endocrine Society

    Dr. Barry I Posner

  64. Insulin action on the CNS

    Article • Proceedings of The Nutrition Society, February 1987, Cambridge University Press

    Dr. Barry I Posner

  65. Internalization of Insulin and Its Receptor: Role in Signaling

    Article • January 1987, Springer Science + Business Media

    Dr. Barry I Posner

  66. Quantitativein VivoAutoradiographic Localization of [125I_Tyr11] Somatostatin-14-and [Leu8,d-Trp22-125ITyr-125] Somatostatin-28-Binding Sites in Rat Brain*

    Article • Endocrinology, November 1986, Endocrine Society

    Dr. Barry I Posner

  67. Increase in the Number of Type II Insulin-Like Growth Factor Receptors during Propylthiouracil-Induced Hyperplasia in the Rat Thyroid*

    Article • Endocrinology, September 1986, Endocrine Society

    Dr. Barry I Posner

  68. Polypeptide Hormone Receptors. Receptors and Ligands in Intercellular Communication, Volume 4.Barry I. Posner , Bernhard Cinader

    Article • The Quarterly Review of Biology, June 1986, University of Chicago Press

    Dr. Barry I Posner

  69. Differential and analytical subfraction of rat liver components internalizing insulin and prolactin

    Article • Biochemistry, April 1986, American Chemical Society (ACS)

    Dr. Barry I Posner

  70. Internalization of Hormone Receptor Complexes: Route and Significance

    Article • January 1986, Springer Science + Business Media

    Dr. Barry I Posner

  71. The ontogeny of specific prolactin binding sites in the rat choroid plexus

    Article • Developmental Brain Research, January 1986, Elsevier

    Dr. Barry I Posner

  72. 93 INCREASE IN SPECIFIC BINDING (SB) OF ERYTHROCYTE (RBC) RECEPTORS FOR INSULIN-LIKE GROWTH FACTOR 2 (IGF-2) WITH GROWTH HORMONE TREATMENT OF HYPOPITUITARY CHILDREN

    Article • Pediatric Research, June 1985, Nature

    Dr. Barry I Posner

  73. Internalization of Insulin: Structures Involved and Significance

    Article • January 1985, Springer Science + Business Media

    Dr. Barry I Posner

  74. [18] Peptide hormone receptors in intracellular structures from rat liver

    Article • January 1985, Elsevier

    Dr. Barry I Posner

  75. Immunoassay of a Somatomedin-Binding Protein from Human Amniotic Fluid: Levels in Fetal, Neonatal, and Adult Sera*

    Article • The Journal of Clinical Endocrinology & Metabolism, November 1984, Endocrine Society

    Dr. Barry I Posner

  76. Effects of Insulin-Like Growth Factors on Adult Male Rat Pituitary Function in Tissue Culture*

    Article • Endocrinology, October 1984, Endocrine Society

    Dr. Barry I Posner

  77. Binding and Uptake of [125I]Iodoprolactin by Epithelial Cells of the Rat Choroid Plexus: Anin VivoAutoradiographic Analysis*

    Article • Endocrinology, May 1984, Endocrine Society

    Dr. Barry I Posner

  78. Characterization of Insulin-Like Growth Factor Receptors in Rat Anterior Pituitary, Hypothalamus, and Brain*

    Article • Endocrinology, April 1984, Endocrine Society

    Dr. Barry I Posner

  79. Insulin Internalization as Studied by Subcellular Fractionation and Electron-Microscopic Radioautography

    Article • January 1984, Springer Science + Business Media

    Dr. Barry I Posner

  80. Origin of Insulin-Receptive Nerve Terminals in Rat Median Eminence*

    Article • Endocrinology, October 1983, Endocrine Society

    Dr. Barry I Posner

  81. Circumventricular Organs: Receptors and Mediators of Direct Peptide Hormone Action on Brain

    Article • January 1983, Elsevier

    Dr. Barry I Posner

  82. Brain Receptors for Blood-Borne Calcitonin in Rats: Circumventricular Localization and Vasopressin-Resistant Deficiency in Hereditary Diabetes Insipidus*

    Article • Endocrinology, November 1982, Endocrine Society

    Dr. Barry I Posner

  83. Ontogeny of Growth Factor Receptors in the Human Placenta

    Article • Pediatric Research, October 1982, Nature

    Dr. Barry I Posner

  84. THE HYPOTHALMIC MEDIAN EMINENCE OF THE HOMOZYGOUS BRATTLEBORO RAT IS DEFICIENT IN CALCITONIN-SPECIFIC BINDING SITES

    Article • Annals of the New York Academy of Sciences, October 1982, Wiley

    Dr. Barry I Posner

  85. The Role of Cell Age in the Difference in Insulin Binding between Adult and Cord Erythrocytes*

    Article • The Journal of Clinical Endocrinology & Metabolism, August 1982, Endocrine Society

    Dr. Barry I Posner

  86. Endocytosis of Peptide Hormones and Other Ligands

    Article • Endocrine Reviews, July 1982, Endocrine Society

    Dr. Barry I Posner

  87. A method for quantitation of protein in the presence of percoll

    Article • Analytical Biochemistry, October 1981, Elsevier

    Dr. Barry I Posner

  88. Specific Binding and Internalization of Blood-Borne [125I]- Iodoinsulin by Neurons of the Rat Area Postrema*

    Article • Endocrinology, September 1981, Endocrine Society

    Dr. Barry I Posner

  89. BLOOD-BORNE ADRENOCORTICOTROPIN BINDS SPECIFICALLY TO THE MEDIAN EMINENCE-ARCUATE REGION OF THE RAT HYPOTHALAMUS

    Article • Endocrinology, June 1981, Endocrine Society

    Dr. Barry I Posner

  90. Diurnal Rhythm of Plasma Immunoreactive β-Endorphin and Its Relationship to Sleep Stages and Plasma Rhythms of Cortisol and Prolactin*

    Article • The Journal of Clinical Endocrinology & Metabolism, May 1981, Endocrine Society

    Dr. Barry I Posner

  91. RECEPTORS FOR INSULIN-LIKE PEPTIDES (ILAs) IN RAT RETICULOCYTES AND ERYTHROCYTES.

    Article • Endocrinology, March 1981, Endocrine Society

    Dr. Barry I Posner

  92. INTRACELLULAR POLYPEPTIDE HORMONE RECEPTORS: LOCATION AND SIGNIFICANCE

    Article • January 1981, Elsevier

    Dr. Barry I Posner

  93. Polypeptide Hormones: Intracellular Receptors and Internalization

    Article • January 1981, Elsevier

    Dr. Barry I Posner

  94. Pituitary-Dependent Growth Hormone Receptors in Rabbit and Sheep Liver*

    Article • Endocrinology, December 1980, Endocrine Society

    Dr. Barry I Posner

  95. Intracellular (Golgi) receptors for insulinlike peptides in rat liver

    Article • Canadian Journal of Biochemistry, October 1980, Canadian Science Publishing

    Dr. Barry I Posner

  96. Radioautographic localization of specific binding sites for blood-borne angiotensin II in the rat brain

    Article • Brain Research, March 1980, Elsevier

    Dr. Barry I Posner

  97. Insulin binds to brain blood vessels in vivo

    Article • Nature, December 1979, Nature

    Dr. Barry I Posner

  98. Insulin-Binding Sites in the Rat Brain: In Vivo Localization to the Circumventricular Organs by Quantitative Radioautography*

    Article • Endocrinology, September 1979, Endocrine Society

    Dr. Barry I Posner

  99. Seminal Fluid Prolactin: Studies in Normal Subjects and in Hypergonadotropic Oligospermia**Supported by grants from the Medical Research Council of Canada (to G. T.) and the Fraser Memorial Fund, Royal Victoria Hospital.

    Article • Fertility and Sterility, July 1979, Elsevier

    Dr. Barry I Posner

  100. Radioreceptor Assay of Insulin-Like Peptides in Human Plasma: Growth Hormone Dependence and Correlation with Sulfation Activity by Two Bioassays*

    Article • The Journal of Clinical Endocrinology & Metabolism, May 1979, Endocrine Society

    Dr. Barry I Posner

  101. Partial Purification, Characterization, and Assay of a Slightly Acidic Insulin-Like Peptide (ILAs) from Human Plasma*

    Article • The Journal of Clinical Endocrinology & Metabolism, December 1978, Endocrine Society

    Dr. Barry I Posner

  102. Insulin, insulin-like activity and the human placenta

    Article • Journal of Steroid Biochemistry, May 1977, Elsevier

    Dr. Barry I Posner

  103. Regulation of Lactogen Specific Binding Sites in Rat Liver: Studies on the Role of Lactogens and Estrogen1

    Article • Endocrinology, November 1976, Endocrine Society

    Dr. Barry I Posner

  104. Characterization and Modulation of Growth Hormone and Prolactin Binding in Mouse Liver

    Article • Endocrinology, March 1976, Endocrine Society

    Dr. Barry I Posner

  105. Effects of Hypophysectomy, Ovariectomy, and Cycloheximide on Specific Binding Sites for Lactogenic Hormones in Rat Liver

    Article • Endocrinology, December 1975, Endocrine Society

    Dr. Barry I Posner

  106. Polypeptide Hormone Receptors: Characteristics and Applications

    Article • Canadian Journal of Physiology and Pharmacology, October 1975, Canadian Science Publishing

    Dr. Barry I Posner

  107. Studies of Insulin, Growth Hormone and Prolactin Binding: Tissue Distribution, Species Variation and Characterization

    Article • Endocrinology, August 1974, Endocrine Society

    Dr. Barry I Posner

  108. Studies of Insulin, Growth Hormone and Prolactin Binding: Ontogenesis, Effects of Sex and Pregnancy

    Article • Endocrinology, August 1974, Endocrine Society

    Dr. Barry I Posner

  109. Cystathionine γ-synthase: Studies on the γ replacement reaction

    Article • Biochimica et Biophysica Acta (BBA) - Enzymology, July 1972, Elsevier

    Dr. Barry I Posner

  110. Studies on the mechanism of induced cardiac hypertrophy

    Article • The American Journal of Cardiology, March 1968, Elsevier

    Dr. Barry I Posner

  111. The Insulin Receptor Kinase: Regulation and Therapeutic Significance

    Article • Springer Science + Business Media

    Dr. Barry I Posner