All Stories

  1. Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report

    Article • The Lancet, July 2023, Elsevier

    Dr Avneesh K Singh

  2. Cardiac xenotransplantation in a human

    Article • Xenotransplantation, September 2022, Wiley

    Dr Avneesh K Singh

  3. The immunobiology and clinical use of genetically engineered porcine hearts for cardiac xenotransplantation

    Article • Nature Cardiovascular Research, August 2022, Springer Science + Business Media

    Dr Avneesh K Singh

  4. Genetically Modified Porcine-to-Human Cardiac Xenotransplantation

    Article • New England Journal of Medicine, July 2022, New England Journal of Medicine (NEJM/MMS)

    Dr Avneesh K Singh

  5. Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months

    Article • Xenotransplantation, March 2022, Wiley

    Dr Avneesh K Singh

  6. Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation

    Article • Transplant International, March 2022, Frontiers

    Dr Avneesh K Singh

  7. Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation

    Article • Frontiers in Immunology, June 2021, Frontiers

    Dr Avneesh K Singh

  8. Heterotopic Porcine Cardiac Xenotransplantation in the Intra-Abdominal Position in a Non-Human Primate Model

    Article • Scientific Reports, July 2020, Springer Science + Business Media

    Dr Avneesh K Singh

  9. Early Experience With Preclinical Perioperative Cardiac Xenograft Dysfunction in a Single Program

    Article • The Annals of Thoracic Surgery, May 2020, Elsevier

    Dr Avneesh K Singh

  10. Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and Pitfalls

    Article • Frontiers in Cardiovascular Medicine, July 2019, Frontiers

    Dr Avneesh K Singh

  11. Xenotransplantation: A Step Closer to Clinical Reality?

    Article • Transplantation, March 2019, Wolters Kluwer Health

    Dr Avneesh K Singh

  12. Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs

    Article • Xenotransplantation, October 2018, Wiley

    Dr Avneesh K Singh

  13. Circulating cell-free DNA as a biomarker of tissue injury: Assessment in a cardiac xenotransplantation model

    Article • The Journal of Heart and Lung Transplantation, August 2018, Elsevier

    Dr Avneesh K Singh

  14. Consideration of appropriate clinical applications for cardiac xenotransplantation

    Article • Clinical Transplantation, June 2018, Wiley

    Dr Avneesh K Singh

  15. CD4+CD25Hi FoxP3+ regulatory T cells in long-term cardiac xenotransplantation

    Article • Xenotransplantation, December 2017, Wiley

    Dr Avneesh K Singh

  16. Encouraging experience using multi-transgenic xenografts in a pig-to-baboon cardiac xenotransplantation model

    Article • Xenotransplantation, September 2017, Wiley

    Dr Avneesh K Singh

  17. Selection of Patients for Initial Clinical Trials of Solid Organ Xenotransplantation

    Article • Transplantation, July 2017, Wolters Kluwer Health

    Dr Avneesh K Singh

  18. Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

    Article • Nature Communications, April 2016, Springer Science + Business Media

    Dr Avneesh K Singh

  19. Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway‐regulatory protein

    Article • Xenotransplantation, July 2015, Wiley

    Dr Avneesh K Singh

  20. Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation

    Article • Journal of Thoracic and Cardiovascular Surgery, September 2014, Elsevier

    Dr Muhammad Mansoor Mohiuddin, Dr Avneesh K Singh

  21. Regulatory T cells enhance mesenchymal stem cell survival and proliferation following autologous cotransplantation in ischemic myocardium

    Article • Journal of Thoracic and Cardiovascular Surgery, September 2014, Elsevier

    Dr Muhammad Mansoor Mohiuddin, Dr Avneesh K Singh

  22. Overexpression of FABP3 inhibits human bone marrow derived mesenchymal stem cell proliferation but enhances their survival in hypoxia

    Article • Experimental Cell Research, April 2014, Elsevier

    Dr Avneesh K Singh

  23. One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

    Article • American Journal of Transplantation, December 2013, Wiley

    Dr Muhammad Mansoor Mohiuddin, Dr Avneesh K Singh

  24. Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model

    Article • Xenotransplantation, October 2013, Wiley

    Dr Muhammad Mansoor Mohiuddin, Dr Avneesh K Singh

  25. Ex-vivo expanded baboon CD4+ CD25Hi Treg cells suppress baboon anti-pig T and B cell immune response

    Article • Xenotransplantation, March 2012, Wiley

    Dr Muhammad Mansoor Mohiuddin, Dr Avneesh K Singh

  26. B-Cell Depletion Extends the Survival of GTKO.hCD46Tg Pig Heart Xenografts in Baboons for up to 8 Months

    Article • American Journal of Transplantation, March 2012, Elsevier

    Dr Avneesh K Singh

  27. Left Ventricular Pressure Measurement by Telemetry Is an Effective Means to Evaluate Transplanted Heart Function in Experimental Heterotopic Cardiac Xenotransplantation

    Article • Transplantation Proceedings, July 2010, Elsevier

    Dr Avneesh K Singh

  28. Surgical and Nonsurgical Complications of a Pig to Baboon Heterotopic Heart Transplantation Model

    Article • Transplantation Proceedings, July 2010, Elsevier

    Dr Avneesh K Singh

  29. Rapid and dynamic alterations of gene expression profiles of adult porcine bone marrow-derived stem cell in response to hypoxia

    Article • Stem Cell Research, March 2010, Elsevier

    Dr Avneesh K Singh

  30. Rapamycin Promotes the Enrichment of CD4+CD25hiFoxP3+ T Regulatory Cells From Naïve CD4+ T Cells of Baboon That Suppress Antiporcine Xenogenic Response In Vitro

    Article • Transplantation Proceedings, January 2009, Elsevier

    Dr Avneesh K Singh

  31. Characterization and expansion of baboon CD4+CD25+Treg cells for potential use in a non-human primate xenotransplantation model

    Article • Xenotransplantation, July 2007, Wiley

    Dr Muhammad Mansoor Mohiuddin, Dr Avneesh K Singh

  32. Glycolipid antigen induces long-term natural killer T cell anergy in mice

    Article • Journal of Clinical Investigation, August 2005, American Society for Clinical Investigation

    Dr Avneesh K Singh

  33. The natural killer T?cell ligand ?-galactosylceramide prevents or promotes pristane-induced lupus in mice

    Article • European Journal of Immunology, April 2005, Wiley

    Dr Avneesh K Singh

  34. Quantitative and Qualitative Differences in the In Vivo Response of NKT Cells to Distinct α- and β-Anomeric Glycolipids

    Article • The Journal of Immunology, September 2004, The American Association of Immunologists

    Dr Avneesh K Singh

  35. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion

    Article • Proceedings of the National Academy of Sciences, September 2003, Proceedings of the National Academy of Sciences

    Prof Cecilia Johansson, Dr Avneesh K Singh

  36. Immunoregulatory Role of CD1d in the Hydrocarbon Oil-Induced Model of Lupus Nephritis

    Article • The Journal of Immunology, August 2003, The American Association of Immunologists

    Dr Avneesh K Singh

  37. Immunotherapy with ligands of natural killer T cells

    Article • Trends in Molecular Medicine, May 2002, Elsevier

    Dr Avneesh K Singh

  38. Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis

    Article • The Journal of Experimental Medicine, December 2001, Rockefeller University Press

    Dr Avneesh K Singh

  39. Age and gender discrepancies in living related renal transplant donors and recipients

    Article • Transplantation Proceedings, November 1998, Elsevier

    Dr Avneesh K Singh

  40. Donor specific CDC lymphocyte crossmatch and five year allograft survival

    Article • Transplantation Proceedings, November 1998, Elsevier

    Dr Avneesh K Singh

  41. In vitro pretransplant mixed lymphocyte culture response and acute rejection episodes

    Article • Transplantation Proceedings, November 1998, Elsevier

    Dr Avneesh K Singh

  42. Long-term allograft survival in renal transplantation from elderly donors

    Article • Transplantation Proceedings, November 1998, Elsevier

    Dr Avneesh K Singh