All Stories

  1. Mining ZINC Database to Discover Potential Phosphodiesterase 9 Inhibitors Using Structure-Based Drug Design Approach

    Article • Medicinal Chemistry, June 2016, Bentham Science Publishers

    Professor Ashraf H. Abadi

  2. Discovery and Optimization of 1,3,5-Trisubstituted Pyrazolines as Potent and Highly Selective Allosteric Inhibitors of Protein Kinase C-ζ

    Article • Journal of Medicinal Chemistry, July 2014, American Chemical Society (ACS)

    Professor Ashraf H. Abadi

  3. Discovery of a Novel Series of Tetrahydro-β-carbolines Inducing Autophagic Cell Death in Human Metastatic Melanoma

    Article • Archiv der Pharmazie, March 2014, Wiley

    Professor Ashraf H. Abadi, Nermin Mostafa

  4. Naphthalene and 2,3-dihydrobenzo[b][1,4]dioxine derivatives with extended side chains as new scaffolds of CB2-selective ligands

    Article • MedChemComm, January 2014, Royal Society of Chemistry

    Professor Ashraf H. Abadi

  5. Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53

    Article • Bioorganic & Medicinal Chemistry, December 2013, Elsevier

    Professor Ashraf H. Abadi

  6. An Interactive SAR Approach to Discover Novel Hybrid Thieno Probes as Ligands for D2-Like Receptors with Affinities in the Subnanomolar Range

    Article • Chemistry & Biodiversity, December 2013, Wiley

    Professor Ashraf H. Abadi

  7. Discovery of highly potent and selective D4 ligands by interactive SAR study

    Article • Bioorganic & Medicinal Chemistry Letters, September 2013, Elsevier

    Professor Ashraf H. Abadi

  8. 6‐Aryl and Heterocycle Quinazoline Derivatives as Potent EGFR Inhibitors with Improved Activity toward Gefitinib‐Sensitive and ‐Resistant Tumor Cell Lines

    Article • ChemMedChem, July 2013, Wiley

    Professor Ashraf H. Abadi

  9. Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents

    Article • European Journal of Medicinal Chemistry, May 2013, Elsevier

    Professor Ashraf H. Abadi, Dr Reem K. Arafa

  10. Quinazoline and tetrahydropyridothieno[2,3-d]pyrimidine derivatives as irreversible EGFR tyrosine kinase inhibitors: influence of the position 4 substituent

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Professor Ashraf H. Abadi

  11. Design of Novel β-Carboline Derivatives with Pendant 5-Bromothienyl and Their Evaluation as Phosphodiesterase-5 Inhibitors

    Article • Archiv der Pharmazie, January 2013, Wiley

    Professor Ashraf H. Abadi, Nermin Mostafa

  12. Modulating the Cyclic Guanosine Monophosphate Substrate Selectivity of the Phosphodiesterase 3 Inhibitors by Pyridine, Pyrido[2,3-d]pyrimidine Derivatives and Their Effects upon the Growth of HT-29 Cancer Cell Line

    Article • Chemical and Pharmaceutical Bulletin, January 2013, Pharmaceutical Society of Japan

    Professor Ashraf H. Abadi

  13. Functional Evaluation of Imatinib mesylate in Hepatocellular Carcinoma Cells

    Article • Recent Patents on Biomarkerse, December 2012, Bentham Science Publishers

    Professor Ashraf H. Abadi

  14. Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives

    Article • European Journal of Medicinal Chemistry, November 2012, Elsevier

    Professor Ashraf H. Abadi, Nermin Mostafa

  15. New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention

    Article • August 2012, Springer Science + Business Media

    Professor Ashraf H. Abadi

  16. CoMFA and CoMSIA Studies of 1,2-dihydropyridine Derivatives as Anticancer Agents

    Article • Medicinal Chemistry, May 2012, Bentham Science Publishers

    Professor Ashraf H. Abadi

  17. Four-Component Synthesis of 1,2-Dihydropyridine Derivatives and their Evaluation as Anticancer Agents

    Article • Medicinal Chemistry, May 2012, Bentham Science Publishers

    Professor Ashraf H. Abadi

  18. Synthesis and binding study of certain 6-arylalkanamides as molecular probes for cannabinoid receptor subtypes

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, January 2012, Taylor & Francis

    Professor Ashraf H. Abadi

  19. Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Professor Ashraf H. Abadi

  20. Synthesis, Antitumor and Antitubercular Evaluation of Certain New Xanthenone and Acridinone Analogs

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    Professor Ashraf H. Abadi, Professor Hussein I. El-Subbagh

  21. Synthesis and Evaluation of Novel 7-Trifluoromethyl-4-(4-substituted anilino)quinolines as Antiparasitic and Antineoplastic Agents

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    Professor Ashraf H. Abadi

  22. Synthesis of Novel Tadalafil Analogues and their Evaluation as Phosphodiesterase Inhibitors and Anticancer Agents

    Article • Arzneimittelforschung, December 2011, Thieme Publishing Group

    Professor Ashraf H. Abadi, Nermin Mostafa

  23. Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors

    Article • International Journal of Medicinal Chemistry, February 2011, Hindawi Publishing Corporation

    Professor Ashraf H. Abadi

  24. Synthesis and Molecular Modeling of Novel Tetrahydro-β-carboline Derivatives with Phosphodiesterase 5 Inhibitory and Anticancer Properties

    Article • Journal of Medicinal Chemistry, December 2010, American Chemical Society (ACS)

    Professor Ashraf H. Abadi

  25. Design, Synthesis and Structure-Activity Relationship of Functionalized Tetrahydro-β-carboline Derivatives as Novel PDE5 Inhibitors

    Article • Archiv der Pharmazie, December 2010, Wiley

    Professor Ashraf H. Abadi, Nermin Mostafa

  26. Synthesis, binding studies and molecular modeling of novel cannabinoid receptor ligands

    Article • Bioorganic & Medicinal Chemistry, December 2010, Elsevier

    Professor Ashraf H. Abadi

  27. New molecules with potential use in Male Erectile Dysfunction

    Article • Medicinal Chemistry, November 2010, Bentham Science Publishers

    Professor Ashraf H. Abadi, Nermin Mostafa

  28. One-Pot Synthesis of 4,6-Diaryl-2-oxo(imino)-1,2-dihydropyridine-3-carbonitrile; a New Scaffold for p38α MAP Kinase Inhibition

    Article • Journal of Combinatorial Chemistry, June 2010, American Chemical Society (ACS)

    Professor Ashraf H. Abadi

  29. Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective

    Article • European Journal of Medicinal Chemistry, April 2010, Elsevier

    Professor Ashraf H. Abadi

  30. Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach

    Article • European Journal of Medicinal Chemistry, January 2010, Elsevier

    Professor Ashraf H. Abadi

  31. Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D4-selective ligand

    Article • Bioorganic & Medicinal Chemistry, September 2007, Elsevier

    Professor Ashraf H. Abadi

  32. Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents

    Article • European Journal of Medicinal Chemistry, March 2006, Elsevier

    Professor Ashraf H. Abadi

  33. Synthesis of novel 4-substituted-7-trifluoromethylquinoline derivatives with nitric oxide releasing properties and their evaluation as analgesic and anti-inflammatory agents

    Article • Bioorganic & Medicinal Chemistry, October 2005, Elsevier

    Professor Ashraf H. Abadi

  34. Phenylpiperazinylmethylheterocycle Derivatives: Synthesis and Dopamine Receptor Binding Profiles

    Article • Archiv der Pharmazie, July 2004, Wiley

    Professor Ashraf H. Abadi

  35. Synthesis and antitubercular activity of 6-chloro (unsubstituted)-2-methoxy-9-substituted acridine derivatives

    Article • Archives of Pharmacal Research, July 2004, Springer Science + Business Media

    Professor Ashraf H. Abadi

  36. Synthesis of Novel 1,3,4-Trisubstituted Pyrazole Derivatives and Their Evaluation as Antitumor and Antiangiogenic Agents

    Article • Chemical and Pharmaceutical Bulletin, January 2003, Pharmaceutical Society of Japan

    Professor Ashraf H. Abadi

  37. Dopamine/Serotonin Receptor Ligands, Part III [1]: Synthesis and Biological Activities of 7, 7′—Alkylene-bis-6, 7, 8, 9, 14, 15-hexahydro-5H-benz[d]indolo[2, 3-g]azecines — Application of the Bivalent Ligand Approach to a Novel Type of Dopamine Recepto...

    Article • Archiv der Pharmazie, November 2002, Wiley

    Professor Ashraf H. Abadi

  38. Synthesis and Cyclooxygenase Inhibitory Properties of Novel (+) 2-(6-Methoxy-2-naphthyl)propanoic Acid (Naproxene) Derivatives

    Article • Archiv der Pharmazie, March 2001, Wiley

    Professor Ashraf H. Abadi

  39. Synthesis and Cyclooxygenase Inhibitory Properties of Novel (+) 2-(6-Methoxy-2-naphthyl)propanoic Acid (Naproxene) Derivatives

    Article • Archiv der Pharmazie, March 2001, Wiley

    Professor Ashraf H. Abadi

  40. Synthesis and Antitumor Activity of Ethyl 2-Substituted-aminothiazole-4-carboxylate Analogs

    Article • Archiv der Pharmazie, April 1999, Wiley

    Professor Ashraf H. Abadi, Professor Hussein I. El-Subbagh

  41. Synthesis and Antitumor Activity of Ethyl 2-Substituted-aminothiazole-4-carboxylate Analogs

    Article • Archiv der Pharmazie, April 1999, Wiley

    Professor Ashraf H. Abadi, Professor Hussein I. El-Subbagh

  42. Synthesis of 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents

    Article • Il Farmaco, April 1999, Elsevier

    Professor Ashraf H. Abadi

  43. Chlorpromazine

    Article • January 1999, Elsevier

    Professor Ashraf H. Abadi