All Stories

  1. Metformin enhances hippocampal excitatory synaptic transmission and preserves synaptic plasticity under amyloid-β oligomer-induced dysfunction

    Article • Neuropharmacology, November 2026, Elsevier

    Andrea Paula-Lima

  2. Metformin Enhances Antioxidant Defenses and Limits Lipid Peroxidation Through the Modulation of Nrf2/KEAP1 Pathway in Hippocampal Neurons Exposed to Amyloid-β Oligomers

    Article • Neurotoxicity Research, August 2026, Springer Science + Business Media

    Andrea Paula-Lima

  3. Immunotherapies based on macrophage reprogramming in periodontitis and apical periodontitis

    Article • Clinical Oral Investigations, May 2026, Springer Science + Business Media

    Andrea Paula-Lima

  4. Reticulon-1 synthesis controls outgrowth and microtubule dynamics in injured cortical axons

    Article • Life Science Alliance, January 2026, Life Science Alliance, LLC

    Andrea Paula-Lima

  5. Calcium release via IP3R/RyR channels contributes to the nuclear and mitochondrial Ca2+ signals elicited by neuronal stimulation

    Article • Biochemical and Biophysical Research Communications, March 2025, Elsevier

    Andrea Paula-Lima

  6. mHealth to enhance oral cancer awareness in older adults in Chile: a preliminary report

    Article • January 2025, Open Exploration Publishing

    Andrea Paula-Lima

  7. Excitatory-inhibitory synaptic imbalance induced by acute intra-hippocampus injections of amyloid-β oligomers

    Article • Biochemical and Biophysical Research Communications, January 2025, Elsevier

    Andrea Paula-Lima

  8. Local synthesis of Reticulon-1C lessens the outgrowth of injured axons and Spastin activity

    Article • August 2024, openRxiv

    Andrea Paula-Lima

  9. RyR-mediated calcium release in hippocampal health and disease

    Article • Trends in Molecular Medicine, January 2024, Elsevier

    Andrea Paula-Lima

  10. Amyloid β-Oligomers Inhibit the Nuclear Ca2+ Signals and the Neuroprotective Gene Expression Induced by Gabazine in Hippocampal Neurons

    Article • Antioxidants, November 2023, MDPI AG

    Andrea Paula-Lima

  11. Amyloid β-Oligomers Inhibit the Nuclear Ca<sup>2+</sup> Signals and the Neuroprotective Gene Expression Induced by Hippocampal Neuronal Activity

    Article • October 2023, MDPI AG

    Andrea Paula-Lima

  12. Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels

    Article • Frontiers in Cellular Neuroscience, March 2023, Frontiers

    Andrea Paula-Lima

  13. Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition

    Article • Antioxidants, March 2023, MDPI AG

    Andrea Paula-Lima

  14. Visual-spatial processing impairment in the occipital-frontal connectivity network at early stages of Alzheimer’s disease

    Article • Frontiers in Aging Neuroscience, February 2023, Frontiers

    Andrea Paula-Lima

  15. Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform

    Article • Biochemical and Biophysical Research Communications, December 2022, Elsevier

    Andrea Paula-Lima

  16. Editorial: Molecular mechanisms of Alzheimer’s disease: From top to bottom

    Article • Frontiers in Aging, September 2022, Frontiers

    Andrea Paula-Lima

  17. Oral-Gut-Brain Axis in Experimental Models of Periodontitis: Associating Gut Dysbiosis With Neurodegenerative Diseases

    Article • Frontiers in Aging, December 2021, Frontiers

    Andrea Paula-Lima

  18. Gingival Crevicular Fluid as Biomarker’s Source for Alzheimer’s Disease

    Article • Odovtos - International Journal of Dental Sciences, November 2021, Universidad de Costa Rica

    Andrea Paula-Lima

  19. Periodontal bacteria in the brain—Implication for Alzheimer's disease: A systematic review

    Article • Oral Diseases, November 2021, Wiley

    Andrea Paula-Lima

  20. The calcium–iron connection in ferroptosis-mediated neuronal death

    Article • Free Radical Biology and Medicine, November 2021, Elsevier

    Andrea Paula-Lima

  21. RyR-mediated Ca 2+ release elicited by neuronal activity induces nuclear Ca 2+ signals, CREB phosphorylation, and Npas4/RyR2 expression

    Article • Proceedings of the National Academy of Sciences, August 2021, Proceedings of the National Academy of Sciences

    Ignacio Vega-Vásquez, Andrea Paula-Lima

  22. Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease

    Article • Frontiers in Aging Neuroscience, August 2020, Frontiers

    Andrea Paula-Lima

  23. Redox modifications in synaptic components as biomarkers of cognitive status, in brain aging and disease

    Article • Mechanisms of Ageing and Development, July 2020, Elsevier

    Andrea Paula-Lima

  24. Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation

    Article • Marine Drugs, June 2020, MDPI AG

    Andrea Paula-Lima

  25. Differential navigational strategies during spatial learning in a new modified version of the Oasis maze

    Article • Behavioural Brain Research, May 2020, Elsevier

    Andrea Paula-Lima

  26. Latin America: Reduced S&T Investment Puts Sustainable Development at Risk

    Article • January 2020, ScienceOpen

    Andrea Paula-Lima

  27. Serotype b of Aggregatibacter actinomycetemcomitans triggers pro-inflammatory responses and amyloid beta secretion in hippocampal cells: a novel link between periodontitis and Alzheimer´s disease?

    Article • Journal of Oral Microbiology, January 2019, Taylor & Francis

    Andrea Paula-Lima

  28. N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer’s Disease Rat Model

    Article • Frontiers in Aging Neuroscience, December 2018, Frontiers

    Andrea Paula-Lima

  29. Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory

    Article • Antioxidants & Redox Signaling, October 2018, Mary Ann Liebert Inc

    Andrea Paula-Lima

  30. The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K

    Article • Biochemical and Biophysical Research Communications, October 2018, Elsevier

    Andrea Paula-Lima

  31. Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content

    Article • Free Radical Biology and Medicine, March 2018, Elsevier

    Andrea Paula-Lima

  32. RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers

    Article • Frontiers in Molecular Neuroscience, April 2017, Frontiers

    Andrea Paula-Lima

  33. Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of Aβ-Oligomers

    Article • Neural Plasticity, January 2016, Wiley

    Andrea Paula-Lima

  34. H2O2activates matrix metalloproteinases through the nuclear factor kappa B pathway and Ca2+signals in human periodontal fibroblasts

    Article • Journal of Periodontal Research, March 2015, Wiley

    Andrea Paula-Lima

  35. Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons

    Article • Biochemical and Biophysical Research Communications, February 2015, Elsevier

    Andrea Paula-Lima

  36. Contribution of Ca2+Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation

    Article • Antioxidants & Redox Signaling, August 2014, Mary Ann Liebert Inc

    Andrea Paula-Lima

  37. Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons

    Article • Frontiers in Molecular Neuroscience, March 2014, Frontiers

    Andrea Paula-Lima

  38. Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

    Article • Journal of Neurochemistry, May 2013, Wiley

    Sergio Ferreira, Andrea Paula-Lima

  39. Amyloid β-peptide oligomers, ryanodine receptor-mediated Ca2+ release, and Wnt-5a/Ca2+ signaling: opposing roles in neuronal mitochondrial dynamics?

    Article • Frontiers in Cellular Neuroscience, January 2013, Frontiers

    Andrea Paula-Lima

  40. Sub-lethal levels of amyloid β-peptide oligomers decrease non-transferrin-bound iron uptake and do not potentiate iron toxicity in primary hippocampal neurons

    Article • BioMetals, April 2012, Springer Science + Business Media

    Andrea Paula-Lima

  41. Amyloid-β Oligomers Induce Differential Gene Expression in Adult Human Brain Slices

    Article • Journal of Biological Chemistry, March 2012, Elsevier

    Sergio Ferreira, Andrea Paula-Lima

  42. The Antioxidant N-Acetylcysteine Prevents the Mitochondrial Fragmentation Induced by Soluble Amyloid-F Peptide Oligomers

    Article • Neurodegenerative Diseases, January 2012, Karger Publishers

    Andrea Paula-Lima

  43. Aβ Oligomers Induce Glutamate Release from Hippocampal Neurons

    Article • Current Alzheimer Research, August 2011, Bentham Science Publishers

    Sergio Ferreira, Andrea Paula-Lima

  44. Amyloid β-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF

    Article • Antioxidants & Redox Signaling, April 2011, Mary Ann Liebert Inc

    Sergio Ferreira, Andrea Paula-Lima

  45. Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation

    Article • Proceedings of the National Academy of Sciences, January 2011, Proceedings of the National Academy of Sciences

    Andrea Paula-Lima

  46. Human apolipoprotein A–I binds amyloid-β and prevents Aβ-induced neurotoxicity

    Article • The International Journal of Biochemistry & Cell Biology, June 2009, Elsevier

    Sergio Ferreira, Andrea Paula-Lima

  47. Activation of GABAA receptors by taurine and muscimol blocks the neurotoxicity of β-amyloid in rat hippocampal and cortical neurons

    Article • Neuropharmacology, December 2005, Elsevier

    Sergio Ferreira, Andrea Paula-Lima

  48. Taurine prevents the neurotoxicity of β‐amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders

    Article • The FASEB Journal, March 2004, Wiley

    Sergio Ferreira, Andrea Paula-Lima

  49. Neuroprotection against Aβ and glutamate toxicity by melatonin: Are GABA receptors involved?

    Article • Neurotoxicity Research, January 2003, Springer Science + Business Media

    Sergio Ferreira, Andrea Paula-Lima

  50. Dual role of glutamatergic neurotransmission on amyloid β1–42 aggregation and neurotoxicity in embryonic avian retina

    Article • Neuroscience Letters, March 2001, Elsevier

    Sergio Ferreira, Andrea Paula-Lima