All Stories

  1. Capsule and PspA Cooperatively Confer Resistance of Streptococcus pneumoniae to the Human Defensin HNP-1

    Article • International Journal of Molecular Sciences, March 2026, MDPI AG

    Juliana Mozer Sciani, Dr Anders P Hakansson

  2. Structural profiling of the pneumolysin epitope landscape uncovers a cross-species neutralising site across cholesterol-dependent cytolysins

    Article • March 2026, openRxiv

    Dr Anders P Hakansson

  3. Capsule Regulation Shapes Klebsiella pneumoniae Pathogenesis by Balancing Adhesion, Biofilm Formation, and Intracellular Survival

    Article • International Journal of Molecular Sciences, February 2026, MDPI AG

    Dr Anders P Hakansson

  4. Identification of a novel gene associated with group B Streptococcus persister cell formation and biofilm production

    Article • Scientific Reports, December 2025, Springer Science + Business Media

    Dr Anders P Hakansson

  5. Overcoming Immune Evasion in Staphylococcus aureus: Strategies for Rational Vaccine Design

    Article • ACS Infectious Diseases, September 2025, American Chemical Society (ACS)

    Dr Anders P Hakansson

  6. Protection Against Pneumonia Induced by Vaccination with Fimbriae Subunits from Klebsiella pneumoniae

    Article • Vaccines, March 2025, MDPI AG

    Dr Anders P Hakansson

  7. Corynebacteria from the respiratory microbiota modulate inflammatory responses and associate with a reduced pneumococcal burden in the lungs

    Article • Frontiers in Cellular and Infection Microbiology, January 2025, Frontiers

    Dr Anders P Hakansson

  8. Pneumococcal surface protein A (PspA) prevents killing of Streptococcus pneumoniae by indolicidin

    Article • Scientific Reports, October 2024, Springer Science + Business Media

    Dr Anders P Hakansson

  9. Role of the polyamine transporter PotABCD during biofilm formation by Streptococcus pneumoniae

    Article • PLOS One, August 2024, PLOS

    Dr Anders P Hakansson

  10. Biofilm-dispersed pneumococci induce elevated leukocyte and platelet activation

    Article • Frontiers in Cellular and Infection Microbiology, August 2024, Frontiers

    Dr Anders P Hakansson

  11. HAMLET, a human milk protein-lipid complex, modulates amoxicillin induced changes in an ex vivo biofilm model of the oral microbiome

    Article • Frontiers in Microbiology, July 2024, Frontiers

    Dr Anders P Hakansson

  12. Cannabis use, mental health, and problematic Internet use in Quebec: A study protocol

    Article • PLOS One, June 2024, PLOS

    Dr Anders P Hakansson

  13. HAMLET, a human milk protein-lipid complex, modulates amoxicillin-induced changes in anex vivobiofilm model of the oral microbiome

    Article • November 2023, Cold Spring Harbor Laboratory Press

    Dr Anders P Hakansson

  14. Role of serotype and virulence determinants of Streptococcus pyogenes biofilm bacteria in internalization and persistence in epithelial cells in vitro

    Article • Frontiers in Cellular and Infection Microbiology, May 2023, Frontiers

    Dr Anders P Hakansson

  15. Treatment of Mouse Infants with Amoxicillin, but Not the Human Milk-Derived Antimicrobial HAMLET, Impairs Lung Th17 Responses

    Article • Antibiotics, February 2023, MDPI AG

    Dr Anders P Hakansson

  16. Measuring Niche-Associated Metabolic Activity in Planktonic and Biofilm Bacteria

    Article • January 2023, Springer Science + Business Media

    Dr Anders P Hakansson

  17. Editorial: Microbial biofilms interacting with host mucosal surfaces

    Article • Frontiers in Cellular and Infection Microbiology, October 2022, Frontiers

    Dr Anders P Hakansson

  18. A Mouse Model for the Transition of <em>Streptococcus pneumoniae</em> from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

    Article • Journal of Visualized Experiments, September 2022, MyJove Corporation

    Dr Anders P Hakansson

  19. A particulate matter: How environmental irritants and particulate matter increase sensitivity to bacterial respiratory tract infections. Commentary for “Underground railway particulate matter and susceptibility to pneumococcal infection”

    Article • EBioMedicine, July 2022, Elsevier

    Dr Anders P Hakansson

  20. Influence of the Polysaccharide Capsule on the Bactericidal Activity of Indolicidin on Streptococcus pneumoniae

    Article • Frontiers in Microbiology, May 2022, Frontiers

    Dr Anders P Hakansson

  21. Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis

    Article • Frontiers in Cellular and Infection Microbiology, May 2022, Frontiers

    Dr Anders P Hakansson

  22. Functional Antibodies Against SARS-CoV-2 Receptor Binding Domain Variants with Mutations N501Y or E484K in Human Milk from COVID-19-Vaccinated, -Recovered, and -Unvaccinated Women

    Article • Breastfeeding Medicine, February 2022, Mary Ann Liebert Inc

    Dr Anders P Hakansson

  23. Capsule Independent Antimicrobial Activity Induced by Nanochitosan against Streptococcus pneumoniae

    Article • Polymers, August 2021, MDPI AG

    Dr Anders P Hakansson

  24. A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity upon Viral Infection and Advanced Age

    Article • Infection and Immunity, July 2021, ASM Journals

    Dr Anders P Hakansson

  25. HAMLET a human milk protein‐lipid complex induces a pro‐inflammatory phenotype of myeloid cells

    Article • European Journal of Immunology, February 2021, Wiley

    Dr Anders P Hakansson

  26. The serine protease HtrA plays a key role in heat-induced dispersal of pneumococcal biofilms

    Article • Scientific Reports, December 2020, Springer Science + Business Media

    Dr Anders P Hakansson

  27. A Role of Epithelial Cells and Virulence Factors in Biofilm Formation by Streptococcus pyogenesIn Vitro

    Article • Infection and Immunity, September 2020, ASM Journals

    Dr Anders P Hakansson

  28. Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion

    Article • Infection and Immunity, September 2020, ASM Journals

    Dr Anders P Hakansson

  29. A Murine Model for Enhancement ofStreptococcus pneumoniaePathogenicity Upon Viral Infection and Advanced Age

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Dr Anders P Hakansson

  30. Chapter 7 – Pathogenesis of otitis media – A review of the literature between 2015 and 2019

    Article • International Journal of Pediatric Otorhinolaryngology, December 2019, Elsevier

    Dr Anders P Hakansson

  31. The human milk protein-lipid complex HAMLET disrupts glycolysis and induces death in Streptococcus pneumoniae

    Article • Journal of Biological Chemistry, November 2019, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Anders P Hakansson

  32. HAMLET, a Protein Complex from Human Milk, Has Bactericidal Activity and Enhances the Activity of Antibiotics against Pathogenic Streptococci

    Article • Antimicrobial Agents and Chemotherapy, October 2019, ASM Journals

    Dr Anders P Hakansson

  33. Growing and Characterizing Biofilms Formed by Streptococcus pneumoniae

    Article • January 2019, Springer Science + Business Media

    Dr Anders P Hakansson

  34. A Protein Complex from Human Milk Enhances the Activity of Antibiotics and Drugs againstMycobacterium tuberculosis

    Article • Antimicrobial Agents and Chemotherapy, November 2018, ASM Journals

    Dr Anders P Hakansson

  35. BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state

    Article • PLOS One, August 2018, PLOS

    Dr Anders P Hakansson

  36. Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection

    Article • Physiological Reviews, April 2018, American Physiological Society

    Dr Anders P Hakansson

  37. Streptococcus pneumoniae Modulates Staphylococcus aureus Biofilm Dispersion and the Transition from Colonization to Invasive Disease

    Article • mBio, January 2018, ASM Journals

    Dr Anders P Hakansson, Anthony A Campagnari

  38. Streptococcus pneumoniae Otitis Media Pathogenesis and How It Informs Our Understanding of Vaccine Strategies

    Article • Current Otorhinolaryngology Reports, May 2017, Springer Science + Business Media

    Dr Anders P Hakansson

  39. Panel 6: Vaccines

    Article • Otolaryngology, April 2017, SAGE Publications

    Professor Melinda M Pettigrew, Dr Stephen J Barenkamp, Dr Anders P Hakansson

  40. Panel 4: Report of the Microbiology Panel

    Article • Otolaryngology, April 2017, SAGE Publications

    Dr Stephen J Barenkamp, Dr Anders P Hakansson

  41. Low NF-κB Activation and Necroptosis in Alveolar Macrophages: A New Virulence Property of Streptococcus pneumoniae

    Article • The Journal of Infectious Diseases, March 2017, Oxford University Press (OUP)

    Dr Anders P Hakansson

  42. In Vitro and In Vivo Biofilm Formation by Pathogenic Streptococci

    Article • December 2016, Springer Science + Business Media

    Dr Anders P Hakansson

  43. Host Physiologic Changes Induced by Influenza A Virus Lead toStaphylococcus aureusBiofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease

    Article • mBio, August 2016, ASM Journals

    Dr Anders P Hakansson, Anthony A Campagnari

  44. In situ pneumococcal vaccine production and delivery through a hybrid biological-biomaterial vector

    Article • Science Advances, July 2016, American Association for the Advancement of Science

    Mingfu Chen, Dr Anders P Hakansson

  45. Directed vaccination against pneumococcal disease

    Article • Proceedings of the National Academy of Sciences, June 2016, Proceedings of the National Academy of Sciences

    Dr Anders P Hakansson

  46. Novel Strategy To Protect against Influenza Virus-Induced Pneumococcal Disease without Interfering with Commensal Colonization

    Article • Infection and Immunity, March 2016, ASM Journals

    Dr Anders P Hakansson

  47. Structure and Potential Cellular Targets of HAMLET-like Anti-Cancer Compounds made from Milk Components

    Article • Journal of Pharmacy & Pharmaceutical Sciences, November 2015, University of Alberta Libraries

    Dr Anders P Hakansson

  48. Halothane Modulates the Type I Interferon Response to Influenza and Minimizes the Risk of Secondary Bacterial Pneumonia through Maintenance of Neutrophil Recruitment in an Animal Model

    Article • Anesthesiology, September 2015, Wolters Kluwer Health

    Dr Anders P Hakansson

  49. Absence of capsule reveals glycan-mediated binding and recognition of salivary mucin MUC7 byStreptococcus pneumoniae

    Article • Molecular Oral Microbiology, August 2015, Wiley

    Dr Anders P Hakansson

  50. Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease

    Article • Frontiers in Cellular and Infection Microbiology, January 2015, Frontiers

    Dr Anders P Hakansson

  51. Protective effects of human milk antimicrobial peptides against bacterial infection

    Article • Jornal de Pediatria, January 2015, Elsevier

    Dr Anders P Hakansson

  52. Mannosylated poly(beta-amino esters) for targeted antigen presenting cell immune modulation

    Article • Biomaterials, January 2015, Elsevier

    Dr Anders P Hakansson, Mingfu Chen

  53. Pneumococcal Genetic Transformation During Colonization and Biofilm Formation

    Article • January 2015, Elsevier

    Dr Anders P Hakansson

  54. Biomaterials at the interface of nano- and micro-scale vector–cellular interactions in genetic vaccine design

    Article • Journal of Materials Chemistry B, September 2014, Royal Society of Chemistry

    Dr Anders P Hakansson

  55. Dynamic Changes in the Streptococcus pneumoniae Transcriptome during Transition from Biofilm Formation to Invasive Disease upon Influenza A Virus Infection

    Article • Infection and Immunity, August 2014, ASM Journals

    Dr Anders P Hakansson, Professor Melinda M Pettigrew

  56. Hybrid bio-synthetic gene delivery

    Article • Proceedings of the National Academy of Sciences, August 2014, Proceedings of the National Academy of Sciences

    Dr Anders P Hakansson, Mingfu Chen

  57. Monitoring Changes in Membrane Polarity, Membrane Integrity, and Intracellular Ion Concentrations in Streptococcus pneumoniae Using Fluorescent Dyes

    Article • Journal of Visualized Experiments, February 2014, MyJove Corporation

    Dr Anders P Hakansson

  58. Pneumococcal Adaptive Responses to Changing Host Environments

    Article • The Journal of Infectious Diseases, February 2014, Oxford University Press (OUP)

    Dr Anders P Hakansson

  59. Small‐angle X‐ray scattering of BAMLET at pH 12: A complex of α‐lactalbumin and oleic acid

    Article • Proteins Structure Function and Bioinformatics, January 2014, Wiley

    Dr Anders P Hakansson

  60. Streptococcus pyogenes Biofilm Growth In Vitro and In Vivo and Its Role in Colonization, Virulence, and Genetic Exchange

    Article • The Journal of Infectious Diseases, January 2014, Oxford University Press (OUP)

    Dr Anders P Hakansson

  61. Biofilm Formation Enhances Fomite Survival of Streptococcus pneumoniae and Streptococcus pyogenes

    Article • Infection and Immunity, December 2013, ASM Journals

    Dr Anders P Hakansson

  62. A Complex of Equine Lysozyme and Oleic Acid with Bactericidal Activity against Streptococcus pneumoniae

    Article • PLOS One, November 2013, PLOS

    Dr Anders P Hakansson

  63. Internalization and Trafficking of Nontypeable Haemophilus influenzae in Human Respiratory Epithelial Cells and Roles of IgA1 Proteases for Optimal Invasion and Persistence

    Article • Infection and Immunity, November 2013, ASM Journals

    Dr Anders P Hakansson

  64. Interkingdom Signaling Induces Streptococcus pneumoniae Biofilm Dispersion and Transition from Asymptomatic Colonization to Disease

    Article • mBio, July 2013, ASM Journals

    Dr Anders P Hakansson

  65. Sensitization of Staphylococcus aureus to Methicillin and Other Antibiotics In Vitro and In Vivo in the Presence of HAMLET

    Article • PLOS One, May 2013, PLOS

    Dr Anders P Hakansson

  66. High Levels of Genetic Recombination during Nasopharyngeal Carriage and Biofilm Formation in Streptococcus pneumoniae

    Article • mBio, September 2012, ASM Journals

    Dr Anders P Hakansson

  67. The Human Milk Protein-Lipid Complex HAMLET Sensitizes Bacterial Pathogens to Traditional Antimicrobial Agents

    Article • PLOS One, August 2012, PLOS

    Dr Anders P Hakansson

  68. A Novel Initiation Mechanism of Death in Streptococcus pneumoniae Induced by the Human Milk Protein-Lipid Complex HAMLET and Activated during Physiological Death

    Article • Journal of Biological Chemistry, June 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Anders P Hakansson

  69. Pneumococcal Interactions with Epithelial Cells Are Crucial for Optimal Biofilm Formation and ColonizationIn VitroandIn Vivo

    Article • Infection and Immunity, May 2012, ASM Journals

    Dr Anders P Hakansson

  70. Oleic acid is a key cytotoxic component of HAMLET-like complexes

    Article • Biological Chemistry, January 2012, De Gruyter

    Dr Anders P Hakansson

  71. A novel method for preparation of HAMLET-like protein complexes

    Article • Biochimie, September 2011, Elsevier

    Dr Anders P Hakansson

  72. Role of Dihydrolipoamide Dehydrogenase in Regulation of Raffinose Transport in Streptococcus pneumoniae

    Article • Journal of Bacteriology, May 2011, ASM Journals

    Dr Anders P Hakansson

  73. Apoptosis-Like Death in Bacteria Induced by HAMLET, a Human Milk Lipid-Protein Complex

    Article • PLOS One, March 2011, PLOS

    Dr Anders P Hakansson

  74. Streptolysin O Inhibits Clathrin-Dependent Internalization of Group A Streptococcus

    Article • mBio, February 2011, ASM Journals

    Dr Anders P Hakansson

  75. PerR Confers Phagocytic Killing Resistance and Allows Pharyngeal Colonization by Group A Streptococcus

    Article • PLoS Pathogens, September 2008, PLOS

    Dr Anders P Hakansson

  76. Enzymatic Characterization of Dihydrolipoamide Dehydrogenase from Streptococcus pneumoniae Harboring Its Own Substrate

    Article • Journal of Biological Chemistry, August 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Anders P Hakansson

  77. Mg2+ signalling defines the group A streptococcal CsrRS (CovRS) regulon

    Article • Molecular Microbiology, July 2007, Wiley

    Dr Anders P Hakansson

  78. Capsule does not block antibody binding to PspA, a surface virulence protein of Streptococcus pneumoniae

    Article • Microbial Pathogenesis, May 2006, Elsevier

    Dr Anders P Hakansson

  79. Enhancement of Streptolysin O Activity and Intrinsic Cytotoxic Effects of the Group A Streptococcal Toxin, NAD-Glycohydrolase

    Article • Journal of Biological Chemistry, January 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Anders P Hakansson, Dr Athanasios Michos

  80. Extracellular group A Streptococcus induces keratinocyte apoptosis by dysregulating calcium signalling

    Article • Cellular Microbiology, April 2005, Wiley

    Dr Anders P Hakansson

  81. Cytolysin-dependent evasion of lysosomal killing

    Article • Proceedings of the National Academy of Sciences, March 2005, Proceedings of the National Academy of Sciences

    Dr Anders P Hakansson

  82. Relative Roles of Genetic Background and Variation in PspA in the Ability of Antibodies to PspA To Protect against Capsular Type 3 and 4 Strains of Streptococcus pneumoniae

    Article • Infection and Immunity, August 2003, ASM Journals

    Dr Anders P Hakansson, Dr Larry S. McDaniel

  83. Regions of PspA/EF3296 Best Able To Elicit Protection against Streptococcus pneumoniae in a Murine Infection Model

    Article • Infection and Immunity, March 2003, ASM Journals

    Dr Anders P Hakansson

  84. Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection

    Article • Molecular Microbiology, April 2002, Wiley

    Dr Anders P Hakansson

  85. Hamlet — A Complex from Human Milk that Induces Apoptosis in Tumor Cells but Spares Healthy Cells

    Article • January 2002, Springer Science + Business Media

    Dr Anders P Hakansson

  86. In Vivo Activation of Dendritic Cells and T Cells during Salmonella enterica Serovar Typhimurium Infection

    Article • Infection and Immunity, September 2001, ASM Journals

    Dr Anders P Hakansson

  87. Characterization of Binding of Human Lactoferrin to Pneumococcal Surface Protein A

    Article • Infection and Immunity, May 2001, ASM Journals

    Dr Anders P Hakansson

  88. Morphological and functionalin vitroandin vivocharacterization of the mouse corpus cavernosum

    Article • British Journal of Pharmacology, March 2001, Wiley

    Dr Anders P Hakansson

  89. A folding variant of human α‐lactalbumin induces mitochondrial permeability transition in isolated mitochondria

    Article • FEBS Journal, January 2001, Wiley

    Dr Anders P Hakansson

  90. Conversion of α-lactalbumin to a protein inducing apoptosis

    Article • Proceedings of the National Academy of Sciences, April 2000, Proceedings of the National Academy of Sciences

    Dr Anders P Hakansson

  91. A folding variant of α‐lactalbumin with bactericidal activity against Streptococcus pneumoniae

    Article • Molecular Microbiology, April 2000, Wiley

    Dr Anders P Hakansson

  92. A folding variant of α‐lactalbumin with bactericidal activity against Streptococcus pneumoniae

    Article • Molecular Microbiology, February 2000, Wiley

    Dr Anders P Hakansson

  93. Protease Activation in Apoptosis Induced by MAL

    Article • Experimental Cell Research, June 1999, Elsevier

    Dr Anders P Hakansson

  94. Molecular Characterization of  -Lactalbumin Folding Variants That Induce Apoptosis in Tumor Cells

    Article • Journal of Biological Chemistry, March 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Anders P Hakansson

  95. Multimeric α-Lactalbumin from Human Milk Induces Apoptosis through a Direct Effect on Cell Nuclei

    Article • Experimental Cell Research, February 1999, Elsevier

    Dr Anders P Hakansson

  96. Aspects on the Interaction ofStreptococcus pneumoniaeandHaemophilus influenzaewith Human Respiratory Tract Mucosa

    Article • American Review of Respiratory Disease, October 1996, American Thoracic Society

    Dr Anders P Hakansson

  97. Antibodies to pneumococcal polysaccharides in human milk: lack of relationship to colonization and acute otitis media

    Article • The Pediatric Infectious Disease Journal, June 1996, Wolters Kluwer Health

    Dr Anders P Hakansson

  98. Apoptosis induced by a human milk protein.

    Article • Proceedings of the National Academy of Sciences, August 1995, Proceedings of the National Academy of Sciences

    Dr Anders P Hakansson

  99. Article • PLOS

    Dr Anders P Hakansson

  100. Article • PLOS

    Dr Anders P Hakansson

  101. Article • PLOS

    Dr Anders P Hakansson

  102. Article • PLOS

    Dr Anders P Hakansson

  103. Article • PLOS

    Dr Anders P Hakansson

  104. Article • PLOS

    Dr Anders P Hakansson

  105. Article • PLOS

    Dr Anders P Hakansson

  106. Article • PLOS

    Dr Anders P Hakansson

  107. Article • PLOS

    Dr Anders P Hakansson

  108. Article • PLOS

    Dr Anders P Hakansson