All Stories

  1. A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach

    Article • EBioMedicine, July 2021, Elsevier

    Professor Allan Lawrie

  2. Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: machine learning on proteomics from the DETECT cohort

    Article • European Respiratory Journal, December 2020, European Respiratory Society (ERS)

    Professor Allan Lawrie

  3. Deprivation and prognosis in patients with pulmonary arterial hypertension: missing the effect of deprivation on a rare disease?

    Article • European Respiratory Journal, April 2020, European Respiratory Society (ERS)

    Eleni Sofianopoulou, Professor Allan Lawrie

  4. A machine learning cardiac magnetic resonance approach to extract disease features and automate pulmonary arterial hypertension diagnosis

    Article • European Heart Journal - Cardiovascular Imaging, January 2020, Oxford University Press (OUP)

    Andrew Swift, Professor Allan Lawrie

  5. Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling

    Article • Circulation Research, January 2020, Wolters Kluwer Health

    Professor Allan Lawrie

  6. A toolbox for the longitudinal assessment of healthspan in aging mice

    Article • Nature Protocols, January 2020, Springer Science + Business Media

    Professor Allan Lawrie

  7. Screening strategies for pulmonary arterial hypertension

    Article • European Heart Journal Supplements, December 2019, Oxford University Press (OUP)

    Professor Allan Lawrie

  8. A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension

    Article • Nature Communications, November 2019, Springer Science + Business Media

    Professor Allan Lawrie

  9. The role of chemokines and chemokine receptors in pulmonary arterial hypertension

    Article • British Journal of Pharmacology, November 2019, Wiley

    Professor Allan Lawrie

  10. Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension

    Article • American Journal of Respiratory and Critical Care Medicine, October 2019, American Thoracic Society

    Professor Allan Lawrie

  11. Identification of Cardiac MRI Thresholds for Risk Stratification in Pulmonary Arterial Hypertension

    Article • American Journal of Respiratory and Critical Care Medicine, October 2019, American Thoracic Society

    Professor Allan Lawrie

  12. Utilising artificial intelligence to determine patients at risk of a rare disease: idiopathic pulmonary arterial hypertension

    Article • October 2019, SAGE Publications

    Professor Allan Lawrie

  13. Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia

    Article • The American Journal of Human Genetics, May 2019, Elsevier

    Professor Allan Lawrie

  14. The incremental shuttle walk test predicts mortality in non-group 1 pulmonary hypertension: results from the ASPIRE Registry

    Article • April 2019, SAGE Publications

    Professor Allan Lawrie

  15. Air pollution in pulmonary arterial hypertension: A United Kingdom cohort study

    Article • European Respiratory Journal, March 2019, European Respiratory Society (ERS)

    Eleni Sofianopoulou, Professor Allan Lawrie

  16. Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension

    Article • Circulation Research, March 2019, Wolters Kluwer Health

    Professor Allan Lawrie

  17. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

    Article • The Lancet Respiratory Medicine, March 2019, Elsevier

    Professor Allan Lawrie

  18. Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension

    Article • American Journal of Respiratory and Critical Care Medicine, January 2019, American Thoracic Society

    Laszlo Farkas, Professor Allan Lawrie

  19. Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension

    Article • Circulation Genomic and Precision Medicine, October 2018, Wolters Kluwer Health

    Dr. Erika Berman Rosenzweig, Professor Allan Lawrie

  20. High levels of healthcare utilization prior to diagnosis in idiopathic pulmonary arterial hypertension support the feasibility of an early diagnosis algorithm: the SPHInX project

    Article • September 2018, SAGE Publications

    Professor Allan Lawrie

  21. Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

    Article • Scientific Reports, September 2018, Springer Science + Business Media

    Professor Allan Lawrie

  22. The Hepcidin/Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells

    Article • Scientific Reports, August 2018, Springer Science + Business Media

    Professor Allan Lawrie

  23. Divergent Roles for TRAIL in Lung Diseases

    Article • Frontiers in Medicine, July 2018, Frontiers

    Professor Allan Lawrie

  24. Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension

    Article • Circulation, July 2018, Wolters Kluwer Health

    Professor Allan Lawrie, Professor Zhi-Cheng JING

  25. The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension

    Article • European Respiratory Journal, July 2018, European Respiratory Society (ERS)

    Professor Allan Lawrie

  26. Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes

    Article • The American Journal of Human Genetics, July 2018, Elsevier

    Mark Ponsford, Professor Allan Lawrie

  27. De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures

    Article • The American Journal of Human Genetics, July 2018, Elsevier

    Mark Ponsford, Professor Allan Lawrie

  28. Incremental Shuttle Walking Test Distance Is Reduced in Patients With Pulmonary Hypertension in World Health Organisation Functional Class I

    Article • Frontiers in Medicine, June 2018, Frontiers

    Professor Allan Lawrie

  29. Circulating Protein Biomarkers in Systemic Sclerosis Related Pulmonary Arterial Hypertension: A Review of Published Data

    Article • Frontiers in Medicine, June 2018, Frontiers

    Professor Allan Lawrie

  30. Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

    Article • Nature Communications, April 2018, Springer Science + Business Media

    Professor Allan Lawrie, Horst Olschewski

  31. Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension

    Article • BMC Pulmonary Medicine, March 2018, Springer Science + Business Media

    Professor Allan Lawrie

  32. Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

    Article • Scientific Reports, January 2018, Springer Science + Business Media

    Mark Ponsford, Professor Allan Lawrie

  33. Selective improvement of pulmonary arterial hypertension with a dual ETA/ETB receptors antagonist in the apolipoprotein E−/− model of PAH and atherosclerosis

    Article • December 2017, SAGE Publications

    Professor Allan Lawrie

  34. Prognostic Significance of Reduced Blood Pressure Response to Exercise in Pediatric Pulmonary Arterial Hypertension

    Article • American Review of Respiratory Disease, December 2017, American Thoracic Society

    Professor Zhi-Cheng JING, Professor Allan Lawrie

  35. Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension

    Article • Circulation, November 2017, Wolters Kluwer Health

    Mark Ponsford, Professor Allan Lawrie

  36. Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling

    Article • Pulmonary Circulation, September 2017, SAGE Publications

    Professor Allan Lawrie

  37. Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study

    Article • The Lancet Respiratory Medicine, September 2017, Elsevier

    Professor Olivier SITBON, Professor Allan Lawrie

  38. Incremental shuttle walk test distance and autonomic dysfunction predict survival in pulmonary arterial hypertension

    Article • The Journal of Heart and Lung Transplantation, August 2017, Elsevier

    Professor Allan Lawrie

  39. Magnetic Resonance Imaging in the Prognostic Evaluation of Patients with Pulmonary Arterial Hypertension

    Article • American Review of Respiratory Disease, July 2017, American Thoracic Society

    Andrew Swift, Professor Allan Lawrie

  40. Specific Alleles of CLN7/MFSD8, a Protein That Localizes to Photoreceptor Synaptic Terminals, Cause a Spectrum of Nonsyndromic Retinal Dystrophy

    Article • Investigative Opthalmology & Visual Science, June 2017, Association for Research in Vision and Ophthalmology (ARVO)

    Professor Allan Lawrie

  41. Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism

    Article • Science Immunology, February 2017, American Association for the Advancement of Science

    Professor Allan Lawrie

  42. Maintained right ventricular pressure overload induces ventricular-arterial decoupling in mice

    Article • Experimental Physiology, February 2017, Wiley

    Professor Allan Lawrie

  43. Biallelic Mutation of ARHGEF18 , Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration

    Article • The American Journal of Human Genetics, February 2017, Elsevier

    Mark Ponsford, Professor Allan Lawrie

  44. Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension

    Article • Circulation, January 2017, Wolters Kluwer Health

    Professor Allan Lawrie

  45. Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease

    Article • The American Journal of Human Genetics, January 2017, Elsevier

    Mark Ponsford, Professor Allan Lawrie

  46. Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension

    Article • Trends in Molecular Medicine, January 2017, Elsevier

    Professor Allan Lawrie

  47. From bones to blood pressure, developing novel biologic approaches targeting the osteoprotegein pathway for pulmonary vascular disease

    Article • Pharmacology & Therapeutics, January 2017, Elsevier

    Professor Allan Lawrie

  48. Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension

    Article • European Respiratory Journal, September 2016, European Respiratory Society (ERS)

    robin condliffe, Professor Allan Lawrie

  49. MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension

    Article • Journal of Clinical Investigation, May 2016, American Society for Clinical Investigation

    Professor Allan Lawrie

  50. Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries

    Article • Thrombosis and Haemostasis, January 2016, Thieme Publishing Group

    Professor Allan Lawrie

  51. Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline

    Article • JACC Cardiovascular Interventions, December 2015, Elsevier

    Professor Allan Lawrie

  52. Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension

    Article • Circulation Cardiovascular Interventions, November 2015, Wolters Kluwer Health

    Professor Allan Lawrie

  53. Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension

    Article • American Journal of Respiratory and Critical Care Medicine, July 2015, American Thoracic Society

    Professor Allan Lawrie

  54. Elevated Plasma CXCL12α Is Associated with a Poorer Prognosis in Pulmonary Arterial Hypertension

    Article • PLoS ONE, April 2015, PLOS

    Professor Allan Lawrie

  55. Osteoprotegerin in Cardiometabolic Disorders

    Article • International Journal of Endocrinology, January 2015, Hindawi Publishing Corporation

    Professor Allan Lawrie

  56. The role of the osteoprotegerin/tumor necrosis factor related apoptosis-inducing ligand axis in the pathogenesis of pulmonary arterial hypertension

    Article • Vascular Pharmacology, December 2014, Elsevier

    Professor Allan Lawrie

  57. Influence of pre-analytical and analytical factors on osteoprotegerin measurements

    Article • Clinical Biochemistry, September 2014, Elsevier

    Professor Allan Lawrie

  58. A Report on the Use of Animal Models and Phenotyping Methods in Pulmonary Hypertension Research

    Article • Pulmonary Circulation, March 2014, SAGE Publications

    Professor Allan Lawrie

  59. MicroRNA in Pulmonary Vascular Disease

    Article • January 2014, Elsevier

    Professor Allan Lawrie

  60. Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling

    Article • Cardiovascular Research, June 2013, European Society of Cardiology

    Professor Allan Lawrie

  61. Reduced MicroRNA-150 Is Associated with Poor Survival in Pulmonary Arterial Hypertension

    Article • American Journal of Respiratory and Critical Care Medicine, February 2013, American Thoracic Society

    Professor Allan Lawrie

  62. No Evidence for Cardiac Dysfunction in Kif6 Mutant Mice

    Article • PLoS ONE, January 2013, PLOS

    Dr Barbara Ciani, Professor Allan Lawrie

  63. Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension

    Article • The Journal of Experimental Medicine, October 2012, Rockefeller University Press

    Professor Allan Lawrie

  64. Pulmonary hypertension in COPD: results from the ASPIRE registry

    Article • European Respiratory Journal, September 2012, European Respiratory Society (ERS)

    Professor Allan Lawrie

  65. Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis

    Article • Thorax, April 2012, BMJ

    Professor Allan Lawrie

  66. Serum Osteoprotegerin is Increased and Predicts Survival in Idiopathic Pulmonary Arterial Hypertension

    Article • Pulmonary Circulation, January 2012, SAGE Publications

    Professor Allan Lawrie

  67. Paigen Diet–Fed Apolipoprotein E Knockout Mice Develop Severe Pulmonary Hypertension in an Interleukin-1–Dependent Manner

    Article • American Journal Of Pathology, October 2011, Elsevier

    Professor Allan Lawrie

  68. ASPIRE registry: Assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre

    Article • European Respiratory Journal, September 2011, European Respiratory Society (ERS)

    Professor Allan Lawrie

  69. TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation

    Article • Journal of Leukocyte Biology, May 2011, Wiley

    Professor Allan Lawrie

  70. S100A4 and Bone Morphogenetic Protein-2 Codependently Induce Vascular Smooth Muscle Cell Migration via Phospho–Extracellular Signal-Regulated Kinase and Chloride Intracellular Channel 4

    Article • Circulation Research, September 2009, Wolters Kluwer Health

    Professor Allan Lawrie

  71. Evidence of a Role for Osteoprotegerin in the Pathogenesis of Pulmonary Arterial Hypertension

    Article • American Journal Of Pathology, January 2008, Elsevier

    Professor Allan Lawrie

  72. Interdependent Serotonin Transporter and Receptor Pathways Regulate S100A4/Mts1, a Gene Associated With Pulmonary Vascular Disease

    Article • Circulation Research, August 2005, Wolters Kluwer Health

    Professor Allan Lawrie

  73. Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model

    Article • Gene Therapy, April 2005, Springer Science + Business Media

    Professor Allan Lawrie

  74. VP22-mediated intercellular transport correlates with enhanced biological activity of MybEngrailed but not (HSV-I) thymidine kinase fusion proteins in primary vascular cells following non-viral transfection

    Article • The Journal of Gene Medicine, January 2005, Wiley

    Professor Allan Lawrie

  75. Apolipoprotein D and Platelet-Derived Growth Factor-BB Synergism Mediates Vascular Smooth Muscle Cell Migration

    Article • Circulation Research, July 2004, Wolters Kluwer Health

    Professor Allan Lawrie

  76. Apolipoprotein D Inhibits Platelet-Derived Growth Factor-BB–Induced Vascular Smooth Muscle Cell Proliferated by Preventing Translocation of Phosphorylated Extracellular Signal Regulated Kinase 1/2 to the Nucleus

    Article • Arteriosclerosis Thrombosis and Vascular Biology, December 2003, Wolters Kluwer Health

    Professor Allan Lawrie

  77. Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals

    Article • Ultrasound in Medicine & Biology, October 2003, Elsevier

    Professor Allan Lawrie

  78. Ultrasound Gene Therapy: On the Road from Concept to Reality

    Article • Echocardiography, May 2001, Wiley

    Professor Allan Lawrie

  79. Microbubble-enhanced ultrasound for vascular gene delivery

    Article • Gene Therapy, December 2000, Springer Science + Business Media

    Professor Allan Lawrie

  80. Ultrasound Enhances Reporter Gene Expression After Transfection of Vascular Cells In Vitro

    Article • Circulation, May 1999, Wolters Kluwer Health

    Professor Allan Lawrie