All Stories

  1. Inhalation-Based Nanoparticle Drug Delivery Targeting the Diseased Lower Airways in Idiopathic Pulmonary Fibrosis

    Article • Pharmaceutics, January 2026, MDPI AG

    allan brasier

  2. RelA Signaling in <em>Scgb1a1</em>+ Progenitors Mediates Lower Airway Epithelial Atypia in RSV-Induced Post Viral Lung Disease

    Article • November 2025, MDPI AG

    allan brasier

  3. Mechanisms on How Matricellular Microenvironments Sustain Idiopathic Pulmonary Fibrosis

    Article • International Journal of Molecular Sciences, June 2025, MDPI AG

    allan brasier

  4. Characterizing Plasma-Based Metabolomic Signatures for Metastasis in Non-Small Cell Lung Cancer

    Article • Metabolites, May 2025, MDPI AG

    allan brasier

  5. SMARCA4 regulates inducible BRD4 genomic redistribution coupling intrinsic immunity and plasticity in epithelial injury-repair

    Article • Nucleic Acids Research, March 2025, Oxford University Press (OUP)

    allan brasier

  6. Characterizing Plasma-based Metabolomic Signatures for Metastasis in Non-Small Cell Lung Cancer

    Article • February 2025, MDPI AG

    allan brasier

  7. Interactions between epithelial mesenchymal plasticity, barrier dysfunction and innate immune pathways shape the genesis of allergic airway disease

    Article • Expert Review of Respiratory Medicine, January 2025, Taylor & Francis

    allan brasier

  8. Beyond deadlines and deliverables: Identifying barriers and facilitators to enhance the PROMICE of translational teams

    Article • Journal of Clinical and Translational Science, January 2025, Cambridge University Press

    allan brasier

  9. Optimizing an evidence-based team-building intervention for dissemination: Collaboration Planning 2.0

    Article • Journal of Clinical and Translational Science, January 2025, Cambridge University Press

    allan brasier

  10. NF-κB/RelA signaling in secretoglobin progenitors mediates plasticity and MMP-induced barrier disruption in house dust mite-induced allergic asthma

    Article • AJP Lung Cellular and Molecular Physiology, July 2024, American Physiological Society

    allan brasier

  11. Optimizing external advisory committee meetings of Clinical and Translational Science Awards through focused pre-review

    Article • Journal of Clinical and Translational Science, January 2024, Cambridge University Press

    allan brasier

  12. Orchestrating epigenetic readers: Progress in understanding the functions of bromodomain-containing protein 4 complexes

    Article • Molecular Therapy — Nucleic Acids, June 2023, Elsevier

    allan brasier

  13. Genomic targets of the IRE1-XBP1s pathway in mediating metabolic adaptation in epithelial plasticity

    Article • Nucleic Acids Research, February 2023, Oxford University Press (OUP)

    allan brasier

  14. Bromodomain-containing Protein 4 Regulates Innate Inflammation in Airway Epithelial Cells via Modulation of Alternative Splicing

    Article • January 2023, Cold Spring Harbor Laboratory Press

    allan brasier

  15. A leadership model supporting maturation of high-performance translational teams

    Article • Journal of Clinical and Translational Science, January 2023, Cambridge University Press

    allan brasier

  16. Competencies supporting high-performance translational teams: A review of the SciTS evidence base

    Article • Journal of Clinical and Translational Science, January 2023, Cambridge University Press

    allan brasier

  17. Developing a Translational Team Training Program using the Wisconsin Interventions in Team Science Framework

    Article • Journal of Clinical and Translational Science, January 2023, Cambridge University Press

    allan brasier

  18. Temporal development of high-performance translational teams

    Article • Journal of Clinical and Translational Science, January 2023, Cambridge University Press

    allan brasier

  19. Win–win interactions: Results and implications of a user needs assessment of clinical and translational scientists

    Article • Journal of Clinical and Translational Science, January 2023, Cambridge University Press

    allan brasier

  20. Special Issue “Next-Generation Technologies to Understand Mechanisms of Virus Infections”

    Article • Viruses, December 2022, MDPI AG

    allan brasier

  21. The IRE1α–XBP1s Arm of the Unfolded Protein Response Activates N-Glycosylation to Remodel the Subepithelial Basement Membrane in Paramyxovirus Infection

    Article • International Journal of Molecular Sciences, August 2022, MDPI AG

    allan brasier

  22. RELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection

    Article • Cells, July 2022, MDPI AG

    allan brasier

  23. Airway fibrin formation cascade in allergic asthma exacerbation: implications for inflammation and remodeling

    Article • Clinical Proteomics, May 2022, Springer Science + Business Media

    allan brasier

  24. Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions

    Article • Journal of Innate Immunity, May 2022, Karger Publishers

    allan brasier

  25. Segmental Bronchial Allergen Challenge Elicits Distinct Metabolic Phenotypes in Allergic Asthma

    Article • Metabolites, April 2022, MDPI AG

    allan brasier

  26. Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry

    Article • February 2022, Cold Spring Harbor Laboratory Press

    allan brasier

  27. Role of Secretoglobin+ (club cell) NFκB/RelA-TGFβ signaling in aero-allergen-induced epithelial plasticity and subepithelial myofibroblast transdifferentiation

    Article • December 2021, Springer Science + Business Media

    allan brasier

  28. Target-Based Small Molecule Drug Discovery Towards Novel Therapeutics for Inflammatory Bowel Diseases

    Article • Inflammatory Bowel Diseases, November 2021, Oxford University Press (OUP)

    allan brasier

  29. Paramyxovirus replication induces the hexosamine biosynthetic pathway and mesenchymal transition via the IRE1α-XBP1s arm of the unfolded protein response

    Article • AJP Lung Cellular and Molecular Physiology, September 2021, American Physiological Society

    allan brasier

  30. Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Top-Down Mass Spectrometry

    Article • Journal of the American Chemical Society, July 2021, American Chemical Society (ACS)

    allan brasier

  31. Discovery of RSV-Induced BRD4 Protein Interactions Using Native Immunoprecipitation and Parallel Accumulation—Serial Fragmentation (PASEF) Mass Spectrometry

    Article • Viruses, March 2021, MDPI AG

    allan brasier

  32. Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Native Top-Down Mass Spectrometry

    Article • March 2021, Cold Spring Harbor Laboratory Press

    allan brasier

  33. Alternative mRNA Processing of Innate Response Pathways in Respiratory Syncytial Virus (RSV) Infection

    Article • Viruses, January 2021, MDPI AG

    allan brasier

  34. Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E2 Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes

    Article • Metabolites, January 2021, MDPI AG

    allan brasier

  35. Introduction to the themed issue on the design, development, evaluation, and dissemination of team science interventions in clinical and translational research

    Article • Journal of Clinical and Translational Science, January 2021, Cambridge University Press

    allan brasier

  36. Respiratory Syncytial Virus Infection Induces Chromatin Remodeling to Activate Growth Factor and Extracellular Matrix Secretion Pathways

    Article • Viruses, July 2020, MDPI AG

    allan brasier

  37. Mechanisms how mucosal innate immunity affects progression of allergic airway disease

    Article • Expert Review of Respiratory Medicine, February 2019, Taylor & Francis

    allan brasier

  38. Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation–Driven Airway Remodeling

    Article • American Journal of Respiratory Cell and Molecular Biology, January 2019, American Thoracic Society

    allan brasier

  39. Towards Team-Centered Informatics: Accelerating Innovation in Multidisciplinary Scientific Teams Through Visual Analytics

    Article • The Journal of Applied Behavioral Science, November 2018, SAGE Publications

    allan brasier

  40. PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome

    Article • Frontiers in Immunology, October 2018, Frontiers

    allan brasier

  41. Therapeutic targets for inflammation-mediated airway remodeling in chronic lung disease

    Article • Expert Review of Respiratory Medicine, October 2018, Taylor & Francis

    allan brasier

  42. Proinflammatory Effects of Respiratory Syncytial Virus–Induced Epithelial HMGB1 on Human Innate Immune Cell Activation

    Article • The Journal of Immunology, October 2018, The American Association of Immunologists

    allan brasier, Dr. Yashoda M Hosakote

  43. The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells

    Article • Journal of Biological Chemistry, October 2018, Elsevier

    allan brasier

  44. Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing

    Article • Scientific Reports, September 2018, Springer Science + Business Media

    allan brasier, Dr Alexander N Freiberg

  45. Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

    Article • Redox Biology, September 2018, Elsevier

    allan brasier

  46. Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia

    Article • Experimental Gerontology, June 2018, Elsevier

    allan brasier

  47. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

    Article • European Journal of Medicinal Chemistry, May 2018, Elsevier

    allan brasier

  48. Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

    Article • Cell Reports, April 2018, Elsevier

    allan brasier

  49. Central Role of the NF-κB Pathway in theScgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-Induced Airway Inflammation

    Article • Journal of Virology, March 2018, ASM Journals

    allan brasier

  50. Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways

    Article • Nature Communications, February 2018, Springer Science + Business Media

    allan brasier

  51. Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation

    Article • AJP Lung Cellular and Molecular Physiology, December 2017, American Physiological Society

    allan brasier

  52. Innate mechanism of pollen- and cat dander–induced oxidative stress and DNA damage in the airways

    Article • Journal of Allergy and Clinical Immunology, November 2017, Elsevier

    allan brasier

  53. Proteome Analysis of Hypoxic Glioblastoma Cells Reveals Sequential Metabolic Adaptation of One-Carbon Metabolic Pathways

    Article • Molecular & Cellular Proteomics, November 2017, Elsevier

    allan brasier

  54. Deletion of NF-κB/RelA in Angiotensin II-Sensitive Mesenchymal Cells Blocks Aortic Vascular Inflammation and Abdominal Aortic Aneurysm Formation

    Article • Arteriosclerosis Thrombosis and Vascular Biology, October 2017, Wolters Kluwer Health

    allan brasier

  55. Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women

    Article • Clinical Nutrition, October 2017, Elsevier

    allan brasier

  56. Major Histocompatibility Complex Class II Alleles Influence Induction of Pathogenic Antiphospholipid Antibodies in a Mouse Model of Thrombosis

    Article • Arthritis & Rheumatology, September 2017, Wiley

    allan brasier

  57. Quantitative Assessment of the Effects of Trypsin Digestion Methods on Affinity Purification–Mass Spectrometry-based Protein–Protein Interaction Analysis

    Article • Journal of Proteome Research, July 2017, American Chemical Society (ACS)

    allan brasier

  58. Selective Affinity Enrichment of Nitrotyrosine-Containing Peptides for Quantitative Analysis in Complex Samples

    Article • Journal of Proteome Research, July 2017, American Chemical Society (ACS)

    allan brasier

  59. Loss of Smooth Muscle α-Actin Leads to NF-κB–Dependent Increased Sensitivity to Angiotensin II in Smooth Muscle Cells and Aortic Enlargement

    Article • Circulation Research, June 2017, Wolters Kluwer Health

    allan brasier

  60. Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition

    Article • Nature Microbiology, June 2017, Springer Science + Business Media

    allan brasier

  61. NF-κB Mediates Mesenchymal Transition, Remodeling, and Pulmonary Fibrosis in Response to Chronic Inflammation by Viral RNA Patterns

    Article • American Journal of Respiratory Cell and Molecular Biology, April 2017, American Thoracic Society

    allan brasier

  62. Systematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights into the Pathogenesis of Respiratory Syncytial Virus–Induced Lower Respiratory Tract Infections

    Article • The Journal of Immunology, March 2017, The American Association of Immunologists

    allan brasier

  63. Drug Discovery Targeting Bromodomain-Containing Protein 4

    Article • Journal of Medicinal Chemistry, March 2017, American Chemical Society (ACS)

    allan brasier

  64. Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation

    Article • Cell Death and Disease, February 2017, Springer Science + Business Media

    allan brasier

  65. Reply: Protease Plays a Role in Ragweed Pollen–Induced Neutrophil Recruitment and Epithelial Barrier Disruption

    Article • American Journal of Respiratory Cell and Molecular Biology, February 2017, American Thoracic Society

    allan brasier

  66. BRD4 Couples NF-κB/RelA with Airway Inflammation and the IRF-RIG-I Amplification Loop in Respiratory Syncytial Virus Infection

    Article • Journal of Virology, January 2017, ASM Journals

    allan brasier

  67. Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses

    Article • Journal of Extracellular Vesicles, January 2017, Taylor & Francis

    Stefan Bossmann, allan brasier

  68. Targeting Chromatin Remodeling in Inflammation and Fibrosis

    Article • January 2017, Elsevier

    allan brasier

  69. Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression

    Article • Journal of Biological Chemistry, December 2016, Elsevier

    allan brasier

  70. BRD4 mediates NF-κB-dependent epithelial-mesenchymal transition and pulmonary fibrosis via transcriptional elongation

    Article • AJP Lung Cellular and Molecular Physiology, December 2016, American Physiological Society

    allan brasier

  71. Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition

    Article • Journal of Proteomics, October 2016, Elsevier

    allan brasier

  72. Generation and characterization of a novel transgenic mouse harboring conditional nuclear factor-kappa B/RelA knockout alleles

    Article • BMC Developmental Biology, September 2016, Springer Science + Business Media

    allan brasier

  73. S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure

    Article • International Journal of Proteomics, August 2016, Hindawi Publishing Corporation

    allan brasier

  74. Respiratory Syncytial Virus Infection Triggers Epithelial HMGB1 Release as a Damage-Associated Molecular Pattern Promoting a Monocytic Inflammatory Response

    Article • Journal of Virology, August 2016, ASM Journals

    Dr. Yashoda M Hosakote, allan brasier

  75. Measurement of Histone Methylation Dynamics by One-Carbon Metabolic Isotope Labeling and High-energy Collisional Dissociation Methylation Signature Ion Detection

    Article • Scientific Reports, August 2016, Springer Science + Business Media

    allan brasier

  76. Cytokine amplification and macrophage effector functions in aortic inflammation and abdominal aortic aneurysm formation

    Article • Journal of Thoracic Disease, August 2016, AME Publishing Company

    allan brasier

  77. Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes

    Article • Cell Reports, June 2016, Elsevier

    allan brasier

  78. Myeloid differentiation protein 2 facilitates pollen- and cat dander–induced innate and allergic airway inflammation

    Article • Journal of Allergy and Clinical Immunology, May 2016, Elsevier

    allan brasier

  79. Changes in Proteome Profile of Peripheral Blood Mononuclear Cells in Chronic Chagas Disease

    Article • PLoS Neglected Tropical Diseases, February 2016, PLOS

    allan brasier

  80. Facilitation of Allergic Sensitization and Allergic Airway Inflammation by Pollen-Induced Innate Neutrophil Recruitment

    Article • American Journal of Respiratory Cell and Molecular Biology, January 2016, American Thoracic Society

    allan brasier

  81. Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity

    Article • Journal of Innate Immunity, January 2016, Karger Publishers

    allan brasier

  82. Endothelial Cell Proteomic Response to Rickettsia conorii Infection Reveals Activation of the Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT)-Inferferon Stimulated Gene (ISG)15 Pathway and Reprogramming Plasma Membrane Integr...

    Article • Molecular & Cellular Proteomics, January 2016, Elsevier

    allan brasier

  83. Introduction to Clinical Proteomics

    Article • January 2016, Springer Science + Business Media

    allan brasier

  84. Qualification and Verification of Protein Biomarker Candidates

    Article • January 2016, Springer Science + Business Media

    allan brasier

  85. Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

    Article • Free Radical Biology and Medicine, December 2015, Elsevier

    allan brasier

  86. Improved Detection of Invasive Pulmonary Aspergillosis Arising during Leukemia Treatment Using a Panel of Host Response Proteins and Fungal Antigens

    Article • PLOS One, November 2015, PLOS

    allan brasier

  87. Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2

    Article • Free Radical Biology and Medicine, November 2015, Elsevier

    allan brasier

  88. Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases*

    Article • Molecular & Cellular Proteomics, October 2015, Elsevier

    allan brasier

  89. Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transition

    Article • BMC Genomics, July 2015, Springer Science + Business Media

    allan brasier

  90. Mixed-effects model of epithelial–mesenchymal transition reveals rewiring of signaling networks

    Article • Cellular Signalling, July 2015, Elsevier

    allan brasier

  91. The Multidisciplinary Translational Team (MTT) Model for Training and Development of Translational Research Investigators

    Article • Clinical and Translational Science, May 2015, Wiley

    allan brasier

  92. Inferring Genome-Wide Functional Modulatory Network: A Case Study on NF-κB/RelA Transcription Factor

    Article • Journal of Computational Biology, April 2015, Mary Ann Liebert Inc

    allan brasier

  93. Unlocking proteomic heterogeneity in complex diseases through visual analytics

    Article • PROTEOMICS, April 2015, Wiley

    allan brasier

  94. Whole transcriptome analysis reveals an 8-oxoguanine DNA glycosylase-1-driven DNA repair-dependent gene expression linked to essential biological processes

    Article • Free Radical Biology and Medicine, April 2015, Elsevier

    allan brasier

  95. Evolution of Multidisciplinary Translational Teams (MTTs): Insights for Accelerating Translational Innovations

    Article • Clinical and Translational Science, March 2015, Wiley

    allan brasier

  96. Molecular classification of outcomes from dengue virus -3 infections

    Article • Journal of Clinical Virology, March 2015, Elsevier

    allan brasier

  97. The Journey of Antiphospholipid Antibodies From Cellular Activation to Antiphospholipid Syndrome

    Article • Current Rheumatology Reports, March 2015, Springer Science + Business Media

    allan brasier

  98. MicroRNA 29 Targets Nuclear Factor-κB–Repressing Factor and Claudin 1 to Increase Intestinal Permeability

    Article • Gastroenterology, January 2015, Elsevier

    allan brasier

  99. Ataxia Telangiectasia Mutated Kinase Mediates NF-κB Serine 276 Phosphorylation and Interferon Expression via the IRF7-RIG-I Amplification Loop in Paramyxovirus Infection

    Article • Journal of Virology, December 2014, ASM Journals

    allan brasier

  100. Innate Inflammation Induced by the 8-Oxoguanine DNA Glycosylase-1–KRAS–NF-κB Pathway

    Article • The Journal of Immunology, September 2014, The American Association of Immunologists

    allan brasier

  101. Complement C5-inhibitor rEV576 (coversin) ameliorates in-vivo effects of antiphospholipid antibodies

    Article • Lupus, September 2014, SAGE Publications

    allan brasier

  102. 8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization

    Article • Free Radical Biology and Medicine, August 2014, Elsevier

    allan brasier

  103. TLR4 Activation Enhances the PD-L1–Mediated Tolerogenic Capacity of Colonic CD90+ Stromal Cells

    Article • The Journal of Immunology, July 2014, The American Association of Immunologists

    allan brasier

  104. Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis

    Article • Cellular Signalling, July 2014, Elsevier

    allan brasier

  105. ATM regulates NF-κB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment

    Article • Nucleic Acids Research, June 2014, Oxford University Press (OUP)

    allan brasier

  106. RIG-I Enhanced Interferon Independent Apoptosis upon Junin Virus Infection

    Article • PLOS One, June 2014, PLOS

    allan brasier

  107. Multiplexed Parallel Reaction Monitoring Targeting Histone Modifications on the QExactive Mass Spectrometer

    Article • Analytical Chemistry, May 2014, American Chemical Society (ACS)

    allan brasier

  108. Dynamic Cross Talk Model of the Epithelial Innate Immune Response to Double-Stranded RNA Stimulation: Coordinated Dynamics Emerging from Cell-Level Noise

    Article • PLOS One, April 2014, PLOS

    allan brasier

  109. Modulation of Gene Expression Regulated by the Transcription Factor NF-κB/RelA

    Article • Journal of Biological Chemistry, April 2014, Elsevier

    allan brasier

  110. 8-Oxoguanine DNA Glycosylase-1 Augments Proinflammatory Gene Expression by Facilitating the Recruitment of Site-Specific Transcription Factors

    Article • The Journal of Immunology, January 2014, The American Association of Immunologists

    allan brasier

  111. IL‐6 Regulates Extracellular Matrix Remodeling Associated With Aortic Dilation in a Fibrillin‐1 Hypomorphic mgR/mgR Mouse Model of Severe Marfan Syndrome

    Article • Journal of the American Heart Association, January 2014, Wolters Kluwer Health

    allan brasier

  112. Diagnostics for Statistical Variable Selection Methods for Prediction of Peptic Ulcer Disease in Helicobacter pylori Infection

    Article • Journal of Proteomics & Bioinformatics, January 2014, OMICS Publishing Group

    allan brasier

  113. Systems biology approaches to understanding Epithelial Mesenchymal Transition (EMT) in mucosal remodeling and signaling in asthma

    Article • World Allergy Organization Journal, January 2014, Elsevier

    allan brasier

  114. Innate Immune Response to Arenaviral Infection: A Focus on the Highly Pathogenic New World Hemorrhagic Arenaviruses

    Article • Journal of Molecular Biology, December 2013, Elsevier

    allan brasier

  115. Analysis and Predictive Modeling of Asthma Phenotypes

    Article • October 2013, Springer Science + Business Media

    allan brasier

  116. Conclusions and Future Directions

    Article • October 2013, Springer Science + Business Media

    allan brasier

  117. Measurement of the Innate Immune Response in the Airway

    Article • October 2013, Springer Science + Business Media

    allan brasier

  118. Assessing and Evaluating Multidisciplinary Translational Teams

    Article • Evaluation & the Health Professions, September 2013, SAGE Publications

    allan brasier

  119. Variable selection methods for developing a biomarker panel for prediction of dengue hemorrhagic fever

    Article • BMC Research Notes, September 2013, Springer Science + Business Media

    allan brasier

  120. Aortic Remodeling After Transverse Aortic Constriction in Mice Is Attenuated With AT 1 Receptor Blockade

    Article • Arteriosclerosis Thrombosis and Vascular Biology, September 2013, Wolters Kluwer Health

    allan brasier

  121. Interleukin-6–Signal Transducer and Activator of Transcription-3 Signaling Mediates Aortic Dissections Induced by Angiotensin II via the T-Helper Lymphocyte 17–Interleukin 17 Axis in C57BL/6 Mice

    Article • Arteriosclerosis Thrombosis and Vascular Biology, July 2013, Wolters Kluwer Health

    allan brasier

  122. Identification of Innate Immune Response Endotypes in Asthma: Implications for Personalized Medicine

    Article • Current Allergy and Asthma Reports, June 2013, Springer Science + Business Media

    allan brasier

  123. Use of Theoretical Peptide Distributions in Phosphoproteome Analysis

    Article • Journal of Proteome Research, June 2013, American Chemical Society (ACS)

    allan brasier

  124. A probabilistic approach to learn chromatin architecture and accurate inference of the NF-κB/RelA regulatory network using ChIP-Seq

    Article • Nucleic Acids Research, June 2013, Oxford University Press (OUP)

    allan brasier

  125. Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults

    Article • AJP Regulatory Integrative and Comparative Physiology, June 2013, American Physiological Society

    Jared M Dickinson, allan brasier

  126. Applications of selected reaction monitoring (SRM)-mass spectrometry (MS) for quantitative measurement of signaling pathways

    Article • Methods, June 2013, Elsevier

    allan brasier

  127. Quantitation of the Dynamic Profiles of the Innate Immune Response Using Multiplex Selected Reaction Monitoring–Mass Spectrometry

    Article • Molecular & Cellular Proteomics, June 2013, Elsevier

    allan brasier

  128. A structured approach to predictive modeling of a two-class problem using multidimensional data sets

    Article • Methods, May 2013, Elsevier

    allan brasier

  129. Inducible Tumor Necrosis Factor (TNF) Receptor-associated Factor-1 Expression Couples the Canonical to the Non-canonical NF-κB Pathway in TNF Stimulation

    Article • Journal of Biological Chemistry, May 2013, Elsevier

    allan brasier

  130. The IL-6 Trans-Signaling-STAT3 Pathway Mediates ECM and Cellular Proliferation in Fibroblasts from Hypertrophic Scar

    Article • Journal of Investigative Dermatology, May 2013, Elsevier

    allan brasier

  131. CDK9-Dependent Transcriptional Elongation in the Innate Interferon-Stimulated Gene Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells

    Article • Journal of Virology, April 2013, ASM Journals

    allan brasier

  132. Systems Approaches to Modeling Chronic Mucosal Inflammation

    Article • BioMed Research International, January 2013, Hindawi Publishing Corporation

    allan brasier

  133. Junín Virus Pathogenesis and Virus Replication

    Article • Viruses, October 2012, MDPI AG

    allan brasier

  134. The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams

    Article • Clinical and Translational Science, October 2012, Wiley

    allan brasier

  135. Strategies for Molecular Classification of Asthma Using Bipartite Network Analysis of Cytokine Expression

    Article • Current Allergy and Asthma Reports, July 2012, Springer Science + Business Media

    allan brasier

  136. Junín Virus Infection Activates the Type I Interferon Pathway in a RIG-I-Dependent Manner

    Article • PLoS Neglected Tropical Diseases, May 2012, PLOS

    allan brasier

  137. Proteomics Improves the Prediction of Burns Mortality: Results from Regression Spline Modeling

    Article • Clinical and Translational Science, May 2012, Wiley

    allan brasier

  138. Preparedness of the CTSA's Structural and Scientific Assets to Support the Mission of the National Center for Advancing Translational Sciences (NCATS)

    Article • Clinical and Translational Science, March 2012, Wiley

    allan brasier

  139. Improved Mass Defect Model for Theoretical Tryptic Peptides

    Article • Analytical Chemistry, March 2012, American Chemical Society (ACS)

    allan brasier

  140. Alternaria-Induced Release of IL-18 from Damaged Airway Epithelial Cells: An NF-κB Dependent Mechanism of Th2 Differentiation?

    Article • PLOS One, February 2012, PLOS

    allan brasier

  141. Discovery Proteomics and Nonparametric Modeling Pipeline in the Development of a Candidate Biomarker Panel for Dengue Hemorrhagic Fever

    Article • Clinical and Translational Science, February 2012, Wiley

    allan brasier

  142. A Three-Component Biomarker Panel for Prediction of Dengue Hemorrhagic Fever

    Article • American Journal of Tropical Medicine and Hygiene, February 2012, American Society of Tropical Medicine and Hygiene

    allan brasier

  143. The dependence of expression of NF-κB-dependent genes: statistics and evolutionary conservation of control sequences in the promoter and in the 3′ UTR

    Article • BMC Genomics, January 2012, Springer Science + Business Media

    allan brasier

  144. How cytokines co-occur across asthma patients: From bipartite network analysis to a molecular-based classification

    Article • Journal of Biomedical Informatics, December 2011, Elsevier

    allan brasier

  145. Two-Step Cross-linking for Analysis of Protein–Chromatin Interactions

    Article • October 2011, Springer Science + Business Media

    allan brasier

  146. High Throughput Short Interfering RNA (siRNA) Screening of the Human Kinome Identifies Novel Kinases Controlling the Canonical Nuclear Factor-κB (NF-κB) Activation Pathway

    Article • Journal of Biological Chemistry, October 2011, Elsevier

    allan brasier

  147. Sources of Cell-to-cell Variability in Canonical Nuclear Factor-κB (NF-κB) Signaling Pathway Inferred from Single Cell Dynamic Images

    Article • Journal of Biological Chemistry, October 2011, Elsevier

    allan brasier

  148. RelA Ser276 Phosphorylation-Coupled Lys310 Acetylation Controls Transcriptional Elongation of Inflammatory Cytokines in Respiratory Syncytial Virus Infection

    Article • Journal of Virology, September 2011, ASM Journals

    allan brasier

  149. Examining Troughs in the Mass Distribution of All Theoretically Possible Tryptic Peptides

    Article • Journal of Proteome Research, August 2011, American Chemical Society (ACS)

    allan brasier

  150. Editorial [Hot Topic: (Guest Editor: Allan R. Brasier)]

    Article • Current Proteomics, July 2011, Bentham Science Publishers

    allan brasier

  151. Methods for Biomarker Verification and Assay Development

    Article • Current Proteomics, July 2011, Bentham Science Publishers

    allan brasier

  152. Quantification of Activated NF-κB/RelA Complexes Using ssDNA Aptamer Affinity – Stable Isotope Dilution—Selected Reaction Monitoring—Mass Spectrometry

    Article • Molecular & Cellular Proteomics, June 2011, Elsevier

    allan brasier

  153. Aortic Adventitial Fibroblasts Participate in Angiotensin-Induced Vascular Wall Inflammation and Remodeling

    Article • Journal of Vascular Research, January 2011, Karger Publishers

    allan brasier

  154. IKKε modulates RSV-induced NF-κB-dependent gene transcription

    Article • Virology, December 2010, Elsevier

    allan brasier

  155. Predicting Intermediate Phenotypes in Asthma Using Bronchoalveolar Lavage-Derived Cytokines

    Article • Clinical and Translational Science, July 2010, Wiley

    allan brasier

  156. Role of Peroxiredoxin 1 and Peroxiredoxin 4 in Protection of Respiratory Syncytial Virus-Induced Cysteinyl Oxidation of Nuclear Cytoskeletal Proteins

    Article • Journal of Virology, July 2010, ASM Journals

    allan brasier

  157. The nuclear factor- B-interleukin-6 signalling pathway mediating vascular inflammation

    Article • Cardiovascular Research, March 2010, European Society of Cardiology

    allan brasier

  158. Regulation of Signal Transducer and Activator of Transcription 3 Enhanceosome Formation by Apurinic/Apyrimidinic Endonuclease 1 in Hepatic Acute Phase Response

    Article • Molecular Endocrinology, February 2010, Endocrine Society

    allan brasier

  159. Viral Induction of the Zinc Finger Antiviral Protein Is IRF3-dependent but NF-κB-independent

    Article • Journal of Biological Chemistry, February 2010, Elsevier

    allan brasier

  160. An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice

    Article • Journal of Clinical Investigation, December 2009, American Society for Clinical Investigation

    allan brasier

  161. Expression of an IKKγ Splice Variant Determines IRF3 and Canonical NF-κB Pathway Utilization in ssRNA Virus Infection

    Article • PLOS One, November 2009, PLOS

    allan brasier

  162. Respiratory Syncytial Virus Infection Induces a Reactive Oxygen Species-MSK1-Phospho-Ser-276 RelA Pathway Required for Cytokine Expression

    Article • Journal of Virology, August 2009, ASM Journals

    allan brasier

  163. Systemic Cytokine Response Profiles Associated With Respiratory Virus-Induced Acute Otitis Media

    Article • The Pediatric Infectious Disease Journal, May 2009, Wolters Kluwer Health

    allan brasier

  164. Hyperspectral Confocal Fluorescence Imaging: Exploring Alternative Multivariate Curve Resolution Approaches

    Article • Applied Spectroscopy, March 2009, SAGE Publications

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  165. The STAT3 NH2-terminal Domain Stabilizes Enhanceosome Assembly by Interacting with the p300 Bromodomain

    Article • Journal of Biological Chemistry, November 2008, Elsevier

    allan brasier

  166. Perspective: Expanding role of cyclin dependent kinases in cytokine inducible gene expression

    Article • Cell Cycle, September 2008, Taylor & Francis

    allan brasier

  167. Trilinear analysis of images obtained with a hyperspectral imaging confocal microscope

    Article • Journal of Chemometrics, September 2008, Wiley

    allan brasier

  168. Model-based analysis of interferon-β induced signaling pathway

    Article • Bioinformatics, August 2008, Oxford University Press (OUP)

    allan brasier

  169. Roles of IL-6-gp130 Signaling in Vascular Inflammation

    Article • Current Cardiology Reviews, August 2008, Bentham Science Publishers

    allan brasier

  170. Respiratory Syncytial Virus Induces RelA Release from Cytoplasmic 100-kDa NF-κB2 Complexes via a Novel Retinoic Acid-inducible Gene-I·NF-κB-inducing Kinase Signaling Pathway

    Article • Journal of Biological Chemistry, August 2008, Elsevier

    allan brasier

  171. Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution

    Article • Nucleic Acids Research, June 2008, Oxford University Press (OUP)

    allan brasier

  172. RelA Ser276 Phosphorylation Is Required for Activation of a Subset of NF-κB-Dependent Genes by Recruiting Cyclin-Dependent Kinase 9/Cyclin T1 Complexes

    Article • Molecular and Cellular Biology, March 2008, ASM Journals

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  173. Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage–derived cytokines

    Article • Journal of Allergy and Clinical Immunology, January 2008, Elsevier

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  174. The Functional Role of an Interleukin 6-inducible CDK9·STAT3 Complex in Human γ-Fibrinogen Gene Expression

    Article • Journal of Biological Chemistry, December 2007, Elsevier

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  175. Single TNFα trimers mediating NF-κ B activation: stochastic robustness of NF-κ B signaling

    Article • BMC Bioinformatics, October 2007, Springer Science + Business Media

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  176. MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor1 and angiotensin II

    Article • Human Molecular Genetics, September 2007, Oxford University Press (OUP)

    allan brasier

  177. Hyperspectral confocal fluorescence imaging of cells

    Article • September 2007, SPIE

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  178. Angiotensin II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL receptor-deficient mice

    Article • Atherosclerosis, September 2007, Elsevier

    allan brasier

  179. Involvement of a Novel Rac/RhoA Guanosine Triphosphatase-Nuclear Factor-κB Inducing Kinase Signaling Pathway Mediating Angiotensin II-Induced RelA Transactivation

    Article • Molecular Endocrinology, September 2007, Endocrine Society

    allan brasier

  180. TNF-α-induced NF-κB/RelA Ser276 phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway

    Article • Cellular Signalling, July 2007, Elsevier

    allan brasier

  181. Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry

    Article • PROTEOMICS, May 2007, Wiley

    allan brasier

  182. MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II

    Article • Human Molecular Genetics, April 2007, Oxford University Press (OUP)

    Dr. Louis Maximilian Buja, allan brasier

  183. Corrigendum to “Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway” [Virology 353 (2006) 155–165]

    Article • Virology, January 2007, Elsevier

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  184. Retinoic Acid-Inducible Gene I Mediates Early Antiviral Response and Toll-Like Receptor 3 Expression in Respiratory Syncytial Virus-Infected Airway Epithelial Cells

    Article • Journal of Virology, November 2006, ASM Journals

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  185. Regulation of CXCL-8 (Interleukin-8) Induction by Double-Stranded RNA Signaling Pathways during Hepatitis C Virus Infection

    Article • Journal of Virology, October 2006, ASM Journals

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  186. RhoA Mediates Angiotensin II–Induced Phospho-Ser536 Nuclear Factor κB/RelA Subunit Exchange on the Interleukin-6 Promoter in VSMCs

    Article • Circulation Research, September 2006, Wolters Kluwer Health

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  187. Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway

    Article • Virology, September 2006, Elsevier

    allan brasier

  188. An Alternative Splice Product of IκB Kinase (IKKγ), IKKγ-Δ, DifferentiallyMediates Cytokine and Human T-Cell Leukemia Virus Type 1 Tax-Induced NF-κB Activation

    Article • Journal of Virology, May 2006, ASM Journals

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  189. Diabetes-Induced NF-kB Activation in Renal Cortex: Mechanisms and Consequences.

    Article • Diabetes, May 2006, American Diabetes Association

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  190. Functional analysis of the nuclear proteome of human A549 alveolar epithelial cells by HPLC-high resolution 2-D gel electrophoresis

    Article • PROTEOMICS, May 2006, Wiley

    allan brasier

  191. Identification of an NF-κB-Dependent Gene Network in Cells Infected by Mammalian Reovirus

    Article • Journal of Virology, February 2006, ASM Journals

    allan brasier

  192. Stochastic Regulation in Early Immune Response

    Article • Biophysical Journal, February 2006, Elsevier

    allan brasier

  193. The NF-κB Regulatory Network

    Article • Cardiovascular Toxicology, January 2006, Springer Science + Business Media

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  194. Transcriptional stochasticity in gene expression

    Article • Journal of Theoretical Biology, January 2006, Elsevier

    allan brasier

  195. Respiratory Syncytial Virus-Inducible BCL-3 Expression Antagonizes the STAT/IRF and NF-κB Signaling Pathways by Inducing Histone Deacetylase 1 Recruitment to the Interleukin-8 Promoter

    Article • Journal of Virology, December 2005, ASM Journals

    allan brasier

  196. Two-step cross-linking method for identification of NF-κB gene network by chromatin immunoprecipitation

    Article • BioTechniques, November 2005, Future Science

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  197. STAT3 NH2-Terminal Acetylation Is Activated by the Hepatic Acute-Phase Response and Required for IL-6 Induction of Angiotensinogen

    Article • Gastroenterology, November 2005, Elsevier

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  198. A TNF-induced gene expression program under oscillatory NF-κB control

    Article • BMC Genomics, September 2005, Springer Science + Business Media

    allan brasier

  199. Respiratory Syncytial Virus Influences NF-κB-Dependent Gene Expression through a Novel Pathway Involving MAP3K14/NIK Expression and Nuclear Complex Formation with NF-κB2

    Article • Journal of Virology, July 2005, ASM Journals

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  200. Identification of Direct Genomic Targets Downstream of the Nuclear Factor-κB Transcription Factor Mediating Tumor Necrosis Factor Signaling

    Article • Journal of Biological Chemistry, April 2005, Elsevier

    allan brasier

  201. Stochastic effects of multiple regulators on expression profiles in eukaryotes

    Article • Journal of Theoretical Biology, April 2005, Elsevier

    allan brasier

  202. Interleukin (IL)-1β in Tracheal Aspirates from Premature Infants Induces Airway Epithelial Cell IL-8 Expression via an NF-κB Dependent Pathway

    Article • Pediatric Research, December 2004, Springer Science + Business Media

    allan brasier

  203. Nuclear Heat Shock Response and Novel Nuclear Domain 10 Reorganization in Respiratory Syncytial Virus-Infected A549 Cells Identified by High-Resolution Two-Dimensional Gel Electrophoresis

    Article • Journal of Virology, November 2004, ASM Journals

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  204. Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway

    Article • Physiological Genomics, September 2004, American Physiological Society

    allan brasier

  205. Genomic Mechanisms of p210BCR-ABL Signaling

    Article • Journal of Biological Chemistry, August 2004, Elsevier

    allan brasier

  206. Mathematical model of NF-κB regulatory module

    Article • Journal of Theoretical Biology, May 2004, Elsevier

    allan brasier

  207. Role of interferon-stimulated responsive element-like element in interleukin-8 promoter in Helicobacter pylori infection☆

    Article • Gastroenterology, April 2004, Elsevier

    allan brasier

  208. IκB Kinase Is a Critical Regulator of Chemokine Expression and Lung Inflammation in Respiratory Syncytial Virus Infection

    Article • Journal of Virology, March 2004, ASM Journals

    allan brasier

  209. Bcr-Abl Regulates Protein Kinase Cι (PKCι) Transcription via an Elk1 Site in the PKCι Promoter

    Article • Journal of Biological Chemistry, March 2004, Elsevier

    allan brasier

  210. Reactive Oxygen Species Mediate Virus-induced STAT Activation

    Article • Journal of Biological Chemistry, January 2004, Elsevier

    allan brasier

  211. Ribavirin Treatment Up-Regulates Antiviral Gene Expression via the Interferon-Stimulated Response Element in Respiratory Syncytial Virus-Infected Epithelial Cells

    Article • Journal of Virology, May 2003, ASM Journals

    allan brasier

  212. Identification of a Nuclear Factor Kappa B-dependent Gene Network

    Article • Recent Progress in Hormone Research, January 2003, Endocrine Society

    allan brasier

  213. Respiratory Syncytial Virus–Induced Activation of Nuclear Factor–κB in the Lung Involves Alveolar Macrophages and Toll‐Like Receptor 4–Dependent Pathways

    Article • The Journal of Infectious Diseases, November 2002, Oxford University Press (OUP)

    allan brasier

  214. Vascular Inflammation and the Renin-Angiotensin System

    Article • Arteriosclerosis Thrombosis and Vascular Biology, August 2002, Wolters Kluwer Health

    allan brasier

  215. Identification of NF-κB-Dependent Gene Networks in Respiratory Syncytial Virus-Infected Cells

    Article • Journal of Virology, July 2002, ASM Journals

    allan brasier

  216. Interleukin-8 Gene Regulation in Intestinal Epithelial Cells Infected with Rotavirus: Role of Viral-Induced IκB Kinase Activation

    Article • Virology, June 2002, Elsevier

    allan brasier

  217. Angiotensinogen Gene Expression Is Dependent on Signal Transducer and Activator of Transcription 3-Mediated p300/cAMP Response Element Binding Protein-Binding Protein Coactivator Recruitment and Histone Acetyltransferase Activity

    Article • Molecular Endocrinology, April 2002, Endocrine Society

    allan brasier

  218. Inhibition of Proteasome Activity Blocks the Ability of TNFα to Down-Regulate GiProteins and Stimulate Lipolysis

    Article • Endocrinology, December 2001, Endocrine Society

    allan brasier

  219. Expression of Respiratory Syncytial Virus-Induced Chemokine Gene Networks in Lower Airway Epithelial Cells Revealed by cDNA Microarrays

    Article • Journal of Virology, October 2001, ASM Journals

    allan brasier

  220. NF-κB/RelA transactivation is required for atypical protein kinase Cι-mediated cell survival

    Article • Oncogene, August 2001, Springer Science + Business Media

    allan brasier

  221. NF-κB-inducible BCL-3 Expression Is an Autoregulatory Loop Controlling Nuclear p50/NF-κB1 Residence

    Article • Journal of Biological Chemistry, August 2001, Elsevier

    allan brasier

  222. Multiple cis Regulatory Elements Control RANTES Promoter Activity in Alveolar Epithelial Cells Infected with Respiratory Syncytial Virus

    Article • Journal of Virology, July 2001, ASM Journals

    allan brasier

  223. Role of Signal Transducers and Activators of Transcription 1 and -3 in Inducible Regulation of the Human Angiotensinogen Gene by Interleukin-6

    Article • Molecular Endocrinology, March 2001, Endocrine Society

    allan brasier

  224. Oxidant Tone Regulates RANTES Gene Expression in Airway Epithelial Cells Infected with Respiratory Syncytial Virus

    Article • Journal of Biological Chemistry, January 2001, Elsevier

    allan brasier

  225. A Novel Glucocorticoid Receptor Binding Element within the Murine c-myc Promoter

    Article • Molecular Endocrinology, September 2000, Endocrine Society

    allan brasier

  226. Requirement of a Novel Upstream Response Element in Respiratory Syncytial Virus-Induced IL-8 Gene Expression

    Article • The Journal of Immunology, June 2000, The American Association of Immunologists

    allan brasier

  227. Article • Molecular and Cellular Biochemistry, January 2000, Springer Science + Business Media

    allan brasier

  228. Angiotensin II Induces Nuclear Factor (NF)- B1 Isoforms to Bind the Angiotensinogen Gene Acute-Phase Response Element: A Stimulus-Specific Pathway for NF- B Activation

    Article • Molecular Endocrinology, January 2000, Endocrine Society

    allan brasier