Contact

All Stories

  1. Design, Synthesis, and Evaluation of Pyrrole-Based Selective MAO-B Inhibitors with Additional AChE Inhibitory and Neuroprotective Properties Identified via Virtual Screening

    Article • Pharmaceuticals, November 2025, MDPI AG

    Alexander Zlatkov

  2. Classical Paal-Knorr Cyclization for Synthesis of Pyrrole-Based Aryl Hydrazones and In Vitro/In Vivo Evaluation on Pharmacological Models of Parkinson’s Disease

    Article • Molecules, July 2025, MDPI AG

    Alexander Zlatkov

  3. Synthesis, biological evaluation, and molecular docking of benzhydrazide derivatives

    Article • Pharmacia, June 2025, Pensoft Publishers

    Alexander Zlatkov

  4. In silico metabolism and toxicity prediction using a knowledge-based approach

    Article • Pharmacia, June 2025, Pensoft Publishers

    Alexander Zlatkov

  5. Antioxidant and Neuroprotective Properties of Selected Pyrrole-Containing Azomethine Compounds in Neurotoxicity Models In Vitro

    Article • International Journal of Molecular Sciences, April 2025, MDPI AG

    Alexander Zlatkov

  6. Effect of pyrrole and xanthine derivatives on the contractility of A. basilaris

    Article • Pharmacia, February 2025, Pensoft Publishers

    Alexander Zlatkov

  7. Hydrazide-hydrazones as novel antioxidants - in vitro, molecular docking and DFT studies

    Article • Pharmacia, October 2024, Pensoft Publishers

    Alexander Zlatkov

  8. Neurotoxicity, Neuroprotection, In Vitro MAOA/MAOB Inhibitory Activity Assessment, Molecular Docking, and Permeability Assay Studies of Newly Synthesized Hydrazones Containing a Pyrrole Ring

    Article • Molecules, September 2024, MDPI AG

    Alexander Zlatkov

  9. Novel Pyrrole Derivatives as Multi-Target Agents for the Treatment of Alzheimer’s Disease: Microwave-Assisted Synthesis, In Silico Studies and Biological Evaluation

    Article • Pharmaceuticals, September 2024, MDPI AG

    Alexander Zlatkov

  10. Development of RP-HPLC methods for the analysis of melatonin alone and in combination with sleep-enhancing dietary supplements

    Article • Pharmacia, September 2024, Pensoft Publishers

    Alexander Zlatkov

  11. Synthesis, Biological Evaluation, Molecular Docking and ADME Studies of Novel Pyrrole-Based Schiff Bases as Dual Acting MAO/AChE Inhibitors

    Article • Scientia Pharmaceutica, March 2024, MDPI AG

    Alexander Zlatkov

  12. In Silico and Chromatographic Methods for Analysis of Biotransformation of Prospective Neuroprotective Pyrrole-Based Hydrazone in Isolated Rat Hepatocytes

    Article • Molecules, March 2024, MDPI AG

    Paraskev Nedialkov, Alexander Zlatkov

  13. Microwave-assisted organic synthesis of pyrroles (Review)

    Article • Pharmacia, March 2024, Pensoft Publishers

    Alexander Zlatkov

  14. In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors

    Article • Pharmacia, February 2024, Pensoft Publishers

    Alexander Zlatkov

  15. Synthesis, DFT Study, and In Vitro Evaluation of Antioxidant Properties and Cytotoxic and Cytoprotective Effects of New Hydrazones on SH-SY5Y Neuroblastoma Cell Lines

    Article • Pharmaceuticals, August 2023, MDPI AG

    Alexander Zlatkov

  16. Simultaneous analysis of water-soluble and fat-soluble vitamins through RP-HPLC/DAD in food supplements and brewer’s yeast

    Article • Heliyon, January 2023, Elsevier

    Alexander Zlatkov

  17. Development of RP-HPLC methods for the analysis of Dexamethasone and Levofloxacin alone and in combinations used in the therapy of Covid-19

    Article • Pharmacia, December 2022, Pensoft Publishers

    Alexander Zlatkov

  18. Quantitative Structure–Neurotoxicity Assessment and In Vitro Evaluation of Neuroprotective and MAO-B Inhibitory Activities of Series N′-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides

    Article • Molecules, August 2022, MDPI AG

    Alexander Zlatkov

  19. Design, synthesis and evaluation of semi- and thiosemicarbazides containing a methylxanthine moiety within vitroneuroprotective and MAO-B inhibitory activities

    Article • Biotechnology & Biotechnological Equipment, July 2022, Taylor & Francis

    Alexander Zlatkov

  20. DESIGN, SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING OF PYRROLE-BASED COMPOUNDS AS ANTIOXIDANT AND MAO-B INHIBITORY AGENTS

    Article • FARMACIA, April 2022, Societatea de Stiinte Farmaceutice din Romania

    Alexander Zlatkov

  21. Synthesis, in silico prediction of sites of metabolism and in-vitro hepatotoxicity evaluationofnew seriesN’-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides

    Article • Pharmacia, April 2022, Pensoft Publishers

    Alexander Zlatkov

  22. Improved Molecular Docking of MAO-B Inhibitors with Glide

    Article • Biointerface Research in Applied Chemistry, March 2022, AMG Transcend Association

    Alexander Zlatkov

  23. Development of Fast, Precise and Selective RP-HPLC Methods for Identification of Possible Degradation Products of Ivermectin in Isolated Rat Hepatocytes and in Different pH Media

    Article • Indian Journal of Pharmaceutical Education and Research, March 2022, EManuscript Services

    Alexander Zlatkov

  24. Pyrrole as an Important Scaffold of Anticancer Drugs: Recent Advances

    Article • Journal of Pharmacy & Pharmaceutical Sciences, January 2022, Frontiers

    Alexander Zlatkov

  25. Suitable Docking Protocol for the Design of Novel Coumarin Derivatives with Selective MAO-B Effects

    Article • Journal of Molecular Docking, June 2021, Universitas Muhammadiyah Palangkaraya

    Alexander Zlatkov

  26. Xanthine Derivatives as Agents Affecting Non-dopaminergic Neuroprotection in Parkinson’s Disease

    Article • Current Medicinal Chemistry, April 2020, Bentham Science Publishers

    Alexandra Kasabova-Angelova, Alexander Zlatkov

  27. Design, Synthesis and Evaluation of 8-Thiosubstituted 1,3,7- Trimethylxanthine Hydrazones with In-vitro Neuroprotective and MAO-B Inhibitory Activities

    Article • Medicinal Chemistry, April 2020, Bentham Science Publishers

    Alexander Zlatkov, Alexandra Kasabova-Angelova

  28. QUANTITATIVE STRUCTURE-HEPATOTOXICITY ASSESSMENT OF SERIES ARYLPIPERAZINE-N1-SUBSTITUTED THEOBROMINE DERIVATIVES

    Article • FARMACIA, February 2020, Societatea de Stiinte Farmaceutice din Romania

    Alexander Zlatkov

  29. Neuroprotective and MAOB inhibitory effects of a series of caffeine-8-thioglycolic acid amides

    Article • January 2020, FapUNIFESP (SciELO)

    Alexander Zlatkov

  30. Synthesis and preliminary hepatotoxicity evaluation of new caffeine-8-(2-thio)-propanoic hydrazid-hydrazone derivatives

    Article • Pharmacia, October 2019, Pensoft Publishers

    Alexander Zlatkov

  31. Synthesis of New N1Arylpiperazine Substituted Xanthine Derivatives and Evaluation of their Antioxidant and Cytotoxic Effects

    Article • Anti-Cancer Agents in Medicinal Chemistry, June 2019, Bentham Science Publishers

    Alexander Zlatkov

  32. Development of a chiral RP-HPLC method for identification of stereomers of newly synthesized xanthine-based hydrazide-hydrazone compound

    Article • Pharmacia, May 2019, Pensoft Publishers

    Alexander Zlatkov

  33. Preliminary in vitro evaluation of neuroprotective and monoamine oxidase type B inhibitory effects of newly synthesized 8-aminocaffeines

    Article • Neural Regeneration Research, January 2019, Medknow

    Alexander Zlatkov

  34. COMPUTER PREDICTION AND SYNTHESIS OF NEW OXAZOLES BASED ON AN 8-THIOSUBSTITUTED 1,3,7-TRIMETHYLXANTHINE SKELETON

    Article • CBU International Conference Proceedings, September 2018, Central Bohemia University

    Alexander Zlatkov

  35. MOLECULAR DOCKING STUDY ON 1-(3-(4-BENZYLPIPERAZIN-1-YL)PROPYL)-3,7-DIMETHYL-1H-PURINE-2,6(3H,7H)-DIONE AS AN ACETYLCHOLINESTERASE INHIBITOR

    Article • CBU International Conference Proceedings, September 2018, Central Bohemia University

    Alexander Zlatkov

  36. VIRTUAL TOXICITY AND DRUG LIKENESS OF NEWLY SYNTHESIZED METHYLXANTHINES WITH N1 ARYLPIPERAZINE MOIETY

    Article • CBU International Conference Proceedings, September 2018, Central Bohemia University

    Alexander Zlatkov

  37. Statins utilization and price variations-comparison between Ukraine and Bulgaria

    Article • Biomedical Research, January 2018, OMICS Publishing Group

    Guenka Petrova, Alexander Zlatkov

  38. SYNTHESIS EVALUATION AND QUANTUM MECHANICAL CHARACTERIZATION OF CYCLOHEXYLAMINE CONTAINING DERIVATIVES OF METHYLXANTHINE

    Article • CBU International Conference Proceedings, September 2016, Central Bohemia University

    Alexander Zlatkov

  39. Determination of the Antiproliferative Activity of New Theobromine Derivatives and Evaluation of Their In Vitro Hepatotoxic Effects

    Article • Anti-Cancer Agents in Medicinal Chemistry, May 2016, Bentham Science Publishers

    Alexander Zlatkov

  40. Synthesis and antioxidant activity of some 1-aryl/aralkyl piperazine derivatives with xanthine moiety at N4

    Article • Biotechnology & Biotechnological Equipment, November 2014, Taylor & Francis

    Alexander Zlatkov

  41. DFT study of the physicochemical characteristics and spectral behavior of new 8-substituted 1,3,7-trimethylxanthines

    Article • International Journal of Quantum Chemistry, August 2012, Wiley

    Alexander Zlatkov

  42. GIAO NMR Calculations of Some Novel 8-Thio-Substituted 1,3,7-Trimethylxanthines: Comparison of Theoretical and Experimental1H Chemical Shifts

    Article • Biotechnology & Biotechnological Equipment, January 2012, Taylor & Francis

    Alexander Zlatkov

  43. Synthesis, 5-HT1A and 5-HT2A receptor affinity and QSAR study of 1-benzhydryl-piperazine derivatives with xanthine moiety at N4

    Article • Medicinal Chemistry Research, January 2011, Springer Science + Business Media

    Alexander Zlatkov

  44. Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid

    Article • Acta Pharmaceutica, September 2007, De Gruyter

    Alexander Zlatkov

  45. Synthesis, brain antihypoxic activity and cell neuroprotection of 1-substituted-3,7-dimethylxanthines

    Article • European Journal of Medicinal Chemistry, October 2000, Elsevier

    Alexander Zlatkov

  46. Biodegradable cross-linked prodrug of the bronchial dilator Vephylline®. 2. Kinetics and quantum chemical studies on the release mechanism

    Article • Journal of Controlled Release, March 1999, Elsevier

    Alexander Zlatkov

  47. Synthesis, Toxicological, Pharmacological Assessment, and in Vitro Bronchodilating Activity of some 7-Theophyllinylacetyloxyglycols

    Article • Archiv der Pharmazie, October 1998, Wiley

    Alexander Zlatkov

  48. Biodegradable cross-linked prodrug of bronchial dilator vephylline. I. Mechanism of the release

    Article • Journal of Controlled Release, March 1997, Elsevier

    Alexander Zlatkov

  49. Polymeric sustained release formulations of the bronchial dilator vephylline

    Article • Journal of Controlled Release, November 1995, Elsevier

    Alexander Zlatkov

  50. Synthesis, Toxicological, Pharmacological, and Bronchodilating Activityin vitro of some Xanthineacetic Acid Derivatives

    Article • Archiv der Pharmazie, January 1995, Wiley

    Alexander Zlatkov

  51. Synthesis, toxicological and pharmacological assessment of 7-substituted derivatives of 1,3-dimethylxanthine

    Article • European Journal of Medicinal Chemistry, January 1994, Elsevier

    Alexander Zlatkov