All Stories

  1. Dietary salt impairs circadian physiological metabolic adaptations in salt-sensitive hypertension

    Article • Function, April 2026, American Physiological Society

    Dr Alexander Staruschenko

  2. Maresin 1 promotes resolution of inflammation and improves left ventricle function in acute heart failure

    Article • British Journal of Pharmacology, January 2026, Wiley

    Dr Alexander Staruschenko

  3. Disrupted Renal Clock and Blood Pressure Rhythms in Type 2 Diabetic Nephropathy

    Article • Clinical Science, January 2026, Portland Press Ltd.

    Dr Alexander Staruschenko

  4. MCD enzyme deficiency drives early mortality and multiorgan metabolic disruption in Dahl salt-sensitive rats

    Article • iScience, January 2026, Elsevier

    Dr Alexander Staruschenko

  5. Maresin 1 modulates renal and cardiac lipid profiles in hypertensive rats

    Article • AJP Renal Physiology, December 2025, American Physiological Society

    Dr Alexander Staruschenko

  6. Mild Hyperuricemia Attenuates Salt-Sensitive Hypertension and Kidney Damage

    Article • Hypertension, November 2025, Wolters Kluwer Health

    Dr Alexander Staruschenko, PhD Ilse Daehn Daehn

  7. The effects of Cannabidiol on podocytes in vitro

    Article • Biochemical and Biophysical Research Communications, October 2025, Elsevier

    Dr Alexander Staruschenko

  8. Spatially patterned kidney assembloids recapitulate progenitor self-assembly and enable high-fidelity in vivo disease modeling

    Article • Cell Stem Cell, October 2025, Elsevier

    Dr Alexander Staruschenko

  9. The role of carnitine palmitoyl transferase 2 in the progression of salt-sensitive hypertension

    Article • AJP Cell Physiology, October 2025, American Physiological Society

    Dr Alexander Staruschenko

  10. Longitudinal Multi-Organ Transcriptomic Atlas of Salt-Induced Hypertension

    Article • September 2025, openRxiv

    Dr Alexander Staruschenko

  11. Serine proteases and protease-activated receptors signaling in the kidney

    Article • AJP Cell Physiology, July 2025, American Physiological Society

    Dr Alexander Staruschenko

  12. Effect of Renal Denervation on Early and Late Stages of Diabetic Nephropathy

    Article • The FASEB Journal, June 2025, Wiley

    Dr Alexander Staruschenko

  13. Discovering physiology: a high school student’s journey into STEM: perspective and advice

    Article • AJP Advances in Physiology Education, June 2025, American Physiological Society

    Dr Alexander Staruschenko

  14. Gliflozins in Hypertension: Basic Mechanisms and Clinical Insights

    Article • AJP Renal Physiology, May 2025, American Physiological Society

    Timo Rieg, Dr Alexander Staruschenko

  15. Potassium supplementation and depletion during development of salt-sensitive hypertension in male and female SS rats

    Article • JCI Insight, April 2025, American Society for Clinical Investigation

    Dr Alexander Staruschenko

  16. Targeting REDD1 in Podocytes: A Promising Strategy for Mitigating Diabetic Kidney Injury

    Article • Diabetes, February 2025, American Diabetes Association

    Dr Alexander Staruschenko

  17. Electrolyte and metabolite composition of cystic fluid from a rat model of ARPKD

    Article • Communications Biology, February 2025, Springer Science + Business Media

    Dr Alexander Staruschenko

  18. Endoplasmic reticulum-associated degradation: a novel therapeutic avenue for ADPKD

    Article • AJP Cell Physiology, February 2025, American Physiological Society

    Dr Alexander Staruschenko

  19. Mechanistic Insights Into Redox Damage of the Podocyte in Hypertension

    Article • Hypertension, January 2025, Wolters Kluwer Health

    Dr Alexander Staruschenko

  20. Role of Kir5.1 (Kcnj16) Channels in Regulating Renal Ammonia Metabolism during Metabolic Acidosis in Dahl Salt-Sensitive Rats

    Article • American Journal Of Pathology, January 2025, Elsevier

    Dr Alexander Staruschenko

  21. Renal Implications of Kappa Opioid Receptor Signaling in Sprague-Dawley Rats

    Article • Function, January 2025, American Physiological Society

    Dr Alexander Staruschenko

  22. Role of cGAS/STING pathway in aging and sexual dimorphism in diabetic kidney disease

    Article • JCI Insight, November 2024, American Society for Clinical Investigation

    Dr Alexander Staruschenko

  23. The effects of cannabinoids on the kidney

    Article • Acta Physiologica, October 2024, Wiley

    Dr Alexander Staruschenko

  24. Characterization of a novel variant in KCNJ16 , encoding K ir 5.1 channel

    Article • Physiological Reports, October 2024, Wiley

    Dr Alexander Staruschenko

  25. Effects of zinc in podocytes and cortical collecting duct in vitro and Dahl salt-sensitive rats in vivo

    Article • Journal of Biological Chemistry, October 2024, Elsevier

    Dr Alexander Staruschenko

  26. Deletion of Kcnj16 altered transcriptomic and metabolomic profiles of Dahl salt-sensitive rats

    Article • iScience, October 2024, Elsevier

    Dr Alexander Staruschenko

  27. Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity

    Article • AJP Renal Physiology, September 2024, American Physiological Society

    Dr Alexander Staruschenko

  28. Renin-angiotensin system-mediated nitric oxide signaling in podocytes

    Article • AJP Renal Physiology, September 2024, American Physiological Society

    Dr Alexander Staruschenko

  29. Vitamin D3 suppresses Npt2c abundance and differentially modulates phosphate and calcium homeostasis in Npt2a knockout mice

    Article • Scientific Reports, July 2024, Springer Science + Business Media

    Timo Rieg, Dr Alexander Staruschenko

  30. SGLT2 inhibitors: not every drug has the same effect

    Article • AJP Renal Physiology, June 2024, American Physiological Society

    Dr Alexander Staruschenko

  31. Calcium signalling and transport in the kidney

    Article • Nature Reviews Nephrology, April 2024, Springer Science + Business Media

    Dr Alexander Staruschenko

  32. Lysine and salt-sensitive hypertension

    Article • Current Opinion in Nephrology & Hypertension, April 2024, Wolters Kluwer Health

    Dr Alexander Staruschenko

  33. Metabolic Communication by SGLT2 Inhibition

    Article • Circulation, March 2024, Wolters Kluwer Health

    Dr Alexander Staruschenko

  34. The presence of xanthine dehydrogenase is crucial for the maturation of the rat kidneys

    Article • Clinical Science, February 2024, Portland Press Ltd.

    Dr Alexander Staruschenko

  35. PAR1-mediated Non-periodical Synchronized Calcium Oscillations in Human Mesangial Cells

    Article • Function, January 2024, American Physiological Society

    Dr Alexander Staruschenko

  36. β-Arrestin pathway activation by selective ATR1 agonism promotes calcium influx in podocytes, leading to glomerular damage

    Article • Clinical Science, December 2023, Portland Press Ltd.

    Dr Alexander Staruschenko

  37. Matrix Metalloproteinase 2 Is Crucial for Hypertension- and Hyperglycemia-Induced Kidney Injury Independent of Blood Pressure

    Article • Journal of Cardiovascular Pharmacology, December 2023, Wolters Kluwer Health

    Dr Alexander Staruschenko

  38. Opioids and the Kidney: A Compendium

    Article • Kidney360, November 2023, Wolters Kluwer Health

    Dr Alexander Staruschenko

  39. Effect of SGLT2 inhibition on salt-induced hypertension in female Dahl SS rats

    Article • Scientific Reports, November 2023, Springer Science + Business Media

    Dr Alexander Staruschenko

  40. Repeated seizures lead to progressive ventilatory dysfunction in SSKcnj16−/− rats

    Article • Journal of Applied Physiology, October 2023, American Physiological Society

    Dr Alexander Staruschenko

  41. Protease-Activated Receptor 1–Mediated Damage of Podocytes in Diabetic Nephropathy

    Article • Diabetes, September 2023, American Diabetes Association

    Dr Alexander Staruschenko

  42. Kir7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats

    Article • AJP Renal Physiology, August 2023, American Physiological Society

    Dr Alexander Staruschenko

  43. The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5

    Article • Kidney International, June 2023, Elsevier

    Dr Alexander Staruschenko

  44. Call for Papers: podocyte physiology and pathophysiology

    Article • AJP Renal Physiology, May 2023, American Physiological Society

    Dr Alexander Staruschenko

  45. The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats

    Article • Canadian Journal of Physiology and Pharmacology, March 2023, Canadian Science Publishing

    Dr Alexander Staruschenko

  46. Ion channels and channelopathies in glomeruli

    Article • Physiological Reviews, January 2023, American Physiological Society

    Dr Alexander Staruschenko

  47. Modulation of P2X 4 receptor activity by ivermectin and 5‐BDBD has no effect on the development of ARPKD ...

    Article • Physiological Reports, November 2022, Wiley

    Dr Alexander Staruschenko

  48. Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats

    Article • Hypertension, November 2022, Wolters Kluwer Health

    Dr Alexander Staruschenko

  49. Kir5.1 channels: potential role in epilepsy and seizure disorders

    Article • AJP Cell Physiology, September 2022, American Physiological Society

    Dr Alexander Staruschenko

  50. Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model

    Article • iScience, September 2022, Elsevier

    Dr Alexander Staruschenko

  51. Modulation of blood pressure regulatory genes in the Agtrap‐Plod1 locus associated with a deletion in Clcn6

    Article • Physiological Reports, August 2022, Wiley

    Dr Alexander Staruschenko

  52. Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension

    Article • Nature Communications, July 2022, Springer Science + Business Media

    Dr Alexander Staruschenko

  53. SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na+ transport in Dahl SS rats

    Article • AJP Renal Physiology, June 2022, American Physiological Society

    Timo Rieg, Dr Alexander Staruschenko

  54. Astrocytic responses to high glucose impair barrier formation in cerebral microvessel endothelial cells

    Article • AJP Regulatory Integrative and Comparative Physiology, June 2022, American Physiological Society

    Dr Alexander Staruschenko

  55. Effects of elevation of ANP and its deficiency on cardiorenal function

    Article • JCI Insight, May 2022, American Society for Clinical Investigation

    Dr Alexander Staruschenko

  56. VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

    Article • Molecular Pharmacology, May 2022, Elsevier

    Dr Alexander Staruschenko

  57. Acute and long-term effects of cannabinoids on hypertension and kidney injury

    Article • Scientific Reports, April 2022, Springer Science + Business Media

    Dr Alexander Staruschenko

  58. Changing the Trajectory of Heart Failure and Kidney Disease

    Article • Clinical Journal of the American Society of Nephrology, March 2022, American Society of Nephrology

    Dr Alexander Staruschenko

  59. Epac1–/– and Epac2–/– mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation

    Article • JCI Insight, February 2022, American Society for Clinical Investigation

    Dr Alexander Staruschenko

  60. Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (Kir4.1/Kir5.1) in the cortical collecting duct

    Article • British Journal of Pharmacology, February 2022, Wiley

    Dr Alexander Staruschenko

  61. Role of collecting duct principal cell NOS1β in sodium and potassium homeostasis

    Article • Physiological Reports, October 2021, Wiley

    Dr Alexander Staruschenko

  62. p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli

    Article • Life Sciences, August 2021, Elsevier

    Dr Alexander Staruschenko

  63. Characterization of purinergic receptor 2 signaling in podocytes from diabetic kidneys

    Article • iScience, June 2021, Elsevier

    Dr Alexander Staruschenko

  64. Sexual dimorphism in the progression of type 2 diabetic kidney disease in T2DN rats

    Article • Physiological Genomics, June 2021, American Physiological Society

    Dr Alexander Staruschenko

  65. Evaluation of podocyte Rac-1 induced kidney disease by modulation of TRPC5

    Article • May 2021, openRxiv

    Dr Alexander Staruschenko

  66. Cytoskeleton Rearrangements Modulate TRPC6 Channel Activity in Podocytes

    Article • International Journal of Molecular Sciences, April 2021, MDPI AG

    Dr Alexander Staruschenko

  67. Defects in KCNJ16 Cause a Novel Tubulopathy with Hypokalemia, Salt Wasting, Disturbed Acid-Base Homeostasis, and Sensorineural Deafness

    Article • Journal of the American Society of Nephrology, April 2021, American Society of Nephrology

    Dr Alexander Staruschenko

  68. Scanning ion conductance microscopy of live human glomerulus

    Article • Journal of Cellular and Molecular Medicine, March 2021, Wiley

    Dr Alexander Staruschenko

  69. Loss of Chloride Channel 6 (CLC-6) Affects Vascular Smooth Muscle Contractility and Arterial Stiffness via Alterations to Golgi Calcium Stores

    Article • Hypertension, February 2021, Wolters Kluwer Health

    Dr Alexander Staruschenko

  70. Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat

    Article • JCI Insight, January 2021, American Society for Clinical Investigation

    Dr Alexander Staruschenko

  71. The Mechanisms of Cellular Plasticity in Collecting Duct Cells: Intermediate Cell Type and Notch-mediated Transdifferentiation

    Article • Function, January 2021, American Physiological Society

    Dr Alexander Staruschenko

  72. American Journal of Physiology-Renal Physiology Collections: Hypertension

    Article • AJP Renal Physiology, December 2020, American Physiological Society

    Dr Alexander Staruschenko

  73. Behavioral, metabolic, and renal outcomes of 1-month isolation in adolescent male Dahl salt-sensitive rats

    Article • AJP Regulatory Integrative and Comparative Physiology, December 2020, American Physiological Society

    Dr Alexander Staruschenko

  74. O’Brien Kidney Research Centers

    Article • AJP Renal Physiology, December 2020, American Physiological Society

    Dr Alexander Staruschenko

  75. Lysine metabolism conveys kidney protection in hypertension

    Article • November 2020, Springer Science + Business Media

    Dr Alexander Staruschenko

  76. SGLT2 inhibitors: diabetic kidney disease and beyond

    Article • AJP Renal Physiology, November 2020, American Physiological Society

    Dr Alexander Staruschenko

  77. Cardiorenal Protection With the Newer Antidiabetic Agents in Patients With Diabetes and Chronic Kidney Disease: A Scientific Statement From the American Heart Association

    Article • Circulation, October 2020, Wolters Kluwer Health

    Dr Alexander Staruschenko

  78. Role of opioid signaling in kidney damage during the development of salt-induced hypertension

    Article • Life Science Alliance, October 2020, Life Science Alliance, LLC

    Dr Alexander Staruschenko

  79. Selective Phosphodiesterase 1 Inhibitor BTTQ Reduces Blood Pressure in Spontaneously Hypertensive and Dahl Salt Sensitive Rats: Role of Peripheral Vasodilation

    Article • Frontiers in Physiology, September 2020, Frontiers

    Dr Alexander Staruschenko

  80. Kir5.1‐dependent CO2/H+‐sensitive currents contribute to astrocyte heterogeneity across brain regions

    Article • Glia, August 2020, Wiley

    Dr Alexander Staruschenko

  81. NOX4‐dependent regulation of ENaC in hypertension and diabetic kidney disease

    Article • The FASEB Journal, August 2020, Wiley

    Dr Alexander Staruschenko

  82. Effects of uric acid dysregulation on the kidney

    Article • AJP Renal Physiology, May 2020, American Physiological Society

    Dr Alexander Staruschenko

  83. Expression, localization, and functional properties of inwardly rectifying K+channels in the kidney

    Article • AJP Renal Physiology, February 2020, American Physiological Society

    Dr Alexander Staruschenko

  84. Metabolic rewiring of the hypertensive kidney

    Article • Science Signaling, December 2019, American Association for the Advancement of Science

    Dr Alexander Staruschenko

  85. Postprandial effects on electrolyte homeostasis in the kidney

    Article • AJP Renal Physiology, December 2019, American Physiological Society

    Dr Alexander Staruschenko

  86. Relationship between the renin–angiotensin–aldosterone system and renal Kir5.1 channels

    Article • Clinical Science, December 2019, Portland Press Ltd.

    Dr Alexander Staruschenko

  87. Progression of diabetic kidney disease in T2DN rats

    Article • AJP Renal Physiology, December 2019, American Physiological Society

    Dr Alexander Staruschenko

  88. Vibrodissociation method for isolation of defined nephron segments from human and rodent kidneys

    Article • AJP Renal Physiology, November 2019, American Physiological Society

    Dr Alexander Staruschenko

  89. Role of TRPC6 in Progression of Diabetic Kidney Disease

    Article • Current Hypertension Reports, May 2019, Springer Science + Business Media

    Dr Alexander Staruschenko

  90. Increased ENaC activity during kidney preservation in Wisconsin solution

    Article • BMC Nephrology, April 2019, Springer Science + Business Media

    Dr Alexander Staruschenko

  91. The importance of the pH-sensitive Kir5.1 channel in short-term and long-term regulation of pH

    Article • The FASEB Journal, April 2019, Federation of American Societies For Experimental Biology (FASEB)

    Dr. Matthew Robert Hodges, Dr Alexander Staruschenko

  92. Postprandial Effects on ENaC-Mediated Sodium Absorption

    Article • Scientific Reports, March 2019, Springer Science + Business Media

    Dr Alexander Staruschenko

  93. Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC)

    Article • EBioMedicine, February 2019, Elsevier

    Dr Alexander Staruschenko

  94. TRPC6 in diabetic kidney disease: good guy or bad guy?

    Article • Kidney International, February 2019, Elsevier

    Dr Alexander Staruschenko

  95. Ion channels and transporters in diabetic kidney disease

    Article • January 2019, Elsevier

    Dr Alexander Staruschenko

  96. Visualization and Quantification of Mitochondrial Structure in the Endothelium of Intact Arteries

    Article • Cardiovascular Research, November 2018, Oxford University Press (OUP)

    Dr Alexander Staruschenko

  97. Characterization of purinergic receptor expression in ARPKD cystic epithelia

    Article • Purinergic Signalling, November 2018, Springer Science + Business Media

    Dr Alexander Staruschenko

  98. Endothelin receptor A and p66Shc regulate spontaneous Ca2+oscillations in smooth muscle cells controlling renal arterial spontaneous motion

    Article • The FASEB Journal, October 2018, Wiley

    Dr Alexander Staruschenko

  99. Protective role of Trpc6 knockout in the progression of diabetic kidney disease

    Article • AJP Renal Physiology, October 2018, American Physiological Society

    Dr Alexander Staruschenko

  100. Distal tubule basolateral potassium channels

    Article • Current Opinion in Nephrology & Hypertension, September 2018, Wolters Kluwer Health

    Dr Alexander Staruschenko

  101. Inactivation of p66Shc Decreases Afferent Arteriolar KATP Channel Activity and Decreases Renal Damage in Diabetic Dahl SS Rats

    Article • Diabetes, August 2018, American Diabetes Association

    Dr Alexander Staruschenko

  102. A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD

    Article • Human Molecular Genetics, June 2018, Oxford University Press (OUP)

    Dr Alexander Staruschenko

  103. Region-Based Convolutional Neural Nets for Localization of Glomeruli in Trichrome-Stained Whole Kidney Sections

    Article • Journal of the American Society of Nephrology, June 2018, American Society of Nephrology

    Dr Alexander Staruschenko

  104. Role of the Scaffold Protein MIM in the Actin-Dependent Regulation of Epithelial Sodium Channels (ENaC)

    Article • Acta Naturae, June 2018, Acta Naturae Ltd

    Dr Alexander Staruschenko

  105. β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells

    Article • Journal of Biological Chemistry, June 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  106. Beneficial Effects of High Potassium

    Article • Hypertension, June 2018, Wolters Kluwer Health

    Dr Alexander Staruschenko

  107. A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease

    Article • Journal of the American Society of Nephrology, May 2018, American Society of Nephrology

    Dr Alexander Staruschenko

  108. Role of adaptor protein p66Shc in renal pathologies

    Article • AJP Renal Physiology, February 2018, American Physiological Society

    Dr Alexander Staruschenko

  109. Nitric oxide production by glomerular podocytes

    Article • Nitric Oxide, January 2018, Elsevier

    Dr Alexander Staruschenko

  110. Essential role of Kir5.1 channels in renal salt handling and blood pressure control

    Article • JCI Insight, September 2017, American Society for Clinical Investigation

    Dr Alexander Staruschenko

  111. Acute In Vivo Analysis of ATP Release in Rat Kidneys in Response to Changes of Renal Perfusion Pressure

    Article • Journal of the American Heart Association, September 2017, Wolters Kluwer Health

    Dr Alexander Staruschenko

  112. Intravital imaging of the kidney in a rat model of salt-sensitive hypertension

    Article • AJP Renal Physiology, August 2017, American Physiological Society

    Dr Alexander Staruschenko

  113. Involvement of ENaC in the development of salt-sensitive hypertension

    Article • AJP Renal Physiology, August 2017, American Physiological Society

    Dr Alexander Staruschenko

  114. The normal increase in insulin after a meal may be required to prevent postprandial renal sodium and volume losses

    Article • AJP Regulatory Integrative and Comparative Physiology, June 2017, American Physiological Society

    Dr Alexander Staruschenko

  115. Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats

    Article • Frontiers in Physiology, April 2017, Frontiers

    Dr Alexander Staruschenko

  116. Hypertension and Diabetes Mellitus

    Article • Hypertension, April 2017, Wolters Kluwer Health

    Dr Alexander Staruschenko

  117. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling

    Article • Scientific Reports, March 2017, Nature

    Dr Alexander Staruschenko

  118. Functional and therapeutic importance of purinergic signaling in polycystic kidney disease

    Article • AJP Renal Physiology, December 2016, American Physiological Society

    Dr Alexander Staruschenko

  119. Protease-activated receptors in kidney disease progression

    Article • AJP Renal Physiology, December 2016, American Physiological Society

    Dr Alexander Staruschenko

  120. The function of SH2B3 (LNK) in the kidney

    Article • AJP Renal Physiology, October 2016, American Physiological Society

    Dr Alexander Staruschenko

  121. High salt diet and caffeine: food for thought

    Article • Journal of Thoracic Disease, October 2016, AME Publishing Company

    Dr Alexander Staruschenko

  122. Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats

    Article • Physiological Reports, September 2016, Wiley

    Dr Alexander Staruschenko

  123. Regulation of Polycystin-1 Function by Calmodulin Binding

    Article • PLOS One, August 2016, PLOS

    Dr Alexander Staruschenko

  124. Two-photon imaging of endothelin-1-mediated intracellular Ca 2+ handling in smooth muscle cells of rat renal resistance arteries

    Article • Life Sciences, August 2016, Elsevier

    Dr Alexander Staruschenko

  125. Renal channels and transporters in Renin KO rats

    Article • Journal of the Renin-Angiotensin-Aldosterone System, July 2016, SAGE Publications

    Dr Alexander Staruschenko

  126. p66Shc regulates renal vascular tone in hypertension-induced nephropathy

    Article • Journal of Clinical Investigation, June 2016, American Society for Clinical Investigation

    Dr Alexander Staruschenko

  127. Role and mechanisms of regulation of the basolateral Kir4.1/Kir5.1K+channels in the distal tubules

    Article • Acta Physiologica, May 2016, Wiley

    Dr Alexander Staruschenko

  128. Mechanosensory and ATP Release Deficits following Keratin14-Cre-Mediated TRPA1 Deletion Despite Absence of TRPA1 in Murine Keratinocytes

    Article • PLOS One, March 2016, PLOS

    Dr Alexander Staruschenko

  129. Insulin and IGF-1 activate Kir4.1/5.1 channels in cortical collecting duct principal cells to control basolateral membrane voltage

    Article • AJP Renal Physiology, February 2016, American Physiological Society

    Dr Alexander Staruschenko

  130. Fundamentals of Epithelial Na+ Absorption

    Article • December 2015, Springer Science + Business Media

    Dr Alexander Staruschenko

  131. Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats

    Article • Hypertension, December 2015, Wolters Kluwer Health

    Dr Alexander Staruschenko

  132. Podocyte injury in diabetic nephropathy: implications of angiotensin II – dependent activation of TRPC channels

    Article • Scientific Reports, December 2015, Nature

    Dr Alexander Staruschenko

  133. Use of Enzymatic Biosensors to Quantify Endogenous ATP or H2O2 in the Kidney

    Article • Journal of Visualized Experiments, October 2015, MyJove Corporation

    Dr Alexander Staruschenko

  134. TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases

    Article • AJP Renal Physiology, September 2015, American Physiological Society

    Dr Alexander Staruschenko

  135. Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

    Article • Journal of Visualized Experiments, September 2015, MyJove Corporation

    Dr Alexander Staruschenko

  136. Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

    Article • Journal of Visualized Experiments, June 2015, MyJove Corporation

    Dr Alexander Staruschenko

  137. Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta

    Article • Journal of Visualized Experiments, June 2015, MyJove Corporation

    Dr Alexander Staruschenko

  138. Cross-talk between insulin and IGF-1 receptors in the cortical collecting duct principal cells: implication for ENaC-mediated Na+ reabsorption

    Article • AJP Renal Physiology, April 2015, American Physiological Society

    Dr Alexander Staruschenko

  139. Acetylation Stimulates the Epithelial Sodium Channel by Reducing Its Ubiquitination and Degradation

    Article • Journal of Biological Chemistry, March 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  140. Inhibition of ENaC by Endothelin-1

    Article • January 2015, Elsevier

    Dr Alexander Staruschenko

  141. Impaired epithelial Na+ channel activity contributes to cystogenesis and development of autosomal recessive polycystic kidney disease in PCK rats

    Article • Pediatric Research, October 2014, Nature

    Dr Alexander Staruschenko

  142. Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition

    Article • Clinical Science, October 2014, Portland Press Ltd.

    Dr Alexander Staruschenko

  143. To cleave or not to cleave: role of ADAM17 in cell proliferation in PKD

    Article • AJP Renal Physiology, September 2014, American Physiological Society

    Dr Alexander Staruschenko

  144. Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli

    Article • Kidney International, September 2014, Elsevier

    Dr Alexander Staruschenko

  145. Role of Rho GDP Dissociation Inhibitor α in Control of Epithelial Sodium Channel (ENaC)-mediated Sodium Reabsorption

    Article • Journal of Biological Chemistry, August 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  146. Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat

    Article • Proceedings of the National Academy of Sciences, August 2014, Proceedings of the National Academy of Sciences

    Dr Alexander Staruschenko

  147. PC and PKC: in vivo vs. in vitro

    Article • AJP Renal Physiology, March 2014, American Physiological Society

    Dr Alexander Staruschenko

  148. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli

    Article • AJP Cell Physiology, November 2013, American Physiological Society

    Dr Alexander Staruschenko

  149. Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine

    Article • AJP Renal Physiology, November 2013, American Physiological Society

    Dr Alexander Staruschenko

  150. Aldosterone-dependent trans-activation and epigenetic derepression of ENaC: where is the balance?

    Article • AJP Renal Physiology, October 2013, American Physiological Society

    Dr Alexander Staruschenko

  151. Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells

    Article • Cell and Tissue Research, September 2013, Springer Science + Business Media

    Dr Alexander Staruschenko

  152. Orally Active Epoxyeicosatrienoic Acid Analog Attenuates Kidney Injury in Hypertensive Dahl Salt-Sensitive Rat

    Article • Hypertension, August 2013, Wolters Kluwer Health

    Dr Alexander Staruschenko

  153. Detection of endogenous substances with enzymatic microelectrode biosensors in the kidney

    Article • AJP Regulatory Integrative and Comparative Physiology, July 2013, American Physiological Society

    Dr Alexander Staruschenko

  154. Epidermal growth factors in the kidney and relationship to hypertension

    Article • AJP Renal Physiology, July 2013, American Physiological Society

    Dr Alexander Staruschenko

  155. Real-time electrochemical detection of ATP and H2O2 release in freshly isolated kidneys

    Article • AJP Renal Physiology, July 2013, American Physiological Society

    Dr Alexander Staruschenko

  156. Deficiency of Renal Cortical EGF Increases ENaC Activity and Contributes to Salt-Sensitive Hypertension

    Article • Journal of the American Society of Nephrology, April 2013, American Society of Nephrology

    Dr Alexander Staruschenko

  157. Regulation of ENaC in mice lacking renal insulin receptors in the collecting duct

    Article • The FASEB Journal, April 2013, Federation of American Societies For Experimental Biology (FASEB)

    Dr Alexander Staruschenko

  158. ROS production as a common mechanism of ENaC regulation by EGF, insulin, and IGF-1

    Article • AJP Cell Physiology, January 2013, American Physiological Society

    Dr Alexander Staruschenko

  159. Recording Ion Channels in Isolated, Split-Opened Tubules

    Article • January 2013, Springer Science + Business Media

    Dr Alexander Staruschenko

  160. Single-Channel Analysis of TRPC Channels in the Podocytes of Freshly Isolated Glomeruli

    Article • January 2013, Springer Science + Business Media

    Dr Alexander Staruschenko

  161. G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease

    Article • Proceedings of the National Academy of Sciences, December 2012, Proceedings of the National Academy of Sciences

    Dr Alexander Staruschenko

  162. Direct Activation of ENaC by Angiotensin II: Recent Advances and New Insights

    Article • Current Hypertension Reports, November 2012, Springer Science + Business Media

    Dr Alexander Staruschenko

  163. Regulation of TRPC6 channels by non-steroidal anti-inflammatory drugs

    Article • Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology, July 2012, Pleiades Publishing Ltd

    Dr Alexander Staruschenko

  164. Ion transport in the connecting tubule and cortical collecting duct

    Article • April 2012, Wiley

    Dr Alexander Staruschenko

  165. Mechanisms of epithelial sodium channel (ENaC) regulation by cortactin: Involvement of dynamin

    Article • Cell and Tissue Biology, February 2012, Pleiades Publishing Ltd

    Dr Alexander Staruschenko

  166. Role of βPix in the Kidney

    Article • Frontiers in Physiology, January 2012, Frontiers

    Dr Alexander Staruschenko

  167. Angiotensin II Increases Activity of the Epithelial Na+Channel (ENaC) in Distal Nephron Additively to Aldosterone

    Article • Journal of Biological Chemistry, November 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  168. Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, October 2011, Elsevier

    Dr Alexander Staruschenko

  169. Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC)

    Article • AJP Renal Physiology, September 2011, American Physiological Society

    Dr Alexander Staruschenko

  170. Cortical actin binding protein cortactin mediates ENaC activity via Arp2/3 complex

    Article • The FASEB Journal, May 2011, Federation of American Societies For Experimental Biology (FASEB)

    Dr Alexander Staruschenko

  171. NSAIDs acutely inhibit TRPC channels in freshly isolated rat glomeruli

    Article • Biochemical and Biophysical Research Communications, May 2011, Elsevier

    Dr Alexander Staruschenko

  172. Novel Role of Rac1/WAVE Signaling Mechanism in Regulation of the Epithelial Na+ Channel

    Article • Hypertension, April 2011, Wolters Kluwer Health

    Dr Alexander Staruschenko

  173. Endothelin-1 Inhibits the Epithelial Na+ Channel through  Pix/14-3-3/Nedd4-2

    Article • Journal of the American Society of Nephrology, March 2010, American Society of Nephrology

    Dr Alexander Staruschenko

  174. Contribution of TRPV1-TRPA1 Interaction to the Single Channel Properties of the TRPA1 Channel

    Article • Journal of Biological Chemistry, March 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  175. Intact Cytoskeleton Is Required for Small G Protein Dependent Activation of the Epithelial Na+ Channel

    Article • PLOS One, January 2010, PLOS

    Dr Alexander Staruschenko

  176. Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors

    Article • PPAR Research, January 2010, Hindawi Publishing Corporation

    Dr Alexander Staruschenko

  177. The actin cytoskeleton and small G protein RhoA are not involved in flow-dependent activation of ENaC

    Article • BMC Research Notes, January 2010, Springer Science + Business Media

    Dr Alexander Staruschenko

  178. Muscarinic M1 modulation of acid-sensing ion channels

    Article • Neuroreport, October 2009, Wolters Kluwer Health

    Dr Alexander Staruschenko

  179. Peroxisome Proliferator-Activated Receptor γ Antagonists Decrease Na+ Transport via the Epithelial Na+ Channel

    Article • Molecular Pharmacology, September 2009, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Alexander Staruschenko

  180. Regulation of the epithelial sodium channels (ENaC) by small G proteins and phosphatidylinositides

    Article • Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology, September 2009, Pleiades Publishing Ltd

    Dr Alexander Staruschenko

  181. Intrinsic Voltage Dependence of the Epithelial Na+Channel Is Masked by a Conserved Transmembrane Domain Tryptophan

    Article • Journal of Biological Chemistry, July 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  182. EGF and its related growth factors mediate sodium transport in mpkCCDc14cells via ErbB2 (neu/HER-2) receptor

    Article • Journal of Cellular Physiology, January 2009, Wiley

    Dr Alexander Staruschenko

  183. Regulation of ENaC expression at the cell surface by Rab11

    Article • Biochemical and Biophysical Research Communications, December 2008, Elsevier

    Dr Alexander Staruschenko

  184. Insight toward epithelial Na+channel mechanism revealed by the acid-sensing ion channel 1 structure

    Article • IUBMB Life, September 2008, Wiley

    Dr Alexander Staruschenko

  185. Mechanisms of non-steroid anti-inflammatory drugs action on ASICs expressed in hippocampal interneurons

    Article • Journal of Neurochemistry, July 2008, Wiley

    Dr Alexander Staruschenko

  186. Ion Channel Regulation by Ras, Rho, and Rab Small GTPases

    Article • Experimental Biology and Medicine, November 2007, SAGE Publications

    Dr Alexander Staruschenko

  187. Molecular Determinants of PI(4,5)P2and PI(3,4,5)P3Regulation of the Epithelial Na+Channel

    Article • Journal of General Physiology, September 2007, Rockefeller University Press

    Dr Alexander Staruschenko

  188. Acute Regulation of the Epithelial Na+ Channel by Phosphatidylinositide 3-OH Kinase Signaling in Native Collecting Duct Principal Cells

    Article • Journal of the American Society of Nephrology, May 2007, American Society of Nephrology

    Dr Alexander Staruschenko

  189. Binding and direct activation of the epithelial Na+channel (ENaC) by phosphatidylinositides

    Article • The Journal of Physiology, April 2007, Wiley

    Dr Alexander Staruschenko

  190. Quantifying RhoA Facilitated Trafficking of the Epithelial Na+Channel toward the Plasma Membrane with Total Internal Reflection Fluorescence-Fluorescence Recovery after Photobleaching

    Article • Journal of Biological Chemistry, March 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  191. Magnesium permeation through mechanosensitive channels: single-current measurements

    Article • BDJ, August 2006, Nature

    Dr Alexander Staruschenko

  192. Rapid Translocation and Insertion of the Epithelial Na+Channel in Response to RhoA Signaling

    Article • Journal of Biological Chemistry, July 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  193. Regulation of the epithelial Na+ channel (ENaC) by phosphatidylinositides

    Article • AJP Renal Physiology, May 2006, American Physiological Society

    Dr Alexander Staruschenko

  194. Subunit-dependent cadmium and nickel inhibition of acid-sensing ion channels

    Article • Developmental Neurobiology, January 2006, Wiley

    Dr Alexander Staruschenko

  195. Regulation of Epithelial Na+Channel Activity by Conserved Serine/Threonine Switches within Sorting Signals

    Article • Journal of Biological Chemistry, October 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  196. Identification of a Functional Phosphatidylinositol 3,4,5-Trisphosphate Binding Site in the Epithelial Na+Channel

    Article • Journal of Biological Chemistry, September 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  197. ENaC stoichiometry

    Article • Biophysical Journal, June 2005, Elsevier

    Dr Alexander Staruschenko

  198. Actin cytoskeleton disassembly affects conductive properties of stretch-activated cation channels in leukaemia cells

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, May 2005, Elsevier

    Dr Alexander Staruschenko

  199. Ras couples phosphoinositide 3-OH kinase to the epithelial Na+ channel

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, May 2005, Elsevier

    Dr Alexander Staruschenko

  200. Rho Small GTPases Activate the Epithelial Na+Channel

    Article • Journal of Biological Chemistry, September 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  201. Ras Activates the Epithelial Na+Channel through Phosphoinositide 3-OH Kinase Signaling

    Article • Journal of Biological Chemistry, June 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  202. Fluorescence Resonance Energy Transfer Analysis of Subunit Stoichiometry of the Epithelial Na+Channel

    Article • Journal of Biological Chemistry, April 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Alexander Staruschenko

  203. Mechanosensitive cation channels in human leukaemia cells: calcium permeation and blocking effect

    Article • The Journal of Physiology, May 2002, Wiley

    Dr Alexander Staruschenko

  204. Giant multimodal heart motoneurons of Achatina fulica: a new cardioregulatory input in pulmonates

    Article • Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, August 2001, Elsevier

    Dr Alexander Staruschenko

  205. Stretch-activated ion channels in human leukemia cells

    Article • Neurophysiology, May 2000, Springer Science + Business Media

    Dr Alexander Staruschenko