All Stories

  1. Maternal food-derived signals oscillate in the fetal suprachiasmatic nucleus before its circadian clock develops

    Article • PLoS Biology, September 2025, PLOS

    Prof. Alena Sumova

  2. Circadian ontogenetic metabolomics atlas: an interactive resource with insights from rat plasma, tissues, and feces

    Article • Cellular and Molecular Life Sciences, June 2025, Springer Science + Business Media

    Prof. Alena Sumova

  3. Feeding regime synchronizes circadian clock in choroid plexus - insight into a complex mechanism

    Article • Cellular and Molecular Life Sciences, June 2025, Springer Science + Business Media

    Prof. Alena Sumova

  4. Chronodisruption that dampens output of the central clock abolishes rhythms in metabolome profiles and elevates acylcarnitine levels in the liver of female rats

    Article • Acta Physiologica, January 2025, Wiley

    Prof. Alena Sumova

  5. Circadian Disruption as a Risk Factor for Development of Cardiovascular and Metabolic Disorders – From Animal Models to Human Population

    Article • Physiological Research, August 2024, Institute of Physiology of the Czech Academy of Sciences

    Prof. Alena Sumova

  6. The circadian clock in the choroid plexus drives rhythms in multiple cellular processes under the control of the suprachiasmatic nucleus

    Article • Fluids and Barriers of the CNS, May 2024, Springer Science + Business Media

    Prof. Alena Sumova, Jihwan Myung

  7. Circadian dysfunction and cardio-metabolic disorders in humans

    Article • Frontiers in Endocrinology, April 2024, Frontiers

    Prof. Alena Sumova

  8. Circadian clock in choroid plexus is resistant to immune challenge but dampens in response to chronodisruption

    Article • Brain Behavior and Immunity, March 2024, Elsevier

    Prof. Alena Sumova

  9. Metabolic regulation of the circadian clock in classically and alternatively activated macrophages

    Article • Immunology and Cell Biology, April 2023, Wiley

    Prof. Alena Sumova

  10. Lithium affects the circadian clock in the choroid plexus – A new role for an old mechanism

    Article • Biomedicine & Pharmacotherapy, March 2023, Elsevier

    Prof. Alena Sumova

  11. Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules

    Article • SLEEP, February 2023, Oxford University Press (OUP)

    Prof. Alena Sumova

  12. The Circadian Clock of Polarized Microglia and Its Interaction with Mouse Brain Oscillators

    Article • Cellular and Molecular Neurobiology, July 2022, Springer Science + Business Media

    Prof. Alena Sumova

  13. The rs10830963 Polymorphism of the MTNR1B Gene: Association With Abnormal Glucose, Insulin and C-peptide Kinetics

    Article • Frontiers in Endocrinology, June 2022, Frontiers

    Prof. Alena Sumova

  14. Misaligned feeding schedule elicits divergent circadian reorganizations in endo- and exocrine pancreas clocks

    Article • Cellular and Molecular Life Sciences, May 2022, Springer Science + Business Media

    Prof. Alena Sumova

  15. Early rhythmicity in the fetal suprachiasmatic nuclei in response to maternal signals detected by omics approach

    Article • PLoS Biology, May 2022, PLOS

    Prof. Alena Sumova

  16. Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a

    Article • Frontiers in Behavioral Neuroscience, March 2022, Frontiers

    Prof. Alena Sumova

  17. Nicotinic Acetylcholine Receptors Expressed by Striatal Interneurons Inhibit Striatal Activity and Control Striatal-Dependent Behaviors

    Article • Journal of Neuroscience, February 2022, Society for Neuroscience

    Prof. Alena Sumova, Dr Veronique Bernard

  18. High Sensitivity of the Circadian Clock in the Hippocampal Dentate Gyrus to Glucocorticoid- and GSK3-Beta-Dependent Signals

    Article • Neuroendocrinology, June 2021, Karger Publishers

    Prof. Alena Sumova

  19. Targeted modification of the Per2 clock gene alters circadian function in mPer2luciferase (mPer2Luc) mice

    Article • PLoS Computational Biology, May 2021, PLOS

    Prof. Alena Sumova

  20. Hormonal fine-tuning of clock in decidual region of mouse placenta by dopamine, melatonin, insulin, leptin and ghrelin

    Article • Placenta, May 2021, Elsevier

    Prof. Alena Sumova

  21. Modulation of single cell circadian response to NMDA by diacylglycerol lipase inhibition reveals a role of endocannabinoids in light entrainment of the suprachiasmatic nucleus

    Article • Neuropharmacology, March 2021, Elsevier

    Prof. Alena Sumova

  22. Glucocorticoids reset circadian clock in choroid plexus via period genes

    Article • Journal of Endocrinology, February 2021, Bioscientifica

    Prof. Alena Sumova

  23. Challenging the Integrity of Rhythmic Maternal Signals Revealed Gene-Specific Responses in the Fetal Suprachiasmatic Nuclei

    Article • Frontiers in Neuroscience, January 2021, Frontiers

    Prof. Alena Sumova

  24. Chronotype assessment via a large scale socio-demographic survey favours yearlong Standard time over Daylight Saving Time in central Europe

    Article • Scientific Reports, January 2020, Springer Science + Business Media

    Prof. Alena Sumova

  25. Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion

    Article • Autism Research, January 2020, Wiley

    Prof. Alena Sumova

  26. Circadian profiling reveals distinct regulation of endocannabinoid system in the rat plasma, liver and adrenal glands by light-dark and feeding cycles

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, December 2019, Elsevier

    Prof. Alena Sumova

  27. Modulation of NMDA-Mediated Clock Resetting in the Suprachiasmatic Nuclei of mPer2Luc Mouse by Endocannabinoids

    Article • Frontiers in Physiology, March 2019, Frontiers

    Prof. Alena Sumova

  28. Development and Entrainment of the Fetal Clock in the Suprachiasmatic Nuclei: The Role of Glucocorticoids

    Article • Journal of Biological Rhythms, March 2019, SAGE Publications

    Prof. Alena Sumova

  29. Implicit time-place conditioning alters Per2 mRNA expression selectively in striatum without shifting its circadian clocks

    Article • Scientific Reports, October 2018, Springer Science + Business Media

    Prof. Alena Sumova

  30. Mystery of rhythmic signal emergence within the suprachiasmatic nuclei

    Article • European Journal of Neuroscience, September 2018, Wiley

    Prof. Alena Sumova

  31. The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity

    Article • Frontiers in Aging Neuroscience, August 2018, Frontiers

    Prof. Alena Sumova

  32. Alteration in glucose homeostasis and persistence of the pancreatic clock in aged mPer2Luc mice

    Article • Scientific Reports, August 2018, Springer Science + Business Media

    Prof. Alena Sumova

  33. Circadian alignment in a foster mother improves the offspring's pathological phenotype

    Article • The Journal of Physiology, May 2018, Wiley

    Prof. Alena Sumova

  34. Stress affects expression of the clock geneBmal1in the suprachiasmatic nucleus of neonatal rats via glucocorticoid-dependent mechanism

    Article • Acta Physiologica, January 2018, Wiley

    Prof. Alena Sumova

  35. Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon

    Article • Chronobiology International, October 2017, Taylor & Francis

    Prof. Alena Sumova

  36. Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection

    Article • Journal of Clinical Neuroscience, May 2017, Elsevier

    Prof. Alena Sumova

  37. Aging does not compromise in vitro oscillation of the suprachiasmatic nuclei but makes it more vulnerable to constant light

    Article • Chronobiology International, October 2016, Taylor & Francis

    Prof. Alena Sumova

  38. Mechanisms of hormonal regulation of the peripheral circadian clock in the colon

    Article • Chronobiology International, September 2016, Taylor & Francis

    Prof. Alena Sumova

  39. Deregulation of peripheral circadian clock in murine colorectal tumor deregulates the genes of cell cycle and proliferation

    Article • European Journal of Cancer, July 2016, Elsevier

    Prof. Alena Sumova

  40. Melatonin is a redundant entraining signal in the rat circadian system

    Article • Hormones and Behavior, July 2016, Elsevier

    Prof. Alena Sumova

  41. Peripheral circadian clocks are diversely affected by adrenalectomy

    Article • Chronobiology International, March 2016, Taylor & Francis

    Dr Matus Sotak, Prof. Alena Sumova

  42. Moderate Changes in the Circadian System of Alzheimer's Disease Patients Detected in Their Home Environment

    Article • PLOS One, January 2016, PLOS

    Prof. Alena Sumova

  43. Diverse development and higher sensitivity of the circadian clocks to changes in maternal-feeding regime in a rat model of cardio-metabolic disease

    Article • Chronobiology International, April 2015, Taylor & Francis

    Prof. Alena Sumova

  44. Corrigendum: Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety, and altered circadian activity patterns

    Article • Frontiers in Behavioral Neuroscience, December 2014, Frontiers

    Prof. Alena Sumova

  45. The circadian system of patients with bipolar disorder differs in episodes of mania and depression

    Article • Bipolar Disorders, October 2014, Wiley

    Professor Jan Prasko, Prof. Alena Sumova

  46. In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei

    Article • PLOS One, September 2014, PLOS

    Prof. Alena Sumova

  47. Melatonin administered during the fetal stage affects circadian clock in the suprachiasmatic nucleus but not in the liver

    Article • Developmental Neurobiology, July 2014, Wiley

    Prof. Alena Sumova

  48. Cross-talk between the circadian clock and the cell cycle in cancer

    Article • Annals of Medicine, April 2014, Taylor & Francis

    Dr Matus Sotak, Prof. Alena Sumova

  49. Nogo-A-deficient Transgenic Rats Show Deficits in Higher Cognitive Functions, Decreased Anxiety, and Altered Circadian Activity Patterns

    Article • Frontiers in Behavioral Neuroscience, March 2014, Frontiers

    Prof. Alena Sumova

  50. Development and entrainment of the colonic circadian clock during ontogenesis

    Article • AJP Gastrointestinal and Liver Physiology, December 2013, American Physiological Society

    Dr Matus Sotak, Prof. Alena Sumova

  51. Entrainment of Spontaneously Hypertensive Rat Fibroblasts by Temperature Cycles

    Article • PLOS One, October 2013, PLOS

    Prof. Alena Sumova

  52. Increased Sensitivity of the Circadian System to Temporal Changes in the Feeding Regime of Spontaneously Hypertensive Rats - A Potential Role for Bmal2 in the Liver

    Article • PLOS One, September 2013, PLOS

    Prof. Alena Sumova

  53. Circadian regulation of epithelial functions in the intestine

    Article • Acta Physiologica, March 2013, Wiley

    Prof. Alena Sumova

  54. Human Chronotype Is Determined in Bodily Cells Under Real-Life Conditions

    Article • Chronobiology International, February 2013, Taylor & Francis

    Prof. Alena Sumova

  55. Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats

    Article • PLOS One, October 2012, PLOS

    Prof. Alena Sumova

  56. An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors

    Article • International Journal of Cancer, August 2012, Wiley

    Dr Matus Sotak, Prof. Alena Sumova

  57. Photoperiodic modulation of the hepatic clock by the suprachiasmatic nucleus and feeding regime in mice

    Article • European Journal of Neuroscience, May 2012, Wiley

    Prof. Alena Sumova

  58. Alteration of the Circadian Clock in Children with Smith-Magenis Syndrome

    Article • The Journal of Clinical Endocrinology & Metabolism, February 2012, Endocrine Society

    Prof. Alena Sumova

  59. Circadian system from conception till adulthood

    Article • January 2012, Elsevier

    Prof. Alena Sumova

  60. Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light

    Article • Neuroscience, December 2011, Elsevier

    Prof. Alena Sumova

  61. Circadian regulation of electrolyte absorption in the rat colon

    Article • AJP Gastrointestinal and Liver Physiology, September 2011, American Physiological Society

    Dr Matus Sotak, Prof. Alena Sumova

  62. Salivary Melatonin Rhythm as a Marker of the Circadian System in Healthy Children and Those With Attention-Deficit/Hyperactivity Disorder

    Article • Chronobiology International, August 2011, Taylor & Francis

    Prof. Alena Sumova

  63. Hepatic, Duodenal, and Colonic Circadian Clocks Differ in their Persistence under Conditions of Constant Light and in their Entrainment by Restricted Feeding

    Article • Chronobiology International, March 2011, Taylor & Francis

    Dr Matus Sotak, Prof. Alena Sumova

  64. Exposure of Pregnant Rats to Restricted Feeding Schedule Synchronizes the SCN Clocks of Their Fetuses under Constant Light but Not under a Light-Dark Regime

    Article • Journal of Biological Rhythms, September 2010, SAGE Publications

    Prof. Alena Sumova

  65. Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats

    Article • The Journal of Comparative Neurology, May 2010, Wiley

    Prof. Alena Sumova

  66. Different mechanisms of adjustment to a change of the photoperiod in the suprachiasmatic and liver circadian clocks

    Article • AJP Regulatory Integrative and Comparative Physiology, April 2010, American Physiological Society

    Prof. Alena Sumova

  67. Influence of photoperiod duration and light-dark transitions on entrainment ofPer1andPer2gene and protein expression in subdivisions of the mouse suprachiasmatic nucleus

    Article • European Journal of Neuroscience, October 2009, Wiley

    Prof. Alena Sumova

  68. Circadian and developmental regulation of N-methyl-d-aspartate-receptor 1 mRNA splice variants and N-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus

    Article • Neuroscience, March 2009, Elsevier

    Prof. Alena Sumova

  69. Development of the light sensitivity of the clock genesPeriod1andPeriod2, and immediate-early genec-foswithin the rat suprachiasmatic nucleus

    Article • European Journal of Neuroscience, February 2009, Wiley

    Prof. Alena Sumova

  70. Temporal Gradient in the Clock Gene and Cell-Cycle Checkpoint KinaseWee1Expression along the Gut

    Article • Chronobiology International, January 2009, Taylor & Francis

    Dr Matus Sotak, Prof. Alena Sumova

  71. Maternal Control of the Fetal and Neonatal Rat Suprachiasmatic Nucleus

    Article • Journal of Biological Rhythms, October 2008, SAGE Publications

    Prof. Alena Sumova

  72. Insight Into the Circadian Clock Within Rat Colonic Epithelial Cells

    Article • Gastroenterology, October 2007, Elsevier

    Prof. Alena Sumova

  73. Immediate-Early Genes and the Neural Bases of Photic and Non-Photic Entrainment

    Article • September 2007, Wiley

    Prof. Alena Sumova

  74. Dynamics of the Adjustment of Clock Gene Expression in the Rat Suprachiasmatic Nucleus to an Asymmetrical Change from a Long to a Short Photoperiod

    Article • Journal of Biological Rhythms, June 2007, SAGE Publications

    Prof. Alena Sumova

  75. Postnatal ontogenesis of the circadian clock within the rat liver

    Article • AJP Regulatory Integrative and Comparative Physiology, March 2007, American Physiological Society

    Prof. Alena Sumova

  76. Expression of Clock and Clock-Driven Genes in the Rat Suprachiasmatic Nucleus during Late Fetal and Early Postnatal Development

    Article • Journal of Biological Rhythms, April 2006, SAGE Publications

    Prof. Alena Sumova

  77. Setting the biological time in central and peripheral clocks during ontogenesis

    Article • FEBS Letters, March 2006, Wiley

    Prof. Alena Sumova

  78. The Rat Circadian Clockwork and its Photoperiodic Entrainment During Development

    Article • Chronobiology International, January 2006, Taylor & Francis

    Prof. Alena Sumova

  79. Ontogenesis of photoperiodic entrainment of the molecular core clockwork in the rat suprachiasmatic nucleus

    Article • Brain Research, December 2005, Elsevier

    Prof. Alena Sumova

  80. Effect of photic stimuli disturbing overt circadian rhythms on the dorsomedial and ventrolateral SCN rhythmicity

    Article • Brain Research, June 2005, Elsevier

    Prof. Alena Sumova

  81. Insight into molecular core clock mechanism of embryonic and early postnatal rat suprachiasmatic nucleus

    Article • Proceedings of the National Academy of Sciences, April 2004, Proceedings of the National Academy of Sciences

    Prof. Alena Sumova

  82. Development of circadian rhythmicity and photoperiodic response in subdivisions of the rat suprachiasmatic nucleus

    Article • Developmental Brain Research, January 2004, Elsevier

    Prof. Alena Sumova

  83. Clock Gene Daily Profiles and Their Phase Relationship in the Rat Suprachiasmatic Nucleus Are Affected by Photoperiod

    Article • Journal of Biological Rhythms, April 2003, SAGE Publications

    Prof. Alena Sumova

  84. The circadian rhythm of Per1 gene product in the rat suprachiasmatic nucleus and its modulation by seasonal changes in daylength

    Article • Brain Research, August 2002, Elsevier

    Prof. Alena Sumova

  85. Daily profiles of arginine vasopressin mRNA in the suprachiasmatic, supraoptic and paraventricular nuclei of the rat hypothalamus under various photoperiods

    Article • Brain Research, December 2000, Elsevier

    Prof. Alena Sumova

  86. Spontaneous c-Fos rhythm in the rat suprachiasmatic nucleus: location and effect of photoperiod

    Article • AJP Regulatory Integrative and Comparative Physiology, December 2000, American Physiological Society

    Prof. Alena Sumova

  87. c-Fos rhythm in subdivisions of the rat suprachiasmatic nucleus under artificial and natural photoperiods

    Article • AJP Regulatory Integrative and Comparative Physiology, December 2000, American Physiological Society

    Prof. Alena Sumova

  88. Gate for photic resetting of intrinsic rhythmicity of the rat suprachiasmatic nucleus under a long photoperiod

    Article • Neuroscience Letters, February 2000, Elsevier

    Prof. Alena Sumova

  89. Spontaneous rhythm in c-Fos immunoreactivity in the dorsomedial part of the rat suprachiasmatic nucleus

    Article • Brain Research, August 1998, Elsevier

    Prof. Alena Sumova

  90. Photic Entrainment of the Mammalian Rhythm in Melatonin Production

    Article • Journal of Biological Rhythms, December 1997, SAGE Publications

    Prof. Alena Sumova

  91. Melatonin Inhibits GnRH‐Induced Increase of cFOS Immunoreactivity in Neonatal Rat Pituitary

    Article • Journal of Neuroendocrinology, February 1997, Wiley

    Prof. Alena Sumova

  92. Melatonin instantaneously resets intrinsic circadian rhythmicity in the rat suprachiasmatic nucleus

    Article • Neuroscience Letters, November 1996, Elsevier

    Prof. Alena Sumova

  93. Photoperiod-dependent correlation between light-induced SCN c-fos expression and resetting of circadian phase

    Article • AJP Regulatory Integrative and Comparative Physiology, October 1996, American Physiological Society

    Prof. Alena Sumova

  94. Endogenous melatonin signal does not mediate the effect of photoperiod on the rat suprachiasmatic nucleus

    Article • Brain Research, July 1996, Elsevier

    Prof. Alena Sumova

  95. Serotonergic antagonists impair arousal-induced phase shifts of the circadian system of the Syrian hamster

    Article • Brain Research, February 1996, Elsevier

    Prof. Alena Sumova

  96. Memory on long but not on short days is stored in the rat suprachiasmatic nucleus

    Article • Neuroscience Letters, November 1995, Elsevier

    Prof. Alena Sumova

  97. The rat suprachiasmatic nucleus is a clock for all seasons.

    Article • Proceedings of the National Academy of Sciences, August 1995, Proceedings of the National Academy of Sciences

    Prof. Alena Sumova

  98. Non-Photic Circadian Entrainment in the Syrian Hamster Is Not Associated with Phosphorylation of the Transcriptional Regulator CREB within the Suprachiasmatic Nucleus, but Is Associated with Adrenocortical Activation

    Article • Neuroendocrinology, January 1994, Karger Publishers

    Prof. Alena Sumova

  99. The influence of conditioned fear-induced stress on the opioid systems in the rat

    Article • Pharmacology Biochemistry and Behavior, December 1990, Elsevier

    Prof. Alena Sumova

  100. Analgesia and impact induced by anticipation stress: involvement of the endogenous opioid peptide system

    Article • Brain Research, December 1989, Elsevier

    Prof. Alena Sumova