All Stories

  1. The cytochrome c oxidase subunit COX6B1 is required for redox-sensitive early assembly and late stabilization of complex IV

    Article • Journal of Biological Chemistry, December 2025, Elsevier

    PhD Alena Pecinova

  2. Development of Cellular Energy Metabolism During Differentiation of Human iPSCs into Cortical Neurons

    Article • Molecular Neurobiology, November 2025, Springer Science + Business Media

    PhD Alena Pecinova

  3. Sequestration of the polyunsaturated fatty acids protects the cells with oxidative phosphorylation deficiency from ferroptosis

    Article • October 2025, openRxiv

    PhD Alena Pecinova

  4. Germline Jak2-R1063H mutation interferes with normal hematopoietic development and increases risk of thrombosis and leukemic transformation

    Article • Leukemia, August 2025, Springer Science + Business Media

    PhD Alena Pecinova

  5. Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

    Article • Molecular Oncology, April 2025, Wiley

    PhD Alena Pecinova

  6. COX6B1 secures a redox-sensitive step in early cytochrome c oxidase assembly

    Article • March 2025, Cold Spring Harbor Laboratory Press

    PhD Alena Pecinova

  7. Cryopreserved PBMCs can be used for the analysis of mitochondrial respiration and serve as a diagnostic tool for mitochondrial diseases

    Article • Analytical Biochemistry, March 2025, Elsevier

    PhD Alena Pecinova

  8. Bioenergetics of human spermatozoa in patients with testicular germ cell tumours

    Article • Molecular Human Reproduction, January 2025, Oxford University Press (OUP)

    PhD Alena Pecinova

  9. Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome

    Article • Communications Biology, September 2024, Springer Science + Business Media

    PhD Alena Pecinova

  10. Czech Footprints in the Bioenergetics Research

    Article • Physiological Research, August 2024, Institute of Physiology of the Czech Academy of Sciences

    PhD Alena Pecinova

  11. Variability of Clinical Phenotypes Caused by Isolated Defects of Mitochondrial ATP Synthase

    Article • Physiological Research, August 2024, Institute of Physiology of the Czech Academy of Sciences

    PhD Alena Pecinova

  12. Mitochondrial translation is the primary determinant of secondary mitochondrial complex I deficiencies

    Article • iScience, August 2024, Elsevier

    PhD Alena Pecinova

  13. Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity

    Article • Communications Biology, October 2023, Springer Science + Business Media

    Harry van Lenthe, PhD Alena Pecinova

  14. Restored biosynthetic pathways induced by MSCs serve as rescue mechanism in leukemia cells after L-asparaginase therapy

    Article • Blood Advances, May 2023, American Society of Hematology

    PhD Alena Pecinova

  15. Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome

    Article • Metabolites, January 2023, MDPI AG

    PhD Alena Pecinova

  16. Restored Biosynthetic Pathways Induced By MSCs Serve As Rescue Mechanism in Leukemia Cells after L-Asparaginase Therapy

    Article • Blood, November 2022, American Society of Hematology

    PhD Alena Pecinova

  17. Novel thiazolidinedione analog reduces a negative impact on bone and mesenchymal stem cell properties in obese mice compared to classical thiazolidinediones

    Article • Molecular Metabolism, November 2022, Elsevier

    Harry van Lenthe, PhD Alena Pecinova

  18. Ketogenic diet can reduce pathologic presentation of TMEM70 deficiency in animal models

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2022, Elsevier

    PhD Alena Pecinova

  19. Metabolic adaptations triggered by impairment of cytochrome c oxidase

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2022, Elsevier

    PhD Alena Pecinova

  20. Metabolic rewiring in a cellular model lacking ATP synthase

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2022, Elsevier

    PhD Alena Pecinova

  21. Oxygen consumption measurements of cryopreserved PBMCs as a new diagnostic tool for mitochondrial diseases

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2022, Elsevier

    PhD Alena Pecinova

  22. The role of SURF1 protein in cytochrome c oxidase biogenesis

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2022, Elsevier

    PhD Alena Pecinova

  23. Transgenic rescue approach ameliorates ATP synthase deficiency caused by the dysfunction of TMEM70 assembly factor in rat

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2022, Elsevier

    PhD Alena Pecinova

  24. Uncovering the OXPHOS complexes' interdependence mechanism

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2022, Elsevier

    PhD Alena Pecinova

  25. Mitochondrial respiration supports autophagy to provide stress resistance during quiescence

    Article • Autophagy, March 2022, Taylor & Francis

    PhD Alena Pecinova

  26. Genetic Complementation of ATP Synthase Deficiency Due to Dysfunction of TMEM70 Assembly Factor in Rat

    Article • Biomedicines, January 2022, MDPI AG

    PhD Alena Pecinova

  27. Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat

    Article • Physiological Research, December 2021, Institute of Physiology of the Czech Academy of Sciences

    PhD Alena Pecinova

  28. POLRMT mutations impair mitochondrial transcription causing neurological disease

    Article • Nature Communications, February 2021, Springer Science + Business Media

    PhD Alena Pecinova

  29. Role of Mitochondrial Glycerol-3-Phosphate Dehydrogenase in Metabolic Adaptations of Prostate Cancer

    Article • Cells, July 2020, MDPI AG

    PhD Alena Pecinova

  30. Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginase

    Article • BMC Cancer, June 2020, Springer Science + Business Media

    PhD Alena Pecinova

  31. Cytochrome c Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity

    Article • Cells, February 2020, MDPI AG

    PhD Alena Pecinova

  32. MLQ is responsible for stabilisation of subunit a in the holoenzyme of mammalian ATP synthase

    Article • February 2020, Cold Spring Harbor Laboratory Press

    PhD Alena Pecinova

  33. Biochemical thresholds for pathological presentation of ATP synthase deficiencies

    Article • Biochemical and Biophysical Research Communications, January 2020, Elsevier

    PhD Alena Pecinova

  34. Mitochondrial targets of metformin—Are they physiologically relevant?

    Article • BioFactors, July 2019, Wiley

    PhD Alena Pecinova

  35. Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production

    Article • Oxidative Medicine and Cellular Longevity, January 2017, Hindawi Publishing Corporation

    PhD Alena Pecinova

  36. Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer

    Article • Molecular Cancer Therapeutics, October 2016, American Association for Cancer Research (AACR)

    PhD Alena Pecinova

  37. Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of l-asparaginase in childhood ALL cells

    Article • Leukemia, August 2015, Springer Science + Business Media

    PhD Alena Pecinova

  38. Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry

    Article • BBA Clinical, December 2014, Elsevier

    PhD Alena Pecinova

  39. ROS production in brown adipose tissue mitochondria: The question of UCP1-dependence

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, December 2014, Elsevier

    PhD Alena Pecinova

  40. Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

    Article • The FASEB Journal, June 2012, Federation of American Societies For Experimental Biology (FASEB)

    PhD Alena Pecinova

  41. Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy

    Article • Mitochondrion, March 2012, Elsevier

    PhD Alena Pecinova

  42. Mitochondrially Targeted α-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing

    Article • Antioxidants & Redox Signaling, December 2011, Mary Ann Liebert Inc

    Associate Professor Mark J Coster, PhD Alena Pecinova

  43. Evaluation of basic mitochondrial functions using rat tissue homogenates

    Article • Mitochondrion, September 2011, Elsevier

    PhD Alena Pecinova

  44. Phosphomimetic Substitution of CytochromecTyrosine 48 Decreases Respiration and Binding to Cardiolipin and Abolishes Ability to Trigger Downstream Caspase Activation

    Article • Biochemistry, August 2010, American Chemical Society (ACS)

    PhD Alena Pecinova

  45. Impaired mitochondrial energetic in patients harbouring SURF1 mutations is caused by uncoupling of cytochrome c oxidase

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2010, Elsevier

    PhD Alena Pecinova

  46. Increased oxidative stress in fibroblasts from patients with ATP synthase deficiency

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2010, Elsevier

    PhD Alena Pecinova

  47. Regulation of mitochondrial respiration and apoptosis through phosphorylation of cytochrome c

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2010, Elsevier

    PhD Alena Pecinova

  48. Mitochondrial ATP synthase deficiency due to a mutation in the ATP5E gene for the F1   subunit

    Article • Human Molecular Genetics, June 2010, Oxford University Press (OUP)

    PhD Alena Pecinova

  49. A suggested role for mitochondria in Noonan syndrome

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, February 2010, Elsevier

    PhD Alena Pecinova

  50. Mitochondrial dysfunction in a neural cell model of spinal muscular atrophy

    Article • Journal of Neuroscience Research, September 2009, Wiley

    PhD Alena Pecinova

  51. Chapter 11 Isolation of Regulatory‐Competent, Phosphorylated Cytochrome c Oxidase

    Article • January 2009, Elsevier

    PhD Alena Pecinova

  52. High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria

    Article • Archives of Biochemistry and Biophysics, January 2009, Elsevier

    PhD Alena Pecinova

  53. Regulation of oxidative phosphorylation, the mitochondrial membrane potential, and their role in human disease

    Article • Journal of Bioenergetics and Biomembranes, October 2008, Springer Science + Business Media

    PhD Alena Pecinova

  54. HIF and reactive oxygen species regulate oxidative phosphorylation in cancer

    Article • Carcinogenesis, May 2008, Oxford University Press (OUP)

    PhD Alena Pecinova

  55. Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains

    Article • Genome Research, July 2007, Cold Spring Harbor Laboratory Press

    PhD Alena Pecinova

  56. Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2007, Elsevier

    PhD Alena Pecinova

  57. Mitochondrial complex I inhibition in cerebral cortex of immature rats following homocysteic acid-induced seizures

    Article • Experimental Neurology, April 2007, Elsevier

    PhD Alena Pecinova

  58. Mitochondrial diseases and genetic defects of ATP synthase

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, September 2006, Elsevier

    PhD Alena Pecinova

  59. Two components in pathogenic mechanism of mitochondrial ATPase deficiency: Energy deprivation and ROS production

    Article • Experimental Gerontology, July 2006, Elsevier

    PhD Alena Pecinova

  60. Evaluation of mitochondrial membrane potential using a computerized device with a tetraphenylphosphonium-selective electrode

    Article • Analytical Biochemistry, June 2006, Elsevier

    PhD Alena Pecinova

  61. Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride

    Article • Biochemical and Biophysical Research Communications, June 2006, Elsevier

    PhD Alena Pecinova

  62. Flow-cytometric monitoring of mitochondrial depolarisation: from fluorescence intensities to millivolts

    Article • Journal of Photochemistry and Photobiology B Biology, February 2005, Elsevier

    PhD Alena Pecinova

  63. Diminished synthesis of subunit a (ATP6) and altered function of ATP synthase and cytochromecoxidase due to the mtDNA 2 bp microdeletion of TA at positions 9205 and 9206

    Article • Biochemical Journal, November 2004, Portland Press Ltd.

    PhD Alena Pecinova

  64. A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis

    Article • Carcinogenesis, September 2004, Oxford University Press (OUP)

    PhD Alena Pecinova

  65. Mitochondrial diseases and ATPase defects of nuclear origin

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2004, Elsevier

    PhD Alena Pecinova

  66. GUG is an efficient initiation codon to translate the human mitochondrial ATP6 gene

    Article • Biochemical and Biophysical Research Communications, January 2004, Elsevier

    PhD Alena Pecinova

  67. Mitochondrial Membrane Potential and ATP Production in Primary Disorders of ATP Synthase

    Article • Toxicology Mechanisms and Methods, January 2004, Taylor & Francis

    PhD Alena Pecinova

  68. Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, September 2003, Elsevier

    PhD Alena Pecinova