All Stories

  1. Voriconazole nanosuspension-loaded ocular bilayer dissolving microneedle patch for the management of fungal keratitis

    Article • Drug Delivery and Translational Research, December 2025, Springer Science + Business Media

    Dr Alejandro Javier Paredes

  2. Nanocrystal-loaded dissolving microneedles: A novel transdermal strategy for long-acting tizanidine administration

    Article • Materials Today Advances, December 2025, Elsevier

    Dr Alejandro Javier Paredes

  3. Nano-PhotoCrystals (Photosensitive Nanocrystals) of Aloe Emodin Combined with Dissolving Microneedles for Dual Smart Targeting of Acute Bacterial Skin and Soft Tissue Infections

    Article • ACS Applied Materials & Interfaces, November 2025, American Chemical Society (ACS)

    Dr Alejandro Javier Paredes

  4. QbD-based development of extended-release floating furosemide tablets: Formulation and in vitro/in vivo evaluation

    Article • Journal of Drug Delivery Science and Technology, November 2025, Elsevier

    Dr Alejandro Javier Paredes

  5. Sub-150 nm drug nanocrystals produced using a milligram-scale media mill

    Article • International Journal of Pharmaceutics, November 2025, Elsevier

    Dr Alejandro Javier Paredes

  6. Correction to “Albendazole Nanocrystal-Based Dissolving Microneedles with Improved Pharmacokinetic Performance for Enhanced Treatment of Cystic Echinococcosis”

    Article • ACS Applied Materials & Interfaces, October 2025, American Chemical Society (ACS)

    Dr Alejandro Javier Paredes

  7. Lymphatic-targeted amphotericin B nanocrystals delivered using microarray patches applied to cutaneous leishmaniasis

    Article • Journal of Controlled Release, October 2025, Elsevier

    Dr Alejandro Javier Paredes

  8. Rasagiline mesylate-based microneedle patches: A patient-friendly treatment regimen for Parkinson’s disease

    Article • International Journal of Pharmaceutics, October 2025, Elsevier

    Dr Alejandro Javier Paredes

  9. Author Correction: Microneedle-based biosensing

    Article • Nature Reviews Bioengineering, August 2025, Springer Science + Business Media

    Dr Alejandro Javier Paredes

  10. Covalent Grafting of Hyaluronic Acid on Drug Nanocrystals - Application in Mucosal Delivery

    Article • July 2025, Springer Science + Business Media

    Dr Alejandro Javier Paredes

  11. Versatile and sensitive dual-detection HPLC method for rapid quantification of apomorphine hydrochloride: application to ex vivo percutaneous permeation and deposition studies utilising novel transdermal pressure-sensitive adhesive patches

    Article • Drug Delivery and Translational Research, July 2025, Springer Science + Business Media

    Dr Alejandro Javier Paredes

  12. A dynamic duo comes of age: Nanocrystals and microneedles for hydrophobic drug delivery

    Article • Expert Opinion on Drug Delivery, July 2025, Taylor & Francis

    Dr Alejandro Javier Paredes

  13. Super-fast production of drug nanocrystals: Dual asymmetric centrifugation-enabled media milling applied to high throughput formulation screening

    Article • Materials & Design, July 2025, Elsevier

    Dr Alejandro Javier Paredes

  14. Progress in the production of nanocrystals through miniaturized milling methods

    Article • RPS Pharmacy and Pharmacology Reports, June 2025, Oxford University Press (OUP)

    Dr Alejandro Javier Paredes

  15. 3D-printed acyclovir nanocrystals: An advanced approach to herpes simplex treatment

    Article • Applied Materials Today, June 2025, Elsevier

    Dr Alejandro Javier Paredes

  16. Bimodal Dissolving Microneedles with Nanoparticle Coating and Encapsulation for Extended Dual‐Drug Delivery

    Article • Small, May 2025, Wiley

    Dr Alejandro Javier Paredes

  17. Enhanced in vivo performance of topical ocular acetazolamide nanocrystals: A novel approach for glaucoma treatment

    Article • International Journal of Pharmaceutics, April 2025, Elsevier

    Dr Alejandro Javier Paredes

  18. Application of microarray patches for the transdermal administration of psychedelic drugs in micro-doses

    Article • European Journal of Pharmaceutics and Biopharmaceutics, February 2025, Elsevier

    Dr Alejandro Javier Paredes

  19. In vivo pharmacokinetic study and PBPK modeling: Comparison between 3D-printed nanocrystals and solid dispersions

    Article • International Journal of Pharmaceutics, January 2025, Elsevier

    Dr Alejandro Javier Paredes

  20. Hydrogels in Drug Delivery

    Article • January 2025, Elsevier

    Dr Alejandro Javier Paredes

  21. Advanced drug delivery systems for the management of local conditions

    Article • Therapeutic Delivery, December 2024, Taylor & Francis

    Dr Alejandro Javier Paredes

  22. A novel temperature-controlled media milling device to produce drug nanocrystals at the laboratory scale

    Article • International Journal of Pharmaceutics, December 2024, Elsevier

    Dr Alejandro Javier Paredes

  23. Olive mill wastewater: From by-product to smart antioxidant material

    Article • International Journal of Pharmaceutics X, December 2024, Elsevier

    Dr Alejandro Javier Paredes

  24. Enhanced long-acting simvastatin delivery via effervescent powder-carrying hollow microneedles and nanocrystal-loaded microneedles

    Article • International Journal of Pharmaceutics, November 2024, Elsevier

    Dr Alejandro Javier Paredes

  25. Novel long-acting treatment for schizophrenia based on paliperidone dissolving and implantable microarray patches

    Article • European Journal of Pharmaceutics and Biopharmaceutics, November 2024, Elsevier

    Dr Alejandro Javier Paredes

  26. Atorvastatin-Loaded Dissolving Microarray Patches for Long-Acting Microdepot Delivery: Comparison of Nanoparticle and Microparticle Drug Formulations

    Article • ACS Applied Materials & Interfaces, October 2024, American Chemical Society (ACS)

    Dr Alejandro Javier Paredes

  27. Corrigendum to “Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch” [Journal of Controlled Release 372 (2024) 304–317]

    Article • Journal of Controlled Release, October 2024, Elsevier

    Dr Alejandro Javier Paredes

  28. Mucoadhesive Itraconazole Nanocrystals With Precise Control of Surface Charge Incorporated to Chitosan Films for Buccal Drug Delivery

    Article • Advanced Therapeutics, September 2024, Wiley

    Dr Alejandro Javier Paredes

  29. Usefulness of a murine model of hepatic cystic echinococcosis for preclinical drug trials: Efficacy of albendazole vs albendazole nanocrystals

    Article • Acta Tropica, September 2024, Elsevier

    Dr Alejandro Javier Paredes

  30. Unveiling the Potential of Surface Polymerized Drug Nanocrystals in Targeted Delivery

    Article • ACS Applied Materials & Interfaces, August 2024, American Chemical Society (ACS)

    Dr Alejandro Javier Paredes

  31. Dissolving microarray patches loaded with a rotigotine nanosuspension: A potential alternative to Neupro® patch

    Article • Journal of Controlled Release, August 2024, Elsevier

    Dr Alejandro Javier Paredes

  32. Publisher Correction: Microneedle-based biosensing

    Article • Nature Reviews Bioengineering, July 2024, Springer Science + Business Media

    Dr Alejandro Javier Paredes

  33. Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management

    Article • International Journal of Pharmaceutics, July 2024, Elsevier

    Dr Alejandro Javier Paredes

  34. Systemic delivery of bictegravir and tenofovir alafenamide using dissolving microneedles for HIV preexposure prophylaxis

    Article • International Journal of Pharmaceutics, July 2024, Elsevier

    Dr Alejandro Javier Paredes

  35. Novel nano-in-micro fabrication technique of diclofenac nanoparticles loaded microneedle patches for localised and systemic drug delivery

    Article • Biomaterials Advances, July 2024, Elsevier

    Dr Alejandro Javier Paredes

  36. Calcipotriol Nanosuspension-Loaded Trilayer Dissolving Microneedle Patches for the Treatment of Psoriasis: In Vitro Delivery and In Vivo Antipsoriatic Activity Studies

    Article • Molecular Pharmaceutics, May 2024, American Chemical Society (ACS)

    Dr Alejandro Javier Paredes

  37. Folic Acid-Decorated Nanocrystals as Highly Loaded Trojan Horses to Target Cancer Cells

    Article • Molecular Pharmaceutics, April 2024, American Chemical Society (ACS)

    Dr Alejandro Javier Paredes

  38. Transdermal Delivery of Pramipexole Using Microneedle Technology for the Potential Treatment of Parkinson’s Disease

    Article • Molecular Pharmaceutics, April 2024, American Chemical Society (ACS)

    Dr Alejandro Javier Paredes

  39. Intradermal delivery of the antiretroviral drugs cabotegravir and rilpivirine by dissolving microarray patches: Investigation of lymphatic uptake

    Article • Journal of Controlled Release, February 2024, Elsevier

    Dr Alejandro Javier Paredes

  40. Preparation of glyburide nanocrystals with improved dissolution properties by dry-ball- and wet-bead- milling: Systematic comparison by experimental design of the performance of the two methods

    Article • Journal of Drug Delivery Science and Technology, January 2024, Elsevier

    Dr Alejandro Javier Paredes

  41. Significant progress in improving Atorvastatin dissolution rate: Physicochemical characterization and stability assessment of self-dispersible Atorvastatin/Tween 80® nanocrystals formulated through wet milling and freeze-drying

    Article • International Journal of Pharmaceutics, January 2024, Elsevier

    Dr Alejandro Javier Paredes

  42. Curcumin nanocrystals-in-nanofibres as a promising platform for the management of periodontal disease

    Article • International Journal of Pharmaceutics, December 2023, Elsevier

    Dr Alejandro Javier Paredes

  43. Formulation and optimization of pH-sensitive nanocrystals for improved oral delivery

    Article • Drug Delivery and Translational Research, November 2023, Springer Science + Business Media

    Dr Alejandro Javier Paredes

  44. Microneedles for advanced ocular drug delivery

    Article • Advanced Drug Delivery Reviews, October 2023, Elsevier

    Dr Alejandro Javier Paredes

  45. Long-acting microneedle formulations

    Article • Advanced Drug Delivery Reviews, October 2023, Elsevier

    Dr Alejandro Javier Paredes

  46. Microneedle-based biosensing

    Article • Nature Reviews Bioengineering, September 2023, Springer Science + Business Media

    Dr Alejandro Javier Paredes

  47. Development of dissolving microneedles for intradermal delivery of the long-acting antiretroviral drug bictegravir

    Article • International Journal of Pharmaceutics, July 2023, Elsevier

    Dr Alejandro Javier Paredes

  48. Polymeric Microarray Patches for Enhanced Transdermal Delivery of the Poorly Soluble Drug Olanzapine

    Article • ACS Applied Materials & Interfaces, June 2023, American Chemical Society (ACS)

    Dr Alejandro Javier Paredes

  49. Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for potential treatment of HIV-associated neurocognitive disorder (HAND)

    Article • International Journal of Pharmaceutics, June 2023, Elsevier

    Dr Alejandro Javier Paredes

  50. Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)

    Article • Pharmaceutics, May 2023, MDPI AG

    Dr Alejandro Javier Paredes

  51. Long-term biophysical stability of nanodiamonds combined with lipid nanocarriers for non-viral gene delivery to the retina

    Article • International Journal of Pharmaceutics, May 2023, Elsevier

    Dr Alejandro Javier Paredes

  52. Development of Triamcinolone Acetonide Nanocrystals for Ocular Administration

    Article • Pharmaceutics, February 2023, MDPI AG

    Dr Alejandro Javier Paredes

  53. Correction to “Nanodiamonds Integration into Niosomes as an Emerging and Efficient Gene Therapy Nanoplatform for Central Nervous System Diseases”

    Article • ACS Applied Materials & Interfaces, January 2023, American Chemical Society (ACS)

    Dr Alejandro Javier Paredes

  54. Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery

    Article • Pharmaceutics, December 2022, MDPI AG

    Dr Alejandro Javier Paredes

  55. Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues

    Article • Materials Today Bio, December 2022, Elsevier

    Dr Alejandro Javier Paredes

  56. On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles

    Article • Applied Materials Today, December 2022, Elsevier

    Dr Alejandro Javier Paredes

  57. Spray-drying-microencapsulated Minthostachys verticillata essential oil and limonene as innovative adjuvant strategy to bovine mastitis vaccines

    Article • Research in Veterinary Science, December 2022, Elsevier

    Dr Alejandro Javier Paredes

  58. Ring inserts as a useful strategy to prepare tip-loaded microneedles for long-acting drug delivery with application in HIV pre-exposure prophylaxis

    Article • Materials & Design, December 2022, Elsevier

    Dr Alejandro Javier Paredes

  59. Trilayer dissolving polymeric microneedle array loading Rose Bengal transfersomes as a novel adjuvant in early-stage cutaneous melanoma management

    Article • International Journal of Pharmaceutics, November 2022, Elsevier

    Dr Alejandro Javier Paredes

  60. Hydrogel-forming microarray patches with cyclodextrin drug reservoirs for long-acting delivery of poorly soluble cabotegravir sodium for HIV Pre-Exposure Prophylaxis

    Article • Journal of Controlled Release, August 2022, Elsevier

    Dr Alejandro Javier Paredes

  61. Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye

    Article • Biomaterials Advances, June 2022, Elsevier

    Dr Alejandro Javier Paredes

  62. Nanocrystals as a master key to deliver hydrophobic drugs via multiple administration routes

    Article • Journal of Controlled Release, May 2022, Elsevier

    Dr Alejandro Javier Paredes

  63. HPLC-MS method for simultaneous quantification of the antiretroviral agents rilpivirine and cabotegravir in rat plasma and tissues

    Article • Journal of Pharmaceutical and Biomedical Analysis, May 2022, Elsevier

    Dr Alejandro Javier Paredes

  64. 3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs

    Article • Drug Delivery, April 2022, Taylor & Francis

    Dr Alejandro Javier Paredes

  65. Nanodiamond Integration into Niosomes as an Emerging and Efficient Gene Therapy Nanoplatform for Central Nervous System Diseases

    Article • ACS Applied Materials & Interfaces, March 2022, American Chemical Society (ACS)

    Dr Alejandro Javier Paredes

  66. Systemic delivery of tenofovir alafenamide using dissolving and implantable microneedle patches

    Article • Materials Today Bio, January 2022, Elsevier

    Dr Alejandro Javier Paredes

  67. Nanocrystal-based 3D-printed tablets: Semi-solid extrusion using melting solidification printing process (MESO-PP) for oral administration of poorly soluble drugs

    Article • International Journal of Pharmaceutics, January 2022, Elsevier

    Dr Alejandro Javier Paredes

  68. Improving the in vitro dissolution rate and pharmacokinetic performance of fenbendazole in sheep using drug nanocrystals

    Article • Research in Veterinary Science, January 2022, Elsevier

    Dr Alejandro Javier Paredes

  69. 3D-Printed Nanocrystals for Oral Administration of the Drugs

    Article • November 2021, Taylor & Francis

    Dr Alejandro Javier Paredes

  70. Manufacturing Techniques for Nanoparticles in Drug Delivery

    Article • November 2021, Taylor & Francis

    Dr Alejandro Javier Paredes

  71. Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs artemether-lumefantrine

    Article • Biomedical Materials, October 2021, Institute of Physics Publishing

    Dr Alejandro Javier Paredes

  72. Formulation, spray-drying and physicochemical characterization of functional powders loaded with chia seed oil and prepared by complex coacervation

    Article • Powder Technology, October 2021, Elsevier

    Dr Alejandro Javier Paredes

  73. Novel tip-loaded dissolving and implantable microneedle array patches for sustained release of finasteride

    Article • International Journal of Pharmaceutics, September 2021, Elsevier

    Dr Alejandro Javier Paredes

  74. Albendazole Nanocrystal-Based Dissolving Microneedles with Improved Pharmacokinetic Performance for Enhanced Treatment of Cystic Echinococcosis

    Article • ACS Applied Materials & Interfaces, August 2021, American Chemical Society (ACS)

    Dr Alejandro Javier Paredes

  75. The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis

    Article • Advanced Drug Delivery Reviews, August 2021, Elsevier

    Dr Alejandro Javier Paredes

  76. Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe

    Article • Advanced Drug Delivery Reviews, June 2021, Elsevier

    Dr Alejandro Javier Paredes

  77. Artemether and lumefantrine dissolving microneedle patches with improved pharmacokinetic performance and antimalarial efficacy in mice infected with Plasmodium yoelii

    Article • Journal of Controlled Release, May 2021, Elsevier

    Dr Alejandro Javier Paredes

  78. Microneedle array systems for long-acting drug delivery

    Article • European Journal of Pharmaceutics and Biopharmaceutics, February 2021, Elsevier

    Dr Alejandro Javier Paredes

  79. Selective delivery of silver nanoparticles for improved treatment of biofilm skin infection using bacteria-responsive microparticles loaded into dissolving microneedles

    Article • Materials Science and Engineering C, January 2021, Elsevier

    Dr Alejandro Javier Paredes

  80. Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs

    Article • Advanced Functional Materials, September 2020, Wiley

    Dr Alejandro Javier Paredes

  81. Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis

    Article • European Journal of Pharmaceutics and Biopharmaceutics, September 2020, Elsevier

    Dr Alejandro Javier Paredes

  82. Nanocrystals of Novel Valerolactam-Fenbendazole Hybrid with Improved in vitro Dissolution Performance

    Article • AAPS PharmSciTech, August 2020, Springer Science + Business Media

    Dr Alejandro Javier Paredes

  83. Ricobendazole nanocrystals obtained by media milling and spray drying: Pharmacokinetic comparison with the micronized form of the drug

    Article • International Journal of Pharmaceutics, July 2020, Elsevier

    Dr Alejandro Javier Paredes

  84. Self-dispersible nanocrystals of azoxystrobin and cyproconazole with increased efficacy against soilborne fungal pathogens isolated from peanut crops

    Article • Powder Technology, July 2020, Elsevier

    Dr Alejandro Javier Paredes

  85. Development of solid self-emulsifying drug delivery systems (SEDDS) to improve the solubility of resveratrol

    Article • Therapeutic Delivery, November 2019, Future Science

    Dr Alejandro Javier Paredes

  86. A Natural Peanut Edible Coating Enhances the Chemical and Sensory Stability of Roasted Peanuts

    Article • Journal of Food Science, May 2019, Wiley

    Dr Alejandro Javier Paredes

  87. Development and in vitro evaluation of solid dispersions as strategy to improve albendazole biopharmaceutical behavior

    Article • Therapeutic Delivery, September 2018, Future Science

    José Bermúdez, Dr Alejandro Javier Paredes

  88. Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin

    Article • International Journal of Biological Macromolecules, June 2018, Elsevier

    Dr Alejandro Javier Paredes

  89. pH-responsive casein-based films and their application as functional coatings in solid dosage formulations

    Article • Colloids and Surfaces A Physicochemical and Engineering Aspects, March 2018, Elsevier

    Dr Alejandro Javier Paredes

  90. Albendazole nanocrystals with improved pharmacokinetic performance in mice

    Article • Therapeutic Delivery, February 2018, Future Science

    Dr Alejandro Javier Paredes

  91. Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice

    Article • Veterinary Parasitology, February 2018, Elsevier

    Dr Alejandro Javier Paredes

  92. Antioxidant Stability Study of Oregano Essential Oil Microcapsules Prepared by Spray-Drying

    Article • Journal of Food Science, November 2017, Wiley

    Dr Alejandro Javier Paredes

  93. Nanocrystals improve the PK and therapeutic response of albendazole in dogs

    Article • Journal of Pharmacy and Pharmacology, October 2017, Wiley

    Sergio Bruni, Santiago Palma, Dr Alejandro Javier Paredes

  94. Study of the preparation process and variation of wall components in chia ( Salvia hispanica L.) oil microencapsulation

    Article • Powder Technology, November 2016, Elsevier

    Dr Alejandro Javier Paredes

  95. Self-dispersible nanocrystals of albendazole produced by high pressure homogenization and spray-drying

    Article • Drug Development and Industrial Pharmacy, March 2016, Taylor & Francis

    Dr Alejandro Javier Paredes

  96. Pharmacokinetic Assessment of Novel Controlled Release Formulations of Ricobendazole Intended for Oral Administration in Dogs

    Article • Clinical and Experimental Pharmacology, January 2015, OMICS Publishing Group

    Dr Alejandro Javier Paredes