All Stories

  1. Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine

    Article • ACS Chemical Neuroscience, July 2015, American Chemical Society (ACS)

    Dr Alan Lars Pehrson

  2. Treatment of cognitive dysfunction in major depressive disorder—a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin–norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxe...

    Article • European Journal of Pharmacology, April 2015, Elsevier

    Dr Alan Lars Pehrson

  3. Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory

    Article • Progress in Neuro-Psychopharmacology and Biological Psychiatry, April 2015, Elsevier

    Dr Alan Lars Pehrson

  4. A 5-HT3 receptor antagonist potentiates the behavioral, neurochemical and electrophysiological actions of an SSRI antidepressant

    Article • Pharmacology Biochemistry and Behavior, April 2015, Elsevier

    Dr Alan Lars Pehrson

  5. Case Study 2

    Article • January 2015, Wiley

    Dr Alan Lars Pehrson

  6. Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants

    Article • Drug Design Development and Therapy, January 2015, Taylor & Francis

    Dr Alan Lars Pehrson

  7. Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine – a quantitative EEG study in rats

    Article • British Journal of Pharmacology, August 2014, Wiley

    Dr Alan Lars Pehrson

  8. Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator

    Article • Journal of Pharmacology and Experimental Therapeutics, June 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Alan Lars Pehrson

  9. Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats

    Article • The International Journal of Neuropsychopharmacology, May 2014, Oxford University Press (OUP)

    Professor David A Morilak, Dr Alan Lars Pehrson

  10. The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse

    Article • Psychopharmacology, May 2014, Springer Science + Business Media

    Dr Alan Lars Pehrson

  11. Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: Evidence for direct 5-HT receptor modulation

    Article • European Neuropsychopharmacology, January 2014, Elsevier

    Dr Alan Lars Pehrson

  12. Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: A potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism

    Article • European Neuropsychopharmacology, January 2014, Elsevier

    Dr Alan Lars Pehrson

  13. Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice

    Article • Neuropharmacology, October 2013, Elsevier

    Dr Alan Lars Pehrson

  14. Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

    Article • CNS Spectrums, August 2013, Cambridge University Press

    Dr Alan Lars Pehrson

  15. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters—A rat microdialysis and electrophysiology study

    Article • European Neuropsychopharmacology, February 2013, Elsevier

    Dr Alan Lars Pehrson

  16. The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT3 receptor antagonism

    Article • The International Journal of Neuropsychopharmacology, October 2012, Oxford University Press (OUP)

    Dr Alan Lars Pehrson

  17. A rodent model of premenstrual dysphoria: Progesterone withdrawal induces depression-like behavior that is differentially sensitive to classes of antidepressants

    Article • Behavioural Brain Research, October 2012, Elsevier

    Dr Alan Lars Pehrson

  18. The influence of NMDA and GABAA receptors and glutamic acid decarboxylase (GAD) activity on attention

    Article • Psychopharmacology, July 2012, Springer Science + Business Media

    Dr Alan Lars Pehrson

  19. Pharmacological Effects of Lu AA21004: A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

    Article • Journal of Pharmacology and Experimental Therapeutics, December 2011, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Alan Lars Pehrson

  20. Impact of metabotropic glutamate 2/3 receptor stimulation on activated dopamine release and locomotion

    Article • Psychopharmacology, June 2010, Springer Science + Business Media

    Dr Alan Lars Pehrson

  21. Disinhibition of Prefrontal Cortex Neurons in Schizophrenia

    Article • September 2009, Springer Science + Business Media

    Dr Alan Lars Pehrson

  22. Acute nicotine reduces and repeated nicotine increases spontaneous activity in male and female Lewis rats

    Article • Pharmacology Biochemistry and Behavior, November 2008, Elsevier

    Dr Alan Lars Pehrson, Professor and Department Head Adam Prus

  23. The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats

    Article • Psychopharmacology, August 2008, Springer Science + Business Media

    Dr Alan Lars Pehrson, Professor and Department Head Adam Prus

  24. The effects of acute and repeated nicotine doses on spontaneous activity in male and female Sprague Dawley rats: Analysis of brain area epibatidine binding and cotinine levels

    Article • Pharmacology Biochemistry and Behavior, May 2008, Elsevier

    Dr Alan Lars Pehrson

  25. Discriminative stimulus properties of the atypical antipsychotic drug clozapine in rats trained to discriminate 1.25???mg/kg clozapine vs. 5.0???mg/kg clozapine vs. vehicle

    Article • Behavioural Pharmacology, March 2006, Wolters Kluwer Health

    Dr Alan Lars Pehrson, Professor and Department Head Adam Prus

  26. Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice

    Article • Psychopharmacology, February 2005, Springer Science + Business Media

    Dr Alan Lars Pehrson, Professor and Department Head Adam Prus

  27. Generalization testing with atypical and typical antipsychotic drugs in rats trained to discriminate 5.0 mg/kg clozapine from vehicle in a two-choice drug discrimination task

    Article • Drug Development Research, January 2005, Wiley

    Dr Alan Lars Pehrson, Professor and Department Head Adam Prus