All Stories

  1. Potential Roles for B cells and Autoantibodies in Ankylosing Spondylitis

    Article • Current Rheumatology Reviews, May 2024, Bentham Science Publishers

    Dr Mahdi Mahmoudi, Abbas Mirshafiey

  2. The Evaluation of Safety Property and Apoptotic Efficacy of α-L-Guluronic Acid (G2013), as a Novel NSAID, Under In Vitro Examination on L929 and Hepatocellular Carcinoma Cell Lines

    Article • Recent Advances in Inflammation & Allergy Drug Discovery, April 2022, Bentham Science Publishers

    Abbas Mirshafiey

  3. Assessment of Biochemical Determinants in Multiple Sclerosis Patients Following the Oral Administration of β-D-Mannuronic Acid (M2000)

    Article • Current Drug Discovery Technologies, September 2021, Bentham Science Publishers

    payam saadat, Abbas Mirshafiey, Mohamad Reza Nikouei Moghaddam

  4. Influence of β-D-mannuronic Acid, As a New Member of Non-steroidal Anti- Inflammatory Drugs Family, on the Expression Pattern of Chemokines and their Receptors in Rheumatoid Arthritis

    Article • Current Drug Discovery Technologies, January 2021, Bentham Science Publishers

    Abbas Mirshafiey

  5. β-D-Mannuronic Acid (M2000) as a Landmark in Pharmacology

    Article • Current Drug Discovery Technologies, January 2021, Bentham Science Publishers

    Abbas Mirshafiey, Nada Osman

  6. The Oral Administration Effect of Drug Mannuronic Acid (M2000) on Gene Expression of Matrix and Tissue Inhibitor of Metalloproteinases in Rheumatoid Arthritis Patients

    Article • Current Drug Discovery Technologies, December 2020, Bentham Science Publishers

    Abbas Mirshafiey, Nada Osman

  7. The Situation of Chemokine Ligands and Receptors Gene Expression, Following the Oral Administration of Drug Mannuronic Acid in Rheumatoid Arthritis Patients

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, March 2020, Bentham Science Publishers

    Abbas Mirshafiey

  8. Anti-Diabetic and Angio-Protective Effect of Guluronic Acid (G2013) as a New Nonsteroidal Anti-Inflammatory Drug in the Experimental Model of Diabetes

    Article • Endocrine Metabolic & Immune Disorders - Drug Targets, March 2020, Bentham Science Publishers

    Seyed Shahabeddin Mortazavi-Jahromi, Shahab Alizadeh, Abbas Mirshafiey

  9. Effects of guluronic acid (G2013) on gene expression of TLR2, TLR4, MyD88, TNF-α and CD52 in multiple sclerosis under in vitro conditions

    Article • Immunopharmacology and Immunotoxicology, October 2019, Taylor & Francis

    Abbas Mirshafiey, payam saadat

  10. Evaluation of the acute and 28-day sub-acute intravenous toxicity of α-l-guluronic acid (ALG; G2013) in mice

    Article • Drug and Chemical Toxicology, September 2019, Taylor & Francis

    Abbas Mirshafiey

  11. The Inhibitory Role of M2000 (β-D-Mannuronic Acid) on Expression of Toll-like Receptor 2 and 4 in HT29 Cell Line

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, August 2019, Bentham Science Publishers

    Laleh Sharifi, Mohammad Hossein Asgardoon, Saied Bokaie, Abbas Mirshafiey

  12. The Immunomodulatory Role of G2013 (α-L-Guluronic Acid) on the Expression of TLR2 and TLR4 in HT29 cell line

    Article • Current Drug Discovery Technologies, April 2019, Bentham Science Publishers

    Saied Bokaie, Abbas Mirshafiey

  13. Antagonistic Property of G2013 (α-L-Guluronic Acid) on Gene Expression of MyD88, Tollip, and NF-κB in HEK293 TLR2 and HEK293 TLR4

    Article • Endocrine Metabolic & Immune Disorders - Drug Targets, February 2019, Bentham Science Publishers

    Saied Bokaie, Gholamreza Azizi, Abbas Mirshafiey, Laleh Sharifi, Mohammad Hossein Asgardoon

  14. The role of T helper 17 and regulatory T cells in tumor microenvironment

    Article • Immunopharmacology and Immunotoxicology, February 2019, Taylor & Francis

    Abbas Mirshafiey

  15. A randomized clinical trial for the assessment of the efficacy and safety of guluronic acid (G2013) in patients with rheumatoid arthritis

    Article • Immunopharmacology and Immunotoxicology, January 2019, Taylor & Francis

    Dr Mahdi Mahmoudi, Ahmadreza Jamshidi, Abbas Mirshafiey

  16. Efficacy of B-D-mannuronic acid [M2000] on pro-apoptotic process and inflammatory related molecules NFKB, IL-8 and Cd49d using healthy donor PBMC

    Article • Current Drug Discovery Technologies, November 2018, Bentham Science Publishers

    Abbas Mirshafiey, Atousa Khalatbari

  17. Modification of Sexual Hormones in Rheumatoid Arthritis Patients by M2000 (β-D-mannuronic Acid) as a Novel NSAID with Immunosuppressive Property

    Article • Endocrine Metabolic & Immune Disorders - Drug Targets, August 2018, Bentham Science Publishers

    Seyed Shahabeddin Mortazavi-Jahromi, Hossein Ahmadi, Abbas Mirshafiey, Maryam Monsef Shokri

  18. Evaluation of the Effect of a-L-Guluronic Acid (G2013) on COX-1, COX-2 Activity and Gene Expression for Introducing this Drug as a Novel NSAID with Immunomodulatory Property

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, June 2018, Bentham Science Publishers

    Seyed Shahabeddin Mortazavi-Jahromi, Abbas Mirshafiey, Salvatore Cuzzocrea

  19. The imbalance of circulating T helper subsets and regulatory T cells in patients with LRBA deficiency: Correlation with disease severity

    Article • Journal of Cellular Physiology, May 2018, Wiley

    Abbas Mirshafiey, Gholamreza Azizi

  20. Immunomodulatory Effect of G2013 (α-L-Guluronic Acid) on the TLR2 and TLR4 in Human Mononuclear Cells

    Article • Current Drug Discovery Technologies, April 2018, Bentham Science Publishers

    Abbas Mirshafiey, Saied Bokaie, Monireh Mohsenzadegan

  21. Cardioprotective effect of β-d-mannuronic acid (M2000) as a novel NSAID on gene expression of oxLDL scavenger receptors in the experimental diabetic model

    Article • Immunopharmacology and Immunotoxicology, April 2018, Taylor & Francis

    Abbas Mirshafiey, Seyed Shahabeddin Mortazavi-Jahromi, Shahab Alizadeh

  22. The Anti-Migraine Effects of M2000 (β-D-Mannuronic Acid) on a Patient with Rheumatoid Arthritis: Case Report

    Article • Current Clinical Pharmacology, February 2018, Bentham Science Publishers

    Hossein Ahmadi, Abbas Mirshafiey, Dr Mahdi Mahmoudi

  23. Anti-angiogenesis effect of β-D-mannuronic acid (M2000) as a novel NSAID with immunosuppressive properties under experimental model

    Article • Clinical and Experimental Pharmacology and Physiology, February 2018, Wiley

    Abbas Mirshafiey, Seyed Shahabeddin Mortazavi-Jahromi

  24. The Potent Inhibitory Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property on Anti-Cyclic Citrullinated Peptide Antibodies, Rheumatoid Factor and Anti-dsDNA Antibodies in Patients with Rheumatoid Arthritis

    Article • Current Drug Discovery Technologies, August 2017, Bentham Science Publishers

    Dr Mahdi Mahmoudi, Abbas Mirshafiey, Hossein Ahmadi, Salvatore Cuzzocrea

  25. Effects of β-D-mannuronic acid, as a novel non-steroidal anti-inflammatory medication within immunosuppressive properties, on IL17, RORγt, IL4 and GATA3 gene expressions in rheumatoid arthritis patients

    Article • Drug Design Development and Therapy, March 2017, Dove Medical Press

    Abbas Mirshafiey, Hossein Ahmadi

  26. Cancer-related inflammation

    Article • Cancer Medicine, February 2017, Wiley

    Abbas Mirshafiey, Targeting of crosstalk between tumor and tumor microenvironment by β-D mannuronic acid (M2000) in murine breast cancer model fatemeh hosseini

  27. Effects of M2000 (D-Mannuronic Acid) on Learning, Memory Retrieval, and Associated Determinants in a Rat Model of Alzheimer’s Disease

    Article • American Journal of Alzheimer s Disease & Other Dementias®, February 2017, SAGE Publications

    Abbas Mirshafiey

  28. Immunomodulatory and Immunosuppressive Roles of 1α,25(OH)2D3 in Autoimmune Diseases

    Article • Scandinavian Journal of Immunology, February 2017, Wiley

    Abbas Mirshafiey

  29. M2000 (β-D-Mannuronic Acid) as a Novel Antagonist for Blocking the TLR2 and TLR4 Downstream Signalling Pathway

    Article • Scandinavian Journal of Immunology, February 2017, Wiley

    Abbas Mirshafiey

  30. Anti-aging effects of M2000 (β-D-mannuronic acid) as a novel immunosuppressive drug on the enzymatic and non-enzymatic oxidative stress parameters in an experimental model

    Article • Journal of Basic and Clinical Physiology and Pharmacology, January 2017, De Gruyter

    Abbas Mirshafiey

  31. The Safety Property of β-D-Mannuronic Acid (M2000) as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells

    Article • Current Drug Discovery Technologies, October 2016, Bentham Science Publishers

    Abbas Mirshafiey

  32. Inhibitory effect of G2013 molecule as a novel immunomodulatory agent, on miR-155 gene expression in HEK-Blue hTLR4 cell line

    Article • European Journal of Inflammation, July 2016, SAGE Publications

    Abbas Mirshafiey, Seyed Shahabeddin Mortazavi-Jahromi

  33. Positive and negative effects of prostaglandins in Alzheimer's disease

    Article • Psychiatry and Clinical Neurosciences, September 2013, Wiley

    Abbas Mirshafiey