All Stories

  1. Matrix stiffness-induced IKBKE and MAPK8 signaling drives a phenotypic switch from DCIS to invasive breast cancer

    Article • April 2025, Cold Spring Harbor Laboratory Press

    Professor Staffan Strömblad

  2. Regulation of protein synthesis and stability by mechanical cues and its implications in cancer

    Article • Current Opinion in Cell Biology, February 2024, Elsevier

    Professor Staffan Strömblad

  3. An extracellular matrix stiffness-induced breast cancer cell transcriptome resembles the transition from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC)

    Article • Biochemical and Biophysical Research Communications, April 2023, Elsevier

    Professor Staffan Strömblad

  4. Local temporal Rac1-GTP nadirs and peaks restrict cell protrusions and retractions

    Article • Science Advances, March 2022, American Association for the Advancement of Science

    Professor Staffan Strömblad

  5. Why is PAK4 overexpressed in cancer?

    Article • The International Journal of Biochemistry & Cell Biology, September 2021, Elsevier

    Professor Staffan Strömblad

  6. Local temporal Rac1-GTP nadirs and peaks restrict cell protrusions and retractions

    Article • June 2021, Cold Spring Harbor Laboratory Press

    Professor Staffan Strömblad

  7. A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells

    Article • eLife, February 2021, eLife

    Professor Staffan Strömblad

  8. In Silico Prediction of Cell Traction Forces

    Article • April 2020, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Staffan Strömblad

  9. Weakly-Supervised Prediction of Cell Migration Modes in Confocal Microscopy Images Using Bayesian Deep Learning

    Article • April 2020, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Staffan Strömblad

  10. New control of the senescence barrier in breast cancer

    Article • Molecular & Cellular Oncology, January 2020, Taylor & Francis

    Professor Staffan Strömblad

  11. Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion

    Article • Scientific Reports, October 2019, Springer Science + Business Media

    Professor Staffan Strömblad

  12. Clathrin-containing adhesion complexes

    Article • Journal of Cell Biology, June 2019, Rockefeller University Press

    Professor Staffan Strömblad

  13. Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion

    Article • June 2019, Cold Spring Harbor Laboratory Press

    Professor Staffan Strömblad

  14. Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis

    Article • Nature Cell Biology, October 2018, Springer Science + Business Media

    Professor Staffan Strömblad

  15. KIF13A‐regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration

    Article • The EMBO Journal, July 2018, EMBO

    Professor Staffan Strömblad

  16. Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions

    Article • Journal of Cell Biology, April 2018, Rockefeller University Press

    Professor Staffan Strömblad

  17. Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1–Rich Endothelial Filopodia Formation

    Article • The Journal of Immunology, January 2018, The American Association of Immunologists

    Professor Staffan Strömblad

  18. Using Systems Microscopy to Understand the Emergence of Cell Migration from Cell Organization

    Article • January 2018, Springer Science + Business Media

    Professor Staffan Strömblad

  19. Reticular adhesions: A new class of adhesion complex that mediates cell-matrix attachment during mitosis

    Article • December 2017, Cold Spring Harbor Laboratory Press

    Professor Staffan Strömblad

  20. Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization

    Article • Oncotarget, August 2017, Impact Journals, LLC

    Professor Staffan Strömblad

  21. Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development

    Article • Scientific Reports, August 2017, Nature

    Professor Staffan Strömblad

  22. Myosin-X is required for ICAM-1-rich endothelial filopodia through the small gtpase CDC42 and PAK4 to functionally support leukocyte adhesion

    Article • Atherosclerosis, August 2017, Elsevier

    Professor Staffan Strömblad

  23. An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes

    Article • eLife, January 2016, eLife

    Professor Staffan Strömblad

  24. p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells

    Article • Oncotarget, November 2015, Impact Journals, LLC

    Professor Staffan Strömblad

  25. Disentangling Membrane Dynamics and Cell Migration; Differential Influences of F-actin and Cell-Matrix Adhesions

    Article • PLOS One, August 2015, PLOS

    Professor Staffan Strömblad

  26. RING finger protein 31 promotes p53 degradation in breast cancer cells

    Article • Oncogene, July 2015, Nature

    Professor Staffan Strömblad

  27. A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime

    Article • Nature Communications, June 2015, Nature

    Professor Staffan Strömblad

  28. An open data ecosystem for cell migration research

    Article • Trends in Cell Biology, February 2015, Elsevier

    Professor Staffan Strömblad, Paola Masuzzo

  29. Non-monotonic cellular responses to heterogeneity in talin protein expression-level

    Article • Integrative Biology, January 2015, Oxford University Press (OUP)

    Professor Staffan Strömblad

  30. Early B Cell Factor 1 Regulates Adipocyte Morphology and Lipolysis in White Adipose Tissue

    Article • Cell Metabolism, June 2014, Elsevier

    Professor Staffan Strömblad

  31. Plasticity in the Macromolecular-Scale Causal Networks of Cell Migration

    Article • PLOS One, February 2014, PLOS

    Professor Staffan Strömblad

  32. The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation

    Article • Oncogene, January 2014, Springer Science + Business Media

    Professor Staffan Strömblad

  33. Cell to extracellular matrix interactions and their reciprocal nature in cancer

    Article • Experimental Cell Research, July 2013, Elsevier

    Professor Staffan Strömblad

  34. Verification of cell viability in bioengineered tissues and organs before clinical transplantation

    Article • Biomaterials, May 2013, Elsevier

    Professor Staffan Strömblad

  35. Molecular Networks of DYX1C1 Gene Show Connection to Neuronal Migration Genes and Cytoskeletal Proteins

    Article • Biological Psychiatry, March 2013, Elsevier

    Professor Staffan Strömblad

  36. A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells

    Article • FEBS Letters, January 2013, Wiley

    Professor Staffan Strömblad

  37. The molecular network of the dyslexia candidate gene DYX1C1 shows connection to neuronal migration genes and cytoskeletal proteins

    Article • International Journal of Developmental Neuroscience, December 2012, Elsevier

    Professor Staffan Strömblad

  38. Focal adhesion disassembly is regulated by a RIAM to MEK-1 pathway

    Article • Journal of Cell Science, September 2012, The Company of Biologists

    Professor Staffan Strömblad

  39. Protein Kinase C  (PKC ) Regulates p53 Localization and Melanoma Cell Survival Downstream of Integrin  v in Three-dimensional Collagen and in Vivo

    Article • Journal of Biological Chemistry, July 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Staffan Strömblad

  40. Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept study

    Article • The Lancet, December 2011, Elsevier

    Professor Staffan Strömblad, Professor Ola Hermanson

  41. Rap1-GTP-interacting Adaptor Molecule (RIAM) Protein Controls Invasion and Growth of Melanoma Cells

    Article • Journal of Biological Chemistry, March 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Staffan Strömblad

  42. PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo

    Article • Cell Cycle, January 2011, Taylor & Francis

    Professor Staffan Strömblad

  43. Functional characterization of human Kindlin-2 core promoter identifies a key role of SP1 in Kindlin-2 transcriptional regulation

    Article • Cellular & Molecular Biology Letters, January 2011, De Gruyter

    Professor Staffan Strömblad

  44. Kindlin-2 controls sensitivity of prostate cancer cells to cisplatin-induced cell death

    Article • Cancer Letters, December 2010, Elsevier

    Professor Staffan Strömblad

  45. WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies

    Article • PLoS Biology, November 2010, PLOS

    Professor Staffan Strömblad

  46. PtdIns(3,4,5)P3 is a regulator of myosin-X localization and filopodia formation

    Article • Journal of Cell Science, October 2010, The Company of Biologists

    Professor Staffan Strömblad

  47. p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients

    Article • Proceedings of the National Academy of Sciences, October 2010, Proceedings of the National Academy of Sciences

    Professor Staffan Strömblad

  48. Integrin-mediated Cell Attachment Induces a PAK4-dependent Feedback Loop Regulating Cell Adhesion through Modified Integrin  v 5 Clustering and Turnover

    Article • Molecular Biology of the Cell, August 2010, American Society for Cell Biology (ASCB)

    Professor Staffan Strömblad

  49. p21-activated Kinase 4 Phosphorylation of Integrin  5 Ser-759 and Ser-762 Regulates Cell Migration

    Article • Journal of Biological Chemistry, May 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Staffan Strömblad

  50. Systems microscopy: An emerging strategy for the life sciences

    Article • Experimental Cell Research, May 2010, Elsevier

    Professor Staffan Strömblad

  51. Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration

    Article • International Journal of Cancer, April 2010, Wiley

    Professor Staffan Strömblad

  52. Anchorage-independent cytokinesis as part of oncogenic transformation?

    Article • Cell Cycle, April 2008, Taylor & Francis

    Professor Staffan Strömblad

  53. Cell–matrix adhesion complexes: Master control machinery of cell migration

    Article • Seminars in Cancer Biology, February 2008, Elsevier

    Professor Staffan Strömblad

  54. Oncogenic H-Ras V12 promotes anchorage-independent cytokinesis in human fibroblasts

    Article • Proceedings of the National Academy of Sciences, December 2007, Proceedings of the National Academy of Sciences

    Professor Staffan Strömblad

  55. Single fluorescent protein-based Ca2+ sensors with increased dynamic range

    Article • BMC Biotechnology, January 2007, Springer Science + Business Media

    Professor Staffan Strömblad

  56. The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity

    Article • Oncogene, September 2006, Springer Science + Business Media

    Professor Staffan Strömblad

  57. Integrin αv-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen

    Article • Journal of Cell Biology, November 2004, Rockefeller University Press

    Professor Staffan Strömblad

  58. Recombinant CD44-HABD is a novel and potent direct angiogenesis inhibitor enforcing endothelial cell-specific growth inhibition independently of hyaluronic acid binding

    Article • Oncogene, September 2004, Springer Science + Business Media

    Professor Staffan Strömblad

  59. Myosin-X provides a motor-based link between integrins and the cytoskeleton

    Article • Nature Cell Biology, May 2004, Springer Science + Business Media

    Professor Staffan Strömblad

  60. Retinoblastoma Susceptibility Gene Product (pRb) and p107 Functionally Separate the Requirements for Serum and Anchorage in the Cell Cycle G1-phase

    Article • Journal of Biological Chemistry, February 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Staffan Strömblad

  61. p21-activated kinase 4 interacts with integrin αvβ5 and regulates αvβ5-mediated cell migration

    Article • Journal of Cell Biology, September 2002, Rockefeller University Press

    Professor Staffan Strömblad

  62. Cell Attachment to the Extracellular Matrix Induces Proteasomal Degradation of p21CIP1 via Cdc42/Rac1 Signaling

    Article • Molecular and Cellular Biology, July 2002, ASM Journals

    Professor Staffan Strömblad

  63. Use of an immobilized monoclonal antibody to examine integrin α5β1 signaling independent of cell spreading

    Article • Biological Procedures Online, June 2002, Springer Science + Business Media

    Professor Staffan Strömblad

  64. Loss of p53 Compensates for α v -Integrin Function in Retinal Neovascularization

    Article • Journal of Biological Chemistry, February 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Staffan Strömblad

  65. RANTES promotes growth and survival of human first-trimester forebrain astrocytes

    Article • Nature Cell Biology, February 2001, Springer Science + Business Media

    Professor Staffan Strömblad, Professor Moiz Bakhiet

  66. Branching out in tumour therapy

    Article • Trends in Cell Biology, October 1998, Elsevier

    Professor Staffan Strömblad

  67. Integrin αvβ3 Requirement for Sustained Mitogen-activated Protein Kinase Activity during Angiogenesis

    Article • Journal of Cell Biology, March 1998, Rockefeller University Press

    Professor Staffan Strömblad

  68. The Role of Integrin αvβ3 in Cell Survival and Angiogenesis

    Article • January 1997, Springer Science + Business Media

    Professor Staffan Strömblad

  69. Cell adhesion and angiogenesis

    Article • Trends in Cell Biology, December 1996, Elsevier

    Professor Staffan Strömblad

  70. Requirement of Receptor-bound Urokinase-type Plasminogen Activator for Integrin αvβ5-directed Cell Migration

    Article • Journal of Biological Chemistry, November 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Staffan Strömblad

  71. Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

    Article • Cell, May 1996, Elsevier

    Professor Staffan Strömblad

  72. Integrins, angiogenesis and vascular cell survival

    Article • Chemistry & Biology, January 1996, Elsevier

    Professor Staffan Strömblad

  73. Increased expression of and sensitivity to transforming growth factor-α: A promotive role during rat liver carcinogenesis

    Article • Molecular Carcinogenesis, June 1994, Wiley

    Professor Staffan Strömblad

  74. The Coupling between Transforming Growth Factor-α and the Epidermal Growth Factor Receptor during Rat Liver Regeneration

    Article • Experimental Cell Research, February 1993, Elsevier

    Professor Staffan Strömblad