All Stories

  1. Tuning Anticancer Activity and Antimicrobial Response of ZnO Nanoparticles Through Halogenosilane Surface Modification

    Article • May 2026, MDPI AG

    Jorge Leitão

  2. Hydrogel dressings loaded with anticancer/antimicrobial Ag(I) camphorimine complexes for treatment of malignant wounds

    Article • International Journal of Pharmaceutics, September 2025, Elsevier

    Jorge Leitão

  3. Gold(III) Complexes with Aromatic Cyano-Substituted Bisdithiolate Ligands as Potential Anticancer and Antimicrobial Agents

    Article • Molecules, August 2025, MDPI AG

    Jorge Leitão

  4. Insights into the Dual Anticancer and Antibacterial Activities of Composites Based on Silver Camphorimine Complexes

    Article • Journal of Functional Biomaterials, August 2024, MDPI AG

    Jorge Leitão

  5. Pseudomonas aestus Isolation from the Nasal Cavity of a Cat with Chronic Rhinitis

    Article • Veterinary Sciences, August 2024, MDPI AG

    Jorge Leitão

  6. Antimicrobial Activity of Water-Soluble Silver Complexes Bearing C-Scorpionate Ligands

    Article • Antibiotics, July 2024, MDPI AG

    Jorge Leitão, Professor Luísa Margarida Martins

  7. Surface-Exposed Protein Moieties of Burkholderia cenocepacia J2315 in Microaerophilic and Aerobic Conditions

    Article • Vaccines, April 2024, MDPI AG

    Jorge Leitão

  8. Non-coding regulatory sRNAs from bacteria of the Burkholderia cepacia complex

    Article • Applied Microbiology and Biotechnology, April 2024, Springer Science + Business Media

    Jorge Leitão

  9. A Polyclonal Antibody against a Burkholderia cenocepacia OmpA-like Protein Strongly Impairs Pseudomonas aeruginosa and B. multivorans Virulence

    Article • Vaccines, February 2024, MDPI AG

    Jorge Leitão

  10. Advances in Human Pathogen Control—A 21st Century Challenge

    Article • Vaccines, September 2023, MDPI AG

    Jorge Leitão

  11. Design and Optimization of Microbial Fuel Cells and Evaluation of a New Air-Breathing Cathode Based on Carbon Felt Modified with a Hydrogel—Ion Jelly®

    Article • Energies, May 2023, MDPI AG

    Jorge Leitão

  12. Identification of Burkholderia cenocepacia non-coding RNAs expressed during Caenorhabditis elegans infection

    Article • Applied Microbiology and Biotechnology, April 2023, Springer Science + Business Media

    Jorge Leitão

  13. Antitumoral and Antimicrobial Activities of Block Copolymer Micelles Containing Gold Bisdithiolate Complexes

    Article • Pharmaceutics, February 2023, MDPI AG

    Jorge Leitão

  14. Comparison of Virulence-Factor-Encoding Genes and Genotype Distribution amongst Clinical Pseudomonas aeruginosa Strains

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Jorge Leitão

  15. Microbial Antigen Identification and Vaccine Delivery Systems

    Article • Vaccines, November 2022, MDPI AG

    Jorge Leitão

  16. Antibody-Based Immunotherapies as a Tool for Tackling Multidrug-Resistant Bacterial Infections

    Article • Vaccines, October 2022, MDPI AG

    Jorge Leitão

  17. Tuning the Biological Activity of Camphorimine Complexes through Metal Selection

    Article • Antibiotics, July 2022, MDPI AG

    Jorge Leitão

  18. Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes

    Article • International Journal of Molecular Sciences, June 2022, MDPI AG

    Jorge Leitão

  19. Estrogens in wastewaters: Can different operating conditions improve their removal in anaerobic conditions?

    Article • Water and Environment Journal, February 2022, Wiley

    Jorge Leitão, Professor Valdemar I. Esteves

  20. Bioelectricity generation using long-term operated biocathode: RFLP based microbial diversity analysis

    Article • Biotechnology Reports, December 2021, Elsevier

    Jorge Leitão

  21. A Polyclonal Antibody Raised against the Burkholderia cenocepacia OmpA-like Protein BCAL2645 Impairs the Bacterium Adhesion and Invasion of Human Epithelial Cells In Vitro

    Article • Biomedicines, November 2021, MDPI AG

    Jorge Leitão

  22. Synthesis and Characterization of Camphorimine Au(I) Complexes with a Remarkably High Antibacterial Activity towards B. contaminans and P. aeruginosa

    Article • Antibiotics, October 2021, MDPI AG

    Jorge Leitão

  23. Bacterial Nosocomial Infections: Multidrug Resistance as a Trigger for the Development of Novel Antimicrobials

    Article • Antibiotics, August 2021, MDPI AG

    Jorge Leitão

  24. Immunization and Immunotherapy Approaches against Pseudomonas aeruginosa and Burkholderia cepacia Complex Infections

    Article • Vaccines, June 2021, MDPI AG

    Jorge Leitão

  25. Sono-Biosynthesis and Characterization of AuNPs from Danube Delta Nymphaea alba Root Extracts and Their Biological Properties

    Article • Nanomaterials, June 2021, MDPI AG

    Jorge Leitão

  26. Impact of UASB reactors operation mode on the removal of estrone and 17α-ethinylestradiol from wastewaters

    Article • The Science of The Total Environment, April 2021, Elsevier

    Jorge Leitão, Professor Valdemar I. Esteves

  27. Key Parameters on the Antibacterial Activity of Silver Camphor Complexes

    Article • Antibiotics, January 2021, MDPI AG

    Jorge Leitão

  28. Extracellular RNAs in Bacterial Infections: From Emerging Key Players on Host-Pathogen Interactions to Exploitable Biomarkers and Therapeutic Targets

    Article • International Journal of Molecular Sciences, December 2020, MDPI AG

    Jorge Leitão

  29. Omics and Bioinformatics Approaches to Identify Novel Antigens for Vaccine Investigation and Development

    Article • Vaccines, November 2020, MDPI AG

    Jorge Leitão

  30. Characterization of the Burkholderia cenocepacia J2315 Surface-Exposed Immunoproteome

    Article • Vaccines, September 2020, MDPI AG

    Jorge Leitão

  31. Listeria monocytogenes as a Vector for Cancer Immunotherapy

    Article • Vaccines, August 2020, MDPI AG

    Jorge Leitão

  32. New Insights into Antibacterial Compounds: From Synthesis and Discovery to Molecular Mechanisms of Action

    Article • Antibiotics, August 2020, MDPI AG

    Jorge Leitão

  33. Microbial Virulence Factors

    Article • International Journal of Molecular Sciences, July 2020, MDPI AG

    Jorge Leitão

  34. Deep Functional Profiling Facilitates the Evaluation of the Antibacterial Potential of the Antibiotic Amicoumacin

    Article • Antibiotics, April 2020, MDPI AG

    Jorge Leitão

  35. Comparative Genomics and Evolutionary Analysis of RNA-Binding Proteins of Burkholderia cenocepacia J2315 and Other Members of the B. cepacia Complex

    Article • Genes, February 2020, MDPI AG

    Jorge Leitão

  36. New insights into the immunoproteome of B. cenocepacia J2315 using serum samples from cystic fibrosis patients

    Article • New Biotechnology, January 2020, Elsevier

    Jorge Leitão

  37. On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities

    Article • Journal of Inorganic Biochemistry, January 2020, Elsevier

    Jorge Leitão

  38. Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents

    Article • Metallomics, January 2020, Oxford University Press (OUP)

    Jorge Leitão

  39. Antifungal, Antitumoral and Antioxidant Potential of the Danube Delta Nymphaea alba Extracts

    Article • Antibiotics, December 2019, MDPI AG

    Jorge Leitão

  40. Investigations into the Structure/Antibacterial Activity Relationships of Cyclam and Cyclen Derivatives

    Article • Antibiotics, November 2019, MDPI AG

    Jorge Leitão

  41. Ag(I) camphor complexes: antimicrobial activity by design

    Article • Journal of Inorganic Biochemistry, October 2019, Elsevier

    Jorge Leitão

  42. Antimicrobial Activity of Silver Camphorimine Complexes against Candida Strains

    Article • Antibiotics, September 2019, MDPI AG

    Jorge Leitão

  43. Determination of estrone and 17α-ethinylestradiol in digested sludge by ultrasonic liquid extraction and high-performance liquid chromatography with fluorescence detection

    Article • Journal of Separation Science, February 2019, Wiley

    Jorge Leitão, Professor Valdemar I. Esteves

  44. Differential effects of Th17 cytokines during the response of neutrophils to Burkholderia cenocepacia outer membrane protein A

    Article • Central European Journal of Immunology, January 2019, Termedia Sp. z.o.o.

    Jorge Leitão

  45. Small Noncoding Regulatory RNAs from Pseudomonas aeruginosa and Burkholderia cepacia Complex

    Article • International Journal of Molecular Sciences, November 2018, MDPI AG

    Jorge Leitão

  46. Silver Camphor Imine Complexes: Novel Antibacterial Compounds from Old Medicines

    Article • Antibiotics, July 2018, MDPI AG

    Jorge Leitão

  47. Postgenomic Approaches and Bioinformatics Tools to Advance the Development of Vaccines against Bacteria of the Burkholderia cepacia Complex

    Article • Vaccines, June 2018, MDPI AG

    Jorge Leitão

  48. Burkholderia puraquae sp. nov., a novel species of the Burkholderia cepacia complex isolated from hospital settings and agricultural soils

    Article • INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, January 2018, Society for General Microbiology

    Prof. Carla CCR de Carvalho, Jorge Leitão

  49. Burkholderia cepacia Complex Infections Among Cystic Fibrosis Patients: Perspectives and Challenges

    Article • July 2017, IntechOpen

    Jorge Leitão

  50. Ag(I) camphorimine complexes with antimicrobial activity towards clinically important bacteria and species of the Candida genus

    Article • PLOS One, May 2017, PLOS

    Jorge Leitão

  51. Synthesis, antimicrobial activity and toxicity to nematodes of cyclam derivatives

    Article • International Journal of Antimicrobial Agents, May 2017, Elsevier

    Jorge Leitão

  52. Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review

    Article • Genes, January 2017, MDPI AG

    Jorge Leitão

  53. Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection

    Article • Virulence, September 2016, Taylor & Francis

    Jorge Leitão

  54. The Burkholderia cenocepacia OmpA-like protein BCAL2958: identification, characterization, and detection of anti-BCAL2958 antibodies in serum from B. cepacia complex-infected Cystic Fibrosis patients

    Article • AMB Express, June 2016, Springer Science + Business Media

    Jorge Leitão

  55. Antibacterial activity of silver camphorimine coordination polymers

    Article • Dalton Transactions, January 2016, Royal Society of Chemistry

    Jorge Leitão

  56. Bioinformatics Applications in Life Sciences and Technologies

    Article • BioMed Research International, January 2016, Hindawi Publishing Corporation

    Jorge Leitão

  57. Hfq: a multifaceted RNA chaperone involved in virulence

    Article • Future Microbiology, January 2016, Future Medicine

    Jorge Leitão

  58. Suitability of a Saccharomyces cerevisiae-based assay to assess the toxicity of pyrimethanil sprayed soils via surface runoff: Comparison with standard aquatic and soil toxicity assays

    Article • The Science of The Total Environment, February 2015, Elsevier

    Jorge Leitão

  59. Retraction for Ramos et al., The Second RNA Chaperone, Hfq2, Is Also Required for Survival under Stress and Full Virulence of Burkholderia cenocepacia J2315

    Article • Journal of Bacteriology, October 2014, ASM Journals

    Jorge Leitão

  60. Retraction for Ramos et al., MtvR Is a Global Small Noncoding Regulatory RNA in Burkholderia cenocepacia

    Article • Journal of Bacteriology, October 2014, ASM Journals

    Jorge Leitão

  61. Effects of operational shocks on key microbial populations for biogas production in UASB (Upflow Anaerobic Sludge Blanket) reactors

    Article • Energy, August 2014, Elsevier

    Jorge Leitão

  62. Regulation of Hfq mRNA and Protein Levels in Escherichia coli and Pseudomonas aeruginosa by the Burkholderia cenocepacia MtvR sRNA

    Article • PLOS One, June 2014, PLOS

    Jorge Leitão

  63. Bioinformatics: A Molecular Microbiologist’s Perspective

    Article • Current Bioinformatics, January 2014, Bentham Science Publishers

    Jorge Leitão

  64. MtvR Is a Global Small Noncoding Regulatory RNA in Burkholderia cenocepacia

    Article • Journal of Bacteriology, May 2013, ASM Journals

    Jorge Leitão

  65. Biochemical and Functional Studies on the Burkholderia cepacia Complex bceN Gene, Encoding a GDP-D-Mannose 4,6-Dehydratase

    Article • PLOS One, February 2013, PLOS

    Jorge Leitão

  66. Experimental identification of small non-coding regulatory RNAs in the opportunistic human pathogen Burkholderia cenocepacia J2315

    Article • Genomics, February 2013, Elsevier

    Jorge Leitão

  67. The Novel Cis-Encoded Small RNA h2cR Is a Negative Regulator of hfq2 in Burkholderia cenocepacia

    Article • PLOS One, October 2012, PLOS

    Jorge Leitão

  68. Synergistic action of azoreductase and laccase leads to maximal decolourization and detoxification of model dye-containing wastewaters

    Article • Bioresource Technology, November 2011, Elsevier

    Dr Ligia O. Martins, Jorge Leitão

  69. Activated Sugar Precursors: Biosynthetic Pathways and Biological Roles of an Important Class of Intermediate Metabolites in Bacteria

    Article • June 2011, IntechOpen

    Jorge Leitão

  70. Enhancing wastewater degradation and biogas production by intermittent operation of UASB reactors

    Article • Energy, April 2011, Elsevier

    Jorge Leitão

  71. A RNomics-based strategy identifies regulatory small RNAs in Burkholderia cepacia complex

    Article • March 2011, Institute of Electrical & Electronics Engineers (IEEE)

    Jorge Leitão

  72. Identification and exploitation of Burkholderia cepacia complex virulence factors as potential antimicrobial targets

    Article • March 2011, Institute of Electrical & Electronics Engineers (IEEE)

    Jorge Leitão

  73. The Second RNA Chaperone, Hfq2, Is Also Required for Survival under Stress and Full Virulence of Burkholderia cenocepacia J2315

    Article • Journal of Bacteriology, January 2011, ASM Journals

    Jorge Leitão

  74. Microbial Ecology and Global Health

    Article • International Journal of Microbiology, January 2011, Hindawi Publishing Corporation

    Jorge Leitão

  75. Burkholderia cepaciaComplex: Emerging Multihost Pathogens Equipped with a Wide Range of Virulence Factors and Determinants

    Article • International Journal of Microbiology, January 2011, Hindawi Publishing Corporation

    Jorge Leitão

  76. The Burkholderia cenocepacia K56-2 pleiotropic regulator Pbr, is required for stress resistance and virulence

    Article • Microbial Pathogenesis, May 2010, Elsevier

    Professor Leo Eberl, Jorge Leitão

  77. Pathogenicity, virulence factors, and strategies to fight against Burkholderia cepacia complex pathogens and related species

    Article • Applied Microbiology and Biotechnology, April 2010, Springer Science + Business Media

    Dr Leonilde M Moreira, Jorge Leitão

  78. Distribution of Cepacian Biosynthesis Genes among Environmental and Clinical Burkholderia Strains and Role of Cepacian Exopolysaccharide in Resistance to Stress Conditions

    Article • Applied and Environmental Microbiology, November 2009, ASM Journals

    Dr Leonilde M Moreira, Jorge Leitão

  79. The hfq gene is required for stress resistance and full virulence of Burkholderia cepacia to the nematode Caenorhabditis elegans

    Article • Microbiology, November 2009, Society for General Microbiology

    Dr Leonilde M Moreira, Jorge Leitão

  80. A new methodology combining PCR, cloning, and sequencing of clones discriminated by RFLP for the study of microbial populations: application to an UASB reactor sample

    Article • Applied Microbiology and Biotechnology, October 2009, Springer Science + Business Media

    Jorge Leitão

  81. Burkholderia cenocepacia J2315 acyl carrier protein: A potential target for antimicrobials' development?

    Article • Microbial Pathogenesis, November 2008, Elsevier

    Professor Leo Eberl, Jorge Leitão

  82. Functional analysis of the Burkholderia cenocepacia J2315 BceAJ protein with phosphomannose isomerase and GDP-d-mannose pyrophosphorylase activities

    Article • Applied Microbiology and Biotechnology, July 2008, Springer Science + Business Media

    Dr Leonilde M Moreira, Jorge Leitão

  83. Variation of the antimicrobial susceptibility profiles of Burkholderia cepacia complex clonal isolates obtained from chronically infected cystic fibrosis patients: a five-year survey in the major Portuguese treatment center

    Article • European Journal of Clinical Microbiology & Infectious Diseases, July 2008, Springer Science + Business Media

    Jorge Leitão

  84. Virulence of Burkholderia cepacia complex strains in gp91phox−/− mice

    Article • Cellular Microbiology, June 2007, Wiley

    Professor Leo Eberl, Jorge Leitão

  85. The Burkholderia cepacia bceA gene encodes a protein with phosphomannose isomerase and GDP-d-mannose pyrophosphorylase activities

    Article • Biochemical and Biophysical Research Communications, February 2007, Elsevier

    Professor Leo Eberl, Dr Leonilde M Moreira, Jorge Leitão

  86. Functional Analysis of Burkholderia cepacia Genes bceD and bceF, Encoding a Phosphotyrosine Phosphatase and a Tyrosine Autokinase, Respectively: Role in Exopolysaccharide Biosynthesis and Biofilm Formation

    Article • Applied and Environmental Microbiology, November 2006, ASM Journals

    Dr Leonilde M Moreira, Jorge Leitão

  87. Studies on the Involvement of the Exopolysaccharide Produced by Cystic Fibrosis-Associated Isolates of the Burkholderia cepacia Complex in Biofilm Formation and in Persistence of Respiratory Infections

    Article • Journal of Clinical Microbiology, July 2004, ASM Journals

    Dr Leonilde M Moreira, Jorge Leitão, Paula Videira

  88. Identification and physical organization of the gene cluster involved in the biosynthesis of Burkholderia cepacia complex exopolysaccharide

    Article • Biochemical and Biophysical Research Communications, December 2003, Elsevier

    Dr Leonilde M Moreira, Jorge Leitão, Paula Videira

  89. Molecular Analysis of Burkholderia cepacia Complex Isolates from a Portuguese Cystic Fibrosis Center: a 7-Year Study

    Article • Journal of Clinical Microbiology, September 2003, ASM Journals

    Professor Peter A Vandamme, Jorge Leitão

  90. Macromolecular and solution properties of Cepacian: the exopolysaccharide produced by a strain of Burkholderia cepacia isolated from a cystic fibrosis patient

    Article • Carbohydrate Research, September 2003, Elsevier

    Jorge Leitão

  91. Chromosomal organization and transcription analysis of genes in the vicinity of Pseudomonas aeruginosa glmM gene encoding phosphoglucosamine mutase

    Article • Biochemical and Biophysical Research Communications, March 2003, Elsevier

    Jorge Leitão

  92. Enzymes Leading to the Nucleotide Sugar Precursors for Exopolysaccharide Synthesis in Burkholderia cepacia

    Article • Biochemical and Biophysical Research Communications, September 2000, Elsevier

    Jorge Leitão

  93. Identification of the Pseudomonas aeruginosa glmM Gene, Encoding Phosphoglucosamine Mutase

    Article • Journal of Bacteriology, August 2000, ASM Journals

    Jorge Leitão

  94. Structural Study of the Exopolysaccharide Produced by a Clinical Isolate of Burkholderia cepacia

    Article • Biochemical and Biophysical Research Communications, July 2000, Elsevier

    Jorge Leitão

  95. Pattern of changes in the activity of enzymes of GDP-D-mannuronic acid synthesis and in the level of transcription of algA, algC and algD genes accompanying the loss and emergence of mucoidy in Pseudomonas aeruginosa

    Article • Research in Microbiology, March 1999, Elsevier

    Jorge Leitão

  96. Oxygen-dependent upregulation of transcription of alginate genes algA, algC and algD in Pseudomonas aeruginosa

    Article • Research in Microbiology, January 1997, Elsevier

    Jorge Leitão

  97. Ribotyping of Pseudomonas aeruginosa isolates from patients and water springs and genome fingerprinting of variants concerning mucoidy

    Article • FEMS Immunology & Medical Microbiology, April 1996, Wiley

    Jorge Leitão

  98. Growth-phase-dependent alginate synthesis, activity of biosynthetic enzymes and transcription of alginate genes in Pseudomonas aeruginosa

    Article • Archives of Microbiology, March 1995, Springer Science + Business Media

    Jorge Leitão

  99. Growth-phase-dependent alginate synthesis, activity of biosynthetic enzymes and transcription of alginate genes in

    Article • Archives of Microbiology, January 1995, Springer Science + Business Media

    Jorge Leitão