What is it about?
This study aimed to evaluate the communication between normal and cancerous cells by applying co-culture principles. In this context, intercellular communication between normal epithelial prostate cells and prostate cancer cell lines and expression changes in marker genes were investigated. The EGFR, SOX2, CD133, CD44, CASPASE 3, CASPASE 9, and IL-6 genes were used as markers and remarkable results were obtained by co-culturing normal and cancer cell lines.
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Why is it important?
Our findings may contribute the hypothesis that cancer cells may interact with the healty cells and alter gene expressions related to diferent mechanisms through carcinogenesis.
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This page is a summary of: Evaluation of intercellular communication between normal human prostate epithelial cells and prostate cancer cell lines in co-culture model, Journal of Cellular Biotechnology, May 2020, IOS Press,
DOI: 10.3233/jcb-190019.
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