What is it about?
we reviewed the current research related to implications of miRNAs during the development of AD, summarized of actively used approaches to identifying potential miRNA biomarkers in body fluids, and discussed the diagnostic potential of microRNAs as biomarkers for AD.
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Why is it important?
Due to the fact that AD has a long period of incubation before clinical symptoms emerge, the available therapeutic treatments can only improve the symptoms but not delay the progression of AD. Therefore, there is an urgent need to explore effective diagnostic approaches to catch and better treat the disease before clinical symptoms appear.
Perspectives
MicroRNAs have a great potential as biomarkers in diagnosis, involving in progression of AD and other neurodegenerative diseases. A better understanding the role of microRNA in physiological and pathological conditions is of great importance to validate their use as non-invasive biomarkers.
Bo Pan
Read the Original
This page is a summary of: Dysregulation and Diagnostic Potential of microRNA in Alzheimer’s Disease, Journal of Alzheimer s Disease, October 2015, IOS Press,
DOI: 10.3233/jad-150451.
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