What is it about?
The diagnosis and prognosis of neck squamous cell carcinoma (HNSC) is a challenge for clinical HNSC management, thus, the investigation of molecular biomarkers of HNSC is urgent.
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Why is it important?
The diagnosis and prognosis of neck squamous cell carcinoma (HNSC) is a challenge for clinical HNSC management, thus, the investigation of molecular biomarkers of HNSC is urgent. We analyzed mRNA seq data, protein staining data, and single-cell expression data of HNSC from open databases and evaluated the diagnostic and prognostic value of CNIH4, and investigated the association of CNIH4 to HNSC cancer biology and immunity. This study demonstrated that CNIH4 is a diagnostic and prognostic biomarker for HNSC patients and can potentially affect the cancer stemness and tumor immune microenvironment of HNSC cells.
Perspectives
This study provided a novel molecular marker for the improvement of clinical HNSC treatment.
Hengrui Liu
Read the Original
This page is a summary of: Potential roles of Cornichon Family AMPA Receptor Auxiliary Protein 4 (CNIH4) in head and neck squamous cell carcinoma, Cancer Biomarkers, December 2022, IOS Press,
DOI: 10.3233/cbm-220143.
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