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Serine proteases are elevated under diabetic kidney disease conditions and promote an excessive calcium influx in podocytes through the protease-activated receptors, ultimately leading to podocyte apoptosis, the development of albuminuria, and kidney injury.
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This page is a summary of: Protease-Activated Receptor 1–Mediated Damage of Podocytes in Diabetic Nephropathy, Diabetes, September 2023, American Diabetes Association,
DOI: 10.2337/db23-0032.
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