Roles of Pancreatic Islet Catecholamine Neurotransmitters in Glycemic Control and in Antipsychotic Drug–Induced Dysglycemia

What is it about?

We show that catecholamines which include dopamine and norepinephrine play important roles in pancreatic function. While these molecules have been studied primarily in the brain, we present evidence that dopamine and norepinephrine are also critical in the regulation of pancreatic insulin and glucagon release. Furthermore, disruption of pancreatic catecholamine function by psychiatric medications leads to metabolic dysfunction that culminates in diabetes.

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