All Stories

  1. Deep Disentangled Representation Learning Reveals Neuron Subtype-Specific Nuclear Morphologies Across Aging in Mice and Humans

    Article • October 2025, Cold Spring Harbor Laboratory Press

    Zachary Freyberg

  2. Preparation of Vitrified Mammalian Cells for In Situ Cryo‐Electron Tomography

    Article • Current Protocols, October 2025, Wiley

    Zachary Freyberg

  3. Additional Cover

    Article • Aging Cell, August 2025, Wiley

    Zachary Freyberg

  4. dVGLUT Is a Mediator of Sex Differences in Dopamine Neuron Mitochondrial Function Across Aging and in a Parkinson's Disease Model

    Article • Aging Cell, May 2025, Wiley

    Zachary Freyberg

  5. Psychiatric factors predict type 2 diabetes mellitus in US Veterans

    Article • Schizophrenia, April 2025, Springer Science + Business Media

    Zachary Freyberg

  6. Making Drosophila Artificial Hemolymph v1

    Article • March 2025, Springer Science + Business Media

    Zachary Freyberg

  7. Metabolism Matters in Mental Health

    Article • Biological Psychiatry Cognitive Neuroscience and Neuroimaging, March 2025, Elsevier

    Zachary Freyberg

  8. TomoPicker: Annotation-Efficient Particle Picking in cryo-electron Tomograms

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Zachary Freyberg

  9. Linking mitochondrial dysfunction, neurotransmitter, neural network abnormalities and mania: Elucidating neurobiological mechanisms of the therapeutic effect of the ketogenic diet in Bipolar Disorder

    Article • Biological Psychiatry Cognitive Neuroscience and Neuroimaging, July 2024, Elsevier

    Zachary Freyberg

  10. Peripheral opioid tolerance involves skin keratinocytes and platelet-derived growth factor type B signaling

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Zachary Freyberg

  11. Volume electron microscopy reveals 3D synaptic nanoarchitecture in postmortem human prefrontal cortex

    Article • February 2024, Cold Spring Harbor Laboratory Press

    Zachary Freyberg

  12. Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration

    Article • October 2023, Cold Spring Harbor Laboratory Press

    Zachary Freyberg

  13. Circadian rhythm disruptions associated with opioid use disorder in synaptic proteomes of human dorsolateral prefrontal cortex and nucleus accumbens

    Article • Molecular Psychiatry, September 2023, Springer Science + Business Media

    Zachary Freyberg

  14. A Spatial Atlas of Wnt Receptors in Adult Mouse Liver

    Article • American Journal Of Pathology, May 2023, Elsevier

    Zachary Freyberg

  15. Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving

    Article • Neuropsychopharmacology, April 2023, Springer Science + Business Media

    Zachary Freyberg

  16. Cryo-FIB workflow for imaging brain tissue viain situcryo-electron microscopy

    Article • February 2023, Cold Spring Harbor Laboratory Press

    Zachary Freyberg

  17. Roles of Pancreatic Islet Catecholamine Neurotransmitters in Glycemic Control and in Antipsychotic Drug–Induced Dysglycemia

    Article • Diabetes, December 2022, American Diabetes Association

    Zachary Freyberg

  18. Editorial: Neuroinflammation, metabolism, and psychiatric disorders

    Article • Frontiers in Psychiatry, October 2022, Frontiers

    Zachary Freyberg

  19. Sex Differences in Dopaminergic Vulnerability to Environmental Toxicants — Implications for Parkinson’s Disease

    Article • Current Environmental Health Reports, October 2022, Springer Science + Business Media

    Zachary Freyberg

  20. A spatial atlas of Wnt and Frizzled receptor expression in adult mouse liver

    Article • September 2022, Cold Spring Harbor Laboratory Press

    Zachary Freyberg

  21. Self-supervised learning for macromolecular structure classification based on cryo-electron tomograms

    Article • Frontiers in Physiology, August 2022, Frontiers

    Zachary Freyberg

  22. Brain region- and sex-specific transcriptional profiles of microglia

    Article • Frontiers in Psychiatry, August 2022, Frontiers

    Zachary Freyberg

  23. Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

    Article • iScience, August 2022, Elsevier

    Zachary Freyberg

  24. Structure Detection in Three-Dimensional Cellular Cryoelectron Tomograms by Reconstructing Two-Dimensional Annotated Tilt Series

    Article • Journal of Computational Biology, August 2022, Mary Ann Liebert Inc

    Zachary Freyberg

  25. Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia

    Article • Molecular Psychiatry, June 2022, Springer Science + Business Media

    Zachary Freyberg

  26. Roles of VGLUT2 and Dopamine/Glutamate Co-Transmission in Selective Vulnerability to Dopamine Neurodegeneration

    Article • ACS Chemical Neuroscience, January 2022, American Chemical Society (ACS)

    Zachary Freyberg

  27. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson’s disease

    Article • Brain, November 2021, Oxford University Press (OUP)

    Zachary Freyberg

  28. Transcriptional Alterations in Dorsolateral Prefrontal Cortex and Nucleus Accumbens Implicate Neuroinflammation and Synaptic Remodeling in Opioid Use Disorder

    Article • Biological Psychiatry, October 2021, Elsevier

    Zachary Freyberg

  29. WNT7B Regulates Cholangiocyte Proliferation and Function During Murine Cholestasis

    Article • Hepatology Communications, August 2021, Wolters Kluwer Health

    Zachary Freyberg

  30. Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age‐related neurodegeneration

    Article • Aging Cell, April 2021, Wiley

    Zachary Freyberg

  31. VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration

    Article • Journal of Neuroscience, April 2021, Society for Neuroscience

    Zachary Freyberg

  32. Roles of inflammation in intrinsic pathophysiology and antipsychotic drug-induced metabolic disturbances of schizophrenia

    Article • Behavioural Brain Research, March 2021, Elsevier

    Zachary Freyberg

  33. Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

    Article • Translational Psychiatry, February 2021, Springer Science + Business Media

    Zachary Freyberg

  34. Serial cryoFIB/SEM Reveals Cytoarchitectural Disruptions in Leigh Syndrome Patient Cells

    Article • Structure, January 2021, Elsevier

    Zachary Freyberg

  35. Vesicular neurotransmitter transporters in Drosophila melanogaster

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, December 2020, Elsevier

    Zachary Freyberg

  36. VGLUT modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration

    Article • November 2020, Cold Spring Harbor Laboratory Press

    Zachary Freyberg

  37. Transcriptional alterations in opioid use disorder reveal an interplay between neuroinflammation and synaptic remodeling

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Zachary Freyberg

  38. Commentary: Ghrelin promotes midbrain neural stem cells differentiation to dopaminergic neurons through the Wnt/β-catenin pathway

    Article • Frontiers in Cellular Neuroscience, August 2020, Frontiers

    Zachary Freyberg

  39. Roles of dopamine and glutamate co‐release in the nucleus accumbens in mediating the actions of drugs of abuse

    Article • European Journal of Biochemistry, August 2020, Wiley

    Zachary Freyberg

  40. Olanzapine-induced liver injury in mice: aggravation by high-fat diet and protection with sulforaphane

    Article • The Journal of Nutritional Biochemistry, July 2020, Elsevier

    Zachary Freyberg

  41. Serial cryoFIB/SEM reveals profound cytoarchitectural disruptions caused by a pathogenic mutation in Leigh syndrome patient cells

    Article • May 2020, Cold Spring Harbor Laboratory Press

    Zachary Freyberg

  42. Chemical Targeting of Voltage Sensitive Dyes to Specific Cells and Molecules in the Brain

    Article • Journal of the American Chemical Society, May 2020, American Chemical Society (ACS)

    Zachary Freyberg

  43. Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells

    Article • Science Advances, April 2020, American Association for the Advancement of Science

    Zachary Freyberg

  44. Dopamine D2 receptor signaling modulates pancreatic beta cell circadian rhythms

    Article • Psychoneuroendocrinology, March 2020, Elsevier

    Zachary Freyberg

  45. Trace Amines and Trace Amine-Associated Receptors: A New Frontier in Cell Signaling

    Article • Cellular and Molecular Neurobiology, January 2020, Springer Science + Business Media

    Zachary Freyberg

  46. Chemical targeting of voltage sensitive dyes to specific cells and molecules in the brain

    Article • January 2020, American Chemical Society (ACS)

    Zachary Freyberg

  47. Chemical targeting of voltage sensitive dyes to specific cells and molecules in the brain

    Article • January 2020, American Chemical Society (ACS)

    Zachary Freyberg

  48. Dopamine D2 receptor modulates Wnt expression and control of cell proliferation

    Article • Scientific Reports, November 2019, Springer Science + Business Media

    Zachary Freyberg

  49. Automatic localization and identification of mitochondria in cellular electron cryo-tomography using faster-RCNN

    Article • BMC Bioinformatics, March 2019, Springer Science + Business Media

    Zachary Freyberg

  50. New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion

    Article • Molecular Psychiatry, January 2019, Springer Science + Business Media

    Zachary Freyberg

  51. Survey of the analysis of continuous conformational variability of biological macromolecules by electron microscopy

    Article • Acta Crystallographica Section F Structural Biology Communications, January 2019, International Union of Crystallography

    Zachary Freyberg

  52. Does the Time of Drug Administration Alter the Metabolic Risk of Aripiprazole?

    Article • Frontiers in Psychiatry, October 2018, Frontiers

    Zachary Freyberg

  53. The intertwined roles of circadian rhythmsand neuronal metabolism fueling drug reward and addiction

    Article • Current Opinion in Physiology, October 2018, Elsevier

    Zachary Freyberg

  54. Deep Learning Based Supervised Semantic Segmentation of Electron Cryo-Subtomograms

    Article • October 2018, Institute of Electrical & Electronics Engineers (IEEE)

    Zachary Freyberg

  55. Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

    Article • iScience, August 2018, Elsevier

    Zachary Freyberg

  56. Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion

    Article • Journal of Visualized Experiments, May 2018, MyJove Corporation

    Zachary Freyberg

  57. Isolation of mitochondria from Saccharomyces cerevisiae using magnetic bead affinity purification

    Article • PLOS One, April 2018, PLOS

    Zachary Freyberg

  58. Pathophysiology of drug induced weight and metabolic effects: findings from an RCT in healthy volunteers treated with olanzapine, iloperidone, or placebo

    Article • Journal of Psychopharmacology, February 2018, SAGE Publications

    Zachary Freyberg

  59. Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons

    Article • Journal of Clinical Investigation, January 2018, American Society for Clinical Investigation

    Zachary Freyberg

  60. Model Compression for Faster Structural Separation of Macromolecules Captured by Cellular Electron Cryo-Tomography

    Article • January 2018, Springer Science + Business Media

    Zachary Freyberg

  61. Distinguishing signal from autofluorescence in cryogenic correlated light and electron microscopy of mammalian cells

    Article • Journal of Structural Biology, January 2018, Elsevier

    Zachary Freyberg

  62. Pathogen manipulation of host metabolism: A common strategy for immune evasion

    Article • PLoS Pathogens, December 2017, PLOS

    Zachary Freyberg

  63. Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease

    Article • The EMBO Journal, October 2017, EMBO

    Zachary Freyberg

  64. Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT

    Article • Neuron, August 2017, Elsevier

    Zachary Freyberg

  65. Intrinsic and Antipsychotic Drug-Induced Metabolic Dysfunction in Schizophrenia

    Article • Frontiers in Neuroscience, July 2017, Frontiers

    Zachary Freyberg

  66. Neuropsychiatric Aspects of Infectious Diseases

    Article • Critical Care Clinics, July 2017, Elsevier

    Zachary Freyberg

  67. Dopamine D2 receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances

    Article • Schizophrenia, April 2017, Springer Science + Business Media

    Zachary Freyberg

  68. Distinguishing signal from autofluorescence in cryogenic correlated light and electron microscopy of mammalian cells

    Article • March 2017, Cold Spring Harbor Laboratory Press

    Zachary Freyberg

  69. Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

    Article • Nature Communications, February 2016, Springer Science + Business Media

    Zachary Freyberg

  70. Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence

    Article • PLOS One, February 2016, PLOS

    Zachary Freyberg

  71. Importance of Substrate-Coupled Proton Antiport by the Vesicular Monoamine Transporter in the Actions of Amphetamines in Drosophila Brain

    Article • Journal of Alcoholism and Drug Dependence, January 2016, OMICS Publishing Group

    Zachary Freyberg

  72. Molecular pathophysiology of metabolic effects of antipsychotic medications

    Article • Trends in Endocrinology and Metabolism, November 2014, Elsevier

    Zachary Freyberg

  73. The write stuff

    Article • Narrative Inquiry, October 2014, John Benjamins

    Zachary Freyberg

  74. Dopamine-Mediated Autocrine Inhibitory Circuit Regulating Human Insulin Secretion in Vitro

    Article • Molecular Endocrinology, October 2012, Endocrine Society

    Zachary Freyberg

  75. The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila

    Article • Molecular Psychiatry, June 2012, Springer Science + Business Media

    Zachary Freyberg

  76. Signaling pathways in schizophrenia: emerging targets and therapeutic strategies

    Article • Trends in Pharmacological Sciences, August 2010, Elsevier

    Zachary Freyberg

  77. Roles of the Akt/GSK-3 and Wnt Signaling Pathways in Schizophrenia and Antipsychotic Drug Action

    Article • American Journal of Psychiatry, April 2010, American Psychiatric Association

    Zachary Freyberg

  78. Structural Basis of Dopamine Receptor Activation

    Article • September 2009, Springer Science + Business Media

    Zachary Freyberg

  79. Neuropsychiatric Aspects of Infectious Diseases

    Article • Critical Care Clinics, October 2008, Elsevier

    Zachary Freyberg

  80. Treatment of depression in HIV positive individuals: A critical review

    Article • International Review of Psychiatry, January 2008, Taylor & Francis

    Zachary Freyberg

  81. 'Slip, sliding away': phospholipase D and the Golgi apparatus

    Article • Trends in Cell Biology, October 2003, Elsevier

    Zachary Freyberg

  82. Phospholipase D2 Is Localized to the Rims of the Golgi Apparatus in Mammalian Cells

    Article • Molecular Biology of the Cell, November 2002, American Society for Cell Biology (ASCB)

    Zachary Freyberg

  83. Intracellular Localization of Phospholipase D1 in Mammalian Cells

    Article • Molecular Biology of the Cell, April 2001, American Society for Cell Biology (ASCB)

    Zachary Freyberg

  84. Expression of Amphiphysin I, an Autoantigen of Paraneoplastic Neurological Syndromes, in Breast Cancer

    Article • World Journal of Surgery, January 1998, Springer Science + Business Media

    Zachary Freyberg

  85. Amphiphysin II (SH3P9; BIN1), a Member of the Amphiphysin/Rvs Family, Is Concentrated in the Cortical Cytomatrix of Axon Initial Segments and Nodes of Ranvier in Brain and around T Tubules in Skeletal Muscle

    Article • Journal of Cell Biology, June 1997, Rockefeller University Press

    Zachary Freyberg

  86. Imaging Protein Kinase C Activation in Living Sea Urchin Eggs after Fertilization

    Article • Developmental Biology, December 1995, Elsevier

    Zachary Freyberg

  87. A New Protein Kinase C, nPKCη′, and nPCKθ Are Expressed in Human Platelets: Involvement of nPKCη′ and nPKCθ in Signal Transduction Stimulated by PAF

    Article • Biochemical and Biophysical Research Communications, February 1993, Elsevier

    Zachary Freyberg