What is it about?
This study aims to isolate, identify, and characterize Streptomyces strains isolated from soil and extract their crude metabolites to determine their hidden therapeutic property. Out of four isolates identified, Streptomyces peucetius and Streptomyces lavendulae have shown significant antimicrobial activity against test organisms.
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Why is it important?
The ever-increasing fatality due to the surge of drug resistance has demanded the development of therapeutic metabolites with novel modes of mechanism. Despite the discovery of new antimicrobials, antibiotic resistance is increasing at an alarming rate. The emergence of novel molecules is necessary for targeting the Multidrug (MDR) and Pan-Drug resistant (PDR) pathogens which are the principal cause of life threatening infections. Streptomyces strains commonly found in the soil produce secondary metabolites which have outstanding potential for being an antifungal and antibacterial agent.
Perspectives
Given the swiftly diminishing arsenal of commercial drugs against major pathogens and steadily expanding drug resistance, the discovery and development of novel therapeutics are imperative, ideally naturally occurring ones with novel modes of action. New therapeutic drugs have entered the clinical field in recent years; however, they are accompanied by unpleasant negative effects. Thus, there is an exclusive demand for novel therapeutic medications to combat the Multi- and Pan-drug resistant pathogens that are the main cause of life-threatening illnesses. Soil, in particular, is a heavily exploited ecological niche. Streptomyces are among the most abundant microorganisms that can be found in soil and aquatic environments. They produce secondary metabolites that have a variety of potential bioactive properties, including antibiotic, antifungal, and antiviral activity against a variety of microorganisms.
Tisha Jain
Ludwig-Maximilians-Universitat Munchen
Read the Original
This page is a summary of: Streptomyces peucetius M1 and Streptomyces lavendulae M3 Soil Isolates as a Promising Source for Antimicrobials Discovery, Journal of Pharmaceutical Research International, September 2022, Sciencedomain International,
DOI: 10.9734/jpri/2022/v34i50b36438.
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