Serrated Polyps of the Colon and Rectum: Clinicopathological Features

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Why is it important?

The serrated neoplasia pathway, in which serrated polyps develop as colorectal cancer, has received a lot of interest in recent years as a new carcinogenic process. Hyperplastic polyps (HPs), sessile serrated lesions, and traditional serrated adenomas are histopathologically characterized colorectal serrated polyps; the latter two are considered premalignant in the serrated neoplasia pathway. Apart from diminutive rectosigmoid HPs, all colorectal polyps, including serrated polyps, are removed in Western countries. The treatment strategy for colorectal serrated polyps in Asian countries, on the other hand, has remained unestablished. Therefore, we detailed the clinicopathological aspects of colorectal serrated polyps in this review and recommended eliminating HPs and sessile serrated lesions ≥ 6 mm in size, as well as traditional serrated adenomas of any size.