Association of Circulating Vitamin D, VDBP, and Vitamin D Receptor Expression with Severity of Diabetic Nephropathy in a Group of Saudi Type 2 Diabetes Mellitus Patients

  • Manal Fawzy, Fatima Beladi
  • Clinical Laboratory, January 2018, Clinical Laboratory Publications
  • DOI: 10.7754/clin.lab.2018.180401

Expression of Circulating Vitamin D, VDBP, and Vitamin D Receptor in Diabetic Nephropathy patients

What is it about?

- Vitamin D receptor expression was elevated in normoalbuminuria group of type 2 diabetes patients compared to micro- and macroalbuminuria groups - Serum vitamin D binding protein (VDBP) levels were significantly elevated in all patient groups (i.e. normo-, micro, and macroalbuminuria) - Serum VDBP levels, HBA1c, and BMI could predict albuminuria in diabetic nephropathy patients studied.

Why is it important?

The study findings suggest a potential role of vitamin D metabolic players in diabetic nephropathy, with a special concern regarding serum VDPB as a putative predictor of DN severity in type 2 DM Saudi patients.

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The following have contributed to this page: Prof. Manal Said Fawzy