What is it about?
he present study evaluated the in vitro cytokine responses of cetacean peripheral blood mononuclear cells (cPBMCs) to 20 nm citrate-AgNPs (C-AgNP20) by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR).
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Why is it important?
Silver nanoparticles (AgNPs) have been widely used in many commercial products due to their excellent antibacterial ability. The AgNPs are released into the environment, gradually accumulate in the ocean, and may affect animals at high trophic levels, such as cetaceans and humans, via the food chain. Hence, the negative health impacts caused by AgNPs in cetaceans are of concern.
Perspectives
The present study has demonstrated: (1) the sublethal dose of C-AgNP20 to cPBMCs (≤1 µg/ml), (2) the time kinetics of mRNA expression levels of selected cytokines in cPBMCs, and (3) the inhibitory effect of C-AgNP20 (0.1 and 1 µg/ml) on the mRNA expression levels of selected cytokines of cPBMCs with evidence of Th2 cytokine bias. Taken together, C-AgNP20 may suppress the cellular immune response and thus inhibit the immunity against intracellular microorganisms in cetaceans.
Dr. Wen-Ta Li
Fishhead Labs LLC
Read the Original
This page is a summary of: Th2 cytokine bias induced by silver nanoparticles in peripheral blood mononuclear cells of common bottlenose dolphins (Tursiops truncatus), PeerJ, September 2018, PeerJ,
DOI: 10.7717/peerj.5432.
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