Crystal Structure Studies and Thermal Characterization of Novel 4-Hydroxychalcone Derivative

  • Chemical Science Transactions, June 2013, Chemical Science Transactions
  • DOI: 10.7598/cst2013.532

Interesting compound, and several derivatives were being explored...!

What is it about?

The derivatives of 4-hydroxychalcones were synthesized and characterized by infrared and 1H NMR spectral studies. The grown crystal was further characterized by single crystal x-ray diffraction studies. The crystal structure of (2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one was determined using single crystal x-ray diffraction. The compound crystallizes in orthorhombic crystal class in the space group P212121 with cell parameters a=5.3738(4) Å, b=12.9239(10) Å, c=17.1310(14) Å, Z=4 and V= 1189.76 Å3. The conjugated compound is slightly twisted with a dihedral angle of 25.00? between the benzene and hydroxyphenyl ring. Differential scanning calorimetric studies shows that the crystal is stable up to 186.C

Why is it important?

Option to prepare many derivatives makes this compound very interesting in the are of materials science.


Dr Subrahmanya Bhat K
Manipal Institute Of Technology, Manipal Academy of Higher Education

These compounds are intermediates in the synthesis of many derivatives. For example, one can convert hydroxy group to tosyl ester and than subject them nucleophilic substitution generating a library of compounds.

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The following have contributed to this page: Dr Subrahmanya Bhat K