CO2 binds directly opens connexin26 hemichannels

What is it about?

CO2 is the unavoidable product of metabolism. Its over-accumulation is dangerous as it makes blood more acidic. Even a small increase in the acidity of blood is fatal. The body must therefore detect and regulate CO2 –most believe this to be achieved by sensing changes in acidity. We now show a mechanism for direct detection of CO2 via the membrane channel connexin26 (Cx26). Cx26 channels are normally closed, but CO2 can bind to Cx26 and form intersubunit bridges which open the channel.

Featured Image

Why is it important?

Cx26 hemichannels are found throughout the human body. They provide a potential mechanism for CO2-mediated signalling that couples metabolic activity to physiological control, which has be so far overlooked. CO2-mediated signalling could contribute to many diverse processes such as the local and global control of blood flow and the regulation of breathing.