This shareable PDF can be hosted on any platform or network and is fully compliant with publisher copyright.
Figure 9. Schematic representation of YAP and NOTCH signaling pathways in normal contracting muscles and paralyzed muscles.
- (A) In contracting muscles, nuclear YAP (green myonuclei) and YAP target gene transcripts (green) are present in post-mitotic muscle fibers. YAP positively regulatesJAG2transcription upon muscle contraction. Ligand-dependent NOTCH activation regulates the muscle progenitor pool, by preventing muscle progenitors to differentiate. (B) In paralyzed muscles, nuclear YAP, YAP target genes andJAG2transcripts are lost in post-mitotic muscle fibers. The absence of the NOTCH ligand JAG2 in fibers, due to the loss of mechanical signals, induces a NOTCH loss-of-function phenotype i.e. a diminution in the number of muscle progenitors and a shift toward differentiation, in a non-cell autonomous manner.
- eLife
- DOI: 10.7554/elife.15593.017