Pyrimidinethione derivatives with tosyl substitution: Synthesis, and antimicrobial property investigation

  • Shubhalaxmi Shubhalaxmi, B. Manjunatha, K. Ananda, K. Bhat
  • Journal of Applied Pharmaceutical Science, January 2016, Journal of Applied Pharmaceutical Science
  • DOI: 10.7324/japs.2016.60613

Pyrimidine derivatives with tosyl substitution....!

What is it about?

Substitution of tosyl group on hydroxyacetophenones orhydroxybenzaldehyde and their subsequent condensation yielded several tosyloxy substituted chalcones which were derivatized to obtain the corresponding pyrimidinethione derivatives. The synthesized compounds were characterized by spectroscopic techniques like FT-IR, 1H NMR, 13C NMR, and mass spectrometry. These compounds were subjected to initial screening for their bioactivity using zone of inhibition method and were found moderately active against the tested microorganisms, viz. Mycobacterium smegmatis, Staphylococcus aureus, Escherichia coli, and Candida albicans.

Why is it important?

These compounds are easy to synthesize in good yield and purity. Moreover, one can derivatize them by nucleophilic displacement of tosyl group.


Dr Subrahmanya Bhat K
Manipal Institute Of Technology, Manipal Academy of Higher Education

These compounds doesn't possess significant antimicrobial activity but gives scope to prepare other derivatives of which the work is in progress.

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The following have contributed to this page: Dr Subrahmanya Bhat K