Synthesis of a series of pyrazoline derivatives carrying tosyl substitution and evaluation of their antimicrobial properties

  • Shubhalaxmi Shubhalaxmi, B. Manjunatha, K. Ananda, K. Bhat
  • Journal of Applied Pharmaceutical Science, January 2016, Journal of Applied Pharmaceutical Science
  • DOI: 10.7324/japs.2016.601133

Synthesis of a series of pyrazoline derivatives carrying tosyl substitution...

What is it about?

A series of pyrazoline derivatives with tosyloxy substitution were synthesized and characterized. They were evaluated for antimicrobial potential against Mycobacterium smegmatis, gram positive Staphylococcus aureus, gram negative Escherichia coli, and a fungi Candida albicans. The initial screening using zones of inhibition at 50µL concentrations revealed that they are moderately active against the tested strains, and therefore further studies have not been carried out.

Why is it important?

Large number of derivatives could be synthesized from these compounds.

Read Publication

http://dx.doi.org/10.7324/japs.2016.601133

The following have contributed to this page: Dr Subrahmanya Bhat K