What is it about?
Somatic mutations of the PIK3CA, CASP8, and NOTCH1 have been frequently detected in various human cancers. Our study aimed to analyze the mutational status of these genes in South Indian oral cancers
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Why is it important?
Our study suggests that either mutation in these genes are uncommon inSouth Indian oral cancer samples or likely other genes in this pathway might be mutated.
Perspectives
The present results suggested that the mutation in the PIK3CA, CASP8, and NOTCH1 genes may be rare in South Indian population or the mutation may also have been harbored in the outside of the analyzed region. It would also possible that other genes of the same pathway may have also genetically deregulated. In oral cancer, many genes are shown to be less frequently mutated in Asian population compared with Caucasian population as the factors such as tumor heterogeneity, ethnicity variation, genome stability, and the range of other associated risk factors could influence the population in different ways, but this requires further verification in large sample size.
Dr ArunKumar Ganesan
Read the Original
This page is a summary of: Absence of the TP53 Poly-A Signal Sequence Variant rs78378222 in Oral, Cervical and Breast Cancers in South India, Asian Pacific Journal of Cancer Prevention, November 2014, Asian Pacific Organization for Cancer Prevention,
DOI: 10.7314/apjcp.2014.15.21.9555.
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