What is it about?
This paper shows that we can improve the in vivo brain delivery of peptides and a protein using BBB modulatory peptides. The depositions of delivered molecules in the brains were detected using various methods, including magnetic resonance imaging (MRI), near IR fluorescence (NIRF), and mass spectrometry (MS).
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Why is it important?
This is important because previously the delivery of peptides and proteins into the brain is very difficult. This work will open many opportunities to deliver peptides and proteins to the brain as therapeutic and diagnostic agents for brain diseases.
Perspectives
This method can also be used to improve our understanding of how brain works by delivering probe or signaling molecules that can trigger biological events in the brain in cellular and molecular levels.
Professor Teruna J Siahaan
University of Kansas
Read the Original
This page is a summary of: Improving Brain Delivery of Biomolecules via BBB Modulation in Mouse and Rat: Detection using MRI, NIRF, and Mass Spectrometry, Nanotheranostics, January 2017, Ivyspring International Publisher,
DOI: 10.7150/ntno.19158.
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