What is it about?
The reduced function of Treg cells in vitamin D deficiency is well documented. The transition from Th1 to type I Treg cells and increased IL-10 production are disrupted. Astier Aetal. 2025 confirm that this dysregulation can be corrected by vitamin D.
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Why is it important?
The complex effects of calcitriol on the course of MS through its influence on disrupted immune homeostasis, as well as fatigue, cognition, depression, anxiety, bone mineralization, pregnancy, gut microbiome, and infections (SARS-CoV-2, Long COVID-19), are the decisive criterion for daily, high-dose vitamin D supplementation, aiming to achieve 25(OH)D serum levels of 50 ng/ml. The individual response is crucial, especially in cases of obesity. Vitamin D intoxication can be easily prevented by determining serum calcium, phosphate, 25(OH)D, and, if necessary, by determining parathyroid hormone in special cases.
Perspectives
Immune dysregulation in MS begins years to decades before clinical manifestation. This has been demonstrated by elevated levels of the neurofilament light chain biomarker years before MS diagnosis. Therefore, early vitamin D supplementation is crucial. The fact that regulatory T cells (Tregs), with their primary function of suppressing autoimmunity in general, are extremely important and must be a therapeutic target is evidenced by the awarding of the 2025 Nobel Prize. Vitamin D contributes to this.
Hans-Klaus Goischke
Read the Original
This page is a summary of: Early Vitamin D Supplementation in Multiple Sclerosis: A Crucial Preventive Approach in 2025, Neurology and Neurological Research, February 2025, ScienceHood LLC,
DOI: 10.64585/3065-0097-2-1-15.
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