What is it about?
Upon dysfunction of the Endoplasmic Reticulum (ER), eukaryotic cells provoke a gene expression program, namely, the Unfolded Protein Response (UPR), leading to an increase in the size and function of the ER. In the yeast Saccharomyces cerevisiae, the UPR is modulated by the Hac1i protein, which is a transcription factor produced by ER stress.
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Why is it important?
When the UPR is artificially triggered under non-stress conditions by artificial expression of the Hac1i protein, S. cerevisiae cells carry an enforced and enlarged ER, which allows us to obtain commercially valuable materials such as secretory proteins and functional lipids abundantly.
Perspectives
Owing to their rapid and cost-effective growth characteristics, various species of yeast are frequently employed as platforms for the production of commercially valuable substances. Saccharomyces cerevisiae, also known as baker’s yeast, is used not only for ethanol fermentation but also for basic and applied molecular biology, partly because a large number of genetic engineering techniques have been developed for this organism.
Richard (Ricky) Smith Jr.
Read the Original
This page is a summary of: Enforcement and Enlargement of the Saccharomyces cerevisiae Endoplasmic Reticulum through Artificial Evocation of the Unfolded Protein Response, IgMin Research, January 2024, IgMin Publications Inc.,
DOI: 10.61927/igmin142.
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