What is it about?
We searched the chemical structure of sterubin in PubChem and conducted ADMET analysis with pkCSM software. To identify probable target genes by using BindingDB Database. We used DAVID tools for GO and KEGG pathway enrichment analysis. We also obtained the protein interaction network using STRING database and visualized it using Cytoscape. Molecular docking was performed with sterubin and target proteins.
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Why is it important?
Sterubin has good biological activity and drug utilization, according to our findings. A total of 32 target genes were discovered. Bioinformatics and network analysis were used, allowing the discovery that these target genes are linked to metabolic and cancer pathways, lipid, atherosclerosis, chemical carcinogenesis-receptor activation, and Alzheimer's disease are the most enriched pathways. Previous studies also reported about sterubin exhibits superior neuroprotective, anti-inflammatory, and antioxidant activities. It was also evaluated in a rat model of chemical-induced cognitive impairment, and the results showed a significant decrease in oxidative stress and inflammatory markers, and improved behavioral studies
Perspectives
We investigated the potential mechanism of action of sterubin, which could be used to develop more potent anti-Alzheimer, anti-inflammatory, and anticancer drugs. Our findings offer a new perspective on the research, development, and therapeutic application of sterubin.
MR SITTARHTHAN VISWANATHAN
Mother Theresa Post Graduate and Research Institute of Health Sciences
Read the Original
This page is a summary of: Insights from molecular network analysis to docking of sterubin with potential targets, Bioinformation, December 2023, Biomedical Informatics,
DOI: 10.6026/973206300191184.
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